Circulation, Vol 89, 2809-2815, Copyright © 1994 by American Heart Association
T Kakuta, JW Currier, CC Haudenschild, TJ Ryan and DP Faxon
BACKGROUND: In de novo human atherosclerosis, compensatory vessel
enlargement limits the effect of intimal plaque formation on lumen
narrowing. We hypothesized that arterial remodeling may also play an
important role in determining the chronic lumen size after angioplasty and
tested this hypothesis using the hypercholesterolemic rabbit iliac artery
angioplasty model. METHODS AND RESULTS: Morphometric analysis of
histological cross-sectional areas of vessels from animals killed
immediately after angioplasty (acute group, n = 11) were compared with the
same areas from animals killed 4 weeks after the procedure (chronic group,
n = 37), when restenosis occurs in this model. The area circumscribed by
the internal elastic lamina (IEL) increased by 20% from acute to 4 week
follow-up after angioplasty (acute group, 2.36 +/- 0.45 mm2, chronic group,
2.84 +/- 0.89 mm2). Over the same time period, intimal area increased by
0.82 mm2. Despite this increase in intimal area, lumen area decreased by
only 0.34 mm2 because of the compensatory enlargement of the IEL area. In
the chronic group, polynomial regression analysis revealed a quadratic
relation between intimal area and lumen area (R2 = .35, P < .001). A
lumen area of 0.45 mm2 (the nadir of the quadratic relation) was used to
divide the chronic group into two subgroups: restenotic (n = 21; lumen
area, < 0.45 mm2) and nonrestenotic (n = 16; lumen area, > 0.45 mm2).
By definition, there was a significant difference in lumen area between the
two subgroups (0.15 +/- 0.15 mm2 for restenotic; 0.73 +/- 0.18 mm2 for
nonrestenotic). Surprisingly, the intimal areas in the two subgroups were
virtually identical (2.41 +/- 0.92 mm2 for restenotic, 2.49 +/- 0.69 mm2
for nonrestenotic, P = NS). The difference in the lumen area between
restenotic and nonrestenotic vessels was a result of the significantly
greater IEL area in the nonrestenotic subgroup (3.22 +/- 0.83 mm2 for
nonrestenotic, 2.56 +/- 0.84 mm2 for restenotic, P < .05). In both
restenotic and nonrestenotic vessels, the IEL area increased with increases
in intimal area. In the restenotic arteries, the slope of this correlation
was < 1, showing inadequate compensatory enlargement for the intimal
plaque. In the nonrestenotic vessels, the slope was > 1, limiting the
effect of intimal plaque on luminal narrowing. CONCLUSIONS: These data
indicate that the iliac artery in an atherosclerotic rabbit model
compensates for intimal formation after angioplasty by vessel enlargement.
Furthermore, the degree of vessel enlargement is more important than
intimal area in determining the chronic lumen size.
ARTICLES
Differences in compensatory vessel enlargement, not intimal formation, account for restenosis after angioplasty in the hypercholesterolemic rabbit model
Department of Medicine, University of Southern California, Los Angeles 90033.
This article has been cited by other articles:
 |
|
 |
|
  R. Kundi, S. T. Hollenbeck, D. Yamanouchi, B. C. Herman, R. Edlin, E. J. Ryer, C. Wang, S. Tsai, B. Liu, and K. C. Kent Arterial gene transfer of the TGF-{beta} signalling protein Smad3 induces adaptive remodelling following angioplasty: a role for CTGF Cardiovasc Res, November 1, 2009; 84(2): 326 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Brasselet, E. Durand, F. Addad, A. A. H. Zen, M. B. Smeets, D. Laurent-Maquin, S. Bouthors, G. Bellon, D. de Kleijn, G. Godeau, et al. Collagen and elastin cross-linking: a mechanism of constrictive remodeling after arterial injury Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2228 - H2233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Pyagay, M. Heroult, Q. Wang, W. Lehnert, J. Belden, L. Liaw, R. E. Friesel, and V. Lindner Collagen Triple Helix Repeat Containing 1, a Novel Secreted Protein in Injured and Diseased Arteries, Inhibits Collagen Expression and Promotes Cell Migration Circ. Res., February 4, 2005; 96(2): 261 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ohtani, K. Egashira, K.