(Circulation. 1996;94:19-25.)
© 1996 American Heart Association, Inc.
Articles |
Modulation of Oxidant Stress In Vivo in Chronic Cigarette Smokers
Presented in part at the annual meeting of the American Society for Clinical Investigation, Washington, DC, May 1994, and at the Ninth International Conference on Prostaglandins and Related Compounds, Florence, Italy, August 1994.
From the Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia.
Background Free radical–induced oxidative damage
is thought to be involved in the pathogenesis of diseases associated
with cigarette smoking. We examined the production of
8-epi-prostaglandin (PG)
F2
, a stable product of lipid
peroxidation in vivo, and its modulation by aspirin and antioxidant
vitamins in chronic cigarette smokers.
Methods and Results We performed the following studies: (1)
a cross-sectional comparison of smokers and control subjects, (2)
an examination of the dose-response relationship, (3) an
exploration of the effect of smoking cessation (3 weeks) and
nicotine patch supplementation, (4) the effect of aspirin
consumption, and (5) the effects of 5 days' dosing with vitamin E (100
and 800 U), vitamin C (2 g), and their combination.
8-epi-PGF2 excretion (in
pmol/mmol, mean±SEM) was 176.5±30.6 in heavy smokers, 92.7±4.8
(P<.05) in moderate smokers, and 54.1±2.7
(P<.005) in nonsmokers. Urinary levels fell from
145.5±24.9 to 114.6±27.1 (week 2, P<.05) and 112.6±24.9
(week 3, P<.05) on cessation of smoking. Aspirin treatment
failed to suppress urinary levels of
8-epi-PGF2 despite a significant
reduction in urinary 11-dehydro-TxB2 production and
suppression of 8-epi-PGF2 and
TxB2 in serum. Vitamin C (pre, 194.6±40.9; post,
137.2±34.1; P<.05) and a combination of vitamin C and E
(pre, 171.0±39.8; post, 133.5±29.6; P<.05) suppressed
urinary 8-epi-PGF2,
whereas vitamin E alone had no effect.
Conclusions Urinary
8-epi-PGF2 may represent
a noninvasive, quantitative index of oxidant stress in vivo. Elevated
levels of 8-epi-PGF2 in smokers
may be modulated by quitting cigarettes and switching to nicotine
patches or by antioxidant vitamin therapy.
Key Words: smoking • prostaglandins • free radicals • isoprostanes • 8-epi-PGF2
This article has been cited by other articles:
 |
|
 |
|
  D. Janicki-Deverts, S. Cohen, K. A. Matthews, M. D. Gross, and D. R. Jacobs Jr Socioeconomic Status, Antioxidant Micronutrients, and Correlates of Oxidative Damage: The Coronary Artery Risk Development in Young Adults (CARDIA) Study Psychosom Med, June 1, 2009; 71(5): 541 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gariballa and S. Forster Effects of Smoking on Nutrition Status and Response to Dietary Supplements During Acute Illness Nutr Clin Pract, February 1, 2009; 24(1): 84 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lin, N. R. Cook, C. Albert, E. Zaharris, J. M. Gaziano, M. Van Denburgh, J. E. Buring, and J. E. Manson Vitamins C and E and Beta Carotene Supplementation and Cancer Risk: A Randomized Controlled Trial J Natl Cancer Inst, January 7, 2009; 101(1): 14 - 23. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Pawlosky, J. R. Hibbeln, D. Herion, D. E. Kleiner, and N. Salem Jr. Compartmental analysis of plasma and liver n-3 essential fatty acids in alcohol-dependent men during withdrawal J. Lipid Res., January 1, 2009; 50(1): 154 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Parastatidis, L. Thomson, A. Burke, I. Chernysh, C. Nagaswami, J. Visser, S. Stamer, D. C. Liebler, G. Koliakos, H. F. G. Heijnen, et al. Fibrinogen {beta}-Chain Tyrosine Nitration Is a Prothrombotic Risk Factor J. Biol. Chem., December 5, 2008; 283(49): 33846 - 33853. