(Circulation. 1995;91:265-269.)
© 1995 American Heart Association, Inc.
Articles |
Apolipoprotein E Polymorphism Predicts Death From Coronary Heart Disease in a Longitudinal Study of Elderly Finnish Men
From the National Public Health Institute (J.H.S., J.P., C.E.), Helsinki, Finland; Department of Human Genetics (J.H.S., K.E.Z., C.F.S.), University of Michigan (Ann Arbor); and Department of Community Health and General Practice (A.N.), University of Kuopio, Finland.
Correspondence to Dr Jari H. Stengård, National Public Health Institute, Department of Epidemiology and Health Promotion, Mannerheimintie 166, FIN-00300, Finland, Helsinki.
Background There is ample evidence from cross-sectional studies of an association between allelic variation of the gene coding for apolipoprotein E (apoE) and interindividual variation in plasma lipids, and the presence of coronary heart disease (CHD). There have been no prospective studies, however, to evaluate the usefulness of allelic variation of the apoE gene for predicting CHD.
Methods and Results Two samples of elderly Finnish men were
followed for 5 years, one in the east (n=297) and the other in the
southwest of Finland (n=369). At baseline, when the apoE genotypes were
assessed, the men were 65 to 84 years old. At the end of the follow-up,
the vital status of each man was determined, and cause of death was
coded. At baseline, relative frequencies of the three alleles–
2,
3, and 4–were 0.037, 0.827, and 0.136 in the eastern and
0.062,
0.763, and 0.175 in the southwestern samples, respectively
(
2=8.89, df=2, P<.012 for
difference between the samples). During the 5-year follow-up, a total
of 28 deaths from CHD were recorded in the eastern and 42 in the
southwestern sample. Relative CHD mortality was not heterogeneous
between the samples. Among those who died from CHD, there was a
doubling of the relative 4 allele frequency in both samples
(2=4.70, df=1, P<.03 for
the eastern sample; 2=7.11, df=1,
P<.01 for the southwestern sample).
Conclusions Allelic variation in the apoE gene is a statistically significant predictor of CHD death in these samples of elderly Finnish men.
Key Words: coronary disease • apolipoproteins • mortality
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