Circulation, Vol 90, 1662-1668, Copyright © 1994 by American Heart Association
B Jude, B Agraou, EP McFadden, S Susen, C Bauters, P Lepelley, C Vanhaesbroucke, P Devos, A Cosson and P Asseman
BACKGROUND: Platelet activation plays a pivotal role in the pathogenesis of
acute coronary disease. Monocytes are involved in the progression of
atherosclerosis and are potent activators of blood coagulation through
their ability to synthesize tissue factor (TF). The aim of this study was
to compare markers of monocyte and coagulation activation in the systemic
blood of patients with unstable angina, acute myocardial infarction, or
stable angina. METHODS AND RESULTS: We studied 26 patients with unstable
angina (10 +/- 5 hours after the onset of the last episode of pain), 18
patients with acute myocardial infarction (5 +/- 4 hours after the onset of
pain), and 34 patients with stable angina. We measured levels of TF
expression in peripheral blood mononuclear cells (isolated by gradient
centrifugation and incubated for 16 hours, with or without endotoxin
stimulation), levels of plasma prothrombin fragment 1 + 2 (F1 + 2), and
levels of fibrinogen in peripheral blood. In patients with unstable angina,
both stimulated and unstimulated cells exhibited higher levels of TF
expression than in patients with stable angina (P = .0001). In patients
with acute myocardial infarction, monocyte TF activity did not differ from
that in patients with stable angina. Mean levels of F1 + 2 and of
fibrinogen did not differ significantly between groups. Only in the
unstable angina group, a modest correlation was found between fibrinogen (r
= .72, P = .005) and F1 + 2 levels (r = .54, P = .001) levels and the
degree of monocyte TF expression. In patients with unstable angina,
monocyte TF expression (both stimulated and unstimulated, assessed by
biological activity and by antigen techniques) and fibrinogen levels were
correlated with the time elapsed from the beginning of the most recent
episode of pain (.61 < r < .72, .02 < P < .0001). By contrast,
there was no correlation between these variables and the time from onset of
pain in patients with acute myocardial infarction. CONCLUSIONS: A
time-dependent activation of systemic monocytes and a time-dependent
increase in fibrinogen levels occurs in unstable angina but not in
myocardial infarction. These findings provide further evidence that a
specific inflammatory process occurs in unstable angina. Further studies
are required to determine whether monocyte activation is a cause or a
consequence of plaque instability in patients with unstable angina and to
clarify the interrelations between platelet and monocyte activation in
these circumstances.
ARTICLES
Evidence for time-dependent activation of monocytes in the systemic circulation in unstable angina but not in acute myocardial infarction or in stable angina
Laboratoire d'Hematologie, Hopital Cardiologique, Lille, France.
This article has been cited by other articles:
 |
|
 |
|
  A. F. Pasini, M. Anselmi, U. Garbin, E. Franchi, C. Stranieri, M.C. Nava, V. Boccioletti, C. Vassanelli, and L. Cominacini Enhanced Levels of Oxidized Low-Density Lipoprotein Prime Monocytes to Cytokine Overproduction via Upregulation of CD14 and Toll-Like Receptor 4 in Unstable Angina Arterioscler Thromb Vasc Biol, September 1, 2007; 27(9): 1991 - 1997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Carmona, M. A. Descalzo, E. Perez-Pampin, D. Ruiz-Montesinos, A. Erra, T. Cobo, J. J Gomez-Reino, and on behalf of the BIOBADASER and EMECAR Groups All-cause and cause-specific mortality in rheumatoid arthritis are not greater than