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Y. Gasparyan, T. Watson, and G. Y.H. Lip The Role of Aspirin in Cardiovascular Prevention: Implications of Aspirin Resistance J. Am. Coll. Cardiol., May 13, 2008; 51(19): 1829 - 1843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Agostoni, E Riva, M Giovannini, F Pinto, C Colombo, P Rise, C Galli, and F Marangoni Maternal smoking habits are associated with differences in infants' long-chain polyunsaturated fatty acids in whole blood: a case-control study Arch. Dis. Child., May 1, 2008; 93(5): 414 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ky, A. Burke, S. Tsimikas, M. L. Wolfe, M. G. Tadesse, P. O. Szapary, J. L. Witztum, G. A. FitzGerald, and D. J. Rader The Influence of Pravastatin and Atorvastatin on Markers of Oxidative Stress in Hypercholesterolemic Humans J. Am. Coll. Cardiol., April 29, 2008; 51(17): 1653 - 1662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Tomey, M. R. Sowers, X. Li, D. S. McConnell, S. Crawford, E. B. Gold, B. Lasley, and J. F. Randolph Jr Dietary Fat Subgroups, Zinc, and Vegetable Components Are Related to Urine F2a-Isoprostane Concentration, a Measure of Oxidative Stress, in Midlife Women J. Nutr., November 1, 2007; 137(11): 2412 - 2419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Wu, W. C. Willett, N. Rifai, and E. B. Rimm Plasma Fluorescent Oxidation Products as Potential Markers of Oxidative Stress for Epidemiologic Studies Am. J. Epidemiol., September 1, 2007; 166(5): 552 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Yan, G. D. Byrd, and M. W. Ogden Quantitation of isoprostane isomers in human urine from smokers and nonsmokers by LC-MS/MS J. Lipid Res., July 1, 2007; 48(7): 1607 - 1617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yang, C. B. Ambrosone, C.-C. Hong, J. Ahn, C. Rodriguez, M. J. Thun, and E. E. Calle Relationships between polymorphisms in NOS3 and MPO genes, cigarette smoking and risk of post-menopausal breast cancer Carcinogenesis, June 1, 2007; 28(6): 1247 - 1253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Yanbaeva, M. A. Dentener, E. C. Creutzberg, G. Wesseling, and E. F. M. Wouters Systemic Effects of Smoking Chest, May 1, 2007; 131(5): 1557 - 1566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Pawlosky, J. R. Hibbeln, and N. Salem Jr. Compartmental analyses of plasma n-3 essential fatty acids among male and female smokers and nonsmokers J. Lipid Res., April 1, 2007; 48(4): 935 - 943. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. S. Waring, J. A. McKnight, D. J. Webb, and S. R.J. Maxwell Uric Acid Restores Endothelial Function in Patients With Type 1 Diabetes and Regular Smokers Diabetes, November 1, 2006; 55(11): 3127 - 3132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Rossner Jr., M. D. Gammon, M. B. Terry, M. Agrawal, F. F. Zhang, S. L. Teitelbaum, S. M. Eng, M. M. Gaudet, A. I. Neugut, and R. M. Santella Relationship between Urinary 15-F2t-Isoprostane and 8-Oxodeoxyguanosine Levels and Breast Cancer Risk. Cancer Epidemiol. Biomarkers Prev., April 1, 2006; 15(4): 639 - 644. