(Circulation. 1995;92:1448-1451.)
© 1995 American Heart Association, Inc.
Articles |
Blockade of Vasospastic Attacks by 
2-Adrenergic but Not 1-Adrenergic Antagonists in Idiopathic Raynaud's Disease
From the Departments of Psychiatry (Cellular and Clinical Neurobiology) and Obstetrics and Gynecology (R.R.F.), the Department of Surgery (R.P.B.), and the Department of Internal Medicine (M.D.M.), Wayne State University School of Medicine, Detroit, Mich.
Correspondence to Robert R. Freedman, PhD, C.S. Mott Center, 275 E Hancock, Detroit, MI 48201.
Background Idiopathic Raynaud's disease is characterized by
cold-induced digital vasospasms, but its origin has not been
established. Previous research has shown that peripheral
vascular 
2-adrenergic receptors are hypersensitive to
local cooling in these patients, but the role of
1-adrenergic receptors is not clear. Moreover, the role
of adrenergic receptors in the production of actual vasospastic
symptoms has not been investigated.
Methods and Results We studied 23 patients with idiopathic
Raynaud's disease who were screened using conservative criteria. They
were randomly assigned to receive brachial artery infusions of an
1-antagonist, an
2-antagonist, or both while vasospastic
attacks were induced by cooling in the laboratory. Each patient's
hands were photographed, and the number of attacks in the infused hand
was compared with the number in the contralateral hand. The number of
fingers (mean±SEM) with attacks in infused hands was yohimbine
0.3±0.3, prazosin 2.3±0.3, and both drugs 0.6±0.2. The
difference
between prazosin and the other two drug groups was significant
(P<.001).
Conclusions These findings demonstrate that activation of
2-adrenergic receptors but not
1-adrenergic receptors is necessary for the
production of vasospastic attacks in idiopathic Raynaud's
disease.
Key Words: Raynaud's disease • receptors, adrenergic, alpha • receptors, adrenergic, beta • vasospasm • drug interactions
This article has been cited by other articles:
 |
|
 |
|
  A. H. Eid, M. A. Chotani, S. Mitra, T. J. Miller, and N. A. Flavahan Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle {alpha}2C-adrenoceptors Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H266 - H272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Eid, K. Maiti, S. Mitra, M. A. Chotani, S. Flavahan, S. R. Bailey, C. S. Thompson-Torgerson, and N. A. Flavahan Estrogen increases smooth muscle expression of {alpha}2C-adrenoceptors and cold-induced constriction of cutaneous arteries Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1955 - H1961. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. G. Lowe, P. D. Allmendinger, and R. Lowe Cold Sensitivity as a New Side Effect After Sympathicotomy for Hyperhidrosis Ann. Thorac. Surg., December 1, 2005; 80(6): 2356 - 2358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P Cooke and J. M Marshall Mechanisms of Raynaud's disease Vascular Medicine, November 1, 2005; 10(4): 293 - 307. [Abstract] [PDF]
|
|
|
|
|
|
S. R. Bailey, S. Mitra, S. Flavahan, and N. A. Flavahan Reactive oxygen species from smooth muscle mitochondria initiate cold-induced constriction of cutaneous arteries Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H243 - H250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Herrick Pathogenesis of Raynaud's phenomenon Rheumatology, May 1, 2005; 44(5): 587 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Chotani, S. Mitra, A. H. Eid, S. A. Han, and N. A. Flavahan Distinct cAMP signaling pathways differentially regulate {alpha}2C-adrenoceptor expression: role in serum induction in human arteriolar smooth muscle cells Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H69 - H76. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.R. Bailey, A.H. Eid, S. Mitra, S. Flavahan, and N.A. Flavahan Rho Kinase Mediates Cold-Induced Constriction of Cutaneous Arteries: Role of {alpha}2C-Adrenoceptor Translocation Circ. Res., May 28, 2004; 94(10): 1367 - 1374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Philipp, M. Brede, and L. Hein Physiological significance of alpha 2-adrenergic receptor subtype diversity: one receptor is not enough Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R287 - R295. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Jeyaraj, M. A. Chotani, S. Mitra, H. E. Gregg, N. A. Flavahan, and K. J. Morrison Cooling Evokes Redistribution of alpha 2C-Adrenoceptors from Golgi to Plasma Membrane in Transfected Human Embryonic Kidney 293 Cells Mol. Pharmacol., December 1, 2001; 60(6): 1195 - 1200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Guimaraes and D. Moura Vascular Adrenoceptors: An Update Pharmacol. Rev., June 1, 2001; 53(2): 319 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hayoz, G. Bizzini, B. Noel, M. Depairon, M. Burnier, C. Fauveau, A. Rouillon, R. Brouard, and H. R. Brunner Effect of SR 49059, a V1a vasopressin receptor antagonist, in Raynaud's phenomenon Rheumatology, October 1, 2000; 39(10): 1132 - 1138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Chotani, S. Flavahan, S. Mitra, D. Daunt, and N. A. Flavahan Silent alpha 2C-adrenergic receptors enable cold-induced vasoconstriction in cutaneous arteries Am J Physiol Heart Circ Physiol, April 1, 2000; 278(4): H1075 - H1083. [Abstract] [Full Text] [PDF]
|
|