(Circulation. 1997;96:3570-3578.)
© 1997 American Heart Association, Inc.
Articles |
Cardiovascular Phenotype of a Mouse Strain With Disruption of Bradykinin B2-Receptor Gene
From Clinica Medica (P.M., N.G.) and Farmacologia (M.V.V., D.P., M.P.D., V.A.), University of Sassari (Italy); the National Institute of Biostructures and Biosystems (P.M.), Osilo, Italy; Farmacologia (C.E.), University of Ferrara (Italy); and Institute of Medicina Clinica (P.D.-F., R.S.), University of Ancona (Italy).
Correspondence to Paolo Madeddu, MD, Clinica Medica, University of Sassari, Viale S Pietro 8, 07100 Sassari, Italy. E-mail madeddu{at}ssmain.uniss.it
Background To evaluate the role of kinins in the regulation of cardiovascular function, we studied the phenotype of a mouse strain with disruption of the bradykinin B2-receptor gene (Bk 2r-/-).
Methods and Results Under basal conditions, tail-cuff blood pressure was higher in Bk2r-/- than in wild-type Bk2r+/+ and heterozygous Bk2r+/- mice (124±1 versus 109±1 and 111±2 mm Hg, respectively; P<.01 for both comparisons), a difference that was confirmed by measurements of intra-arterial blood pressure in unanesthetized mice. Heart weight was greater in Bk2r-/- than in Bk2r+/+ and Bk2r+/- mice (505±10 versus 449±12 and 477±10 mg/100 g body wt, P<.05). Chronic blockade of B2-receptors by Icatibant (50 nmol/100 g body wt twice a day SC) or inhibition of nitric oxide synthase by nitro-L-arginine-methyl ester (0.14 mmol/100 g body wt orally) increased the blood pressure of Bk2r+/+ to the levels of Bk2r-/- mice. Compared with the wild-type strain, both Bk2r-/- and Bk2r+/- mice showed exaggerated vasopressor responses to angiotensin II. In addition, chronic administration of an angiotensin AT1-receptor antagonist reduced the basal blood pressure of Bk2r-/- by 21±3 mm Hg (P<.05) to the levels of Bk2r+/+. No difference was detected between strains as far as plasma renin activity and the expression of renin and AT1-receptor genes are concerned. Chronic salt loading (0.84 mmol/g chow for 15 days) increased the blood pressure of Bk2r-/- and Bk2r+/- by 34±3 and 14±6 mm Hg, respectively, whereas it was ineffective in Bk2r+/+.
Conclusions Our results suggest that a normally functioning B2-receptor is essential for the maintenance of cardiovascular homeostasis in mice. Dysfunction of the kallikrein-kinin system could contribute to increase blood pressure levels by leaving the activity of vasoconstrictor agents unbalanced.
Key Words: kinins • bradykinin • receptors • genes
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|
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|
|
|
|
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|
|
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|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
C. Emanueli, M. B. Salis, J. Chao, L. Chao, J. Agata, K.-F. Lin, A. Munao, S. Straino, A. Minasi, M. C. Capogrossi, et al. Adenovirus-Mediated Human Tissue Kallikrein Gene Delivery Inhibits Neointima Formation Induced by Interruption of Blood Flow in Mice Arterioscler Thromb Vasc Biol, June 1, 2000; 20(6): 1459 - 1466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
L. J. Dell’Italia and S. Oparil Bradykinin in the Heart : Friend Or Foe? Circulation, December 7, 1999; 100(23): 2305 - 2307. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
N. TAKAHASHI and O. SMITHIES Gene Targeting Approaches to Analyzing Hypertension J. Am. Soc. Nephrol., July 1, 1999; 10(7): 1598 - 1605. [Abstract] [Full Text]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 W. C. Wolf, R. A. Harley, D. Sluce, L. Chao, and J. Chao Localization and Expression of Tissue Kallikrein and Kallistatin in Human Blood Vessels J. Histochem. Cytochem., February 1, 1999; 47(2): 221 - 228. [Abstract] [Full Text]
|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
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