Circulation, Vol 89, 2519-2524, Copyright © 1994 by American Heart Association
K Egashira, Y Hirooka, H Kai, M Sugimachi, S Suzuki, T Inou and A Takeshita
BACKGROUND: This study aimed to determine if cholesterol-lowering therapy
improves endothelium-dependent coronary vasomotion in patients with
hypercholesterolemia. METHODS AND RESULTS: Nine patients with
hypercholesterolemia were studied before and after cholesterol-lowering
therapy with pravastatin (an inhibitor of HMG-CoA reductase) for 6 +/- 3
months, which lowered serum cholesterol from 272 +/- 8 to 187 +/- 16 mg/dL
(P < .01). Control patients with serum cholesterol of 218 +/- 23 mg/dL
also were studied twice in a similar interval (8 +/- 2 months) with no
cholesterol-lowering drugs. Acetylcholine (the endothelium- dependent
vasodilator) and papaverine and nitrate (endothelium- independent
vasodilators) were infused into the study coronary artery. Changes in the
diameter of the epicardial coronary artery and coronary blood flow were
assessed by quantitative coronary arteriography and an intracoronary
Doppler catheter. In patients with hypercholesterolemia,
acetylcholine-induced vasoconstriction of the epicardial artery was less (P
< .05) and the acetylcholine-induced increases in coronary blood flow
were greater (P < .001) after than before pravastatin. In control
patients, responses of the epicardial coronary artery and coronary blood
flow to acetylcholine did not change over the follow-up period. The
vasomotor responses to papaverine or nitrate were similar between the two
groups, and no interval changes in their responses were noted in either
group. CONCLUSIONS: These results suggest that cholesterol-lowering therapy
with pravastatin may improve endothelium- dependent coronary vasomotion,
which may possibly contribute to the improvement of myocardial perfusion as
well as the regression of coronary atherosclerosis.
ARTICLES
Reduction in serum cholesterol with pravastatin improves endothelium- dependent coronary vasomotion in patients with hypercholesterolemia
Research Institute of Angiocardiology, Kyushu University School of Medicine, Fukuoka, Japan.
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J. H. Stein, J. G. Keevil, D. A. Wiebe, S. Aeschlimann, and J. D. Folts Purple Grape Juice Improves Endothelial Function and Reduces the Susceptibility of LDL Cholesterol to Oxidation in Patients With Coronary Artery Disease Circulation, September 7, 1999; 100(10): 1050 - 1055. [Abstract] [Full Text] [PDF]
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C. J. Vaughan and N. Delanty Neuroprotective Properties of Statins in Cerebral Ischemia and Stroke Stroke, September 1, 1999; 30(9): 1969 - 1973. [Abstract] [Full Text] [PDF]
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H. Drexler Nitric oxide and coronary endothelial dysfunction in humans Cardiovasc Res, August 15, 1999; 43(3): 572 - 579. [Full Text] [PDF]
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I. Yokoyama, S.-i. Momomura, T. Ohtake, K. Yonekura, W. Yang, N. Kobayakawa, T. Aoyagi, S. Sugiura, N. Yamada, K. Ohtomo, et al. Improvement of Impaired Myocardial Vasodilatation Due to Diffuse Coronary Atherosclerosis in Hypercholesterolemics After Lipid-Lowering Therapy Circulation, July 13, 1999; 100(2): 117 - 122. [Abstract] [Full Text] [PDF]
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D. Baller, G. Notohamiprodjo, U. Gleichmann, J. Holzinger, R. Weise, and J. Lehmann Improvement in Coronary Flow Reserve Determined by Positron Emission Tomography After 6 Months of Cholesterol-Lowering Therapy in Patients With Early Stages of Coronary Atherosclerosis Circulation, June 8, 1999; 99(22): 2871 - 2875. [Abstract] [Full Text] [PDF]