-i. Hiasa, Q. Zhao, S. Kitamoto, M. Ishibashi, M. Usui, S. Inoue, Y. Yonemitsu, K. Sueishi, et al. Blockade of Vascular Endothelial Growth Factor Suppresses Experimental Restenosis After Intraluminal Injury by Inhibiting Recruitment of Monocyte Lineage Cells Circulation, October 19, 2004; 110(16): 2444 - 2452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Jeanpierre, T. Le Tourneau, I. Six, C. Zawadzki;, E. Van Belle, M. D. Ezekowitz, R. Bordet, S. Susen, B. Jude, and D. Corseaux Dietary Lipid Lowering Modifies Plaque Phenotype in Rabbit Atheroma After Angioplasty: A Potential Role of Tissue Factor Circulation, October 7, 2003; 108(14): 1740 - 1745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Yin, C. Yutani, Y. Ikeda, K. Enjyoji, H. Ishibashi-Ueda, S. Yasuda, Y. Tsukamoto, H. Nonogi, Y. Kaneda, and H. Kato Tissue factor pathway inhibitor gene delivery using HVJ-AVE liposomes markedly reduces restenosis in atherosclerotic arteries Cardiovasc Res, December 1, 2002; 56(3): 454 - 463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. S. Galis, C. Johnson, D. Godin, R. Magid, J. M. Shipley, R. M. Senior, and E. Ivan Targeted Disruption of the Matrix Metalloproteinase-9 Gene Impairs Smooth Muscle Cell Migration and Geometrical Arterial Remodeling Circ. Res., November 1, 2002; 91(9): 852 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Sullivan and J. B. Hoying Flow-Dependent Remodeling in the Carotid Artery of Fibroblast Growth Factor-2 Knockout Mice Arterioscler Thromb Vasc Biol, July 1, 2002; 22(7): 1100 - 1105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Mori, K. Komori, T. Yamaoka, M. Tanii, C. Kataoka, A. Takeshita, M. Usui, K. Egashira, and K. Sugimachi Essential Role of Monocyte Chemoattractant Protein-1 in Development of Restenotic Changes (Neointimal Hyperplasia and Constrictive Remodeling) After Balloon Angioplasty in Hypercholesterolemic Rabbits Circulation, June 18, 2002; 105(24): 2905 - 2910. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Durand, Z. Mallat, F. Addad, F. Vilde, M. Desnos, C. Guerot, A. Tedgui, and A. Lafont Time courses of apoptosis and cell proliferation and their relationship to arterial remodeling and restenosis after angioplasty in an atherosclerotic rabbit model J. Am. Coll. Cardiol., May 15, 2002; 39(10): 1680 - 1685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kozuma, M.A. Costa, W.J. van der Giessen, M. Sabate, J.M.R. Ligthart, V.L.M.A. Coen, I.P. Kay, A.J. Wardeh, A.H.M. Knook, P.J de Feyter, et al. Initial observation regarding changes in vessel dimensions after balloon angioplasty and stenting followed by catheter-based {beta}-radiation. Is stenting necessary in the setting of catheter-based radiotherapy? Eur. Heart J., April 2, 2002; 23(8): 641 - 649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. S. Galis and J. J. Khatri Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis: The Good, the Bad, and the Ugly Circ. Res., February 22, 2002; 90(3): 251 - 262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S Conte, G. A VanMeter, L. M Akst, T. Clemons, M. Kashgarian, and J. R Bender Endothelial cell seeding influences lesion development following arterial injury in the cholesterol-fed rabbit Cardiovasc Res, February 1, 2002; 53(2): 502 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Cherr, S. J. Motew, J. A. Travis, J. Fingerle, L. Fisher, M. Brandl, J. K. Williams, and R. L. Geary Metalloproteinase Inhibition and the Response to Angioplasty and Stenting in Atherosclerotic Primates Arterioscler Thromb Vasc Biol, January 1, 2002; 22(1): 161 - 166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Kingston, S. Sinha, A. David, M. G. Castro, P. R. Lowenstein, and A. M. Heagerty Adenovirus-Mediated Gene Transfer of a Secreted Transforming Growth Factor-{beta} Type II Receptor Inhibits Luminal Loss and Constrictive Remodeling After Coronary Angioplasty and Enhances Adventitial Collagen Deposition Circulation, November 20, 2001; 104(21): 2595 - 2601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. M. Hassan, I. M. Lang, M. Ignatescu, R. Ullrich, D. Bonderman, P. Wexberg, F. Weidinger, and H. D. Glogar Increased intimal