Circulation, Vol 88, 1004-1009, Copyright © 1993 by American Heart Association
CM Wei, DM Heublein, MA Perrella, A Lerman, RJ Rodeheffer, CG McGregor, WD Edwards, HV Schaff and JC Burnett Jr
BACKGROUND. Atrial natriuretic peptide (ANP), brain natriuretic peptide
(BNP), and C-type natriuretic peptide (CNP) are a family of structurally
related peptides that participate in the integrated control of renal and
cardiovascular function. Previous studies suggest a functional role for
these hormonal peptides in cardiorenal regulation in congestive heart
failure (CHF). METHODS AND RESULTS. The present studies were performed in
normal subjects (n = 6) and in patients with mild (New York Heart
Association [NYHA] class I to II, n = 20) and severe (NYHA class III to IV,
n = 20) CHF by use of radioimmunoassay and immunohistochemical staining
(IHCS). Plasma ANP was significantly increased in both mild and severe CHF
compared with normal subjects. In contrast, plasma BNP was only moderately
increased in the severe CHF group, and plasma CNP concentration was
unchanged in CHF compared with normal subjects. Atrial tissue
concentrations of the natriuretic peptides did not parallel circulating
concentrations. ANP predominated in normal atrial tissue, but BNP
predominated in CHF. In ventricular tissue, IHCS staining was present for
all three peptides in normal ventricular myocardium and was markedly
enhanced in CHF. CONCLUSIONS. These studies support a differential
regulation of ANP, BNP, and CNP circulating concentrations and tissue
activity in human CHF.
ARTICLES
Natriuretic peptide system in human heart failure
Cardiorenal Research Laboratory, Mayo Clinic and Foundation, Rochester, MN 55905.
This article has been cited by other articles:
 |
|
 |
|
  K. Kusunose, H. Yamada, S. Nishio, N. Tomita, T. Niki, K. Yamaguchi, K. Koshiba, S. Yagi, Y. Taketani, T. Iwase, et al. Clinical Utility of Single-Beat E/e' Obtained by Simultaneous Recording of Flow and Tissue Doppler Velocities in Atrial Fibrillation With Preserved Systolic Function J. Am. Coll. Cardiol. Img., October 1, 2009; 2(10): 1147 - 1156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Palmer, T. C.R. Prickett, E. A. Espiner, T. G. Yandle, and A. M. Richards Regional Release and Clearance of C-Type Natriuretic Peptides in the Human Circulation and Relation to Cardiac Function Hypertension, September 1, 2009; 54(3): 612 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Toischer, H. Kogler, G. Tenderich, C. Grebe, T. Seidler, P. N. Van, K. Jung, R. Knoll, R. Korfer, and G. Hasenfuss Elevated Afterload, Neuroendocrine Stimulation, and Human Heart Failure Increase BNP Levels and Inhibit Preload-Dependent SERCA Upregulation Circ Heart Fail, November 1, 2008; 1(4): 265 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Cataliotti, H. H. Chen, J. A. Schirger, F. L. Martin, G. Boerrigter, L. C. Costello-Boerrigter, K. D. James, K. Polowy, M. A. Miller, N. B. Malkar, et al. Chronic Actions of a Novel Oral B-Type Natriuretic Peptide Conjugate in Normal Dogs and Acute Actions in Angiotensin II-Mediated Hypertension Circulation, October 21, 2008; 118(17): 1729 - 1736. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Rose and W. R. Giles Natriuretic peptide C receptor signalling in the heart and vasculature J. Physiol., January 15, 2008; 586(2): 353 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Nielsen, J. F. Rehfeld, and J. P. Goetze Mismeasure of C-Type Natriuretic Peptide Clin. Chem., January 1, 2008; 54(1): 225 - 227. [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wang, M. C. de Waard, A. Sterner-Kock, H. Stepan, H.