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Cavalca, E. Sisillo, F. Veglia, E. Tremoli, G. Cighetti, L. Salvi, A. Sola, L. Mussoni, P. Biglioli, G. Folco, et al. Isoprostanes and Oxidative Stress in Off-Pump and On-Pump Coronary Bypass Surgery Ann. Thorac. Surg., February 1, 2006; 81(2): 562 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. S. Perlstein and R. T. Lee Smoking, Metalloproteinases, and Vascular Disease Arterioscler Thromb Vasc Biol, February 1, 2006; 26(2): 250 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Hirano-Ohmori, R. Takahashi, Y. Momiyama, H. Taniguchi, A. Yonemura, S. Tamai, K. Umegaki, H. Nakamura, K. Kondo, and F. Ohsuzu Green Tea Consumption and Serum Malondialdehyde-Modified LDL Concentrations in Healthy Subjects J. Am. Coll. Nutr., October 1, 2005; 24(5): 342 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Santus, A. Sola, P. Carlucci, F. Fumagalli, A. Di Gennaro, M. Mondoni, C. Carnini, S. Centanni, and A. Sala Lipid Peroxidation and 5-Lipoxygenase Activity in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., April 15, 2005; 171(8): 838 - 843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. G. Young, C. A. Knight, K. C. Vickers, D. Westbrook, N. R. Madamanchi, M. S. Runge, H. Ischiropoulos, and S. W. Ballinger Differential effects of exercise on aortic mitochondria Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1683 - H1689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sanderson, J. Emery, T. Baglin, and A.-L. Kinmonth Narrative Review: Aspirin Resistance and Its Clinical Implications Ann Intern Med, March 1, 2005; 142(5): 370 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Morita, H. Ikeda, N. Haramaki, H. Eguchi, and T. Imaizumi Only two-week smoking cessation improves platelet aggregability and intraplatelet redox imbalance of long-term smokers J. Am. Coll. Cardiol., February 15, 2005; 45(4): 589 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Morrow Quantification of Isoprostanes as Indices of Oxidant Stress and the Risk of Atherosclerosis in Humans Arterioscler Thromb Vasc Biol, February 1, 2005; 25(2): 279 - 286. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S Bruno, R. Ramakrishnan, T. J Montine, T. M Bray, and M. G Traber {alpha}-Tocopherol disappearance is faster in cigarette smokers and is inversely related to their ascorbic acid status Am. J. Clinical Nutrition, January 1, 2005; 81(1): 95 - 103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Davi, M. Neri, A. Falco, D. Festi, T. Taraborelli, G. Ciabattoni, S. Basili, F. Cuccurullo, and C. Patrono Helicobacter Pylori Infection Causes Persistent Platelet Activation In Vivo Through Enhanced Lipid Peroxidation Arterioscler Thromb Vasc Biol, January 1, 2005; 25(1): 246 - 251. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. MONTUSCHI, P. J. BARNES, and L. J. ROBERTS II Isoprostanes: markers and mediators of oxidative stress FASEB J, December 1, 2004; 18(15): 1791 - 1800. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Kojda Direct vasoprotection by aspirin: a significant bonus to antiplatelet activity? Cardiovasc Res, November 1, 2004; 64(2): 192 - 194. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Sanchez-Moreno, J. F. Dashe, T. Scott, D. Thaler, M. F. Folstein, and A. Martin Decreased Levels of Plasma Vitamin C and Increased Concentrations of Inflammatory and Oxidative Stress Markers After Stroke Stroke, January 1, 2004; 35(1): 163 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E Upritchard, C. R. Schuurman, A. Wiersma, L. B. Tijburg, S. A. Coolen, P. J Rijken, and S. A Wiseman Spread supplemented with moderate doses of vitamin E and carotenoids reduces lipid peroxidation in healthy, nonsmoking adults Am. J. Clinical Nutrition, November 1, 2003; 78(5): 985 - 992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Griendling and G. A. FitzGerald Oxidative Stress and Cardiovascular Injury: Part II: Animal and Human Studies Circulation, October 28, 2003; 108(17): 2034 - 2040. [Full Text] [PDF]
|
|
|
|
|
|