apoptosis in coronary atherosclerotic vessel segments lacking compensatory enlargement J. Am. Coll. Cardiol., November 1, 2001; 38(5): 1333 - 1339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lutgens, E. D. de Muinck, S. Heeneman, and M. J.A.P. Daemen Compensatory Enlargement and Stenosis Develop in ApoE-/- and ApoE*3-Leiden Transgenic Mice Arterioscler Thromb Vasc Biol, August 1, 2001; 21(8): 1359 - 1365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.A Costa, L.E.A de Wit, V de Valk, P Serrano, A.J Wardeh, P.W Serruys, and W Sluiter Indirect evidence for a role of a subpopulation of activated neutrophils in the remodelling process after percutaneous coronary intervention Eur. Heart J., April 1, 2001; 22(7): 580 - 586. [Abstract] [PDF]
|
|
|
|
|
|
M. J. Sierevogel, G. Pasterkamp, E. Velema, P. P. T. de Jaegere, B. J. G. L. de Smet, J. H. Verheijen, D. P. V. de Kleijn, and C. Borst Oral Matrix Metalloproteinase Inhibition and Arterial Remodeling After Balloon Dilation : An Intravascular Ultrasound Study in the Pig Circulation, January 16, 2001; 103(2): 302 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M A Costa, K Kozuma, A L Gaster, W J van der Giessen, M Sabaté, D P Foley, I P Kay, J M R Ligthart, P Thayssen, M J van den Brand, et al. Three dimensional intravascular ultrasonic assessment of the local mechanism of restenosis after balloon angioplasty Heart, January 1, 2001; 85(1): 73 - 79. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. Sasaki, Y. Tanahashi, Y. Yamasaki, N. Oda, Y. Nozawa, H. Terakawa, K. Miyoshi, Y. Muranaka, H. Miyake, and N. Matsuura Inhibitory Effect of TAS-301, a New Synthesized Constrictive Remodeling Regulator, on Renarrowing after Balloon Overstretch Injury of Porcine Coronary Artery J. Pharmacol. Exp. Ther., December 1, 2000; 295(3): 1043 - 1050. [Abstract] [Full Text]
|
|
|
|
 |
|
 B. Zhu, D. G. Kuhel, D. P. Witte, and D. Y. Hui Apolipoprotein E Inhibits Neointimal Hyperplasia after Arterial Injury in Mice Am. J. Pathol., December 1, 2000; 157(6): 1839 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Wexberg, M. Gyongyosi, W. Sperker, K. Kiss, P. Yang, A. Hassan, G. Pasterkamp, and D. Glogar Pre-existing arterial remodeling is associated with in-hospital and late adverse cardiac events after coronary interventions in patients with stable angina pectoris J. Am. Coll. Cardiol., November 15, 2000; 36(6): 1860 - 1869. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Gallagher, Y. Jin, G. Killough, E. K. Blue, and V. Lindner Alterations in expression of myosin and myosin light chain kinases in response to vascular injury Am J Physiol Cell Physiol, October 1, 2000; 279(4): C1078 - C1087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kozuma, M. A. Costa, M. Sabate, I. P. Kay, J. P. A. Marijnissen, V. L. M. A. Coen, P. Serrano, J. M. R. Ligthart, P. C. Levendag, and P. W. Serruys Three-Dimensional Intravascular Ultrasound Assessment of Noninjured Edges of {beta}-Irradiated Coronary Segments Circulation, September 26, 2000; 102(13): 1484 - 1489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Ward, G. Pasterkamp, A. C. Yeung, and C. Borst Arterial Remodeling : Mechanisms and Clinical Implications Circulation, September 5, 2000; 102(10): 1186 - 1191. [Full Text] [PDF]
|
|
|
|
|
|
E. H. Ohlstein, A. M. Romanic, L. V. Clark, R. D. Kapadia, S. K. Sarkar, R. Gagnon, and S. Chandra Application of in vivo and ex vivo magnetic resonance imaging for evaluation of tranilast on neointima formation following balloon angioplasty of the rat carotid artery Cardiovasc Res, September 1, 2000; 47(4): 759 - 768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. G. L. de Smet, D. de Kleijn, R. Hanemaaijer, J. H. Verheijen, L. Robertus, Y. J. M. van der Helm, C. Borst, and M. J. Post Metalloproteinase Inhibition Reduces Constrictive Arterial Remodeling After Balloon Angioplasty : A Study in the Atherosclerotic Yucatan Micropig Circulation, June 27, 2000; 101(25): 2962 - 2967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Harmon, L. L. Couper, and V. Lindner Strain-Dependent Vascular Remodeling Phenotypes in Inbred Mice Am. J. Pathol., May 1, 2000; 156(5): 1741 - 1748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Moreno and I. F. Palacios Cytomegalovirus and Restenosis After Percutaneous Transluminal Coronary Angioplasty Circulation, April 11, 2000; 101 (14): e163 - e163. [Full Text] [PDF]
