(Circulation. 1995;92:835-841.)
© 1995 American Heart Association, Inc.
Articles |
Left Atrial Size and the Risk of Stroke and Death
The Framingham Heart Study
From The Framingham Heart Study, Framingham, Mass (E.J.B., R.B.D., A.J.B., P.A.W., D.L.); the Departments of Cardiology (E.J.B.), Neurology (P.A.W.), and Preventive Medicine (E.J.B., P.A.W., D.L.), Boston (Mass) University School of Medicine; the Department of Mathematics, Boston (Mass) University (R.B.D., A.J.B.); the Division of Cardiology and Clinical Epidemiology, Beth Israel Hospital, Boston, Mass (D.L.); and the NHLBI, Bethesda, Md (D.L.).
Correspondence and reprint requests to Emelia J. Benjamin, MD, ScM, The Framingham Heart Study, 5 Thurber St, Framingham, MA 01701.
Background The medical literature contains conflicting reports on the association of left atrial (LA) enlargement with risk of stroke. The relation of LA size to risk of stroke and death in the general population remains largely unexplored.
Methods and Results Subjects 50 years of age and older from the Framingham Heart Study were studied to assess the relations between echocardiographic LA size and risk of stroke and death. During 8 years of follow-up, 64 of 1371 (4.7%) men and 73 of 1728 (4.2%) women sustained a stroke, and 296 (21.6%) men and 271 (15.7%) women died. Sex-specific Cox proportional-hazards models were adjusted for age, hypertension, diabetes, atrial fibrillation, smoking, ECG left ventricular (LV) hypertrophy, and congestive heart failure or myocardial infarction. After multivariable adjustment, for every 10-mm increase in LA size, the relative risk of stroke was 2.4 in men (95% CI, 1.6 to 3.7) and 1.4 in women (95% CI, 0.9 to 2.1); the relative risk of death was 1.3 in men (95% CI, 1.0 to 1.5) and 1.4 in women (95% CI, 1.1 to 1.7). Adjusting for ECG LV mass/height attenuated the relation of LA size to stroke and death.
Conclusions After multivariable adjustment, LA enlargement remained a significant predictor of stroke in men and death in both sexes. The relation of LA enlargement to stroke and death appears to be partially mediated by LV mass.
Key Words: echocardiography • cerebrovascular disorders • heart atrium • hypertrophy • risk factors • mortality
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|
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|
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|
|
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|
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|
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 J. A. Laukkanen, S. Kurl, J. Eranen, M. Huttunen, and J. T. Salonen Left Atrium Size and the Risk of Cardiovascular Death in Middle-aged Men Arch Intern Med, August 8, 2005; 165(15): 1788 - 1793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
M. E. Barnes, Y. Miyasaka, J. B. Seward, B. J. Gersh, A. G. Rosales, K. R. Bailey, G. W. Petty, D. O. Wiebers, and T. S. M. Tsang Left Atrial Volume in the Prediction of First Ischemic Stroke in an Elderly Cohort Without Atrial Fibrillation Mayo Clin. Proc., August 1, 2004; 79(8): 1008 - 1014. [Abstract] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
J Kawai, K Tanabe, C.-L Wang, T Tani, T Yagi, H Shiotani, and S Morioka Comparison of left atrial size by freehand scanning three-dimensional echocardiography and two-dimensional echocardiography Eur J Echocardiogr, January 1, 2004; 5(1): 18 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
A. Rossi, M. Cicoira, L. Zanolla, R. Sandrini, G. Golia, P. Zardini, and M. Enriquez-Sarano Determinants and prognostic value of left atrial volume in patients with dilated cardiomyopathy J. Am. Coll. Cardiol., October 16, 2002; 40(8): 1425 - 1430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Halperin and V. Fuster Patent Foramen Ovale and Recurrent Stroke: Another Paradoxical Twist Circulation, June 4, 2002; 105(22): 2580 - 2582. [Full Text] [PDF]
|
|
|
|
|
|
E. Gerdts, L. Oikarinen, V. Palmieri, J. E. Otterstad, K. Wachtell, K. Boman, B. Dahlof, and R. B. Devereux Correlates of Left Atrial Size in Hypertensive Patients With Left Ventricular Hypertrophy: The Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study Hypertension, March 1, 2002; 39(3): 739 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Disertori, L. Padeletti, M. Santini, P. Dini, M. Gasparini, G. Inama, M. Botto, G. Boriani, A. Capucci, R. Ricci, et al. Antitachycardia pacing therapies to terminate atrial tachyarrhythmias: the AT500 Italian Registry Eur. Heart J. Suppl., November 1, 2001; 3(suppl_P): P16 - P24. [Abstract] [PDF]
|
|
|
|
|
|
S. Sadanandan and M. V. Sherrid Clinical and echocardiographic characteristics of left atrial spontaneous echo contrast in sinus rhythm J. Am. Coll. Cardiol., June 1, 2000; 35(7): 1932 - 1938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Di Tullio, R. L. Sacco, R. R. Sciacca, and S. Homma Left Atrial Size and the Risk of Ischemic Stroke in an Ethnically Mixed Population Stroke, October 1, 1999; 30(10): 2019 - 2024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H R Andersen, J C Nielsen, P E B Thomsen, L Thuesen, A K Pedersen, P T Mortensen, and T Vesterlund Arterial thromboembolism in patients with sick sinus syndrome: prediction from pacing mode, atrial fibrillation, and echocardiographic findings Heart, April 1, 1999; 81(4): 412 - 418. [Abstract] [Full Text]
|
|
|
|
|
|
J. S. Gottdiener, D. J. Reda, D. W. Williams, B. J. Materson, W. Cushman, and R. J. Anderson Effect of Single-Drug Therapy on Reduction of Left Atrial Size in Mild to Moderate Hypertension : Comparison of Six Antihypertensive Agents Circulation, July 14, 1998; 98(2): 140 - 148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Nielsen, H. R. Andersen, P. E. B. Thomsen, L. Thuesen, P. T. Mortensen, T. Vesterlund, and A. K. Pedersen Heart Failure and Echocardiographic Changes During Long-term Follow-up of Patients With Sick Sinus Syndrome Randomized to Single-Chamber Atrial or Ventricular Pacing Circulation, March 17, 1998; 97(10): 987 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Sacco, E. J. Benjamin, J. P. Broderick, M. Dyken, J. D. Easton, W. M. Feinberg, L. B. Goldstein, P. B. Gorelick, G. Howard, S. J. Kittner, et al. Risk Factors Stroke, July 1, 1997; 28(7): 1507 - 1517. [Full Text]
|
|
|
|
 |
|
 Y. Sato, H. Kiriazis, A. Yatani, A. G. Schmidt, H. Hahn, D. G. Ferguson, H. Sako, S. Mitarai, R. Honda, L. Mesnard-Rouiller, et al. Rescue of Contractile Parameters and Myocyte Hypertrophy in Calsequestrin Overexpressing Myocardium by Phospholamban Ablation J. Biol. Chem., March 16, 2001; 276(12): 9392 - 9399. [Abstract] [Full Text] [PDF]
|
|