C. Sanchez-Moreno, M P. Cano, B. de Ancos, L. Plaza, B. Olmedilla, F. Granado, and A. Martin Effect of orange juice intake on vitamin C concentrations and biomarkers of antioxidant status in humans Am. J. Clinical Nutrition, September 1, 2003; 78(3): 454 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. R. Hackett, A. Heguy, B.-G. Harvey, T. P. O'Connor, K. Luettich, D. B. Flieder, R. Kaplan, and R. G. Crystal Variability of Antioxidant-Related Gene Expression in the Airway Epithelium of Cigarette Smokers Am. J. Respir. Cell Mol. Biol., September 1, 2003; 29(3): 331 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Sanchez-Moreno, M. P. Cano, B. de Ancos, L. Plaza, B. Olmedilla, F. Granado, and A. Martin High-Pressurized Orange Juice Consumption Affects Plasma Vitamin C, Antioxidative Status and Inflammatory Markers in Healthy Humans J. Nutr., July 1, 2003; 133(7): 2204 - 2209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Chabrashvili, C. Kitiyakara, J. Blau, A. Karber, S. Aslam, W. J. Welch, and C. S. Wilcox Effects of ANG II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expression Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2003; 285(1): R117 - R124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Davi, F. Chiarelli, F. Santilli, M. Pomilio, S. Vigneri, A. Falco, S. Basili, G. Ciabattoni, and C. Patrono Enhanced Lipid Peroxidation and Platelet Activation in the Early Phase of Type 1 Diabetes Mellitus: Role of Interleukin-6 and Disease Duration Circulation, July 1, 2003; 107(25): 3199 - 3203. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Meghdadi, M. Rodrigues, A. Oguogho, R. Santler, and H. Sinzinger 8-epi-PGF 2{alpha} and 6-oxo-PGF{alpha} in Human (Varicose) Veins: Influence of Age, Sex, and Risk Factors Angiology, May 1, 2003; 54(3): 317 - 324. [Abstract] [PDF]
|
|
|
|
|
|
J. V. Higdon and B. Frei Obesity and Oxidative Stress: A Direct Link to CVD? Arterioscler Thromb Vasc Biol, March 1, 2003; 23(3): 365 - 367. [Full Text] [PDF]
|
|
|
|
|
|
R. A. Jacob, G. M. Aiello, C. B. Stephensen, J. B. Blumberg, P. E. Milbury, L. M. Wallock, and B. N. Ames Moderate Antioxidant Supplementation Has No Effect on Biomarkers of Oxidant Damage in Healthy Men with Low Fruit and Vegetable Intakes J. Nutr., March 1, 2003; 133(3): 740 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. Mayne Antioxidant Nutrients and Chronic Disease: Use of Biomarkers of Exposure and Oxidative Stress Status in Epidemiologic Research J. Nutr., March 1, 2003; 133(3): 933S - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Padayatty, A. Katz, Y. Wang, P. Eck, O. Kwon, J.-H. Lee, S. Chen, C. Corpe, A. Dutta, S. K Dutta, et al. Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention J. Am. Coll. Nutr., February 1, 2003; 22(1): 18 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G Wood, D. A Fitzgerald, A. K Lee, and M. L Garg Improved antioxidant and fatty acid status of patients with cystic fibrosis after antioxidant supplementation is linked to improved lung function Am. J. Clinical Nutrition, January 1, 2003; 77(1): 150 - 159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Yan, D. Kim, T. Aizawa, and B. C. Berk Functional Interplay Between Angiotensin II and Nitric Oxide: Cyclic GMP as a Key Mediator Arterioscler Thromb Vasc Biol, January 1, 2003; 23(1): 26 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Morrow and L. J. Roberts The Isoprostanes: Their Role as an Index of Oxidant Stress Status in Human Pulmonary Disease Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): S25 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. De Caterina, F. Cipollone, F. P. Filardo, M. Zimarino, W. Bernini, G. Lazzerini, T. Bucciarelli, A. Falco, P. Marchesani, R. Muraro, et al. Low-Density