| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 1995;91:663-670.)
© 1995 American Heart Association, Inc.
Articles |
Dobutamine Echocardiography in Myocardial Hibernation
Optimal Dose and Accuracy in Predicting Recovery of Ventricular Function After Coronary Angioplasty
Presented in part at the 66th Annual Scientific Session of the American Heart Association, November 1993, Atlanta, Ga.
From the Section of Cardiology, Department of Medicine, Baylor College of Medicine, The Methodist Hospital, Echocardiography Laboratory, Houston, Tex.
Correspondence to William A. Zoghbi, MD, The Methodist Hospital, Section of Cardiology, 6535 Fannin, F905, Houston, TX 77030.
Background Myocardial hibernation is a condition of chronic left ventricular dysfunction associated with severe coronary artery disease whereby significant recovery of function occurs after revascularization. Identification of hibernating myocardium has important prognostic and therapeutic implications. The presence of contractile reserve as assessed by dobutamine echocardiography may be promising in the detection of hibernation. We designed a prospective study to evaluate the accuracy and optimal dose of dobutamine echocardiography for predicting recovery of ventricular function after angioplasty in patients with stable coronary artery disease and ventricular dysfunction.
Methods and Results Twenty patients with stable coronary artery
disease and segmental ventricular dysfunction scheduled for coronary
angioplasty underwent dobutamine echocardiography before
revascularization using incremental doses of 2.5, 5, 7.5, 10, 20, 30,
and 40 µg/kg per minute every 3 minutes. Digital images of all eight
stages were displayed simultaneously (two quad screens side by side)
and interpreted using a 16-segment ventricular model and a 6-grade
scoring system. Serial resting echocardiograms before, early (<1
week), and late (
6 weeks) after angioplasty were digitized and
randomized in a quad-screen format for the assessment of recovery of
function. Wall motion score index in the revascularized regions
decreased from 2.86±0.76 before angioplasty to 2.12±1.03 late
after
angioplasty (P<.05). Of 320 ventricular segments, 148 had
abnormal wall motion at baseline and 114 were revascularized. Recovery
of function (2 grades) occurred in 25% of revascularized segments
early and in 33% late after angioplasty. Of the 34 abnormal segments
not revascularized, recovery of function occurred in only 1. During
dobutamine echocardiography, abnormal segments exhibited one of four
responses: biphasic (improvement at low dose and worsening at high
dose) in 28% of segments, sustained improvement (persistent
improvement till peak dose) in 18%, worsening in 15%, and no change
in 39%. A biphasic response had the highest predictive value (72%)
for recovery of function followed by worsening only (35%), while the
lowest was seen with a "no change" or sustained improvement
response (13% and 15%). Combining biphasic and worsening responses
resulted in a sensitivity of 74% and specificity of 73% for
assessment of recovery of individual segments and 90% and 60%,
respectively, for functional recovery of individual patients (n=10). In
segments with a biphasic response, the low dose at which improvement in
wall motion was most prevalent (84%) was 7.5 µg/kg per minute and
increased to 94% when the 5 and 7.5 µg/kg per minute doses were
displayed. The reworsening phase of the biphasic response was usually
seen with doses 20 µg/kg per minute but was also observed as early
as the 7.5 µg/kg per minute dose.
Conclusions The wall motion response during dobutamine echocardiography is useful in the prediction of recovery of ventricular function after revascularization in patients with stable coronary artery disease and ventricular dysfunction. The administration of low as well as high doses of dobutamine is needed for optimal evaluation.
