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Circulation. 1995;92:1393-1398

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(Circulation. 1995;92:1393-1398.)
© 1995 American Heart Association, Inc.


Articles

Interstitial Collagenase (MMP-1) Expression in Human Carotid Atherosclerosis

Seppo T. Nikkari, MD, PhD; Kevin D. O'Brien, MD; Marina Ferguson, BS; Thomas Hatsukami, MD; Howard G. Welgus, MD; Charles E. Alpers, MD; Alexander W. Clowes, MD

From the Departments of Surgery (T.H., A.W.C.), Medicine (K.D.O.), and Pathology (M.F., C.E.A.), University of Washington, Seattle; the Department of Medicine, Washington University School of Medicine at the Jewish Hospital, St Louis, Mo (H.G.W.); and the Department of Medical Biochemistry, University of Tampere (Finland) Medical School (S.T.N.).

Correspondence to Alexander W. Clowes, MD, Professor, Department of Surgery, RF-25, University of Washington, Seattle, WA 98195. E-mail clowes@u.washington.edu.

Background In human atherosclerosis, most clinical events occur when plaque integrity is compromised and hemorrhage and thrombosis result. One mechanism for this might be the release by plaque cells of matrix-degrading proteases, such as interstitial collagenase (matrix metalloproteinase-1, MMP-1), which degrades two major plaque structural proteins, types I and III collagen. This study was undertaken to determine whether MMP-1 is expressed in human atherosclerotic plaques.

Methods and Results To determine the cellular source and location of MMP-1 in human carotid atherosclerotic lesions, in situ hybridization and immunohistochemistry were performed on 20 endarterectomy specimens. Six nonatherosclerotic carotid arteries also were studied. Intense MMP-1 expression (mRNA and protein) was detected in a subset of plaque macrophages located at the borders of the lipid cores adjacent to fibrous caps and shoulder regions. Subsets of plaque smooth muscle cells and endothelial cells also expressed MMP-1. There was a strong correlation between the percentage of the lipid core occupied by hemorrhage and the percentage of the lipid core perimeter positive for MMP-1 (r=.823, P=.0001). MMP-1 was not detected in any cell type in nonatherosclerotic carotid arteries.

Conclusions This study demonstrates that MMP-1 is expressed by several cell types in human carotid atherosclerosis and that there is a correlation between the expression of the protease and histopathological evidence of plaque instability. Since MMP-1 may degrade the major structural collagens of the plaque, expression of the protease by macrophages in regions critical to plaque integrity could contribute to plaque expansion, rupture, and hemorrhage.


Key Words: atherosclerosis • collagenase




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[Abstract] [Full Text] [PDF]


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[Abstract] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
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Circ. Res., February 22, 2002; 90(3): 251 - 262.
[Abstract] [Full Text] [PDF]


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Circulation, October 16, 2001; 104(16): 1878 - 1880.
[Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


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[Full Text] [PDF]


Home page
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Cardiovasc Res, June 1, 2001; 50(3): 556 - 565.
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Home page
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Home page
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Hypertension, September 1, 2000; 36(3): 325 - 329.
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Home page
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Home page
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Stroke, January 1, 2000; 31(1): 40 - 47.
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Home page
Mol. Cell. Biol.Home page
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Identification of a Novel Dexamethasone-Sensitive RNA-Destabilizing Region on Rat Monocyte Chemoattractant Protein 1 mRNA
Mol. Cell. Biol., October 1, 1999; 19(10): 6471 - 6478.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
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J. Biol. Chem., August 6, 1999; 274(32): 22627 - 22634.
[Abstract] [Full Text] [PDF]


Home page
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Membrane Type 1 Matrix Metalloproteinase Expression in Human Atherosclerotic Plaques : Evidence for Activation by Proinflammatory Mediators
Circulation, June 22, 1999; 99(24): 3103 - 3109.
[Abstract] [Full Text] [PDF]