|
|
|
|
|
|
C. J. Bruce, R. E. Kuntz, J. J. Popma, K. S. Pieper, E. J. Topol, and D. R. Holmes Jr. Application of a continuous regression model of restenosis to saphenous vein grafts after successful percutaneous transluminal coronary angioplasty or directional coronary atherectomy J. Am. Coll. Cardiol., March 1, 2000; 35(3): 619 - 623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Pasterkamp, D. P.V de Kleijn, and C. Borst Arterial remodeling in atherosclerosis, restenosis and after alteration of blood flow: potential mechanisms and clinical implications Cardiovasc Res, March 1, 2000; 45(4): 843 - 852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Roque, J. T. Fallon, J. J. Badimon, W. X. Zhang, M. B. Taubman, and E. D. Reis Mouse Model of Femoral Artery Denudation Injury Associated With the Rapid Accumulation of Adhesion Molecules on the Luminal Surface and Recruitment of Neutrophils Arterioscler Thromb Vasc Biol, February 1, 2000; 20(2): 335 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. H. Strauss and M. Rabinovitch Adventitial Fibroblasts . Defining a Role in Vessel Wall Remodeling Am. J. Respir. Cell Mol. Biol., January 1, 2000; 22(1): 1 - 3. [Full Text]
|
|
|
|
|
|
I. Kosa, R. Blasini, J. Schneider-Eicke, T. Dickfeld, F. J. Neumann, S. Ziegler, I. Matsunari, J. Neverve, A. Schomig, and M. Schwaiger Early recovery of coronary flow reserve after stent implantation as assessed by positron emission tomography J. Am. Coll. Cardiol., October 1, 1999; 34(4): 1036 - 1041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Moreno, J. T. Fallon, A. M. Murcia, M. N. Leon, H. Simosa, V. Fuster, and I. F. Palacios Tissue characteristics of restenosis after percutaneous transluminal coronary angioplasty in diabetic patients J. Am. Coll. Cardiol., October 1, 1999; 34(4): 1045 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lafont, E. Durand, J. L. Samuel, B. Besse, F. Addad, B. I. Levy, M. Desnos, C. Guerot, and C. M. Boulanger Endothelial Dysfunction and Collagen Accumulation : Two Independent Factors for Restenosis and Constrictive Remodeling After Experimental Angioplasty Circulation, September 7, 1999; 100(10): 1109 - 1115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Smith, S. R. Bryant, L. L. Couper, C. P. H. Vary, P. J. Gotwals, V. E. Koteliansky, and V. Lindner Soluble Transforming Growth Factor-ß Type II Receptor Inhibits Negative Remodeling, Fibroblast Transdifferentiation, and Intimal Lesion Formation But Not Endothelial Growth Circ. Res., May 28, 1999; 84(10): 1212 - 1222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Meerkin, J.-C. Tardif, I. R. Crocker, A. Arsenault, M. Joyal, G. Lucier, S. B. King III, D. O. Williams, P. W. Serruys, and R. Bonan Effects of Intracoronary ß-Radiation Therapy After Coronary Angioplasty : An Intravascular Ultrasound Study Circulation, April 6, 1999; 99(13): 1660 - 1665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Rogers, D. Y. Tseng, J. C. Squire, and E. R. Edelman Balloon-Artery Interactions During Stent Placement : A Finite Element Analysis Approach to Pressure, Compliance, and Stent Design as Contributors to Vascular Injury Circ. Res., March 5, 1999; 84(4): 378 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Le Tourneau, E. Van Belle, D. Corseaux, B. Vallet, G. Lebuffe, B. Dupuis, J.-M. Lablanche, E. McFadden, C. Bauters, and M. E. Bertrand Role of nitric oxide in restenosis after experimental balloon angioplasty in the hypercholesterolemic rabbit: effects on neointimal hyperplasia and vascular remodeling J. Am. Coll. Cardiol., March 1, 1999; 33(3): 876 - 882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Bosmans, C. J. Vrints, M. M. Kockx, H. Bult, K. M. C. Cromheeke, and A. G. Herman Continuous Perivascular L-Arginine Delivery Increases Total Vessel Area and Reduces Neointimal Thickening After Experimental Balloon Dilatation Arterioscler Thromb Vasc Biol, March 1, 1999; 19(3): 767 - 776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Bryant, R. J. Bjercke, D. A. Erichsen, A. Rege, and V. Lindner Vascular Remodeling in Response to Altered Blood Flow Is Mediated by Fibroblast Growth Factor-2 Circ. Res., February 19, 1999; 84(3): 323 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. J. Kullo, R. D. Simari, and R. S. Schwartz Vascular Gene Transfer : From Bench to Bedside Arterioscler Thromb Vasc Biol, February 1, 1999; 19(2): 196 - 207. [Full Text] [PDF]