-P. Schultheiss, D. J. Duncker, and T. Walther Cardiomyocyte-restricted over-expression of C-type natriuretic peptide prevents cardiac hypertrophy induced by myocardial infarction in mice Eur J Heart Fail, June 1, 2007; 9(6-7): 548 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Rose, N. Hatano, S. Ohya, Y. Imaizumi, and W. R. Giles C-type natriuretic peptide activates a non-selective cation current in acutely isolated rat cardiac fibroblasts via natriuretic peptide C receptor-mediated signalling J. Physiol., April 1, 2007; 580(1): 255 - 274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Abe, T. Matsunaga, K. Kameda, H. Tomita, T. Fujiwara, H. Ishizaka, H. Hanada, K. Fukui, I. Fukuda, T. Osanai, et al. Increased Level of Pericardial Insulin-Like Growth Factor-1 in Patients With Left Ventricular Dysfunction and Advanced Heart Failure J. Am. Coll. Cardiol., October 3, 2006; 48(7): 1387 - 1395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rienstra, I. C. Van Gelder, M. P. Van den Berg, F. Boomsma, and D. J. Van Veldhuisen Natriuretic peptides in patients with atrial fibrillation and advanced chronic heart failure: determinants and prognostic value of (NT-)ANP and (NT-pro)BNP Europace, July 1, 2006; 8(7): 482 - 487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kogler, P. Schott, K. Toischer, H. Milting, P. N. Van, M. Kohlhaas, C. Grebe, A. Kassner, E. Domeier, N. Teucher, et al. Relevance of Brain Natriuretic Peptide in Preload-Dependent Regulation of Cardiac Sarcoplasmic Reticulum Ca2+ ATPase Expression Circulation, June 13, 2006; 113(23): 2724 - 2732. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Xydas, A. R. Kherani, J. S. Chang, S. Klotz, I. Hay, C. J. Mutrie, G. W. Moss, A. Gu, A. R. Schulman, D. Gao, et al. beta2-Adrenergic Stimulation Attenuates Left Ventricular Remodeling, Decreases Apoptosis, and Improves Calcium Homeostasis in a Rodent Model of Ischemic Cardiomyopathy J. Pharmacol. Exp. Ther., May 1, 2006; 317(2): 553 - 561. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Potter, S. Abbey-Hosch, and D. M. Dickey Natriuretic Peptides, Their Receptors, and Cyclic Guanosine Monophosphate-Dependent Signaling Functions Endocr. Rev., February 1, 2006; 27(1): 47 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Costello-Boerrigter, G. Boerrigter, M. M. Redfield, R. J. Rodeheffer, L. H. Urban, D. W. Mahoney, S. J. Jacobsen, D. M. Heublein, and J. C. Burnett Jr Amino-Terminal Pro-B-Type Natriuretic Peptide and B-Type Natriuretic Peptide in the General Community: Determinants and Detection of Left Ventricular Dysfunction J. Am. Coll. Cardiol., January 17, 2006; 47(2): 345 - 353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Del Ry, C. Passino, M. Maltinti, M. Emdin, and D. Giannessi C-type natriuretic peptide plasma levels increase in patients with chronic heart failure as a function of clinical severity Eur J Heart Fail, December 1, 2005; 7(7): 1145 - 1148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cataliotti, J. A. Schirger, F. L. Martin, H. H. Chen, P. M. McKie, G. Boerrigter, L. C. Costello-Boerrigter, G. Harty, D. M. Heublein, S. M. Sandberg, et al. Oral Human Brain Natriuretic Peptide Activates Cyclic Guanosine 3',5'-Monophosphate and Decreases Mean Arterial Pressure Circulation, August 9, 2005; 112(6): 836 - 840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Zhu, S. Strada, and T. Stevens Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L196 - L206. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Rose, M. B. Anand-Srivastava, W. R. Giles, and J. S. Bains C-type Natriuretic Peptide Inhibits L-type Ca2+ Current in Rat Magnocellular Neurosecretory Cells by Activating the NPR-C Receptor J Neurophysiol, July 1, 2005; 94(1): 612 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Luchner, C. Hengstenberg, H. Lowel, G. A.J. Riegger, H. Schunkert, and S. Holmer Effect of Compensated Renal Dysfunction on Approved Heart Failure Markers: Direct Comparison of Brain Natriuretic Peptide (BNP) and N-Terminal Pro-BNP Hypertension, July 1, 2005; 46(1): 118 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. S. Sun, C. Dominguez, N. A. Mallavaram, and J. M. Quaegebeur Dysfunction of atrial and B-type natriuretic peptides in congenital univentricular defects J. Thorac. Cardiovasc. Surg., May 1, 2005; 129(5): 1104 - 1110. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. O'Dell, J. S. Kalus, S. Kucukarslan, and B. Czerska Nesiritide for secondary pulmonary hypertension in patients with end-stage heart failure Am. J. Health Syst. Pharm., March 15, 2005; 62(6): 606 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wang, X.-F. Liu, K. G. Cornish, I. H. Zucker, and K. P. Patel Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H205 - H213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Gao, C. Wei, L. Chen, J. Huang, S. Yang, and A. M. Diehl Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease Am J Physiol Gastrointest Liver Physiol, November 1, 2004; 287(5): G1070 - G1077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Patrianakos, F. I. Parthenakis, E. A. Papadimitriou, G. F. Diakakis, P. G. Tzerakis, D. Nikitovic, and P. E. Vardas Restrictive filling pattern is associated with increased humoral activation and impaired exercise capacity in dilated cardiomyopathy Eur J Heart Fail, October 1, 2004; 6(6): 735 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Rose, A. E. Lomax, C. S. Kondo, M. B. Anand-Srivastava, and W. R. Giles Effects of C-type natriuretic peptide on ionic currents in mouse sinoatrial node: a role for the NPR-C receptor Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1970 - H1977. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. de Denus, C. Pharand, and D. R. Williamson Brain Natriuretic Peptide in the Management of Heart Failure: The Versatile Neurohormone Chest, February 1, 2004; 125(2): 652 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. Knudsen, J. S. Riis, A. V. Finsen, L. Eikvar, C. Muller, A. Westheim, and T. Omland Diagnostic value of a rapid test for B-type natriuretic peptide in patients presenting with acute dyspnoe: effect of age and gender Eur J Heart Fail, January 1, 2004; 6(1): 55 - 62. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Berendes, C. Schmidt, H. Van Aken, M. G. Hartlage, M. Rothenburger, S. Wirtz, H. H. Scheld, G. Brodner, and M. Walter A-Type and B-Type Natriuretic Peptides in Cardiac Surgical Procedures Anesth. Analg., January 1, 2004; 98(1): 11 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Wright, T. C.R. Prickett, R. N. Doughty, C. Frampton, G. D. Gamble, T. G. Yandle, N. Sharpe, and M. Richards Amino-Terminal Pro-C-Type Natriuretic Peptide in Heart Failure Hypertension, January 1, 2004; 43(1): 94 - 100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. D. White and J. K. French Use of brain natriuretic peptide levels for risk assessment in non-ST-elevation acute coronary syndromes J. Am. Coll. Cardiol., December 3, 2003; 42(11): 1917 - 1920. [Full Text] [PDF]
|
|
|
|
|
|
