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(Circulation. 1996;93:1346-1353.)
© 1996 American Heart Association, Inc.
Articles |
Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia
Role of Oxidized LDL
From Medizinische Klinik III (T.H., S.K., T.M., H.J., H.D.) and Medizinische Biometrie und Statistik (M.O.), Universität Freiburg, Germany, and A.I. Virtanen Institute and Department of Medicine, University of Kuopio (S.Y.-H., J.L.), Finland.
Correspondence to Helmut Drexler, MD, Medizinische Klinik III, Hugstetterstr 55, 79106 Freiburg, Germany.
Background Risk factors for atherosclerosis such as hypercholesterolemia and hypertension are associated with endothelial dysfunction of conduit and resistance vessels; however, the interaction of these risk factors and underlying mechanisms affecting endothelial function remain to be determined. The present study investigated the role of long-term smoking and hypercholesterolemia and their impact on endothelial function of peripheral resistance vessels in relation to plasma levels of autoantibodies against oxidized LDL, which has been implicated in the development of endothelial dysfunction and atherosclerosis.
Methods and Results The vascular responses to the endothelium-dependent agent acetylcholine (7.5, 15, 30, and 60 µg/min) and the endothelium-independent agent sodium nitroprusside (1, 3, and 10 µg/min) were studied in normal control subjects (n=10), patients with hypercholesterolemia (n=15), long-term smokers (n=15), and hypercholesterolemic patients who smoked (n=15). Drugs were infused into the brachial artery, and forearm blood flow (FBF) was measured by venous occlusion plethysmography. The FBF responses to acetylcholine were significantly blunted in all three patient groups compared with normal control subjects (P<.05). The acetylcholine-induced increase in FBF was significantly attenuated in patients with hypercholesterolemia who smoked compared with hypercholesterolemic nonsmokers and normocholesterolemic smokers (P<.05 for both). The response to sodium nitroprusside was not statistically different in all four groups. Plasma levels of autoantibody titer against oxidized LDL were inversely related to acetylcholine-induced changes in FBF (r=-.53, P<.002) and were substantially increased in the group with both risk factors.
Conclusions These results demonstrate that cigarette smoking and hypercholesterolemia synergistically impair endothelial function and that their combined presence is associated with increased plasma levels of autoantibodies against oxidized LDL. These observations raise the possibility that long-term smoking potentiates endothelial dysfunction in hypercholesterolemic patients by enhancing the oxidation of LDL.
Key Words: hypercholesterolemia • endothelium • lipoproteins • smoking
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|
|
|
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
H. Drexler Nitric oxide and coronary endothelial dysfunction in humans Cardiovasc Res, August 15, 1999; 43(3): 572 - 579. [Full Text] [PDF]
|
|
|
|
|
|
F. Cosentino and T. F Luscher Tetrahydrobiopterin and endothelial nitric oxide synthase activity Cardiovasc Res, August 1, 1999; 43(2): 274 - 278. [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
R. Wever, P. Boer, M. Hijmering, E. Stroes, M. Verhaar, J. Kastelein, K. Versluis, F. Lagerwerf, H. van Rijn, H. Koomans, et al. Nitric Oxide Production Is Reduced in Patients With Chronic Renal Failure Arterioscler. Thromb. Vasc. Biol., May 1, 1999; 19(5): 1168 - 1172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. G. Mayhan and G. M. Sharpe Chronic exposure to nicotine alters endothelium-dependent arteriolar dilatation: effect of superoxide dismutase J Appl Physiol, April 1, 1999; 86(4): 1126 - 1134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 S. Islam, B. Gutin, F. Treiber, G. Hobbs, I. Kamboh, and M. Lopes-Virella Association of Apolipoprotein A Phenotypes and Oxidized Low-Density Lipoprotein Immune Complexes in Children Arch Pediatr Adolesc Med, January 1, 1999; 153(1): 57 - 62. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Muiesan, M. Salvetti, C. Monteduro, D. Rizzoni, R. Zulli, C. Corbellini, C. Brun, and E. Agabiti-Rosei Effect of Treatment on Flow-Dependent Vasodilation of the Brachial Artery in Essential Hypertension Hypertension, January 1, 1999; 33(1): 575 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
W. G. Mayhan and G. M. Sharpe Superoxide dismutase restores endothelium-dependent arteriolar dilatation during acute infusion of nicotine J Appl Physiol, October 1, 1998; 85(4): 1292 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Moreno Jr., S. Chalon, A. Urae, O. Tangphao, A. K. Abiose, B. B. Hoffman, and T. F. Blaschke Endothelial dysfunction in human hand veins is rapidly reversible after smoking cessation Am J Physiol Heart Circ Physiol, September 1, 1998; 275(3): H1040 - H1045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Hein and L. Kuo LDLs Impair Vasomotor Function of the Coronary Microcirculation : Role of Superoxide Anions Circ. Res., August 24, 1998; 83(4): 404 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Miller, D. Aiello, H. Pritchard, G. Friel, and K. Zeller Apolipoprotein A-IZavalla (Leu159->Pro) : HDL Cholesterol Deficiency in a Kindred Associated With Premature Coronary Artery Disease Arterioscler. Thromb. Vasc. Biol., August 1, 1998; 18(8): 1242 - 1247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kugiyama, T. Motoyama, O. Hirashima, M. Ohgushi, H. Soejima, K. Misumi, H. Kawano, Y. Miyao, M. Yoshimura, H. Ogawa, et al. Vitamin C attenuates abnormal vasomotor reactivity in spasm coronary arteries in patients with coronary spastic angina J. Am. Coll. Cardiol., July 1, 1998; 32(1): 103 - 109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Thorne, M. J. Mullen, P. Clarkson, A. E. Donald, and J. E. Deanfield Early endothelial dysfunction in adults at risk from atherosclerosis: different responses to L-arginine J. Am. Coll. Cardiol., July 1, 1998; 32(1): 110 - 116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ghiadoni, S. Taddei, A. Virdis, I. Sudano, V. Di Legge, M. Meola, L. Di Venanzio, and A. Salvetti Endothelial Function and Common Carotid Artery Wall Thickening in Patients With Essential Hypertension Hypertension, July 1, 1998; 32(1): 25 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.P. Mikhailidis, J.A. Papadakis, and E.S. Ganotakis Smoking, Diabetes and Hyperlipidaemia Perspectives in Public Health, April 1, 1998; 118(2): 91 - 93. [Abstract]
|
|
|
|
 |
|
 J. T Powell Vascular damage from smoking: disease mechanisms at the arterial wall Vascular Medicine, February 1, 1998; 3(1): 21 - 28. [Abstract] [PDF]
|
|
|
|
|
|
R. M. F. Wever, T. F. Luscher, F. Cosentino, and T. J. Rabelink Atherosclerosis and the Two Faces of Endothelial Nitric Oxide Synthase Circulation, January 13, 1998; 97(1): 108 - 112. [Full Text] [PDF]
|
|
|
|
|
|
S. Taddei, A. Virdis, L. Ghiadoni, S. Uleri, A. Magagna, and A. Salvetti Lacidipine Restores Endothelium-Dependent Vasodilation in Essential Hypertensive Patients Hypertension, December 1, 1997; 30(6): 1606 - 1612. [Abstract] [Full Text]
|
|
|
|
 |
|
 SMOKING MAY POTENTIATE EFFECTS OF HYPERCHOLESTEROLEMIA Journal Watch (General), April 16, 1996; 1996(416): 5 - 5. [Full Text]
|
|