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D. M. Herrington, B. L. Werbel, W. A. Riley, B. E. Pusser, and T. M. Morgan Individual and combined effects of estrogen/progestin therapy and lovastatin on lipids and flow-mediated vasodilation in postmenopausal women with coronary artery disease J. Am. Coll. Cardiol., June 1, 1999; 33(7): 2030 - 2037. [Abstract] [Full Text] [PDF]
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M. C. Verhaar, M. L.H. Honing, T. van Dam, M. Zwart, H. A. Koomans, J. J.P. Kastelein, and T. J. Rabelink Nifedipine improves endothelial function in hypercholesterolemia, independently of an effect on blood pressure or plasma lipids Cardiovasc Res, June 1, 1999; 42(3): 752 - 760. [Abstract] [Full Text] [PDF]
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G. Dangas, J. J. Badimon, D. A. Smith, A. H. Unger, D. Levine, J. H. Shao, P. Meraj, C. Fier, J. T. Fallon, and J. A. Ambrose Pravastatin therapy in hyperlipidemia: effects on thrombus formation and the systemic hemostatic profile J. Am. Coll. Cardiol., April 1, 1999; 33(5): 1294 - 1304. [Abstract] [Full Text] [PDF]
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K. K. Koh, C. Cardillo, M. N. Bui, L. Hathaway, G. Csako, M. A. Waclawiw, J. A. Panza, and R. O. Cannon III Vascular Effects of Estrogen and Cholesterol-Lowering Therapies in Hypercholesterolemic Postmenopausal Women Circulation, January 26, 1999; 99(3): 354 - 360. [Abstract] [Full Text] [PDF]
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T. Akasaka, K. Yoshida, T. Hozumi, T. Takagi, S. Kaji, T. Kawamoto, Y. Ueda, Y. Okada, S. Morioka, and J. Yoshikawa Restricted coronary flow reserve in patients with mitral regurgitation improves after mitral reconstructive surgery J. Am. Coll. Cardiol., December 1, 1998; 32(7): 1923 - 1930. [Abstract] [Full Text] [PDF]
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R. J. Bache Vasodilator Reserve : A Functional Assessment of Coronary Health Circulation, September 29, 1998; 98(13): 1257 - 1260. [Full Text] [PDF]
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M. Gerhard, B. W. Walsh, A. Tawakol, E. A. Haley, S. J. Creager, E. W. Seely, P. Ganz, and M. A. Creager Estradiol Therapy Combined With Progesterone and Endothelium-Dependent Vasodilation in Postmenopausal Women Circulation, September 22, 1998; 98(12): 1158 - 1163. [Abstract] [Full Text] [PDF]
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T. Neunteufl, K. Kostner, R. Katzenschlager, M. Zehetgruber, G. Maurer, and F. Weidinger Additional benefit of vitamin E supplementation to simvastatin therapy on vasoreactivity of the brachial artery of hypercholesterolemic men J. Am. Coll. Cardiol., September 1, 1998; 32(3): 711 - 716. [Abstract] [Full Text] [PDF]
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P. M. Ridker, N. Rifai, M. A. Pfeffer, F. M. Sacks, L. A. Moye, S. Goldman, G. C. Flaker, and E. Braunwald Inflammation, Pravastatin, and the Risk of Coronary Events After Myocardial Infarction in Patients With Average Cholesterol Levels Circulation, September 1, 1998; 98(9): 839 - 844. [Abstract] [Full Text] [PDF]
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 R. O. Cannon III Role of nitric oxide in cardiovascular disease: focus on the endothelium Clin. Chem., August 1, 1998; 44(8): 1809 - 1819. [Abstract] [Full Text] [PDF]
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S.-i. Saitoh, T. Saito, T. Ohwada, A. Ohtake, F. Onogi, K. Aikawa, K. Maehara, and Y. Maruyama Morphological and functional changes in coronary vessel evoked by repeated endothelial injury in pigs Cardiovasc Res, June 1, 1998; 38(3): 772 - 781. [Abstract] [Full Text] [PDF]
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 R. S. Rosenson and C. C. Tangney Antiatherothrombotic Properties of Statins: Implications for Cardiovascular Event Reduction JAMA, May 27, 1998; 279(20): 1643 - 1650. [Abstract] [Full Text] [PDF]