R. A. Rose, A. E. Lomax, and W. R. Giles Inhibition of L-type Ca2+ current by C-type natriuretic peptide in bullfrog atrial myocytes: an NPR-C-mediated effect Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2454 - H2462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Goto, H Takase, T Toriyama, T Sugiura, K Sato, R Ueda, and Y Dohi Circulating concentrations of cardiac proteins indicate the severity of congestive heart failure Heart, November 1, 2003; 89(11): 1303 - 1307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Herrmann-Lingen, L. Binder, M. Klinge, J. Sander, W. Schenker, B. Beyermann, D. von Lewinski, and B. Pieske High Plasma Levels of N-Terminal Pro-Atrial Natriuretic Peptide Associated With Low Anxiety in Severe Heart Failure Psychosom Med, July 1, 2003; 65(4): 517 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ruskoaho Cardiac Hormones as Diagnostic Tools in Heart Failure Endocr. Rev., June 1, 2003; 24(3): 341 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Horio, T. Tokudome, T. Maki, F. Yoshihara, S.-i. Suga, T. Nishikimi, M. Kojima, Y. Kawano, and K. Kangawa Gene Expression, Secretion, and Autocrine Action of C-Type Natriuretic Peptide in Cultured Adult Rat Cardiac Fibroblasts Endocrinology, June 1, 2003; 144(6): 2279 - 2284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Jourdain, F. Funck, M. Bellorini, N. Guillard, J. Loiret, B. Thebault, M. Desnos, and D. Duboc Bedside B-type natriuretic peptide and functional capacity in chronic heart failure Eur J Heart Fail, March 1, 2003; 5(2): 155 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Kalra, J. R. Clague, A. P. Bolger, S. D. Anker, P. A. Poole-Wilson, A. D. Struthers, and A. J. Coats Myocardial Production of C-Type Natriuretic Peptide in Chronic Heart Failure Circulation, February 4, 2003; 107(4): 571 - 573. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Vichiendilokkul, A. Tran, and E. Racine Nesiritide: A Novel Approach for Acute Heart Failure Ann. Pharmacother., February 1, 2003; 37(2): 247 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pedram, M. Razandi, and E. R. Levin Deciphering Vascular Endothelial Cell Growth Factor/Vascular Permeability Factor Signaling to Vascular Permeability. INHIBITION BY ATRIAL NATRIURETIC PEPTIDE J. Biol. Chem., November 8, 2002; 277(46): 44385 - 44398. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.A. Kelly, D.E. Newby, T.A. Mcdonagh, T.W. Mackay, J. Barr, N.A. Boon, H.J. Dargie, and N.J. Douglas Randomised controlled trial of continuous positive airway pressure and standard oxygen therapy in acute pulmonary oedema. Effects on plasma brain natriuretic peptide concentrations Eur. Heart J., September 1, 2002; 23(17): 1379 - 1386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J.M Best, J. C Burnett Jr., S. H Wilson, D. R Holmes Jr., and A. Lerman Dendroaspis natriuretic peptide relaxes isolated human arteries and veins Cardiovasc Res, August 1, 2002; 55(2): 375 - 384. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Shimizu, Y. Murakami, S.-i. Inoue, Y. Ohta, K. Nakamura, H. Katoh, T. Sakne, N. Takahashi, S. Ohata, T. Sugamori, et al. High Plasma Brain Natriuretic Polypeptide Level as a Marker of Risk for Thromboembolism in Patients With Nonvalvular Atrial Fibrillation Stroke, April 1, 2002; 33(4): 1005 - 1010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Naitoh, J. Risvanis, L. C. Balding, C. I. Johnston, and L. M. Burrell Neurohormonal antagonism in heart failure; beneficial effects of vasopressin V1a and V2 receptor blockade and ACE inhibition Cardiovasc Res, April 1, 2002; 54(1): 51 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.o. Koglin, S. Pehlivanli, M. Schwaiblmair, M. Vogeser, P. Cremer, and W. vonScheidt Role of brain natriuretic peptide in risk stratification of patients with congestive heart failure J. Am. Coll. Cardiol., December 1, 2001; 38(7): 1934 - 1941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Herring, J. A. B. Zaman, and D. J. Paterson Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2318 - H2327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Kim, J. H. Han, S. H. Lim, S. J. Lee, S. Z. Kim, and K. W. Cho Attenuation of inhibitory effect of CNP on the secretion of ANP from hypertrophied atria Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1456 - R1463. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Bialik, Z. A. Abassi, I. Hammel, J. Winaver, and D. Lewinson Evaluation of Atrial Natriuretic Peptide and Brain Natriuretic Peptide in Atrial Granules of Rats with Experimental Congestive Heart Failure J. Histochem. Cytochem., October 1, 2001; 49(10): 1293 - 1300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Scheuermann-Freestone, N. S. Freestone, T. Langenickel, K. Hohnel, R. Dietz, and R. Willenbrock A new model of congestive heart failure in the mouse due to chronic volume overload Eur J Heart Fail, October 1, 2001; 3(5): 535 - 543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Berendes, H. Van Aken, C. Raufhake, C. Schmidt, G. Assmann, and M. Walter Differential Secretion of Atrial and Brain Natriuretic Peptide in Critically Ill Patients Anesth. Analg., September 1, 2001; 93(3): 676 - 682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R Kalra, S. D Anker, and A. J.S Coats Water and sodium regulation in chronic heart failure: the role of natriuretic peptides and vasopressin Cardiovasc Res, August 15, 2001; 51(3): 495 - 509. [Full Text] [PDF]
|
|
|
|
|
|
W.J. Paulus Natriuretic peptides to probe haemodynamic overload in hypertrophic cardiomyopathy Eur. Heart J., August 1, 2001; 22(15): 1249 - 1251. [Abstract] [PDF]
|
|
|
|
|
|
C-M Yu, B M Y Cheung, R Leung, Q Wang, W-H Lai, and C-P Lau Increase in plasma adrenomedullin in patients with heart failure characterised by diastolic dysfunction Heart, August 1, 2001; 86(2): 155 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T A McDonagh, A D Cunningham, C E Morrison, J J V McMurray, I Ford, J J Morton, and H J Dargie Left ventricular dysfunction, natriuretic peptides, and mortality in an urban population Heart, July 1, 2001; 86(1): 21 - 26. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Y. T. Hart, E. L. Hahn, D. M. Meyer, J. C. Burnett Jr., and M. M. Redfield Differential effects of natriuretic peptides and NO on LV function in heart failure and normal dogs Am J Physiol Heart Circ Physiol, July 1, 2001; 281(1): H146 - H154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.R Kalra, S.D Anker, A.D Struthers, and A.J.S Coats The role of C-type natriuretic peptide in cardiovascular medicine Eur. Heart J., June 2, 2001; 22(12): 997 - 1007. [PDF]
|
|
|
|
|
|
A. Pedram, M. Razandi, and E. R. Levin Natriuretic Peptides Suppress Vascular Endothelial Cell Growth Factor Signaling to Angiogenesis Endocrinology, April 1, 2001; 142(4): 1578 - 1586. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. R Weir and Chiming Wei The role of angiotensin II and TGF-beta on the progression of chronic allograft nephropathy Journal of Renin-Angiotensin-Aldosterone System, March 1, 2001; 2(1_suppl): S188 - S190. [Abstract] [PDF]
|
|
|
|
|
|
T. Walther, H. Stepan, and R. Faber Dual natriuretic peptide response to volume load in the fetal circulation Cardiovasc Res, March 1, 2001; 49(4): 817 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Chiming Wei, M. G Cardarelli, S. W Downing, and J. S McLaughlin The effect of angiotensin II on mitogen-activated protein kinase in human cardiomyocytes Journal of Renin-Angiotensin-Aldosterone System, December 1, 2000; 1(4): 379 - 384. [Abstract] [PDF]
|
|
|
|
|
|