Home page
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Circulation, June 8, 1999; 99(22): 2876 - 2882.
[Abstract] [Full Text] [PDF]


Home page
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Atrophic Remodeling of the Artery-Cuffed Artery
Arterioscler Thromb Vasc Biol, June 1, 1999; 19(6): 1499 - 1505.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
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Home page
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Circulation, April 20, 1999; 99(15): 1965 - 1971.
[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
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Strategies to achieve coronary arterial plaque stabilization
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[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
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Circ. Res., November 16, 1998; 83(10): 1015 - 1026.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
J. L. Johnson, C. L. Jackson, G. D. Angelini, and S. J. George
Activation of Matrix-Degrading Metalloproteinases by Mast Cell Proteases in Atherosclerotic Plaques
Arterioscler Thromb Vasc Biol, November 1, 1998; 18(11): 1707 - 1715.
[Abstract] [Full Text] [PDF]


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Vasc MedHome page
P. K Shah
Role of inflammation and metalloproteinases in plaque disruption and thrombosis
Vascular Medicine, August 1, 1998; 3(3): 199 - 206.
[Abstract] [PDF]


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CirculationHome page
E. Allaire, D. Hasenstab, R. D. Kenagy, B. Starcher, M. M. Clowes, and A. W. Clowes
Prevention of Aneurysm Development and Rupture by Local Overexpression of Plasminogen Activator Inhibitor-1
Circulation, July 21, 1998; 98(3): 249 - 255.
[Abstract] [Full Text] [PDF]


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Am. J. Pathol.Home page
N. Marx, G. Sukhova, C. Murphy, P. Libby, and J. Plutzky
Macrophages in Human Atheroma Contain PPAR{gamma} : Differentiation-Dependent Peroxisomal Proliferator-ActivatedReceptor {gamma} (PPAR{gamma}) Expression and Reduction of MMP-9 Activitythrough PPAR{gamma} Activation in Mononuclear Phagocytes inVitro
Am. J. Pathol., July 1, 1998; 153(1): 17 - 23.
[Abstract] [Full Text] [PDF]


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Arterioscler. Thromb. Vasc. Bio.Home page
R. B. Wesley II, X. Meng, D. Godin, and Z. S. Galis
Extracellular Matrix Modulates Macrophage Functions Characteristic to Atheroma : Collagen Type I Enhances Acquisition of Resident Macrophage Traits by Human Peripheral Blood Monocytes In Vitro
Arterioscler Thromb Vasc Biol, March 1, 1998; 18(3): 432 - 440.
[Abstract] [Full Text] [PDF]


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CirculationHome page
R. Brandl, T. Richter, K. Haug, M. G. Wilhelm, P. C. Maurer, and W. Nathrath
Topographic Analysis of Proliferative Activity in Carotid Endarterectomy Specimens by Immunocytochemical Detection of the Cell Cycle–Related Antigen Ki-67
Circulation, November 18, 1997; 96(10): 3360 - 3368.
[Abstract] [Full Text]


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Arterioscler. Thromb. Vasc. Bio.Home page
R. T. Lee and P. Libby
The Unstable Atheroma
Arterioscler Thromb Vasc Biol, October 1, 1997; 17(10): 1859 - 1867.
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Arterioscler. Thromb. Vasc. Bio.Home page
K. Kaikita, H. Ogawa, H. Yasue, M. Takeya, K. Takahashi, T. Saito, K. Hayasaki, K. Horiuchi, A. Takizawa, Y. Kamikubo, et al.
Tissue Factor Expression on Macrophages in Coronary Plaques in Patients with Unstable Angina
Arterioscler Thromb Vasc Biol, October 1, 1997; 17(10): 2232 - 2237.
[Abstract] [Full Text]