Key Words: echocardiography • coronary disease • myocardium • angioplasty
This article has been cited by other articles:
 |
|
 |
|
  V Rizzello, D Poldermans, E Biagini, A F L Schinkel, E Boersma, A Boccanelli, T Marwick, J R T C Roelandt, and J J Bax Prognosis of patients with ischaemic cardiomyopathy after coronary revascularisation: relation to viability and improvement in left ventricular ejection fraction Heart, August 1, 2009; 95(15): 1273 - 1277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hoeks and D. Poldermans CHAPTER 34 Non-cardiac Surgery in Cardiac Patients ESC Textbook of Cardiovascular Medicine, January 1, 2009; 2(1): med-9780199566990-chapter - med-9780199566990-chapter. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Rahimtoola, V. Dilsizian, C. M. Kramer, T. H. Marwick, and J.-L. J. Vanoverschelde Chronic ischemic left ventricular dysfunction from pathophysiology to imaging and its integration into clinical practice. J. Am. Coll. Cardiol. Img., July 1, 2008; 1(4): 536 - 555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Cianfrocca, F. Pelliccia, A. Auriti, V. Guido, V. Pasceri, X. Li, G. Richichi, G. Mercuro, and M. Santini Levosimendan allows detection of contractile reserve in patients with chronic ischaemic left ventricular dysfunction and non-diagnostic dobutamine echocardiography Eur J Heart Fail, September 1, 2007; 9(9): 897 - 900. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Banas, S. Baldwa, G. Suzuki, J. M. Canty Jr., and J. A. Fallavollita Determinants of contractile reserve in viable, chronically dysfunctional myocardium Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2791 - H2797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Karagiannis, H. H.H. Feringa, J. J. Bax, A. Elhendy, M. Dunkelgrun, R. Vidakovic, S.E. Hoeks, R. van Domburg, R. Valhema, D. V. Cokkinos, et al. Myocardial viability estimation during the recovery phase of stress echocardiography after acute beta-blocker administration Eur J Heart Fail, April 1, 2007; 9(4): 403 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Mazzadi, X. Andre-Fouet, N. Costes, P. Croisille, D. Revel, and M. F. Janier Mechanisms leading to reversible mechanical dysfunction in severe CAD: alternatives to myocardial stunning Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2570 - H2582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Bove, J. M. DiMaria, S. Voros, M. R. Conaway, and C. M. Kramer Dobutamine Response and Myocardial Infarct Transmurality: Functional Improvement after Coronary Artery Bypass Grafting--Initial Experience Radiology, September 1, 2006; 240(3): 835 - 841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Rizzello, D. Poldermans, E. Biagini, A. F.L. Schinkel, E. Boersma, A. Elhendy, F. B. Sozzi, A. Maat, J. R.T.C. Roelandt, and J. J. Bax Benefits of coronary revascularisation in diabetic and non-diabetic patients with ischaemic cardiomyopathy: Role of myocardial viability Eur J Heart Fail, May 1, 2006; 8(3): 314 - 320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hasegawa, H. Takano, K. Iwanaga, M. Ohtsuka, Y. Qin, Y. Niitsuma, K. Ueda, T. Toyoda, H. Tadokoro, and I. Komuro Cardioprotective Effects of Granulocyte Colony-Stimulating Factor in Swine With Chronic Myocardial Ischemia J. Am. Coll. Cardiol., February 21, 2006; 47(4): 842 - 849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V Rizzello, D Poldermans, A F L Schinkel, E Biagini, E Boersma, A Elhendy, F B Sozzi, A Maat, F Crea, J R T C Roelandt, et al. Long term prognostic value of myocardial viability and ischaemia during dobutamine stress echocardiography in patients with ischaemic cardiomyopathy undergoing coronary revascularisation Heart, February 1, 2006; 92(2): 239 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gorcsan III Echocardiographic Strain Imaging for Myocardial Viability: An Improvement Over Visual Assessment? Circulation, December 20, 2005; 112(25): 3820 - 3822. [Full Text] [PDF]
|
|
|
|
|
|