L. M. Burrell, N. K. Farina, L. C. Balding, and C. I. Johnston Beneficial Renal and Cardiac Effects of Vasopeptidase Inhibition With S21402 in Heart Failure Hypertension, December 1, 2000; 36(6): 1105 - 1111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. S. Colucci, U. Elkayam, D. P. Horton, W. T. Abraham, R. C. Bourge, A. D. Johnson, L. E. Wagoner, M. M. Givertz, C.-s. Liang, M. Neibaur, et al. Intravenous Nesiritide, a Natriuretic Peptide, in the Treatment of Decompensated Congestive Heart Failure N. Engl. J. Med., July 27, 2000; 343(4): 246 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Lisy, M. M. Redfield, S. Jovanovic, M. Jougasaki, A. Jovanovic, H. Leskinen, A. Terzic, and J. C. Burnett Jr Mechanical Unloading Versus Neurohumoral Stimulation on Myocardial Structure and Endocrine Function In Vivo Circulation, July 18, 2000; 102(3): 338 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Kim and M. R. Piano The Natriuretic Peptides: Physiology and Role in Left-Ventricular Dysfunction Biol Res Nurs, July 1, 2000; 2(1): 15 - 29. [Abstract] [PDF]
|
|
|
|
 |
|
 Y. Moriyama, H. Yasue, M. Yoshimura, Y. Mizuno, K. Nishiyama, R. Tsunoda, H. Kawano, K. Kugiyama, H. Ogawa, Y. Saito, et al. The Plasma Levels of Dehydroepiandrosterone Sulfate Are Decreased in Patients with Chronic Heart Failure in Proportion to the Severity J. Clin. Endocrinol. Metab., May 1, 2000; 85(5): 1834 - 1840. [Abstract] [Full Text]
|
|
|
|
|
|
T. Langenickel, I. Pagel, K. Hohnel, R. Dietz, and R. Willenbrock Differential regulation of cardiac ANP and BNP mRNA in different stages of experimental heart failure Am J Physiol Heart Circ Physiol, May 1, 2000; 278(5): H1500 - H1506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rossi, M. Enriquez-Sarano, J. C. Burnett Jr., A. Lerman, M. D. Abel, and J. B. Seward Natriuretic peptide levels in atrial fibrillation: A prospective hormonal and Doppler-echocardiographic study J. Am. Coll. Cardiol., April 1, 2000; 35(5): 1256 - 1262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Tiret, C. Mallet, O. Poirier, V. Nicaud, A. Millaire, J.-B. Bouhour, G.e. Roizes, M. Desnos, R. Dorent, K. Schwartz, et al. Lack of association between polymorphisms of eight candidate genes and idiopathic dilated cardiomyopathy: The CARDIGENE study J. Am. Coll. Cardiol., January 1, 2000; 35(1): 29 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-L. Liu and I. H. Zucker Regulation of Sympathetic Nerve Activity in Heart Failure : A Role for Nitric Oxide and Angiotensin II Circ. Res., March 5, 1999; 84(4): 417 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hirose, Y. Furukawa, Y. Miyashita, F. Kurogouchi, K. Nakajima, M. Tsuboi, and S. Chiba CNP causes receptor-mediated positive dromotropic effects in anesthetized dog hearts Am J Physiol Heart Circ Physiol, August 1, 1998; 275(2): H717 - H720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hirose, Y. Furukawa, F. Kurogouchi, K. Nakajima, Y. Miyashita, and S. Chiba C-Type Natriuretic Peptide Increases Myocardial Contractility and Sinus Rate Mediated by Guanylyl Cyclase-Linked Natriuretic Peptide Receptors in Isolated, Blood-Perfused Dog Heart Preparations J. Pharmacol. Exp. Ther., July 1, 1998; 286(1): 70 - 76. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Numata, K. Dohi, A. Furukawa, S. Kikuoka, H. Asada, T. Fukunaga, Y. Taniguchi, K. Sasakura, T. Tsuji, K. Inouye, et al. Immunoradiometric assay for the N-terminal fragment of proatrial natriuretic peptidein human plasma Clin. Chem., May 1, 1998; 44(5): 1008 - 1013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Luchner, T. L. Stevens, D. D. Borgeson, M. Redfield, C.