| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 1996;93:229-237.)
© 1996 American Heart Association, Inc.
Articles |
Platelet Function in Acute Myocardial Infarction Treated With Direct Angioplasty
Presented in part at the 67th Scientific Sessions of the American Heart Association, Dallas, Tex, November 1994.
From the 1. Medizinische Klinik der Technischen Universität München, Germany.
Correspondence to Dr Meinrad Gawaz, 1. Medizinische Klinik der Technischen Universität München, Klinikum rechts der Isar, Ismaninger Straße 22, 81675 München, Germany.
Background In acute myocardial infarction (AMI), platelets play a key role in thrombotic processes that limit the patency of the recanalized, infarct-related coronary artery and contribute to reperfusion injury. Platelet function in the course of AMI treated by direct percutaneous transluminal coronary angioplasty (PTCA) has not been evaluated.
Methods and Results In 15 patients with anterior AMI, peripheral venous blood samples were obtained before and 4, 8, 24, and 48 hours after recanalization of the occluded artery by PTCA. Fifteen patients who had stable coronary heart disease and were undergoing elective balloon angioplasty served as control subjects. Fibrinogen receptor function and surface expression of P-selectin on platelets were determined by flow cytometry. In addition, we evaluated generation of platelet-derived microparticles and the effect of systemic plasma from patients with AMI on normal platelet function and on platelet adhesion to human endothelial cells in culture. We found fibrinogen receptor activity and P-selectin expression on circulating platelets 8 hours after direct PTCA are decreased (P<.01). This coincided with a decrease in peripheral platelet count (P<.05) and an increase in generation of microparticles (P<.002). Twenty-four to 48 hours after PTCA, fibrinogen receptor activity and P-selectin expression increased again. Systemic plasma obtained before and after direct PTCA sensitized normal platelets to hyperaggregate in vitro (P<.001) and stimulated platelet adhesion to endothelial cells in culture (P<.01). None of the changes found in AMI were detectable in the control group.
Conclusions After transient apparent deactivation of circulating platelets, probably caused by sequestration of hyperactive platelets, the level of platelet activation increases in patients with AMI treated by direct PTCA. These findings underscore the need for novel antiplatelet strategies in AMI.
Key Words: platelets • revascularization • myocardial infarction • thrombosis • angioplasty
This article has been cited by other articles:
 |
|
 |
|
  K.-Y. Chen, S.-W. Rha, Y.-J. Li, K. L. Poddar, Z. Jin, Y. Minami, L. Wang, E. J. Kim, C. G. Park, H. S. Seo, et al. Triple Versus Dual Antiplatelet Therapy in Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention Circulation, June 30, 2009; 119(25): 3207 - 3214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Palmerini, A. Marzocchi, C. Tamburino, I. Sheiban, M. Margheri, G. Vecchi, G. Sangiorgi, A. Santarelli, A. L. Bartorelli, C. Briguori, et al. Temporal pattern of ischemic events in relation to dual antiplatelet therapy in patients with unprotected left main coronary artery stenosis undergoing percutaneous coronary intervention. J. Am. Coll. Cardiol., April 7, 2009; 53(14): 1176 - 1181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Trenk and F.-J. Neumann Aspirin Resistance: An Underestimated Risk in Patients With Drug-Eluting Stents? J. Am. Coll. Cardiol., August 26, 2008; 52(9): 740 - 742. [Full Text] [PDF]
|
|
|
|
 |
|