L. Hanekom, C. Jenkins, L. Jeffries, C. Case, J. Mundy, C. Hawley, and T. H. Marwick Incremental Value of Strain Rate Analysis as an Adjunct to Wall-Motion Scoring for Assessment of Myocardial Viability by Dobutamine Echocardiography: A Follow-Up Study After Revascularization Circulation, December 20, 2005; 112(25): 3892 - 3900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. F. Armstrong and W. A. Zoghbi Stress Echocardiography: Current Methodology and Clinical Applications J. Am. Coll. Cardiol., June 7, 2005; 45(11): 1739 - 1747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yoshinaga, C. Katoh, R. S.B. Beanlands, K. Noriyasu, K. Komuro, S. Yamada, Y. Kuge, K. Morita, A. Kitabatake, and N. Tamaki Reduced Oxidative Metabolic Response in Dysfunctional Myocardium with Preserved Glucose Metabolism but with Impaired Contractile Reserve J. Nucl. Med., November 1, 2004; 45(11): 1885 - 1891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Rizzello, D. Poldermans, E. Boersma, E. Biagini, A. F.L. Schinkel, B. Krenning, A. Elhendy, E. C. Vourvouri, F. B. Sozzi, A. Maat, et al. Opposite Patterns of Left Ventricular Remodeling After Coronary Revascularization in Patients With Ischemic Cardiomyopathy: Role of Myocardial Viability Circulation, October 19, 2004; 110(16): 2383 - 2388. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zaugg, M. C. Schaub, and P. Foex Myocardial injury and its prevention in the perioperative setting Br. J. Anaesth., July 1, 2004; 93(1): 21 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Go, M. R. Bhatt, and R. C. Hendel The Diagnostic and Prognostic Value of ECG-Gated SPECT Myocardial Perfusion Imaging J. Nucl. Med., May 1, 2004; 45(5): 912 - 921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J H McGowan Hibernating myocardium: high or low risk? Heart, March 1, 2004; 90(3): 237 - 238. [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Biswas, G. C. Hughes, J. E. Scarborough, P. W. Domkowski, L. Diodato, M. L. Smith, C. Landolfo, J. E. Lowe, B. H. Annex, and K. P. Landolfo Intramyocardial and intracoronary basic fibroblast growth factor in porcine hibernating myocardium: A comparative study J. Thorac. Cardiovasc. Surg., January 1, 2004; 127(1): 34 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Cheitlin, W. F. Armstrong, G. P. Aurigemma, G. A. Beller, F. Z. Bierman, J. L. Davis, P. S. Douglas, D. P. Faxon, L. D. Gillam, T. R. Kimball, et al. ACC/AHA/ASE 2003 guideline update for the clinical application of echocardiography: summary article: a report of the American college of cardiology/American heart association task force on practice guidelines (ACC/AHA/ASE committee to update the 1997 guidelines for the clinical application of echocardiography) J. Am. Coll. Cardiol., September 3, 2003; 42(5): 954 - 970. [Full Text] [PDF]
|
|
|
|
|
|
M. D. Cheitlin, W. F. Armstrong, G. P. Aurigemma, G. A. Beller, F. Z. Bierman, J. L. Davis, P. S. Douglas, D. P. Faxon, L. D. Gillam, T. R. Kimball, et al. ACC/AHA/ASE 2003 Guideline Update for the Clinical Application of Echocardiography: Summary Article: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASE Committee to Update the 1997 Guidelines for the Clinical Application of Echocardiography) Circulation, September 2, 2003; 108(9): 1146 - 1162. [Full Text] [PDF]
|
|
|
|
|
|
R. Southworth and P. B. Garlick Dobutamine responsiveness, PET mismatch, and lack of necrosis in low-flow ischemia: is this hibernation in the isolated rat heart? Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H316 - H324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. C. Hughes, M. J. Post, M. Simons, and B. H. Annex Translational Physiology: Porcine models of human coronary artery disease: implications for preclinical trials of therapeutic angiogenesis J Appl Physiol, May 1, 2003; 94(5): 1689 - 1701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Lancellotti, E. P. Hoffer, and L. A. Pierard Detection and clinical usefulness of a biphasic response during exercise echocardiography early after myocardial infarction J. Am. Coll. Cardiol., April 2, 2003; 41(7): 1142 - 1147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shimoni, N. G. Frangogiannis, C. J. Aggeli, K. Shan, M. S. Verani, M. A. Quinones, R. Espada, G. V. Letsou, G. M. Lawrie, W. L. Winters, et al. Identification of Hibernating Myocardium With Quantitative Intravenous Myocardial Contrast Echocardiography: Comparison With Dobutamine Echocardiography and Thallium-201 Scintigraphy Circulation, February 4, 2003; 107(4): 538 - 544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Meluzin, J. Cerny, L. Spinarova, J. Toman, L. Groch, F. Stetka, M. Frelich, P. Hude, J. Krejci, L. Rambouskova, et al. Prognosis of patients with chronic coronary artery disease and severe left ventricular dysfunction. The importance of myocardial viability Eur J Heart Fail, January 1, 2003; 5(1): 85 - 93. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Yetkin, K. Senen, M. Ileri, R. Atak, B. Battaoglu, O. Yetkin, I. Tandogan, H. Turhan, and S. Cehreli Identification of Viable Myocardium in Patients with Chronic Coronary Artery Disease and Myocardial Dysfunction: Comparison of Low-Dose Dobutamine Stress Echocardiography and Echocardiography During Glucose-Insulin-Potassium Infusion Angiology, November 1, 2002; 53(6): 671 - 676. [Abstract] [PDF]