Lipoprotein Level Reduction by the 3-Hydroxy-3-Methylglutaryl Coenzyme-A Inhibitor Simvastatin Is Accompanied by a Related Reduction of F2-Isoprostane Formation in Hypercholesterolemic Subjects: No Further Effect of Vitamin E Circulation, November 12, 2002; 106(20): 2543 - 2549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-Y. Huang, L. J Appel, K. D Croft, E. R Miller III, T. A Mori, and I. B Puddey Effects of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trial Am. J. Clinical Nutrition, September 1, 2002; 76(3): 549 - 555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Wolfram, A. C. Budinsky, B. Palumbo, R. Palumbo, and H. Sinzinger Radioiodine Therapy Induces Dose-Dependent In Vivo Oxidation Injury: Evidence by Increased Isoprostane 8-Epi-PGF2{alpha} J. Nucl. Med., September 1, 2002; 43(9): 1254 - 1258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Forgione, A. Cap, R. Liao, N. I. Moldovan, R. T. Eberhardt, C. C. Lim, J. Jones, P. J. Goldschmidt-Clermont, and J. Loscalzo Heterozygous Cellular Glutathione Peroxidase Deficiency in the Mouse: Abnormalities in Vascular and Cardiac Function and Structure Circulation, August 27, 2002; 106(9): 1154 - 1158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Block, M. Dietrich, E. P. Norkus, J. D. Morrow, M. Hudes, B. Caan, and L. Packer Factors Associated with Oxidative Stress in Human Populations Am. J. Epidemiol., August 1, 2002; 156(3): 274 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R Chiong and A. B Miller Review: Renin-angiotensin system antagonism and lipid-lowering therapy in cardiovascular risk management Journal of Renin-Angiotensin-Aldosterone System, June 1, 2002; 3(2): 96 - 102. [Abstract] [PDF]
|
|
|
|
|
|
T. Ide, H. Tsutsui, N. Ohashi, S. Hayashidani, N. Suematsu, M. Tsuchihashi, H. Tamai, and A. Takeshita Greater Oxidative Stress in Healthy Young Men Compared With Premenopausal Women Arterioscler Thromb Vasc Biol, March 1, 2002; 22(3): 438 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bolego, A. Poli, and R. Paoletti Smoking and gender Cardiovasc Res, February 15, 2002; 53(3): 568 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Dillon, G. M. Lowe, D. Billington, and K. Rahman Dietary Supplementation with Aged Garlic Extract Reduces Plasma and Urine Concentrations of 8-Iso-Prostaglandin F2{alpha} in Smoking and Nonsmoking Men and Women J. Nutr., February 1, 2002; 132(2): 168 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Dietrich, G. Block, M. Hudes, J. D. Morrow, E. P. Norkus, M. G. Traber, C. E. Cross, and L. Packer Antioxidant Supplementation Decreases Lipid Peroxidation Biomarker F2-isoprostanes in Plasma of Smokers Cancer Epidemiol. Biomarkers Prev., January 1, 2002; 11(1): 7 - 13. [Abstract] [Full Text]
|
|
|
|
|
|
J. M. Hodgson, K. D. Croft, T. A. Mori, V. Burke, L. J. Beilin, and I. B. Puddey Regular Ingestion of Tea Does Not Inhibit In Vivo Lipid Peroxidation in Humans J. Nutr., January 1, 2002; 132(1): 55 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. N. Chan, H. M. Colhoun, and P. Vallance Cardiovascular risk factors as determinants of endothelium-dependent and endothelium-independent vascular reactivity in the general population J. Am. Coll. Cardiol., December 1, 2001; 38(7): 1814 - 1820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mak and G. E. Newton The Oxidative Stress Hypothesis of Congestive Heart Failure : Radical Thoughts Chest, December 1, 2001; 120(6): 2035 - 2046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Cyrus, L. X. Tang, J. Rokach, G. A. FitzGerald, and D. Pratico Lipid Peroxidation and Platelet Activation in Murine Atherosclerosis Circulation, October 16, 2001; 104(16): 1940 - 1945. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. McNamara and G. A. FitzGerald Smoking-Induced Vascular Disease: A New Twist on an Old Theme Circ. Res., September 28, 2001; 89(7): 563 - 565. [Full Text] [PDF]