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F.-C. Schoebel, T. W. Jax, B.-E. Strauer, M. Leschke, and W. R. M. A. A. J. v. B. A. H. Z. J. W. J. A. V. G. van der Werf Functional Evaluation of Lipid-Lowering Therapy by Pravastatin • Response Circulation, May 12, 1998; 97(18): 1874 - 1875. [Full Text]
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A. Lucas, E. Dai, L.-Y. Liu, and P. N Nation Atherosclerosis in Marek's disease virus infected hypercholesterolemic roosters is reduced by HMGCoA reductase and ACE inhibitor therapy Cardiovasc Res, April 1, 1998; 38(1): 237 - 246. [Abstract] [Full Text] [PDF]
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H. Kato, R. Okada, K. Oogushi, S. Emura, H. Kishikawa, S. Kawazoye, M. Fukuoka, T. Takashima, and K. Ohmori Suppressive Effect of Simvastatin on Intramural Small Coronary Arterial Lesions in Cholesterol-Fed Rabbits Angiology, March 1, 1998; 49(3): 211 - 220. [Abstract] [PDF]
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M. Gheorghiade and R. O. Bonow Chronic Heart Failure in the United States : A Manifestation of Coronary Artery Disease Circulation, January 27, 1998; 97(3): 282 - 289. [Full Text] [PDF]
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 K. Sudhir Review : Recent Advances in the Prevention of Coronary Artery Disease: Focus on Primary Prevention Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 1998; 3(1): 77 - 83. [Abstract] [PDF]
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M. Takemoto, K. Egashira, H. Tomita, M. Usui, H. Okamoto, A. Kitabatake, H. Shimokawa, K. Sueishi, and A. Takeshita Chronic Angiotensin-Converting Enzyme Inhibition and Angiotensin II Type 1 Receptor Blockade : Effects on Cardiovascular Remodeling in Rats Induced by the Long-term Blockade of Nitric Oxide Synthesis Hypertension, December 1, 1997; 30(6): 1621 - 1627. [Abstract] [Full Text]
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G. D. Plotnick, M. C. Corretti, and R. A. Vogel Effect of Antioxidant Vitamins on the Transient Impairment of Endothelium--Dependent Brachial Artery Vasoactivity Following a Single High-Fat Meal JAMA, November 26, 1997; 278(20): 1682 - 1686. [Abstract] [PDF]
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N. Delanty and C. J. Vaughan Vascular Effects of Statins in Stroke Stroke, November 1, 1997; 28(11): 2315 - 2320. [Abstract] [Full Text]
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T. Akasaka, K. Yoshida, A. Yamamuro, T. Hozumi, T. Takagi, S. Morioka, and J. Yoshikawa Phasic Coronary Flow Characteristics in Patients With Constrictive Pericarditis : Comparison With Restrictive Cardiomyopathy Circulation, September 16, 1997; 96(6): 1874 - 1881. [Abstract] [Full Text]
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R. H. Boger, S. M. Bode-Boger, R. P. Brandes, L. Phivthong-ngam, M. Bohme, R. Nafe, A. Mugge, and J. C. Frolich Dietary L-Arginine Reduces the Progression of Atherosclerosis in Cholesterol-Fed Rabbits : Comparison With Lovastatin Circulation, August 19, 1997; 96(4): 1282 - 1290. [Abstract] [Full Text]
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W. R. M. Aengevaeren, G. J. H. Uijen, J. W. Jukema, A. V. G. Bruschke, and T. van der Werf Functional Evaluation of Lipid-Lowering Therapy by Pravastatin in the Regression Growth Evaluation Statin Study (REGRESS) Circulation, July 15, 1997; 96(2): 429 - 435. [Abstract] [Full Text]
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M. Mohri, K. Egashira, T. Tagawa, T. Kuga, H. Tagawa, Y. Harasawa, H. Shimokawa, and A. Takeshita Basal Release of Nitric Oxide Is Decreased in the Coronary Circulation in Patients With Heart Failure Hypertension, July 1, 1997; 30(1): 50 - 56. [Abstract] [Full Text]
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