|
|
|
|
 |
|
 F. W. Dupont, R. M. Lang, M. L. Drum, and S. Aronson Is There a Long-Term Predictive Value of Intraoperative Low-Dose Dobutamine Echocardiography in Patients Who Have Coronary Artery Bypass Graft Surgery with Cardiopulmonary Bypass? Anesth. Analg., September 1, 2002; 95(3): 517 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shimoni, N. G. Frangogiannis, C. J. Aggeli, K. Shan, M. A. Quinones, R. Espada, G. V. Letsou, G. M. Lawrie, W. L. Winters, M. J. Reardon, et al. Microvascular Structural Correlates of Myocardial Contrast Echocardiography in Patients With Coronary Artery Disease and Left Ventricular Dysfunction: Implications for the Assessment of Myocardial Hibernation Circulation, August 20, 2002; 106(8): 950 - 956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F.M van den Heuvel, J. J Bax, P. K Blanksma, W. Vaalburg, H. J.G.M Crijns, and D. J van Veldhuisen Abnormalities in myocardial contractility, metabolism and perfusion reserve in non-stenotic coronary segments in heart failure patients Cardiovasc Res, July 1, 2002; 55(1): 97 - 103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Bax, J. Maddahi, D. Poldermans, A. Elhendy, J. H. Cornel, E. Boersma, J. R.T.C. Roelandt, and P. M. Fioretti Sequential 201Tl Imaging and Dobutamine Echocardiography to Enhance Accuracy of Predicting Improved Left Ventricular Ejection Fraction After Revascularization J. Nucl. Med., June 1, 2002; 43(6): 795 - 802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. B. Chin, G. Esposito, and D. L. Kraitchman Myocardial Contractile Reserve and Perfusion Defect Severity with Rest and Stress Dobutamine 99mTc-Sestamibi SPECT in Canine Stunning and Subendocardial Infarction J. Nucl. Med., April 1, 2002; 43(4): 540 - 550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Zaglavara, R Haaverstad, B Cumberledge, T Irvine, H Karvounis, G Parharidis, G Louridas, and A Kenny Dobutamine stress echocardiography for the detection of myocardial viability in patients with left ventricular dysfunction taking {beta} blockers: accuracy and optimal dose Heart, April 1, 2002; 87(4): 329 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. G. Frangogiannis, S. Shimoni, S. M. Chang, G. Ren, K. Shan, C. Aggeli, M. J. Reardon, G. V. Letsou, R. Espada, M. Ramchandani, et al. Evidence for an Active Inflammatory Process in the Hibernating Human Myocardium Am. J. Pathol., April 1, 2002; 160(4): 1425 - 1433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F Piscione, P Perrone-Filardi, G De Luca, M Prastaro, C Indolfi, P Golino, S Dellegrottaglie, and M Chiariello Low dose dobutamine echocardiography for predicting functional recovery after coronary revascularisation Heart, December 1, 2001; 86(6): 679 - 686. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. del Mar de la Torre, J. A. San Roman, J. Bermejo, G. Pastor, J. Alonso, and F. Fernandez-Aviles Prognostic Power of Dobutamine Echocardiography After Uncomplicated Acute Myocardial Infarction in the Elderly Chest, October 1, 2001; 120(4): 1200 - 1205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. C. Hughes, C. K. Landolfo, B. Yin, T. R. DeGrado, R. E. Coleman, K. P. Landolfo, and J. E. Lowe Is chronically dysfunctional yet viable myocardium distal to a severe coronary stenosis hypoperfused? Ann. Thorac. Surg., July 1, 2001; 72(1): 163 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Iglesias-Garriz, F.e. Corral, M. A. Rodriguez, C. Garrote, M. Montes, and E. Sevillano Pre-infarction angina elicits greater myocardial viability on reperfusion after myocardial infarction: a dobutamine stress echocardiographic study J. Am. Coll. Cardiol., June 1, 2001; 37(7): 1846 - 1850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yoshinaga, K. Morita, S. Yamada, K. Komuro, C. Katoh, Y. Ito, Y. Kuge, T. Kohya, A. Kitabatake, and N. Tamaki Low-Dose Dobutamine Electrocardiograph-Gated Myocardial SPECT for Identifying Viable Myocardium: Comparison with Dobutamine Stress Echocardiography and PET J. Nucl. Med., June 1, 2001; 42(6): 838 - 844. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Sicari, A Ripoli, E Picano, A.C Borges, A Varga, W Mathias, L Cortigiani, R Bigi, J Heyman, S Polimeno, et al. The prognostic value of myocardial viability recognized by low dose dipyridamole echocardiography in patients with chronic ischaemic left ventricular dysfunction Eur. Heart J., May 2, 2001; 22(10): 837 - 844. [Abstract] [PDF]