|
|
|
|
|
|
K. Pels, M. Labinaz, C. Hoffert, and E. R. O'Brien Adventitial Angiogenesis Early After Coronary Angioplasty : Correlation With Arterial Remodeling Arterioscler Thromb Vasc Biol, February 1, 1999; 19(2): 229 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R Bennett Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture Cardiovasc Res, February 1, 1999; 41(2): 361 - 368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Cote, J.-C. Tardif, J. Lesperance, J. Lambert, M. Bourassa, R. Bonan, G. Gosselin, M. Joyal, J.-F. Tanguay, S. Nattel, et al. Effects of Probucol on Vascular Remodeling After Coronary Angioplasty Circulation, January 12, 1999; 99(1): 30 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Labinaz, K. Pels, C. Hoffert, S. Aggarwal, and E. R O'Brien Time course and importance of neoadventitial formation in arterial remodeling following balloon angioplasty of porcine coronary arteries Cardiovasc Res, January 1, 1999; 41(1): 255 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. de Vrey, G. S. Mintz, C. von Birgelen, T. Kimura, M. Noboyoshi, J. J. Popma, P. W. Serruys, and M. B. Leon Serial volumetric (three-dimensional) intravascular ultrasound analysis of restenosis after directional coronary atherectomy J. Am. Coll. Cardiol., December 1, 1998; 32(7): 1874 - 1880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Thome, L. W. Gimple, B. G. Bachhuber, C. A. McNamara, M. Ragosta, S. D. Gertz, E. R. Powers, G. K. Owens, J. E. Humphries, and I. J. Sarembock Early Plus Delayed Hirudin Reduces Restenosis in the Atherosclerotic Rabbit More Than Early Administration Alone : Potential Implications for Dosing of Antithrombin Agents Circulation, November 24, 1998; 98(21): 2301 - 2306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Corseaux, T. Le Tourneau, I. Six, M. D. Ezekowitz, E. P. Mc Fadden, T. Meurice, P. Asseman, C. Bauters, and B. Jude Enhanced Monocyte Tissue Factor Response After Experimental Balloon Angioplasty in Hypercholesterolemic Rabbit: Inhibition With Dietary L-Arginine Circulation, October 27, 1998; 98(17): 1776 - 1782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Lansky, G. S. Mintz, J. J. Popma, A. D. Pichard, K. M. Kent, L. F. Satler, D. S. Baim, R. E. Kuntz, C. Simonton, R. M. Bersin, et al. Remodeling after directional coronary atherectomy (with and without adjunct percutaneous transluminal coronary angioplasty): a serial angiographic and intravascular ultrasound analysis from the optimal atherectomy restenosis study J. Am. Coll. Cardiol., August 1, 1998; 32(2): 329 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Carmeliet, L. Moons, and D. Collen Mouse models of angiogenesis, arterial stenosis, atherosclerosis and hemostasis Cardiovasc Res, July 1, 1998; 39(1): 8 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lafont and D. Faxon Why do animal models of post-angioplasty restenosis sometimes poorly predict the outcome of clinical trials? Cardiovasc Res, July 1, 1998; 39(1): 50 - 59. [Full Text] [PDF]
|
|
|
|
|
|