expected when treated with tumour necrosis factor antagonists Ann Rheum Dis, July 1, 2007; 66(7): 880 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Eligini, F. Violi, C. Banfi, S. S. Barbieri, M. Brambilla, M. Saliola, E. Tremoli, and S. Colli Indobufen inhibits tissue factor in human monocytes through a thromboxane-mediated mechanism Cardiovasc Res, January 1, 2006; 69(1): 218 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Methe, S. Brunner, D. Wiegand, M. Nabauer, J. Koglin, and E. R. Edelman Enhanced T-Helper-1 Lymphocyte Activation Patterns in Acute Coronary Syndromes J. Am. Coll. Cardiol., June 21, 2005; 45(12): 1939 - 1945. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. O'Connor, M. W. Dunne, M. A. Pfeffer, J. B. Muhlestein, L. Yao, S. Gupta, R. J. Benner, M. R. Fisher, and T. D. Cook Azithromycin for the Secondary Prevention of Coronary Heart Disease Events: The WIZARD Study: A Randomized Controlled Trial JAMA, September 17, 2003; 290(11): 1459 - 1466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-P. Yang, L.-J. Ho, Y.-L. Lin, S.-M. Cheng, T.-P. Tsao, D.-M. Chang, Y.-L. Hsu, C.-Y. Shih, T.-Y. Juan, and J.-H. Lai Carvedilol, a new antioxidative {beta}-blocker, blocks in vitro human peripheral blood T cell activation by downregulating NF-{kappa}B activity Cardiovasc Res, September 1, 2003; 59(3): 776 - 787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Soejima, A. Irie, S. Miyamoto, I. Kajiwara, S. Kojima, J. Hokamaki, T. Sakamoto, T. Tanaka, M. Yoshimura, Y. Nishimura, et al. Preference Toward a T-Helper Type 1 Response in Patients With Coronary Spastic Angina Circulation, May 6, 2003; 107(17): 2196 - 2200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Oldgren, L Wallentin, L Grip, R Linder, B.L Norgaard, and A Siegbahn Myocardial damage, inflammation and thrombin inhibition in unstable coronary artery disease Eur. Heart J., January 1, 2003; 24(1): 86 - 93. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H.M Moons, M. Levi, and R. J.G Peters Tissue factor and coronary artery disease Cardiovasc Res, February 1, 2002; 53(2): 313 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. V. Zalai, M. D. Kolodziejczyk, L. Pilarski, A. Christov, P. N. Nation, M. Lundstrom-Hobman, W. Tymchak, V. Dzavik, D. P. Humen, W. J. Kostuk, et al. Increased circulating monocyte activation in patients with unstable coronary syndromes J. Am. Coll. Cardiol., November 1, 2001; 38(5): 1340 - 1347. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Mallat and A. Tedgui Current Perspective on the Role of Apoptosis in Atherothrombotic Disease Circ. Res., May 25, 2001; 88(10): 998 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Liuzzo, A. N. Vallejo, S. L. Kopecky, R. L. Frye, D. R. Holmes, J. J. Goronzy, and C. M. Weyand Molecular Fingerprint of Interferon-{{gamma}} Signaling in Unstable Angina Circulation, March 20, 2001; 103(11): 1509 - 1514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.R Azar, S Rinfret, P Theroux, P.H Stone, R Dakshinamurthy, Y.-J Feng, A.H.B Wu, G Range, and D.D Waters A randomized placebo-controlled trial to assess the efficacy of antiinflammatory therapy with methylprednisolone in unstable angina (MUNA trial) Eur. Heart J., December 2, 2000; 21(24): 2026 - 2032. [Abstract] [PDF]
|
|
|
|
|
|