 L. T. Newsome, R. S. Weller, J. C. Gerancher, M. A. Kutcher, and R. L. Royster Coronary Artery Stents: II. Perioperative Considerations and Management Anesth. Analg., August 1, 2008; 107(2): 570 - 590. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Geisler, M Kapp, K Gohring-Frischholz, K Daub, C Dosch, B Bigalke, H Langer, C Herdeg, and M Gawaz Residual platelet activity is increased in clopidogrel- and ASA-treated patients with coronary stenting for acute coronary syndromes compared with stable coronary artery disease Heart, June 1, 2008; 94(6): 743 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. May, P. Seizer, and M. Gawaz Platelets: Inflammatory Firebugs of Vascular Walls Arterioscler. Thromb. Vasc. Biol., March 1, 2008; 28(3): s5 - s10. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Stellos, H. Langer, K. Daub, T. Schoenberger, A. Gauss, T. Geisler, B. Bigalke, I. Mueller, M. Schumm, I. Schaefer, et al. Platelet-Derived Stromal Cell-Derived Factor-1 Regulates Adhesion and Promotes Differentiation of Human CD34+ Cells to Endothelial Progenitor Cells Circulation, January 15, 2008; 117(2): 206 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Inami, S. Nomura, Y. Kimura, K. Yamada, H. Nakamori, N. Takahashi, S. Fukuhara, and T. Iwasaka Evaluation of Platelet and Leukocyte Functions in Effort Angina Patients Using High Shear Conditions in Small-Sized Collagen Bead Columns Clinical and Applied Thrombosis/Hemostasis, October 1, 2007; 13(4): 428 - 431. [Abstract] [PDF]
|
|
|
|
|
|
P. Buonamici, R. Marcucci, A. Migliorini, G. F. Gensini, A. Santini, R. Paniccia, G. Moschi, A. M. Gori, R. Abbate, and D. Antoniucci Impact of Platelet Reactivity After Clopidogrel Administration on Drug-Eluting Stent Thrombosis J. Am. Coll. Cardiol., June 19, 2007; 49(24): 2312 - 2317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Morel, F. Toti, B. Hugel, B. Bakouboula, L. Camoin-Jau, F. Dignat-George, and J.-M. Freyssinet Procoagulant Microparticles: Disrupting the Vascular Homeostasis Equation? Arterioscler. Thromb. Vasc. Biol., December 1, 2006; 26(12): 2594 - 2604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Htun, S. Fateh-Moghadam, B. Tomandl, R. Handschu, K. Klinger, K. Stellos, C. Garlichs, W. Daniel, and M. Gawaz Course of Platelet Activation and Platelet-Leukocyte Interaction in Cerebrovascular Ischemia Stroke, September 1, 2006; 37(9): 2283 - 2287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. van der Zee, E. Biro, Y. Ko, R. J. de Winter, C. E. Hack, A. Sturk, and R. Nieuwland P-Selectin- and CD63-Exposing Platelet Microparticles Reflect Platelet Activation in Peripheral Arterial Disease and Myocardial Infarction Clin. Chem., April 1, 2006; 52(4): 657 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-W. Lee, S.-W. Park, M.-K. Hong, Y.-H. Kim, B.-K. Lee, J.-M. Song, K. H. Han, C. W. Lee, D.-H. Kang, J.-K. Song, et al. Triple Versus Dual Antiplatelet Therapy After Coronary Stenting: Impact on Stent Thrombosis J. Am. Coll. Cardiol., November 15, 2005; 46(10): 1833 - 1837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Inami, S. Nomura, T. Kajiura, K. Yamada, H. Nakamori, N. Takahashi, N. Tsuda, S. Fukuhara, and T. Iwasaka Significance of {alpha}IIb{beta}3 in Subacute Stent ThrombosisAfter Percutaneous Coronary Intervention Clinical and Applied Thrombosis/Hemostasis, October 1, 2005; 11(4): 455 - 459. [Abstract] [PDF]
|
|
|
|
 |
|
 M. S. Sabatine, C. P. Cannon, C. M. Gibson, J. L. Lopez-Sendon, G. Montalescot, P. Theroux, B. S. Lewis, S. A. Murphy, C. H. McCabe, E. Braunwald, et al. Effect of Clopidogrel Pretreatment Before Percutaneous Coronary Intervention in Patients With ST-Elevation Myocardial Infarction Treated With Fibrinolytics: The PCI-CLARITY Study JAMA, September 14, 2005; 294(10): 1224 - 1232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Schulman Antiplatelet Therapy in Non-ST-Segment Elevation Acute Coronary Syndromes JAMA, October 20, 2004; 292(15): 1875 - 1882. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nomura, N. Inami, S. Kanazawa, T. Iwasaka, and S. Fukuhara Elevation of Platelet Activation Markers and Chemokines during Peripheral Blood Stem Cell Harvest with G-CSF Stem Cells, September 1, 2004; 22(5): 696 - 703. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Cabeza, Z. Li, C. Schulz, E. Kremmer, S. Massberg, A. Bultmann, and M. Gawaz Surface Expression of Collagen Receptor Fc Receptor-{gamma}/Glycoprotein VI Is Enhanced on Platelets in Type 2 Diabetes and Mediates Release of CD40 Ligand and Activation of Endothelial Cells Diabetes, August 1, 2004; 53(8): 2117 - 2121. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J A Zeller, K Frahm, R Baron, R Stingele, and G Deuschl Platelet-leukocyte interaction and platelet activation in migraine: a link to ischemic stroke? J. Neurol. Neurosurg. Psychiatry, July 1, 2004; 75(7): 984 - 987. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Matetzky, B. Shenkman, V. Guetta, M. Shechter, R. Bienart, I. Goldenberg, I. Novikov, H. Pres, N. Savion, D. Varon, et al. Clopidogrel Resistance Is Associated With Increased Risk of Recurrent Atherothrombotic Events in Patients With Acute Myocardial Infarction Circulation, June 29, 2004; 109(25): 3171 - 3175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tsiara, M. Elisaf, I. A. Jagroop, and D. P. Mikhailidis Platelets as Predictors of Vascular Risk: Is There a Practical Index of Platelet Activity? Clinical and Applied Thrombosis/Hemostasis, July 1, 2003; 9(3): 177 - 190. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Mossinger, W. Dietrich, S. L. Braun, M. Jochum, H. Meisner, and J. A. Richter High-dose aprotinin reduces activation of hemostasis, allogeneic blood requirement, and duration of postoperative ventilation in pediatric cardiac surgery Ann. Thorac. Surg., February 1, 2003; 75(2): 430 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Bonz, B. Lengenfelder, J.o. Strotmann, S. Held, O. Turschner, K. Harre, C. Wacker, C. Waller, N. Kochsiek, M. Meesmann, et al. effect of additional temporary glycoprotein IIb/IIIa receptor inhibition on troponin release in elective percutaneous coronary interventions after pretreatment with aspirin and clopidogrel (TOPSTAR trial) J. Am. Coll. Cardiol., August 21, 2002; 40(4): 662 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Matsumoto, S. Nomura, H. Kamihata, Y. Kimura, and T. Iwasaka Association of Platelet-Derived Microparticles With C-C Chemokines on Vascular Complication in Patients With Acute Myocardial Infarction Clinical and Applied Thrombosis/Hemostasis, July 1, 2002; 8(3): 279 - 286. [Abstract] [PDF]
|
|
|
|
|
|
N. C. Kaneider, P. Egger, S. Dunzendorfer, and C. J. Wiedermann Rho-GTPase-Dependent Platelet-Neutrophil Interaction Affected by HMG-CoA Reductase Inhibition With Altered Adenosine Nucleotide Release and Function Arterioscler. Thromb. Vasc. Biol., June 1, 2002; 22(6): 1029 - 1035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Horigome, Y. Hiramatsu, O. Shigeta, T. Nagasawa, and A. Matsui Overproduction of platelet microparticles in cyanotic congenital heart disease with polycythemia J. Am. Coll. Cardiol., March 20, 2002; 39(6): 1072 - 1077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Graff, U. Klinkhardt, V. B. Schini-Kerth, S. Harder, N. Franz, S. Bassus, and C. M. Kirchmaier Close Relationship between the Platelet Activation Marker CD62 and the Granular Release of Platelet-Derived Growth Factor J. Pharmacol. Exp. Ther., March 1, 2002; 300(3): 952 - 957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Mallat and A. Tedgui Current Perspective on the Role of Apoptosis in Atherothrombotic Disease Circ. Res., May 25, 2001; 88(10): 998 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Merten, T. Chow, J. D. Hellums, and P. Thiagarajan A New Role for P-Selectin in Shear-Induced Platelet Aggregation Circulation, October 24, 2000; 102(17): 2045 - 2050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Moshfegh, M. Redondo, F. Julmy, W. A. Wuillemin, M. U. Gebauer, A. Haeberli, and B. J. Meyer Antiplatelet effects of clopidogrel compared with aspirin after myocardial infarction: enhanced inhibitory effects of combination therapy J. Am. Coll. Cardiol., September 1, 2000; 36(3): 699 - 705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Brodison, R. Katira, R. S More, and A. Chauhan Current practice: Antiplatelet use in interventional cardiology Postgrad. Med. J., February 1, 2000; 76(892): 70 - 79. [Abstract] [Full Text]