|
|
|
|
|
|
P Lancellotti, A Albert, C Berthe, and L A Piérard Full recovery of contraction late after acute myocardial infarction: determinants and early predictors Heart, May 1, 2001; 85(5): 521 - 526. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Yong, S. F. Nagueh, S. Shimoni, K. Shan, Z.-X. He, M. J. Reardon, G. V. Letsou, J. F. Howell, M. S. Verani, M. A. Quinones, et al. Deceleration Time in Ischemic Cardiomyopathy : Relation to Echocardiographic and Scintigraphic Indices of Myocardial Viability and Functional Recovery After Revascularization Circulation, March 6, 2001; 103(9): 1232 - 1237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-M. J. Siebelink, P. K. Blanksma, H. J. G. M. Crijns, J. J. Bax, A. J. van Boven, T. Kingma, D. A. Piers, J. Pruim, P. L. Jager, W. Vaalburg, et al. No difference in cardiac event-free survival between positron emission tomography-guided and single-photon emission computed tomography-guided patient management: A prospective, randomized comparison of patients with suspicion of jeopardized myocardium J. Am. Coll. Cardiol., January 1, 2001; 37(1): 81 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Wolf, L. Gepstein, G. Hayam, A. Zaretzky, R. Shofty, D. Kirshenbaum, G. Uretzky, U. Oron, and S. A. Ben-Haim Three-dimensional endocardial impedance mapping: a new approach for myocardial infarction assessment Am J Physiol Heart Circ Physiol, January 1, 2001; 280(1): H179 - H188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-P. Bin, R. A. Pelberg, K. Wei, M. Coggins, N. C. Goodman, and S. Kaul Relation between regional function and coronary blood flow reserve in multivessel coronary artery stenosis Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H3058 - H3064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Shan, R. J. Bick, B. J. Poindexter, S. F. Nagueh, S. Shimoni, M. S. Verani, F. Keng, M. J. Reardon, G. V. Letsou, J. F. Howell, et al. Altered Adrenergic Receptor Density in Myocardial Hibernation in Humans : A Possible Mechanism of Depressed Myocardial Function Circulation, November 21, 2000; 102(21): 2599 - 2606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G LaCanna, S.H Rahimtoola, O Visioli, R Giubbini, O Alfieri, M Zognio, E Milan, C Ceconi, M Gargano, R LoRusso, et al. Sensitivity, specificity, and predictive accuracies of non-invasive tests, singly and in combination, for diagnosis of hibernating myocardium Eur. Heart J., August 2, 2000; 21(16): 1358 - 1367. [Abstract] [PDF]
|
|
|
|
|
|
F.M Baer, P Theissen, J Crnac, M Schmidt, H.J Deutsch, U Sechtem, H Schicha, and E Erdmann Head to head comparison of dobutamine-transoesophageal echocardiography and dobutamine-magnetic resonance imaging for the prediction of left ventricular functional recovery in patients with chronic coronary artery disease Eur. Heart J., June 2, 2000; 21(12): 981 - 991. [Abstract] [PDF]
|
|
|
|
|
|
K. Takehana, M. Ruiz, F. D. Petruzella, D. D. Watson, G. A. Beller, and D. K. Glover Response to incremental doses of dobutamine early after reperfusion is predictive of the degree of myocardial salvage in dogs with experimental acute myocardial infarction J. Am. Coll. Cardiol., June 1, 2000; 35(7): 1960 - 1968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. St. Louis, G. C. Hughes, A. P. Kypson, T. R. DeGrado, C. L. Donovan, R. E. Coleman, B. Yin, C. Steenbergen, K. P. Landolfo, and J. E. Lowe An experimental model of chronic myocardial hibernation Ann. Thorac. Surg., May 1, 2000; 69(5): 1351 - 1357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Cwajg, E. Cwajg, S. F. Nagueh, Z.