J. Figueras, Y. Monasterio, R. M. Lidon, E. Nieto, and J. Soler-Soler Thrombin formation and fibrinolytic activity in patients with acute myocardial infarction or unstable angina: in-hospital course and relationship with recurrent angina at rest J. Am. Coll. Cardiol., December 1, 2000; 36(7): 2036 - 2043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Bladbjerg, A.-M. Munster, P. Marckmann, N. Keller, and J. Jespersen Dietary Factor VII Activation Does Not Increase Plasma Concentrations of Prothrombin Fragment 1+2 in Patients With Stable Angina Pectoris and Coronary Atherosclerosis Arterioscler Thromb Vasc Biol, November 1, 2000; 20(11): 2494 - 2499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Liuzzo, J. J. Goronzy, H. Yang, S. L. Kopecky, D. R. Holmes, R. L. Frye, and C. M. Weyand Monoclonal T-Cell Proliferation and Plaque Instability in Acute Coronary Syndromes Circulation, June 27, 2000; 101(25): 2883 - 2888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Arnaud, V. Barbalat, V. Nicaud, F. Cambien, A. Evans, C. Morrison, D. Arveiler, G. Luc, J.-B. Ruidavets, J. Emmerich, et al. Polymorphisms in the 5' Regulatory Region of the Tissue Factor Gene and the Risk of Myocardial Infarction and Venous Thromboembolism : The ECTIM and PATHROS Studies Arterioscler Thromb Vasc Biol, March 1, 2000; 20(3): 892 - 898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Liuzzo, S. L. Kopecky, R. L. Frye, W. M. O’ Fallon, A. Maseri, J. J. Goronzy, and C. M. Weyand Perturbation of the T-Cell Repertoire in Patients With Unstable Angina Circulation, November 23, 1999; 100(21): 2135 - 2139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Liuzzo, L. M. Biasucci, J. R. Gallimore, G. Caligiuri, A. Buffon, A. G. Rebuzzi, M. B. Pepys, and A. Maseri Enhanced inflammatory response in patients with preinfarction unstable angina J. Am. Coll. Cardiol., November 15, 1999; 34(6): 1696 - 1703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Peter, M. Schwarz, C. Conradt, T. Nordt, M. Moser, W. Kubler, and C. Bode Heparin Inhibits Ligand Binding to the Leukocyte Integrin Mac-1 (CD11b/CD18) Circulation, October 5, 1999; 100(14): 1533 - 1539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Comini, T. Bachetti, L. Agnoletti, G. Gaia, S. Curello, B. Milanesi, M. Volterrani, G. Parrinello, C. Ceconi, A. Giordano, et al. Induction of functional inducible nitric oxide synthase in monocytes of patients with congestive heart failure. Link with tumour necrosis factor-{alpha} Eur. Heart J., October 2, 1999; 20(20): 1503 - 1513. [Abstract] [PDF]
|
|
|
|
|
|
P. W. H. M. Verheggen, M. P. M. de Maat, V. M. Cats, F. Haverkate, A. H. Zwinderman, C. Kluft, and A. V. G. Bruschke Inflammatory status as a main determinant of outcome in patients with unstable angina, independent of coagulation activation and endothelial cell function Eur. Heart J., April 2, 1999; 20(8): 567 - 574. [Abstract] [PDF]
|
|
|
|
|
|
D. Moatti, P. Seknadji, C. Galand, O. Poirier, F. Fumeron, S. Desprez, M. Garbarz, D. Dhermy, D. Arveiler, A. Evans, et al. Polymorphisms of the Tissue Factor Pathway Inhibitor (TFPI) Gene in Patients With Acute Coronary Syndromes and in Healthy Subjects : Impact of the V264M Substitution on Plasma Levels of TFPI Arterioscler Thromb Vasc Biol, April 1, 1999; 19(4): 862 - 869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Manten, R. J. de Winter, M. C. Minnema, H. ten Cate, J. G. Lijmer, R. Adams, R. J.G. Peters, and S. J.H. van Deventer Procoagulant and proinflammatory activity in acute coronary syndromes Cardiovasc Res, November 1, 1998; 40(2): 389 - 395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Corseaux, T. Le Tourneau, I. Six, M. D. Ezekowitz, E. P. Mc Fadden, T. Meurice, P. Asseman, C. Bauters, and B. Jude Enhanced Monocyte Tissue Factor Response After Experimental Balloon Angioplasty in Hypercholesterolemic Rabbit: Inhibition With Dietary L-Arginine Circulation, October 27, 1998; 98(17): 1776 - 