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Arterioscler. Thromb. Vasc. Bio.Home page
K. E. Webb, A. M. Henney, S. Anglin, S. E. Humphries, and J. R. McEwan
Expression of Matrix Metalloproteinases and Their Inhibitor TIMP-1 in the Rat Carotid Artery After Balloon Injury
Arterioscler Thromb Vasc Biol, September 1, 1997; 17(9): 1837 - 1844.
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Arterioscler. Thromb. Vasc. Bio.Home page
C. Yuan, C. Petty, K. D. O'Brien, T. S. Hatsukami, J. F. Eary, and B. G. Brown
In Vitro and In Situ Magnetic Resonance Imaging Signal Features of Atherosclerotic Plaque-Associated Lipids
Arterioscler Thromb Vasc Biol, August 1, 1997; 17(8): 1496 - 1503.
[Abstract] [Full Text]


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J. Biol. Chem.Home page
G. A. R. Doyle, R. A. Pierce, and W. C. Parks
Transcriptional Induction of Collagenase-1 in Differentiated Monocyte-like (U937) Cells is Regulated by AP-1 and an Upstream C/EBP-beta Site
J. Biol. Chem., May 2, 1997; 272(18): 11840 - 11849.
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CirculationHome page
W. D. Coats, P. Whittaker, D. T. Cheung, J. W. Currier, B. Han, and D. P. Faxon
Collagen Content Is Significantly Lower in Restenotic Versus Nonrestenotic Vessels After Balloon Angioplasty in the Atherosclerotic Rabbit Model
Circulation, March 4, 1997; 95(5): 1293 - 1300.
[Abstract] [Full Text]


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Circ. Res.Home page
R. Forough, N. Koyama, D. Hasenstab, H. Lea, M. Clowes, S. T. Nikkari, and A. W. Clowes
Overexpression of Tissue Inhibitor of Matrix Metalloproteinase-1 Inhibits Vascular Smooth Muscle Cell Functions In Vitro and In Vivo
Circ. Res., October 1, 1996; 79(4): 812 - 820.
[Abstract] [Full Text]


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J. Biol. Chem.Home page
S. Ye, P. Eriksson, A. Hamsten, M. Kurkinen, S. E. Humphries, and A. M. Henney
Progression of Coronary Atherosclerosis Is Associated with a Common Genetic Variant of the Human Stromelysin-1 Promoter Which Results in Reduced Gene Expression
J. Biol. Chem., May 31, 1996; 271(22): 13055 - 13060.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
M. W. Feinberg, M. K. Jain, F. Werner, N. E. S. Sibinga, P. Wiesel, H. Wang, J. N. Topper, M. A. Perrella, and M.-E. Lee
Transforming Growth Factor-beta 1 Inhibits Cytokine-mediated Induction of Human Metalloelastase in Macrophages
J. Biol. Chem., August 11, 2000; 275(33): 25766 - 25773.
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J. Biol. Chem.Home page
A. a. Belaaouaj, A. Li, T.-C. Wun, H. G. Welgus, and S. D. Shapiro
Matrix Metalloproteinases Cleave Tissue Factor Pathway Inhibitor. EFFECTS ON COAGULATION
J. Biol. Chem., August 25, 2000; 275(35): 27123 - 27128.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
S. Li, L. H. Chow, and J. G. Pickering
Cell Surface-bound Collagenase-1 and Focal Substrate Degradation Stimulate the Rear Release of Motile Vascular Smooth Muscle Cells
J. Biol. Chem., November 3, 2000; 275(45): 35384 - 35392.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
X. Fu, S. Y. Kassim, W. C. Parks, and J. W. Heinecke
Hypochlorous Acid Oxygenates the Cysteine Switch Domain of Pro-matrilysin (MMP-7). A MECHANISM FOR MATRIX METALLOPROTEINASE ACTIVATION AND ATHEROSCLEROTIC PLAQUE RUPTURE BY MYELOPEROXIDASE
J. Biol. Chem., October 26, 2001; 276(44): 41279 - 41287.
[Abstract] [Full Text] [PDF]