-X. He, U. Qureshi, L. I. Olmos, M. A. Quinones, M. S. Verani, W. L. Winters, and W. A. Zoghbi End-diastolic wall thickness as a predictor of recovery of function in myocardial hibernation: Relation to rest-redistribution Tl-201 tomography and dobutamine stress echocardiography J. Am. Coll. Cardiol., April 1, 2000; 35(5): 1152 - 1161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lu, M. Carlino, G. Fragasso, F. Maisano, A. Margonato, A. Cappelletti, and S. L. Chierchia Enoximone Echocardiography for Predicting Recovery of Left Ventricular Dysfunction After Revascularization : A Novel Test for Detecting Myocardial Viability Circulation, March 21, 2000; 101(11): 1255 - 1260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pasquet, M.S. Lauer, M.J. Williams, M.-A. Secknus, B. Lytle, and T.H. Marwick Prediction of global left ventricular function after bypass surgery in patients with severe left ventricular dysfunction. Impact of pre-operative myocardial function, perfusion, and metabolism Eur. Heart J., January 2, 2000; 21(2): 125 - 136. [Abstract] [PDF]
|
|
|
|
|
|
F. Barilla Reply J. Am. Coll. Cardiol., January 1, 2000; 35(1): 258 - 259. [Full Text] [PDF]
|
|
|
|
|
|
R J Trent, G D Waiter, G S Hillis, F I McKiddie, T W Redpath, and S Walton Dobutamine magnetic resonance imaging as a predictor of myocardial functional recovery after revascularisation Heart, January 1, 2000; 83(1): 40 - 46. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. P. Hoffer, W. Dewe, C. Celentano, and L. A. Pierard Low-level exercise echocardiography detects contractile reserve and predicts reversible dysfunction after acute myocardial infarction: Comparison with low-dose dobutamine echocardiography J. Am. Coll. Cardiol., October 1, 1999; 34(4): 989 - 997. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-L. Monin, J.e. Garot, M. Scherrer-Crosbie, J. Rosso, A.-M. Duval-Moulin, P. Dupouy, E. Teiger, A. Castaigne, J.-C. Cachin, J.-L. Dubois-Rande, et al. Prediction of functional recovery of viable myocardium after delayed revascularization in postinfarction patients: Accuracy of dobutamine stress echocardiography and influence of long-term vessel patency J. Am. Coll. Cardiol., October 1, 1999; 34(4): 1012 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F Larrazet, D Pellerin, D Daou, S Witchitz, C Fournier, A Prigent, and C Veyrat Concordance between dobutamine Doppler tissue imaging echocardiography and rest reinjection thallium-201 tomography in dysfunctional hypoperfused myocardium Heart, October 1, 1999; 82(4): 432 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Chaudhry, J. T. Tauke, R. S. Alessandrini, G. Vardi, M. A. Parker, and R. O. Bonow Prognostic implications of myocardial contractile reserve in patients with coronary artery disease and left ventricular dysfunction J. Am. Coll. Cardiol., September 1, 1999; 34(3): 730 - 738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. Nagueh, I. Mikati, D. Weilbaecher, M. J. Reardon, G. J. Al-Zaghrini, D. Cacela, Z.-X. He, G. Letsou, G. Noon, J. F. Howell, et al. Relation of the Contractile Reserve of Hibernating Myocardium to Myocardial Structure in Humans Circulation, August 3, 1999; 100(5): 490 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F Fath-Ordoubadi, K J Beatt, N Spyrou, and P G Camici Efficacy of coronary angioplasty for the treatment of hibernating myocardium Heart, August 1, 1999; 82(2): 210 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Bax, D. Poldermans, A. Elhendy, J. H. Cornel, E. Boersma, R. Rambaldi, J. R. T. C. Roelandt, and P. M. Fioretti Improvement of left ventricular ejection fraction, heart failure symptoms and prognosis after revascularization in patients with chronic coronary artery disease and viable myocardium detected by dobutamine stress echocardiography J. Am. Coll. Cardiol., July 1, 1999; 34(1): 163 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Auerbach, H. Schoder, C. Hoh, S. S. Gambhir, S. Yaghoubi, J. W. Sayre, D. Silverman, M. E. Phelps, H. R. Schelbert, and J. Czernin Prevalence of Myocardial Viability as Detected by Positron Emission Tomography in Patients With Ischemic Cardiomyopathy Circulation, June 8, 1999; 99(22): 2921 - 2926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Barilla, G. De Vincentis, E. Mangieri, M. Ciavolella, G. Pannitteri, F. Scopinaro, G. Critelli, and P. P. Campa Recovery of contractility of viable myocardium during inotropic stimulation is not dependent on an increase of myocardial blood