1782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Gertz, J. T. Fallon, R. Gallo, M. B. Taubman, S. Banai, W. L. Barry, L. W. Gimple, Y. Nemerson, S. Thiruvikraman, S. S. Naidu, et al. Hirudin Reduces Tissue Factor Expression in Neointima After Balloon Injury in Rabbit Femoral and Porcine Coronary Arteries Circulation, August 11, 1998; 98(6): 580 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kai, H. Ikeda, H. Yasukawa, M. Kai, Y. Seki, F. Kuwahara, T. Ueno, K. Sugi, and T. Imaizumi Peripheral blood levels of matrix metalloproteases-2 and -9 are elevated in patients with acute coronary syndromes J. Am. Coll. Cardiol., August 1, 1998; 32(2): 368 - 372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A C van der Wal, J J Piek, O J de Boer, K T Koch, P Teeling, C M van der Loos, and A E Becker Recent activation of the plaque immune response in coronary lesions underlying acute coronary syndromes Heart, July 1, 1998; 80(1): 14 - 18. [Abstract] [Full Text]
|
|
|
|
|
|
N P Curzen, D J Patel, M Kemp, J Hooper, C J Knight, D Clarke, C Wright, and K M Fox Can C reactive protein or troponins T and I predict outcome in patients with intractable unstable angina? Heart, July 1, 1998; 80(1): 23 - 27. [Abstract] [Full Text]
|
|
|
|
|
|
H. Holschermann, O. Kohl, U. Maus, F. Durfeld, A. Bierhaus, P. P. Nawroth, J. Lohmeyer, H. Tillmanns, and W. Haberbosch Cyclosporin A Inhibits Monocyte Tissue Factor Activation in Cardiac Transplant Recipients Circulation, December 16, 1997; 96(12): 4232 - 4238. [Abstract] [Full Text]
|
|
|
|
|
|
F. Khechai, V. Ollivier, F. Bridey, M. Amar, J. Hakim, and D. de Prost Effect of Advanced Glycation End Product–Modified Albumin on Tissue Factor Expression by Monocytes : Role of Oxidant Stress and Protein Tyrosine Kinase Activation Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2885 - 2890. [Abstract] [Full Text]
|
|
|
|
|
|
R. T. Lee and P. Libby The Unstable Atheroma Arterioscler Thromb Vasc Biol, October 1, 1997; 17(10): 1859 - 1867. [Full Text]
|
|
|
|
|
|
K. Kaikita, H. Ogawa, H. Yasue, M. Takeya, K. Takahashi, T. Saito, K. Hayasaki, K. Horiuchi, A. Takizawa, Y. Kamikubo, et al. Tissue Factor Expression on Macrophages in Coronary Plaques in Patients with Unstable Angina Arterioscler Thromb Vasc Biol, October 1, 1997; 17(10): 2232 - 2237. [Abstract] [Full Text]
|
|
|
|
|
|
G. G. Neri Serneri, D. Prisco, F. Martini, A. Gori, T. Brunelli, L. Poggesi, C. Rostagno, G. F. Gensini, and R. Abbate Acute T-Cell Activation Is Detectable in Unstable Angina Circulation, April 1, 1997; 95(7): 1806 - 1812. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. W. Roach, M. Kanchuger, C. M. Mangano, M. Newman, N. Nussmeier, R. Wolman, A. Aggarwal, K. Marschall, S. H. Graham, C. Ley, et al. Adverse Cerebral Outcomes after Coronary Bypass Surgery N. Engl. J. Med., December 19, 1996; 335(25): 1857 - 1864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Liuzzo, L. M. Biasucci, A. G. Rebuzzi, J. R. Gallimore, G. Caligiuri, G. A. Lanza, G. Quaranta, C. Monaco, M. B. Pepys, and A. Maseri Plasma Protein Acute-Phase Response in Unstable Angina Is Not Induced by Ischemic Injury Circulation, November 15, 1996; 94(10): 2373 - 2380. [Abstract] [Full Text]
|
|
|
|
|
|
R. T. Lee, F. J. Schoen, H. M. Loree, M. W. Lark, and P. Libby Circumferential Stress and Matrix Metalloproteinase 1 in Human Coronary Atherosclerosis: Implications for Plaque Rupture Arterioscler Thromb Vasc Biol, August 1, 1996; 16(8): 1070 - 1073. [Abstract] [Full Text]
|
|
|
|
|
|
E. Falk, P. K. Shah, and V. Fuster Coronary Plaque Disruption Circulation, August 1, 1995; 92(3): 657 - 671. [Full Text]
|
|