(Circulation. 1996;94:2856-2864.)
© 1996 American Heart Association, Inc.
Articles |
Mechanism of Ventricular Rate Control After Radiofrequency Modification of Atrioventricular Conduction in Patients With Atrial Fibrillation
the Department of Medicine, Division of Cardiology, The New York Hospital–Cornell University Medical Center, New York, NY.
Correspondence to Bruce B. Lerman, MD, Division of Cardiology, New York Hospital–Cornell Medical Center, 525 E 68th St, Starr Pavilion, 4th Floor, New York, NY 10021. E-mail blerman@mail.med.cornell.edu.
Background Modification of atrioventricular (AV) conduction during atrial fibrillation (AF) may be achieved by radiofrequency ablation in the posteroseptal region of the tricuspid annulus. We tested the hypothesis that elimination of the posterior atrionodal input rather than direct damage to the compact AV node accounts for the decrease in ventricular rate after AV nodal modification.
Methods and Results Twenty-four patients with the typical form of AV nodal reentrant tachycardia (AVNRT) underwent selective radiofrequency ablation of the slow AV nodal pathway in the posteroseptal tricuspid annulus. AF was induced before ablation (phase 1), 30 minutes after ablation (phase 2), and during follow-up 24 hours after ablation (phase 3), both with and without concurrent infusion of isoproterenol (4 µg/min). Successful elimination of AVNRT was achieved in all patients. During phase 3, 11 patients (46%) had residual dual pathway physiology. AV nodal Wenckebach cycle length (AVNW-CL) increased progressively during each phase of the protocol (356±72 versus 371±78 ms versus 432±104 ms, P<.0001), as did the effective refractory period of the AV node (279±60 versus 304±67 ms versus 372±56 ms, P<.0001). Minimal, mean, and maximal RR intervals during AF progressively increased immediately after ablation and 24 hours later (485±88 versus 533±116 ms versus 637±142 ms for mean RR, P<.0001). The changes in AVNW-CL, AV nodal effective refractory period, and ventricular response during AF were independent of residual dual pathway physiology after ablation. Similar observations were observed during isoproterenol infusion.
Conclusions Modification of AV nodal conduction during AF by radiofrequency ablation in the posteroseptal tricuspid annulus is independent of the presence or absence of a residual slow AV nodal pathway. On the basis of these observations, the mechanism of AV nodal modification is consistent with elimination of the posterior atrionodal input.
Key Words: atrioventricular node • catheter ablation • fibrillation • tachycardia
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