|
|
|
|
|
|
G. Davi, G. Di Minno, A. Coppola, G. Andria, A. M. Cerbone, P. Madonna, A. Tufano, A. Falco, P. Marchesani, G. Ciabattoni, et al. Oxidative Stress and Platelet Activation in Homozygous Homocystinuria Circulation, September 4, 2001; 104(10): 1124 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Trevisan, R. Browne, M. Ram, P. Muti, J. Freudenheim, A. M. Carosella, and D. Armstrong Correlates of Markers of Oxidative Status in the General Population Am. J. Epidemiol., August 15, 2001; 154(4): 348 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. L. Wang, D. L. Rainwater, J. F. VandeBerg, B. D. Mitchell, and M. C. Mahaney Genetic Contributions to Plasma Total Antioxidant Activity Arterioscler Thromb Vasc Biol, July 1, 2001; 21(7): 1190 - 1195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Palaniappan, L. J. Starkey, J. O'Loughlin, and K. Gray-Donald Fruit and Vegetable Consumption Is Lower and Saturated Fat Intake Is Higher among Canadians Reporting Smoking J. Nutr., July 1, 2001; 131(7): 1952 - 1958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Weinberg, B. S. VanderWerken, R. A. Anderson, J. E. Stegner, and M. J. Thomas Pro-Oxidant Effect of Vitamin E in Cigarette Smokers Consuming a High Polyunsaturated Fat Diet Arterioscler Thromb Vasc Biol, June 1, 2001; 21(6): 1029 - 1033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Janssen Isoprostanes: an overview and putative roles in pulmonary pathophysiology Am J Physiol Lung Cell Mol Physiol, June 1, 2001; 280(6): L1067 - L1082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Basu, M Whiteman, D L Mattey, and B Halliwell Raised levels of F2-isoprostanes and prostaglandin F2{alpha} in different rheumatic diseases Ann Rheum Dis, June 1, 2001; 60(6): 627 - 631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Meagher, O. P. Barry, J. A. Lawson, J. Rokach, and G. A. FitzGerald Effects of Vitamin E on Lipid Peroxidation in Healthy Persons JAMA, March 7, 2001; 285(9): 1178 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. P. Brass, W. R. Hiatt, A. W. Gardner, and C. L. Hoppel Decreased NADH dehydrogenase and ubiquinol-cytochrome c oxidoreductase in peripheral arterial disease Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H603 - H609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Whitehead and G. A. FitzGerald Twenty-First Century Phox: Not Yet Ready for Widespread Screening Circulation, January 2, 2001; 103(1): 7 - 9. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hioki, N. Aoki, K. Kawano, M. Homori, Y. Hasumura, T. Yasumura, A. Maki, H. Yoshino, A. Yanagisawa, and K. Ishikawa Acute effects of cigarette smoking on platelet-dependent thrombin generation Eur. Heart J., January 1, 2001; 22(1): 56 - 61. [Abstract] [PDF]
|
|
|
|
|
|
L. Iuliano, D. Pratico, C. Greco, E. Mangieri, G. Scibilia, G. A. FitzGerald, and F. Violi Angioplasty increases coronary sinus F2-isoprostane formation: evidence for in vivo oxidative stress during PTCA J. Am. Coll. Cardiol., January 1, 2001; 37(1): 76 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Pignatelli, C.-Q. Li, P. Boffetta, Q. Chen, W. Ahrens, F. Nyberg, A. Mukeria, I. Bruske-Hohlfeld, C. Fortes, V. Constantinescu, et al. Nitrated and Oxidized Plasma Proteins in Smokers and Lung Cancer Patients Cancer Res., January 1, 2001; 61(2): 778 - 784. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. J. Janssen, M. Premji, S. Netherton, A. Catalli, G. Cox, S. Keshavjee, and D. J. Crankshaw Excitatory and Inhibitory Actions of Isoprostanes in Human and Canine Airway Smooth Muscle J. Pharmacol. Exp. Ther., November 1, 2000; 295(2): 506 - 511. [Abstract] [Full Text]
