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(Circulation. 1996;94:3123-3129.)
© 1996 American Heart Association, Inc.
Articles |
Depression, Psychotropic Medication, and Risk of Myocardial Infarction
Prospective Data From the Baltimore ECA Follow-up
the Department of Epidemiology (L.A.P., D.E.F., R.M.C., H.K.A.) and the Department of Mental Hygiene (R.M.C., J.J.G., W.W.E.), Johns Hopkins School of Hygiene and Public Health; and the Department of Psychiatry (R.M.C.) and the Department of Medicine (D.E.F.), Johns Hopkins School of Medicine, Baltimore, Md.
Correspondence to Laura A. Pratt, Johns Hopkins University, School of Hygiene and Public Health, 615 N Wolfe St, Box 188, Baltimore, MD 21205. E-mail lpratt@welchlink.welch.jhu.edu.
Background There is suggestive evidence that depression increases risk of myocardial infarction (MI), but there are no prospective studies in which the measure of depression corresponds to clinical criteria. This study examines prospectively whether a major depressive episode increases the risk of incident MI and evaluates the role of psychotropic medication use in this relationship.
Methods and Results The study is based on a follow-up of the Baltimore cohort of the Epidemiologic Catchment Area Study, a survey of psychiatric disorders in the general population. A history of major depressive episode, dysphoria (2 weeks of sadness), and psychotropic medication use were assessed in 1981, and self-reported MI was assessed in 1994. Sixty-four MIs were reported among 1551 respondents free of heart trouble in 1981. Compared with respondents with no history of dysphoria, the odds ratio for MI associated with a history of dysphoria was 2.07 (95% CI, 1.16 to 3.71), and the odds ratio associated with a history of major depressive episode was 4.54 (95% CI, 1.65 to 12.44), independent of coronary risk factors. In multivariate models, use of barbiturates, meprobamates, phenothiazines, and lithium was associated with an increased risk of MI, whereas use of tricyclic antidepressants and benzodiazepines was not. Among individuals with no history of dysphoria, only lithium use was significantly associated with MI.
Conclusions These data suggest that a history of dysphoria and a major depressive episode increase the risk of MI. The association between psychotropic medication use and MI is probably a reflection of the primary relationship between depression and MI.
Key Words: drugs • myocardial infarction • risk factors • depression
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D. E. Ford, L. A. Mead, P. P. Chang, L. Cooper-Patrick, N.-Y. Wang, and M. J. Klag Depression Is a Risk Factor for Coronary Artery Disease in Men: The Precursors Study Arch Intern Med, July 13, 1998; 158(13): 1422 - 1426. [Abstract] [Full Text]
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D. L. Musselman, D. L. Evans, and C. B. Nemeroff The Relationship of Depression to Cardiovascular Disease: Epidemiology, Biology, and Treatment Arch Gen Psychiatry, July 1, 1998; 55(7): 580 - 592. [Abstract] [Full Text] [PDF]
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F. C. Notzon, Y. M. Komarov, S. P. Ermakov, C. T. Sempos, J. S. Marks, and E. V. Sempos Causes of Declining Life Expectancy in Russia JAMA, March 11, 1998; 279(10): 793 - 800. [Abstract] [Full Text] [PDF]
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A. H. Glassman and P. A. Shapiro Depression and the Course of Coronary Artery Disease Am J Psychiatry, January 1, 1998; 155(1): 4 - 11. [Abstract] [Full Text]
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P. M. Marzuk and J. D. Barchas Psychiatry JAMA, June 18, 1997; 277(23): 1892 - 1894. [PDF]
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 Major Depression May Increase MI Risk Journal Watch Psychiatry, March 1, 1997; 1997(301): 17 - 17. [Full Text]
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 MAJOR DEPRESSION ASSOCIATED WITH INCREASED MI RISK Journal Watch (General), January 17, 1997; 1997(117): 2 - 2. [Full Text]
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