B.J.G.L de Smet, J van der Zande, Y.J.M van der Helm, R.E Kuntz, C Borst, and M.J Post The atherosclerotic Yucatan animal model to study the arterial response after balloon angioplasty: the natural history of remodeling Cardiovasc Res, July 1, 1998; 39(1): 224 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chandra, L. V. Clark, R. W. Coatney, L. Phan, S. K. Sarkar, and E. H. Ohlstein Application of Serial In Vivo Magnetic Resonance Imaging to Evaluate the Efficacy of Endothelin Receptor Antagonist SB 217242 in the Rat Carotid Artery Model of Neointima Formation Circulation, June 9, 1998; 97(22): 2252 - 2258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Courtman, S. M. Schwartz, and C. E. Hart Sequential Injury of the Rabbit Abdominal Aorta Induces Intramural Coagulation and Luminal Narrowing Independent of Intimal Mass : Extrinsic Pathway Inhibition Eliminates Luminal Narrowing Circ. Res., May 19, 1998; 82(9): 996 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. G. L. de Smet, G. Pasterkamp, Y. J. van der Helm, C. Borst, and M. J. Post The Relation Between De Novo Atherosclerosis Remodeling and Angioplasty-Induced Remodeling in an Atherosclerotic Yucatan Micropig Model Arterioscler Thromb Vasc Biol, May 1, 1998; 18(5): 702 - 707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nikol, S. Esin, S. Nekolla, T. Y. Huehns, J. Schirmer, M. Schwaiger, and B. Hofling Use of Nuclear Magnetic Resonance Imaging Angiography to Follow-Up Arterial Remodeling in an Animal Model Angiology, April 1, 1998; 49(4): 251 - 258. [Abstract] [PDF]
|
|
|
|
|
|
E. Van Belle, C. Bauters, T. Asahara, and J. M. Isner Endothelial regrowth after arterial injury: from vascular repair to therapeutics Cardiovasc Res, April 1, 1998; 38(1): 54 - 68. [Full Text] [PDF]
|
|
|
|
|
|
P. Holvoet, G. Theilmeier, B. Shivalkar, W. Flameng, and D. Collen LDL Hypercholesterolemia Is Associated With Accumulation of Oxidized LDL, Atherosclerotic Plaque Growth, and Compensatory Vessel Enlargement in Coronary Arteries of Miniature Pigs Arterioscler Thromb Vasc Biol, March 1, 1998; 18(3): 415 - 422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Libby Gene Therapy of Restenosis : Promise and Perils Circ. Res., February 23, 1998; 82(3): 404 - 406. [Full Text] [PDF]
|
|
|
|
|
|
M. Challah, E. Villard, M. Philippe, A. Ribadeau-Dumas, B. Giraudeau, P. Janiak, J.-P. Vilaine, F. Soubrier, and J.-B. Michel Angiotensin I-Converting Enzyme Genotype Influences Arterial Response to Injury in Normotensive Rats Arterioscler Thromb Vasc Biol, February 1, 1998; 18(2): 235 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kakuta, M. Usui, W. D. Coats Jr, J. W. Currier, F. Numano, and D. P. Faxon Arterial Remodeling at the Reference Site After Angioplasty in the Atherosclerotic Rabbit Model Arterioscler Thromb Vasc Biol, January 1, 1998; 18(1): 47 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kumar, J. L. Hoover, C. A. Simmons, V. Lindner, and R. J. Shebuski Remodeling and Neointimal Formation in the Carotid Artery of Normal and P-Selectin–Deficient Mice Circulation, December 16, 1997; 96(12): 4333 - 4342. [Abstract] [Full Text]
|
|
|
|
|
|
H. S. Seo, D. M. Lombardi, P. Polinsky, L. Powell-Braxton, S. Bunting, S. M. Schwartz, and M. E. Rosenfeld Peripheral Vascular Stenosis in Apolipoprotein E-Deficient Mice : Potential Roles of Lipid Deposition, Medial Atrophy, and Adventitial Inflammation Arterioscler Thromb Vasc Biol, December 1, 1997; 17(12): 3593 - 3601. [Abstract] [Full Text]
|
|
|
|
|
|
M. Takagi, M. Ueda, A. E. Becker, K. Takeuchi, and T. Takeda The Watanabe Heritable Hyperlipidemic Rabbit Is a Suitable Experimental Model to Study Differences in Tissue Response Between Intimal and Medial Injury After Balloon Angioplasty Arterioscler Thromb Vasc Biol, December 1, 1997; 17(12): 3611 - 3619. [Abstract] [Full Text]
|
|
|
|
|
|
S.D. Gertz, W. L Barry, L. W Gimple, Shmuel Banai, L. S Perez, C. A McNamara, E. R Powers, M. Ragosta, G. K Owens, W. C Roberts, et al. Predictors of luminal narrowing by neointima after angioplasty in atherosclerotic rabbits Cardiovasc Res, December 1, 1997; 36(3): 396 - 407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Lablanche, E. P. McFadden, N. Meneveau, J. R. Lusson, B. Bertrand, J.-P. Metzger, V. Legrand, G. Grollier, C. Macaya, B. de Bruyne, et al. Effect of Nadroparin, a Low-Molecular-Weight Heparin, on Clinical and Angiographic Restenosis After Coronary Balloon Angioplasty : The FACT Study Circulation, November 18, 1997; 96(10): 3396 - 3402. [Abstract] [Full Text]
|
|
|
|
|
|
