(Circulation. 1997;96:44-49.)
© 1997 American Heart Association, Inc.
Articles |
Intermittent Claudication
A Risk Profile From The Framingham Heart Study
From the Framingham Heart Study (J.M.M., R.B.D., H.S., P.W.F.W.) Framingham, Mass; Section of Preventive Medicine and Epidemiology (J.M.M.) and Section of General Internal Medicine (J.M.M.) of Boston University School of Medicine, Boston, Mass; Division of Epidemiology and Clinical Applications of the National Heart, Lung, and Blood Institute (P.W.F.W.), Bethesda, Md; and the Department of Mathematics of Boston University (R.B.D., H.S.), Boston, Mass.
Correspondence to Dr Joanne Murabito, Framingham Heart Study, 5 Thurber St, Framingham, MA 01701. E-mail joanne{at}fram.nhlbi.nih.gov
Background Intermittent claudication identifies persons at increased risk for death and disability.
Methods and Results Using 38-year follow-up data for the original cohort in the Framingham Heart Study, we developed an intermittent claudication risk profile. Intermittent claudication occurred in a total of 381 men and women. Age, sex, serum cholesterol, hypertension, cigarette smoking, diabetes, and coronary heart disease were associated with an increased risk for claudication and were included in the profile. A pooled logistic regression model was used to compute the probability of intermittent claudication for specified levels of risk factors.
Conclusions The intermittent claudication risk profile allows physicians to identify high-risk individuals during a routine office visit and can be used to educate patients about modifiable risk factors, particularly smoking and blood pressure. Improved compliance with risk factor modification strategies may result in a beneficial impact on survival.
Key Words: claudication • hypertension • risk factors • smoking
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