flow in the absence of collateral filling J. Am. Coll. Cardiol., March 1, 1999; 33(3): 697 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Smart, P. N. Dionisopoulos, T. A. Knickelbine, T. Schuchard, and K. B. Sagar Dobutamine-atropine stress echocardiography for risk stratification in patients with chronic left ventricular dysfunction J. Am. Coll. Cardiol., February 1, 1999; 33(2): 512 - 521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Acquatella, J. E. Perez, J. A. Condado, and I. Sanchez Limited myocardial contractile reserve and chronotropic incompetence in patients with chronic Chagas' disease: Assessment by dobutamine stress echocardiography J. Am. Coll. Cardiol., February 1, 1999; 33(2): 522 - 529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Baumgartner, G. Porenta, Y.-K. Lau, M. Wutte, U. Klaar, M. Mehrabi, R. J. Siegel, J. Czernin, G.u. Laufer, H. Sochor, et al. Assessment of myocardial viability by dobutamine echocardiography, positron emission tomography and thallium-201 SPECT: Correlation with histopathology in explanted hearts J. Am. Coll. Cardiol., November 15, 1998; 32(6): 1701 - 1708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Gunning, C. Anagnostopoulos, C. J. Knight, J. Pepper, E. D. Burman, G. Davies, K. M. Fox, D. J. Pennell, P. J. Ell, and S. R. Underwood Comparison of 201Tl, 99mTc-Tetrofosmin, and Dobutamine Magnetic Resonance Imaging for Identifying Hibernating Myocardium Circulation, November 3, 1998; 98(18): 1869 - 1874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Meluzin, J. Cerny, M. Frelich, F. Stetka, L. Spinarova, J. Popelova, R. Stipal, and on behalf of the Investigators of This Multicenter Prognostic value of the amount of dysfunctional but viable myocardium in revascularized patients with coronary artery disease and left ventricular dysfunction J. Am. Coll. Cardiol., October 1, 1998; 32(4): 912 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Afridi, P. A. Grayburn, J. A. Panza, J. K. Oh, W. A. Zoghbi, and T. H. Marwick Myocardial viability during dobutamine echocardiography predicts survival in patients with coronary artery disease and severe left ventricular systolic dysfunction J. Am. Coll. Cardiol., October 1, 1998; 32(4): 921 - 926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Steendijk, J. Baan Jr., E. T. Van Der Velde, and J. Baan Effects of critical coronary stenosis on global systolic left ventricular function quantified by pressure-volume relations during dobutamine stress in the canine heart J. Am. Coll. Cardiol., September 1, 1998; 32(3): 816 - 826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S R Redwood, R Ferrari, and M S Marber Myocardial hibernation and stunning: from physiological principles to clinical practice Heart, September 1, 1998; 80(3): 218 - 222. [Full Text]
|
|
|
|
 |
|
 W. Wijns, S. F. Vatner, and P. G. Camici Hibernating Myocardium N. Engl. J. Med., July 16, 1998; 339(3): 173 - 181. [Full Text] [PDF]
|
|
|
|
|
|
D Pagano, R S Bonser, J N Townend, F Ordoubadi, R Lorenzoni, and P G Camici Predictive value of dobutamine echocardiography and positron emission tomography in identifying hibernating myocardium in patients with postischaemic heart failure Heart, March 1, 1998; 79(3): 281 - 288. [Abstract] [Full Text]
|
|
|
|
|
|
L. Ma, L. Chen, L. Gillam, D. D Waters, and C. Chen Nitroglycerin Enhances the Ability of Dobutamine Stress Echocardiography to Detect Hibernating Myocardium Circulation, December 2, 1997; 96(11): 3992 - 4001. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Genma, S. Ogawa, J. Zhang, and M. Yamamoto Evaluation of myocardial ischemia in Kawasaki disease by dobutamine stress signal-averaged ventricular late potentials Cardiovasc Res, December 1, 1997; 36(3): 323 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ogawa, R. Fukazawa, T. Ohkubo, J. Zhang, N. Takechi, Y. Kuramochi, Y. Hino, O. Jimbo, Y. Katsube, M. Kamisago, et al. Silent Myocardial Ischemia in Kawasaki Disease : Evaluation of Percutaneous Transluminal Coronary Angioplasty by Dobutamine Stress Testing Circulation, November 18, 1997; 96(10): 3384 - 3389. [Abstract] [Full Text]
|
|
|
|
|
|
M. F. Meza, S. Ramee, T. Collins, D. Stapleton, R. V. Milani, J. P. Murgo, and J. Cheirif Knowledge of Perfusion and Contractile Reserve Improves the Predictive Value of Recovery of Regional Myocardial Function Postrevascularization : A Study Using the Combination of Myocardial Contrast Echocardiography and Dobutamine Echocardiography Circulation, November 18, 1997; 96(10): 3459 - 3465. [Abstract] [Full Text]