M. C.J Persoons, M. J.A.P Daemen, E. M van Kleef, G. E.L.M Grauls, E. Wijers, and C. A Bruggeman Neointimal smooth muscle cell phenotype is important in its susceptibility to cytomegalovirus (CMV) infection: a study in rat Cardiovasc Res, November 1, 1997; 36(2): 282 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Miyashiro, V. Poppa, and B. C. Berk Flow-Induced Vascular Remodeling in the Rat Carotid Artery Diminishes With Age Circ. Res., September 19, 1997; 81(3): 311 - 319. [Abstract] [Full Text]
|
|
|
|
|
|
R. Waksman, J. C. Rodriguez, K. A. Robinson, G. D. Cipolla, I. R. Crocker, N. A. Scott, S. B. King III, and J. N. Wilcox Effect of Intravascular Irradiation on Cell Proliferation, Apoptosis, and Vascular Remodeling After Balloon Overstretch Injury of Porcine Coronary Arteries Circulation, September 16, 1997; 96(6): 1944 - 1952. [Abstract] [Full Text]
|
|
|
|
|
|
E. Van Belle, C. Bauters, E. Hubert, J.-C. Bodart, K. Abolmaali, T. Meurice, E. P. McFadden, J.-M. Lablanche, and M. E. Bertrand Restenosis Rates in Diabetic Patients : A Comparison of Coronary Stenting and Balloon Angioplasty in Native Coronary Vessels Circulation, September 2, 1997; 96(5): 1454 - 1460. [Abstract] [Full Text]
|
|
|
|
|
|
M. E. Staab, R. D. Simari, S. S. Srivatsa, D. Hasdai, V. J. Pompili, D. R. Holmes, R. S. Schwartz, and R. S. Schwartz Enhanced Angiogenesis and Unfavorable Remodeling in Injured Porcine Coronary Artery Lesions: Effects of Local Basic Fibroblast Growth Factor Delivery Angiology, September 1, 1997; 48(9): 753 - 760. [Abstract] [PDF]
|
|
|
|
|
|
T. Kimura, S. Kaburagi, T. Tamura, H. Yokoi, Y. Nakagawa, H. Yokoi, N. Hamasaki, H. Nosaka, M. Nobuyoshi, G. S. Mintz, et al. Remodeling of Human Coronary Arteries Undergoing Coronary Angioplasty or Atherectomy Circulation, July 15, 1997; 96(2): 475 - 483. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. E. O'Brien Jr., Y. Shi, A. Fard, T. Bauer, A. Zalewski, and J. D. Mannion WOUND HEALING AROUND AND WITHIN SAPHENOUS VEIN BYPASS GRAFTS J. Thorac. Cardiovasc. Surg., July 1, 1997; 114(1): 38 - 45. [Abstract] [Full Text]
|
|
|
|
|
|
C. Amant, C. Bauters, J.-C. Bodart, J.-M. Lablanche, G. Grollier, N. Danchin, M. Hamon, F. Richard, N. Helbecque, E. P. McFadden, et al. D Allele of the Angiotensin I–Converting Enzyme Is a Major Risk Factor for Restenosis After Coronary Stenting Circulation, July 1, 1997; 96(1): 56 - 60. [Abstract] [Full Text]
|
|
|
|
|
|
D. P. Faxon Identifying the Predictors of Restenosis: Do We Need New Glasses? Circulation, May 6, 1997; 95(9): 2244 - 2246. [Full Text]
|
|
|
|
|
|
G. S. Mintz, K. M. Kent, A. D. Pichard, L. F. Satler, J. J. Popma, and M. B. Leon Contribution of Inadequate Arterial Remodeling to the Development of Focal Coronary Artery Stenoses : An Intravascular Ultrasound Study Circulation, April 1, 1997; 95(7): 1791 - 1798. [Abstract] [Full Text]
|
|
|
|
|
|
S. P. Schwarzacher, T. T. Lim, B. Wang, R. S. Kernoff, J. Niebauer, J. P. Cooke, and A. C. Yeung Local Intramural Delivery of L-Arginine Enhances Nitric Oxide Generation and Inhibits Lesion Formation After Balloon Angioplasty Circulation, April 1, 1997; 95(7): 1863 - 1869. [Abstract] [Full Text]
|
|
|
|
|
|
W. D. Coats, P. Whittaker, D. T. Cheung, J. W. Currier, B. Han, and D. P. Faxon Collagen Content Is Significantly Lower in Restenotic Versus Nonrestenotic Vessels After Balloon Angioplasty in the Atherosclerotic Rabbit Model Circulation, March 4, 1997; 95(5): 1293 - 1300. [Abstract] [Full Text]
|
|
|
|
|
|
T. T. Lim, D. H. Liang, J. Botas, J. S. Schroeder, S. N. Oesterle, and A. C. Yeung Role of Compensatory Enlargement and Shrinkage in Transplant Coronary Artery Disease: Serial Intravascular Ultrasound Study Circulation, February 18, 1997; 95(4): 855 - 859. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Shi, J. E. O'Brien, L. Ala-Kokko, W. Chung, J. D. Mannion, and A. Zalewski Origin of Extracellular Matrix Synthesis During Coronary Repair Circulation, February 18, 1997; 95(4): 997 - 1006. [Abstract] [Full Text]
|
|
|
|
|
|
M. K. Hong, K. M. Kent, R. Mehran, G. S. Mintz, F. O. Tio, M. Foegh, S. C. Wong, S. S. Cathapermal, and M. B. Leon Continuous Subcutaneous Angiopeptin Treatment Significantly Reduces Neointimal Hyperplasia in a Porcine Coronary In-Stent Restenosis Model Circulation, January 21, 1997; 95(2): 449 - 454. [Abstract] [Full Text]
