(Circulation. 1996;93:1334-1338.)
© 1996 American Heart Association, Inc.
Articles |
Levels of Soluble Cell Adhesion Molecules in Patients With Dyslipidemia
From the Sections of Atherosclerosis and Leukocyte Biology, Department of Medicine, Baylor College of Medicine, Houston, Tex.
Correspondence to Christie M. Ballantyne, MD, Department of Internal Medicine, 6565 Fannin St, MS A-601, Houston, TX 77030.
Background Increased expression of cell adhesion molecules (CAMs) on the vascular endothelium has been postulated to play an important role in atherogenesis. Both in vitro and in vivo studies have suggested that dyslipidemia may increase expression of CAMs.
Methods and Results To determine whether
dyslipidemia is associated with increased expression of
CAMs, we examined the levels of soluble intercellular adhesion molecule
1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), and
soluble E-selectin (sE-selectin) in individuals with either
hypercholesterolemia or
hypertriglyceridemia and in control
subjects matched for age and sex. Patients with
hypertriglyceridemia had significantly
higher levels of sVCAM-1 (739±69 ng/mL) compared with patients with
hypercholesterolemia (552±63 ng/mL) and
control subjects (480±56 ng/mL). Levels of sICAM-1 were significantly
increased in both the hypercholesterolemic and
hypertriglyceridemic groups (298±29 and
342±31 ng/mL, respectively) compared with the control group (198±14
ng/mL). Levels of sE-selectin were significantly increased in
hypercholesterolemic patients (74±9 ng/mL)
compared with control subjects (48±5 ng/mL). Ten
hypercholesterolemic patients were treated
aggressively with atorvastatin alone or a combination of colestipol and
either atorvastatin or simvastatin for a mean of 42 weeks
and had an average LDL cholesterol reduction of 51%.
Comparison of soluble CAMs before and after treatment showed a
significant reduction only in sE-selectin (77±11 versus 56±6 ng/mL,
P
.03) but not for sVCAM-1 or sICAM-1.
Conclusions Although severe hyperlipidemia is associated with increased levels of soluble CAMs, aggressive lipid-lowering treatment had only limited effects on the levels. Increased levels of soluble CAMs in patients with hyperlipidemia may be a marker for atherosclerosis.
Key Words: lipids • arteriosclerosis • adhesion molecules
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