|
|
|
|
|
|
E. Porkkala-Sarataho, J. T. Salonen, K. Nyyssonen, J. Kaikkonen, R. Salonen, U. Ristonmaa, U. Diczfalusy, R. Brigelius-Flohe, S. Loft, and H. E. Poulsen Long-Term Effects of Vitamin E, Vitamin C, and Combined Supplementation on Urinary 7-Hydro-8-Oxo-2'-Deoxyguanosine, Serum Cholesterol Oxidation Products, and Oxidation Resistance of Lipids in Nondepleted Men Arterioscler Thromb Vasc Biol, September 1, 2000; 20(9): 2087 - 2093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Cipollone, G. Ciabattoni, P. Patrignani, M. Pasquale, D. Di Gregorio, T. Bucciarelli, G. Davi, F. Cuccurullo, and C. Patrono Oxidant Stress and Aspirin-Insensitive Thromboxane Biosynthesis in Severe Unstable Angina Circulation, August 29, 2000; 102(9): 1007 - 1013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Halliwell Lipid peroxidation, antioxidants and cardiovascular disease: how should we move forward? Cardiovasc Res, August 18, 2000; 47(3): 410 - 418. [Full Text] [PDF]
|
|
|
|
|
|
A. Mezzetti, F. Cipollone, and F. Cuccurullo Oxidative stress and cardiovascular complications in diabetes: isoprostanes as new markers on an old paradigm Cardiovasc Res, August 18, 2000; 47(3): 475 - 488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Patrignani, M. R. Panara, S. Tacconelli, F. Seta, T. Bucciarelli, G. Ciabattoni, P. Alessandrini, A. Mezzetti, G. Santini, M. G. Sciulli, et al. Effects of Vitamin E Supplementation on F2-Isoprostane and Thromboxane Biosynthesis in Healthy Cigarette Smokers Circulation, August 1, 2000; 102(5): 539 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Frey, R. Haupt, S. Alms, G. Holzmann, T. König, H. Kern, W. Kox, B. Rüstow, and M. Schlame Increase in fragmented phosphatidylcholine in blood plasma by oxidative stress J. Lipid Res., July 1, 2000; 41(7): 1145 - 1153. [Abstract] [Full Text]
|
|
|
|
|
|
R. A Riemersma, K. F Carruthers, R. A Elton, and K. A. Fox Vitamin C and the risk of acute myocardial infarction Am. J. Clinical Nutrition, May 1, 2000; 71(5): 1181 - 1186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. T. Raitakari, M. R. Adams, R. J. McCredie, K. A. Griffiths, R. Stocker, and D. S. Celermajer Oral vitamin C and endothelial function in smokers: short-term improvement, but no sustained beneficial effect J. Am. Coll. Cardiol., May 1, 2000; 35(6): 1616 - 1621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Heitzer, C. Brockhoff, B. Mayer, A. Warnholtz, H. Mollnau, S. Henne, T. Meinertz, and T. Munzel Tetrahydrobiopterin Improves Endothelium-Dependent Vasodilation in Chronic Smokers : Evidence for a Dysfunctional Nitric Oxide Synthase Circ. Res., February 4, 2000; 86 (2): e36 - e41. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Neunteufl, U. Priglinger, S. Heher, M. Zehetgruber, G. Soregi, S. Lehr, K. Huber, G. Maurer, F. Weidinger, and K. Kostner Effects of vitamin E on chronic and acute endothelial dysfunction in smokers J. Am. Coll. Cardiol., February 1, 2000; 35(2): 277 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Burke, J. A. Lawson, E. A. Meagher, J. Rokach, and G. A. FitzGerald Specific Analysis in Plasma and Urine of 2,3-Dinor-5,6-dihydro-isoprostane F2alpha -III, a Metabolite of Isoprostane F2alpha -III and an Oxidation Product of gamma -Linolenic Acid J. Biol. Chem., January 28, 2000; 275(4): 2499 - 2504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Södergren, J. Cederberg, S. Basu, and B. Vessby Vitamin E Supplementation Decreases Basal Levels of F2-Isoprostanes and Prostaglandin F2{alpha} in Rats J. Nutr., January 1, 2000; 130(1): 10 - 14. [Abstract] [Full Text]