|
|
|
|
|
|
H. Luo, T. Nishioka, N. L. Eigler, J. S. Forrester, M. C. Fishbein, H. Berglund, and R. J. Siegel Coronary Artery Restenosis After Balloon Angioplasty in Humans Is Associated With Circumferential Coronary Constriction Arterioscler Thromb Vasc Biol, November 1, 1996; 16(11): 1393 - 1398. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. A. Bittl Advances in Coronary Angioplasty N. Engl. J. Med., October 24, 1996; 335(17): 1290 - 1302. [Full Text] [PDF]
|
|
|
|
|
|
Y. Shi, J. E. O'Brien, A. Fard, and A. Zalewski Transforming Growth Factor-ß1 Expression and Myofibroblast Formation During Arterial Repair Arterioscler Thromb Vasc Biol, October 1, 1996; 16(10): 1298 - 1305. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Shi, J. E. O'Brien, A. Fard, J. D. Mannion, D. Wang, and A. Zalewski Adventitial Myofibroblasts Contribute to Neointimal Formation in Injured Porcine Coronary Arteries Circulation, October 1, 1996; 94(7): 1655 - 1664. [Abstract] [Full Text]
|
|
|
|
|
|
L. A. Guzman, V. Labhasetwar, C. Song, Y. Jang, A. M. Lincoff, R. Levy, and E. J. Topol Local Intraluminal Infusion of Biodegradable Polymeric Nanoparticles: A Novel Approach for Prolonged Drug Delivery After Balloon Angioplasty Circulation, September 15, 1996; 94(6): 1441 - 1448. [Abstract] [Full Text]
|
|
|
|
|
|
G. S. Mintz, J. J. Popma, A. D. Pichard, K. M. Kent, L. F. Satler, S. Chiu Wong, M. K. Hong, J. A. Kovach, and M. B. Leon Arterial Remodeling After Coronary Angioplasty : A Serial Intravascular Ultrasound Study Circulation, July 1, 1996; 94(1): 35 - 43. [Abstract] [Full Text]
|
|
|
|
|
|
H. Rud Andersen, M. Mæng, M. Thorwest, and E. Falk Remodeling Rather Than Neointimal Formation Explains Luminal Narrowing After Deep Vessel Wall Injury : Insights From a Porcine Coronary (Re)stenosis Model Circulation, May 1, 1996; 93(9): 1716 - 1724. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. R. Makkar, N. Eigler, F. Litvack, and J. S. Forrester Prevention of Restenosis by Local Drug Delivery Journal of Cardiovascular Pharmacology and Therapeutics, April 1, 1996; 1(2): 177 - 188. [Abstract] [PDF]
|
|
|
|
|
|
R. Riessen, T. N. Wight, C. Pastore, C. Henley, and J. M. Isner Distribution of Hyaluronan During Extracellular Matrix Remodeling in Human Restenotic Arteries and Balloon-Injured Rat Carotid Arteries Circulation, March 15, 1996; 93(6): 1141 - 1147. [Abstract] [Full Text]
|
|
|
|
|
|
L. A. Guzman, M. J. Mick, A. M. Arnold, F. Forudi, and P. L. Whitlow Role of Intimal Hyperplasia and Arterial Remodeling After Balloon Angioplasty : An Experimental Study in the Atherosclerotic Rabbit Model Arterioscler Thromb Vasc Biol, March 1, 1996; 16(3): 479 - 487. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Shi, M. Pieniek, A. Fard, J. O'Brien, J. D. Mannion, and A. Zalewski Adventitial Remodeling After Coronary Arterial Injury Circulation, January 15, 1996; 93(2): 340 - 348. [Abstract] [Full Text]
|
|
|
|
|
|
R. L. Geary, J. K. Williams, D. Golden, D. G. Brown, M. E. Benjamin, and M. R. Adams Time Course of Cellular Proliferation, Intimal Hyperplasia, and Remodeling Following Angioplasty in Monkeys With Established Atherosclerosis : A Nonhuman Primate Model of Restenosis Arterioscler Thromb Vasc Biol, January 1, 1996; 16(1): 34 - 43. [Abstract] [Full Text]
|
|
|
|
|
|
R. L. Wilensky, K. L. March, I. Gradus-Pizlo, G. Sandusky, N. Fineberg, and D. R. Hathaway Vascular Injury, Repair, and Restenosis After Percutaneous Transluminal Angioplasty in the Atherosclerotic Rabbit Circulation, November 15, 1995; 92(10): 2995 - 3005. [Abstract] [Full Text]
|
|
|
|
|
|
P. G. Steg, M. Ziol, O. Tahlil, C. Robert, P. Masson, D. Pruneau, P. Bruneval, and P. Belichard Reduction of Intimal Hyperplasia by Naroparcil, a 4-Methylumbelliferyl ß-D-Xyloside Analogue, After Arterial Injury in the Hypercholesterolemic Rabbit Circ. Res., November 1, 1995; 77(5): 919 - 926. [Abstract] [Full Text]
|
|
|
|
|
|
M. R. Bennett and S. M. Schwartz Antisense Therapy for Angioplasty Restenosis : Some Critical Considerations Circulation, October 1, 1995; 92(7): 1981 - 1993. [Full Text]
|
|