|
|
|
|
|
|
M. Merten, R. Pakala, P. Thiagarajan, and C. R. Benedict Platelet Microparticles Promote Platelet Interaction With Subendothelial Matrix in a Glycoprotein IIb/IIIa–Dependent Mechanism Circulation, May 18, 1999; 99(19): 2577 - 2582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bihour, C. Durrieu-Jais, L. Macchi, C. Poujol, P. Coste, P. Besse, P. Nurden, and A. T. Nurden Expression of Markers of Platelet Activation and the Interpatient Variation in Response to Abciximab Arterioscler. Thromb. Vasc. Biol., February 1, 1999; 19(2): 212 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gawaz, F.-J. Neumann, and A. Schomig Evaluation of Platelet Membrane Glycoproteins in Coronary Artery Disease : Consequences for Diagnosis and Therapy Circulation, January 12, 1999; 99 (1): e1 - e11. [Full Text] [PDF]
|
|
|
|
|
|
J. K. Mickelson, M. N. Ali, N. S. Kleiman, N. M. Lakkis, T. W. Chow, B. J. Hughes, and C. W. Smith Chimeric 7e3 Fab (ReoPro) decreases detectable CD11b on neutrophils from patients undergoing coronary angioplasty J. Am. Coll. Cardiol., January 1, 1999; 33(1): 97 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gawaz, F.-J. Neumann, T. Dickfeld, W. Koch, K.-L. Laugwitz, H. Adelsberger, K. Langenbrink, S. Page, D. Neumeier, A. Schomig, et al. Activated Platelets Induce Monocyte Chemotactic Protein-1 Secretion and Surface Expression of Intercellular Adhesion Molecule-1 on Endothelial Cells Circulation, September 22, 1998; 98(12): 1164 - 1171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Aoki and H. Tomoda Plasma Soluble P-Selectin in Acute Myocardial Infarction: Effects of Coronary Recanalization Therapy Angiology, September 1, 1998; 49(9): 807 - 813. [Abstract] [PDF]
|
|
|
|
|
|
T. Geiser, M. Sturzenegger, U. Genewein, A. Haeberli, and J. H. Beer Mechanisms of Cerebrovascular Events as Assessed by Procoagulant Activity, Cerebral Microemboli, and Platelet Microparticles in Patients With Prosthetic Heart Valves Stroke, September 1, 1998; 29(9): 1770 - 1777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Konstantopoulos, S. Neelamegham, A. R. Burns, E. Hentzen, G. S. Kansas, K. R. Snapp, E. L. Berg, J. D. Hellums, C. W. Smith, L. V. McIntire, et al. Venous Levels of Shear Support Neutrophil-Platelet Adhesion and Neutrophil Aggregation in Blood via P-Selectin and ß2-Integrin Circulation, September 1, 1998; 98(9): 873 - 882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Brener, L. A. Barr, J. E. B. Burchenal, S. Katz, B. S. George, A. A. Jones, E. D. Cohen, P. C. Gainey, H. J. White, H. B. Cheek, et al. Randomized, Placebo-Controlled Trial of Platelet Glycoprotein IIb/IIIa Blockade With Primary Angioplasty for Acute Myocardial Infarction Circulation, August 25, 1998; 98(8): 734 - 741. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Z. Naqvi, P. K. Shah, P. A. Ivey, M. D. Molloy, P. Linn, M. Linker-Israeli, B. Cercek, and S. Kaul Therapeutic Concentrations of Heparin Augment Platelet Activation at the Time of Coronary Angiography Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 1998; 3(2): 91 - 101. [Abstract] [PDF]
|
|
|
|
|
|
M. Gawaz, F.-J. Neumann, T. Dickfeld, A. Reininger, H. Adelsberger, A. Gebhardt, and A. Schomig Vitronectin Receptor ({alpha}vß3) Mediates Platelet Adhesion to the Luminal Aspect of Endothelial Cells : Implications for Reperfusion in Acute Myocardial Infarction Circulation, September 16, 1997; 96(6): 1809 - 1818. [Abstract] [Full Text]
|
|
|
|
|
|
F.-J. Neumann, N. Marx, M. Gawaz, K. Brand, I. Ott, C. Rokitta, C. Sticherling, C. Meinl, A. May, and A. Schomig Induction of Cytokine Expression in Leukocytes by Binding of Thrombin-Stimulated Platelets Circulation, May 20, 1997; 95(10): 2387 - 2394. [Abstract] [Full Text]
|
|
|
|
|
|
M. Gawaz, F.-J. Neumann, I. Ott, A. May, and A. Schomig Platelet Activation and Coronary Stent Implantation: Effect of Antithrombotic Therapy Circulation, August 1, 1996; 94(3): 279 - 285. [Abstract] [Full Text]
|
|