Circulation, Vol 88, 2190-2197, Copyright © 1993 by American Heart Association
EJ Mayer, B Newman, CP Quesenberry Jr, GD Friedman and JV Selby
BACKGROUND. The relation between alcohol intake and insulin levels may
explain, in part, the reported associations of alcohol with cardiovascular
disease risk factors, including high-density lipoprotein (HDL) cholesterol,
triglycerides, blood pressure, and glucose levels, each of which has been
recognized as a component of the insulin resistance syndrome. METHODS AND
RESULTS. Subjects included nondiabetic participants of the Kaiser
Permanente Women Twins Study (1989 through 1990). Usual alcohol intake was
assessed as part of a food frequency questionnaire. For women from twin
pairs in which both twins drank (n = 338), an increment of 12 g of alcohol
per day (about one drink) was associated with an 8% lower 2-hour
post-glucose-load insulin (P < .01) in a multiple regression analysis
for twin data, adjusted for age, body mass index, waist-to-hip ratio, total
caloric intake, and family history of diabetes. With genetic influences
removed by matched analysis of the subset of 98 monozygotic twin pairs, an
intrapair difference of 12 g of alcohol per day was associated with a 12.4%
intrapair decrement in postload insulin (P < .01). Inverse associations
were also seen for fasting insulin. Alcohol consumption was inversely
associated with postload glucose but not with fasting glucose in unmatched
(P = .05) and matched (P = .005) analyses. A significant positive
association of alcohol intake with high-density lipoprotein cholesterol and
an inverse relation of alcohol intake with triglycerides were each
independent of insulin levels (P < or = .02 in the matched models).
Neither systolic nor diastolic blood pressures were related to alcohol
consumption in this sample, perhaps because of the rather low level of
alcohol intake in the study population (median, 4 g/d). CONCLUSIONS. Within
the range of light to moderate drinking habits, alcohol consumption was
inversely related to fasting and postload insulin levels. This relation did
not explain associations of alcohol intake with lipid levels and may
instead reflect an additional mechanism by which moderate alcohol
consumption impacts cardiovascular disease risk.
ARTICLES
Alcohol consumption and insulin concentrations. Role of insulin in associations of alcohol intake with high-density lipoprotein cholesterol and triglycerides
Division of Research, Permanente Medical Group, Inc., Oakland, Calif. 94611.
This article has been cited by other articles:
 |
|
 |
|
  K. K. Sato, T. Hayashi, Y. Nakamura, N. Harita, T. Yoneda, G. Endo, and H. Kambe Liver Enzymes Compared With Alcohol Consumption in Predicting the Risk of Type 2 Diabetes: The Kansai Healthcare Study Diabetes Care, June 1, 2008; 31(6): 1230 - 1236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-C. Sung, S. H. Kim, and G. M. Reaven Relationship Among Alcohol, Body Weight, and Cardiovascular Risk Factors in 27,030 Korean Men Diabetes Care, October 1, 2007; 30(10): 2690 - 2694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Gigleux, J. Gagnon, A. St-Pierre, B. Cantin, G. R. Dagenais, F. Meyer, J.-P. Despres, and B. Lamarche Moderate Alcohol Consumption Is More Cardioprotective in Men with the Metabolic Syndrome J. Nutr., December 1, 2006; 136(12): 3027 - 3032. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S.V. Elkind, R. Sciacca, B. Boden-Albala, T. Rundek, M. C. Paik, and R. L. Sacco Moderate Alcohol Consumption Reduces Risk of Ischemic Stroke: The Northern Manhattan Study Stroke, January 1, 2006; 37(1): 13 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Bazzano, M. Serdula, and S. Liu Prevention of Type 2 Diabetes by Diet and Lifestyle Modification J. Am. Coll. Nutr., October 1, 2005; 24(5): 310 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Lindeman, S. J. Wayne, R. N. Baumgartner, and P. J. Garry Cognitive Function in Drinkers Compared to Abstainers in The New Mexico Elder Health Survey J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2005; 60(8): 1065 - 1070. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Freiberg, H. J. Cabral, T. C. Heeren, R. S. Vasan, and R. Curtis Ellison Alcohol Consumption and the Prevalence of the Metabolic Syndrome in the U.S.: A cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey Diabetes Care, December 1, 2004; 27(12): 2954 - 2959. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Vliegenthart, H.-H. S. Oei, A. P. M. van den Elzen, F. J. A. van Rooij, A. Hofman, M. Oudkerk, and J. C. M. Witteman Alcohol Consumption and Coronary Calcification in a General Population Arch Intern Med, November 22, 2004; 164(21): 2355 - 2360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Carnethon, C. M. Loria, J. O. Hill, S. Sidney, P. J. Savage, and K. Liu Risk Factors for the Metabolic Syndrome: The Coronary Artery Risk Development in Young Adults (CARDIA) study, 1985-2001 Diabetes Care, November 1, 2004; 27(11): 2707 - 2715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. S. Yoon, S. W. Oh, H. W. Baik, H. S. Park, and W. Y. Kim Alcohol consumption and the metabolic syndrome in Korean adults: the 1998 Korean National Health and Nutrition Examination Survey Am. J. Clinical Nutrition, July 1, 2004; 80(1): 217 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Howard, J. H. Arnsten, and M. N. Gourevitch Effect of Alcohol Consumption on Diabetes Mellitus: A Systematic Review Ann Intern Med, February 3, 2004; 140(3): 211 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sierksma, H. Patel, N. Ouchi, S. Kihara, T. Funahashi, R. J. Heine, D. E. Grobbee, C. Kluft, and H. F.J. Hendriks Effect of Moderate Alcohol Consumption on Adiponectin, Tumor Necrosis Factor-{alpha}, and Insulin Sensitivity Diabetes Care, January 1, 2004; 27(1): 184 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. V. Kenkre, R. D. Lindeman, C. Lillian Yau, R. N. Baumgartner, and P. J. Garry Serum Insulin Concentrations in Daily Drinkers Compared With Abstainers in the New Mexico Elder Health Survey J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2003; 58(10): M960 - 963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Greenfield, K. Samaras, A. B. Jenkins, P. J. Kelly, T. D. Spector, and L. V. Campbell Moderate Alcohol Consumption, Estrogen Replacement Therapy, and Physical Activity Are Associated With Increased Insulin Sensitivity: Is abdominal adiposity the mediator? Diabetes Care, October 1, 2003; 26(10): 2734 - 2740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Carlsson, N. Hammar, V. Grill, and J. Kaprio Alcohol Consumption and the Incidence of Type 2 Diabetes: A 20-year follow-up of the Finnish Twin Cohort Study Diabetes Care, October 1, 2003; 26(10): 2785 - 2790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Kroenke, N.-F. Chu, N. Rifai, D. Spiegelman, S. E. Hankinson, J. E. Manson, and E. B. Rimm A Cross-Sectional Study of Alcohol Consumption Patterns and Biologic Markers of Glycemic Control Among 459 Women Diabetes Care, July 1, 2003; 26(7): 1971 - 1978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Wannamethee, C. A. Camargo Jr, J. E. Manson, W. C. Willett, and E. B. Rimm Alcohol Drinking Patterns and Risk of Type 2 Diabetes Mellitus Among Younger Women Arch Intern Med, June 9, 2003; 163(11): 1329 - 1336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Meyer, K. M. Conigrave, N.-F. Chu, N. Rifai, D. Spiegelman, M. J. Stampfer, and E. B. Rimm Alcohol Consumption Patterns and HbA1c, C-Peptide and Insulin Concentrations in Men J. Am. Coll. Nutr., June 1, 2003; 22(3): 185 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Zilkens, V. Burke, G. Watts, L. J. Beilin, and I. B. Puddey The Effect of Alcohol Intake on Insulin Sensitivity in Men: A randomized controlled trial Diabetes Care, March 1, 2003; 26(3): 608 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Nakanishi, K. Suzuki, and K. Tatara Alcohol Consumption and Risk for Development of Impaired Fasting Glucose or Type 2 Diabetes in Middle-Aged Japanese Men Diabetes Care, January 1, 2003; 26(1): 48 - 54. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S G Wannamethee, A G Shaper, I J Perry, and K G M M Alberti Alcohol consumption and the incidence of type II diabetes J Epidemiol Community Health, July 1, 2002; 56(7): 542 - 548. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. J. Davies, D. J. Baer, J. T. Judd, E. D. Brown, W. S. Campbell, and P. R. Taylor Effects of Moderate Alcohol Intake on Fasting Insulin and Glucose Concentrations and Insulin Sensitivity in Postmenopausal Women: A Randomized Controlled Trial JAMA, May 15, 2002; 287(19): 2559 - 2562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Franz, J. P. Bantle, C. A. Beebe, J. D. Brunzell, J.-L. Chiasson, A. Garg, L. A. Holzmeister, B. Hoogwerf, E. Mayer-Davis, A. D. Mooradian, et al. Evidence-Based Nutrition Principles and Recommendations for the Treatment and Prevention of Diabetes and Related Complications Diabetes Care, January 1, 2002; 25(1): 148 - 198. [Full Text] [PDF]
|
|
|
|
 |
|
 W. H. L. Kao, I. B. Puddey, L. L. Boland, R. L. Watson, and F. L. Brancati Alcohol Consumption and the Risk of Type 2 Diabetes Mellitus: Atherosclerosis Risk in Communities Study Am. J. Epidemiol., October 15, 2001; 154(8): 748 - 757. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Conigrave, B. F. Hu, C. A. Camargo, M. J. Stampfer, W. C. Willett, and E. B. Rimm A Prospective Study of Drinking Patterns in Relation to Risk of Type 2 Diabetes Among Men Diabetes, October 1, 2001; 50(10): 2390 - 2395. [Abstract] [Full Text]
|
|
|
|
 |
|
 U. A. Ajani, J. M. Gaziano, P. A. Lotufo, S. Liu, C. H. Hennekens, J. E. Buring, and J. E. Manson Alcohol Consumption and Risk of Coronary Heart Disease by Diabetes Status Circulation, August 1, 2000; 102(5): 500 - 505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. A. Ajani, C. H. Hennekens, A. Spelsberg, and J. E. Manson Alcohol Consumption and Risk of Type 2 Diabetes Mellitus Among US Male Physicians Arch Intern Med, April 10, 2000; 160(7): 1025 - 1030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. T. Valmadrid, R. Klein, S. E. Moss, B. E. K. Klein, and K. J. Cruickshanks Alcohol Intake and the Risk of Coronary Heart Disease Mortality in Persons With Older-Onset Diabetes Mellitus JAMA, July 21, 1999; 282(3): 239 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Criqui and B. A. Golomb Should Patients With Diabetes Drink to Their Health? JAMA, July 21, 1999; 282(3): 279 - 280. [Full Text] [PDF]
|
|
|
|
|
|
A. L. Romero, J. E. Romero, S. Galaviz, and M. L. Fernandez Cookies Enriched with Psyllium or Oat Bran Lower Plasma LDL Cholesterol in Normal and Hypercholesterolemic Men from Northern Mexico J. Am. Coll. Nutr., December 1, 1998; 17(6): 601 - 608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Mitchell, C. M. Kammerer, J. Blangero, M. C. Mahaney, D. L. Rainwater, B. Dyke, J. E. Hixson, R. D. Henkel, R. M. Sharp, A. G. Comuzzie, et al. Genetic and Environmental Contributions to Cardiovascular Risk Factors in Mexican Americans: The San Antonio Family Heart Study Circulation, November 1, 1996; 94(9): 2159 - 2170. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Kiechl, J. Willeit, W. Poewe, G. Egger, F. Oberhollenzer, M. Muggeo, and E. Bonora Insulin sensitivity and regular alcohol consumption: large, prospective, cross sectional population study (Bruneck study) BMJ, October 26, 1996; 313(7064): 1040 - 1044. [Abstract] [Full Text]
|
|
|
|
|
|
E. B Rimm, J. Chan, M. J Stampfer, G. A Colditz, and W. C Willett Prospective study of cigarette smoking, alcohol use, and the risk of diabetes in men BMJ, March 4, 1995; 310(6979): 555 - 559. [Abstract] [Full Text]
|
|