|
|
|
|
 |
|
 H. Li, J. A. Lawson, M. Reilly, M. Adiyaman, S.-W. Hwang, J. Rokach, and G. A. FitzGerald Quantitative high performance liquid chromatography/tandem mass spectrometric analysis of the four classes of F2-isoprostanes in human urine PNAS, November 9, 1999; 96(23): 13381 - 13386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Lawson, J. Rokach, and G. A. FitzGerald Isoprostanes: Formation, Analysis and Use As Indices of Lipid Peroxidation in Vivo J. Biol. Chem., August 27, 1999; 274(35): 24441 - 24444. [Full Text] [PDF]
|
|
|
|
|
|
M. Reza Mehrabi, C. Ekmekcioglu, F. Tatzber, A. Oguogho, R. Ullrich, A. Morgan, F. Tamaddon, M. Grimm, H. D Glogar, and H. Sinzinger The isoprostane, 8-epi-PGF2{alpha}, is accumulated in coronary arteries isolated from patients with coronary heart disease Cardiovasc Res, August 1, 1999; 43(2): 492 - 499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. BRIGELIUS-FLOHÉ and M. G. TRABER Vitamin E: function and metabolism FASEB J, July 1, 1999; 13(10): 1145 - 1155. [Abstract] [Full Text]
|
|
|
|
|
|
A. C Carr and B. Frei Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans Am. J. Clinical Nutrition, June 1, 1999; 69(6): 1086 - 1107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. CARR and B. FREI Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J, June 1, 1999; 13(9): 1007 - 1024. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. Pratico, D. Ferro, L. Iuliano, J. Rokach, F. Conti, G. Valesini, G. A. FitzGerald, and F. Violi Ongoing Prothrombotic State in Patients With Antiphospholipid Antibodies: A Role for Increased Lipid Peroxidation Blood, May 15, 1999; 93(10): 3401 - 3407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Wever, P. Boer, M. Hijmering, E. Stroes, M. Verhaar, J. Kastelein, K. Versluis, F. Lagerwerf, H. van Rijn, H. Koomans, et al. Nitric Oxide Production Is Reduced in Patients With Chronic Renal Failure Arterioscler Thromb Vasc Biol, May 1, 1999; 19(5): 1168 - 1172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Ferro, S. Basili, D. Pratico, L. Iuliano, G. A. FitzGerald, and F. Violi Vitamin E Reduces Monocyte Tissue Factor Expression in Cirrhotic Patients Blood, May 1, 1999; 93(9): 2945 - 2950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Heitzer, S. Y. Herttuala, E. Wild, J. Luoma, and H. Drexler Effect of vitamin E on endothelial vasodilator function in patients with hypercholesterolemia, chronic smoking or both J. Am. Coll. Cardiol., February 1, 1999; 33(2): 499 - 505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Davi, G. Ciabattoni, A. Consoli, A. Mezzetti, A. Falco, S. Santarone, E. Pennese, E. Vitacolonna, T. Bucciarelli, F. Costantini, et al. In Vivo Formation of 8-Iso-Prostaglandin F2{alpha} and Platelet Activation in Diabetes Mellitus : Effects of Improved Metabolic Control and Vitamin E Supplementation Circulation, January 19, 1999; 99(2): 224 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chiabrando, A. Valagussa, C. Rivalta, T. Durand, A. Guy, E. Zuccato, P. Villa, J.-C. Rossi, and R. Fanelli Identification and Measurement of Endogenous beta -Oxidation Metabolites of 8-epi-Prostaglandin F2alpha J. Biol. Chem., January 15, 1999; 274(3): 1313 - 1319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Witztum To E or Not To E—How Do We Tell? Circulation, December 22, 1998; 98(25): 2785 - 2787. [Full Text] [PDF]
|
|