|
|
|
|
|
|
H. H. Lee, V. G. Davila-Roman, P. A. Ludbrook, M. Courtois, J. F. Walsh, D. A. Delano, P. J. Rubin, and R. J. Gropler Dependency of Contractile Reserve on Myocardial Blood Flow : Implications for the Assessment of Myocardial Viability With Dobutamine Stress Echocardiography Circulation, November 4, 1997; 96(9): 2884 - 2891. [Abstract] [Full Text]
|
|
|
|
|
|
A. Elsasser, M. Schlepper, W.-P. Klovekorn, W.-j. Cai, R. Zimmermann, K.-D. Muller, R. Strasser, S. Kostin, C. Gagel, B. Munkel, et al. Hibernating Myocardium : An Incomplete Adaptation to Ischemia Circulation, November 4, 1997; 96(9): 2920 - 2931. [Abstract] [Full Text]
|
|
|
|
|
|
A. Cohen, C. Chauvel, B. Benhalima, P. Guyon, I. Desert, J. Valty, and A. Cohen Is Dobutamine Stress Echocardiography Useful for Noninvasive Differentiation of Ischemic from Idiopathic Dilated Cardiomyopathy? Angiology, September 1, 1997; 48(9): 783 - 793. [Abstract] [PDF]
|
|
|
|
|
|
G. von Degenfeld, W. Giehrl, and P. Boekstegers Targeting of dobutamine to ischemic myocardium without systemic effects by selective suction and pressure-regulated retroinfusion Cardiovasc Res, August 1, 1997; 35(2): 233 - 240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-L. J. Vanoverschelde, W. Wijns, M. Borgers, G. Heyndrickx, C. Depre, W. Flameng, and J. A. Melin Chronic Myocardial Hibernation in Humans: From Bedside to Bench Circulation, April 1, 1997; 95(7): 1961 - 1971. [Full Text]
|
|
|
|
|
|
M. D. Cheitlin, J. S. Alpert, W. F. Armstrong, G. P. Aurigemma, G. A. Beller, F. Z. Bierman, T. W. Davidson, J. L. Davis, P. S. Douglas, L. D. Gillam, et al. ACC/AHA Guidelines for the Clinical Application of Echocardiography : A Report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Committee on Clinical Application of Echocardiography) Developed in Collaboration With the American Society of Echocardiography Circulation, March 18, 1997; 95(6): 1686 - 1744. [Full Text]
|
|
|
|
|
|
U. Qureshi, S. F. Nagueh, I. Afridi, P. Vaduganathan, A. Blaustein, M. S. Verani, W. L. Winters, and W. A. Zoghbi Dobutamine Echocardiography and Quantitative Rest-Redistribution 201Tl Tomography in Myocardial Hibernation: Relation of Contractile Reserve to 201Tl Uptake and Comparative Prediction of Recovery of Function Circulation, February 4, 1997; 95(3): 626 - 635. [Abstract] [Full Text]
|
|
|
|
|
|
S. H. Rahimtoola Hibernating Myocardium Has Reduced Blood Flow at Rest That Increases With Low-Dose Dobutamine Circulation, December 15, 1996; 94(12): 3055 - 3061. [Full Text]
|
|
|
|
|
|
R. O. Bonow Identification of Viable Myocardium Circulation, December 1, 1996; 94(11): 2674 - 2680. [Full Text]
|
|
|
|
|
|
C. R. deFilippi, D. L. Willett, W. N. Irani, E. J. Eichhorn, C. E. Velasco, and P. A. Grayburn Comparison of Myocardial Contrast Echocardiography and Low-Dose Dobutamine Stress Echocardiography in Predicting Recovery of Left Ventricular Function After Coronary Revascularization in Chronic Ischemic Heart Disease Circulation, November 15, 1995; 92(10): 2863 - 2868. [Abstract] [Full Text]
|
|
|
|
 |
|
 Finding Hibernating Myocardium with Dobutamine Echo Journal Watch Cardiology, April 1, 1995; 1995(401): 11 - 11. [Full Text]
|
|
|
|
|
|
J. N. Oshinski, H.-C. Han, D. N. Ku, and R. I. Pettigrew Quantitative Prediction of Improvement in Cardiac Function after Revascularization with MR Imaging and Modeling: Initial Results Radiology, November 1, 2001; 221(2): 515 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Choi, R. J. Kim, G. Gubernikoff, J. D. Vargas, M. Parker, and R. M. Judd Transmural Extent of Acute Myocardial Infarction Predicts Long-Term Improvement in Contractile Function Circulation, September 4, 2001; 104(10): 1101 - 1107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. Kalra, X. Zhu, M. K. Ramchandani, G. Lawrie, M. J. Reardon, D. Lee-Jackson, W. L. Winters, N. Sivasubramanian, D. L. Mann, and W. A. Zoghbi Increased Myocardial Gene Expression of Tumor Necrosis Factor-{alpha} and Nitric Oxide Synthase-2: A Potential Mechanism for Depressed Myocardial Function in Hibernating Myocardium in Humans Circulation, April 2, 2002; 105(13): 1537 - 1540. [Abstract] [Full Text] [PDF]
|
|