-M. Wei, J. G. Porter, and J. C. Burnett Jr. Differential atrial and ventricular expression of myocardial BNP during evolution of heart failure Am J Physiol Heart Circ Physiol, May 1, 1998; 274(5): H1684 - H1689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Barletta, C. Lazzeri, S. Vecchiarino, R. Del Bene, G. Messeri, A. Dello Sbarba, M. Mannelli, and G. La Villa Low-Dose C-Type Natriuretic Peptide Does Not Affect Cardiac and Renal Function in Humans Hypertension, March 1, 1998; 31(3): 802 - 808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Miyao, T. Nishikimi, Y. Goto, S. Miyazaki, S. Daikoku, I. Morii, T. Matsumoto, S. Takishita, A. Miyata, H. Matsuo, et al. Increased plasma adrenomedullin levels in patients with acute myocardial infarction in proportion to the clinical severity Heart, January 1, 1998; 79(1): 39 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bevilacqua, T. Vago, G. Baldi, G. Norbiato, S. Masson, and R. Latini Analytical Agreement and Clinical Correlates of Plasma Brain Natriuretic Peptide Measured by Three Immunoassays in Patients with Heart Failure Clin. Chem., December 1, 1997; 43(12): 2439 - 2440. [Full Text]
|
|
|
|
|
|
K. Yamamoto, J. C. Burnett Jr., and M. M. Redfield Effect of endogenous natriuretic peptide system on ventricular and coronary function in failing heart Am J Physiol Heart Circ Physiol, November 1, 1997; 273(5): H2406 - H2414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Daggubati, J. R Parks, R. M Overton, G. Cintron, D. D Schocken, and D. L Vesely Adrenomedullin, endothelin, neuropeptide Y, atrial, brain, and C-natriuretic prohormone peptides compared as early heart failure indicators Cardiovasc Res, November 1, 1997; 36(2): 246 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Kiemer and A. M. Vollmar Effects of Different Natriuretic Peptides on Nitric Oxide Synthesis in Macrophages Endocrinology, October 1, 1997; 138(10): 4282 - 4290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jougasaki, T. L. Stevens, D. D. Borgeson, A. Luchner, M. M. Redfield, and J. C. Burnett Jr. Adrenomedullin in experimental congestive heart failure: cardiorenal activation Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1997; 273(4): R1392 - R1399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Lainchbury, A. M. Richards, M. G. Nicholls, P. J. Hunt, H. Ikram, E. A. Espiner, T. G. Yandle, and E. Begg The Effects of Pathophysiological Increments in Brain Natriuretic Peptide in Left Ventricular Systolic Dysfunction Hypertension, September 1, 1997; 30(3): 398 - 404. [Abstract] [Full Text]
|
|
|
|
|
|
C.-F. Wu, N. H. Bishopric, and R. E. Pratt Atrial Natriuretic Peptide Induces Apoptosis in Neonatal Rat Cardiac Myocytes J. Biol. Chem., June 6, 1997; 272(23): 14860 - 14866. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Gamel, N. A. Yonan, B. Keevil, R. Warbuton, J. Kakadellis, A. Woodcock, C. S. Campbell, A. N. Rahman, and A. K. Deiraniya Significance of Raised Natriuretic Peptides After Bicaval and Standard Cardiac Transplantation Ann. Thorac. Surg., April 1, 1997; 63(4): 1095 - 1100. [Abstract] [Full Text]
|
|
|
|
|
|
K. Yamamoto, J. C. Burnett Jr, M. Jougasaki, R. A. Nishimura, K. R. Bailey, Y. Saito, K. Nakao, and M. M. Redfield Superiority of Brain Natriuretic Peptide as a Hormonal Marker of Ventricular Systolic and Diastolic Dysfunction and Ventricular Hypertrophy Hypertension, December 1, 1996; 28(6): 988 - 994. [Abstract] [Full Text]
|
|
|
|
|
|
M. Marttila, O. Vuolteenaho, D. Ganten, K. Nakao, and H. Ruskoaho Synthesis and Secretion of Natriuretic Peptides in the Hypertensive TGR(mREN-2)27 Transgenic Rat Hypertension, December 1, 1996; 28(6): 995 - 1004. [Abstract] [Full Text]
|
|
|
|
|
|
R. O. Bonow New Insights Into the Cardiac Natriuretic Peptides Circulation, June 1, 1996; 93(11): 1946 - 1950. [Full Text]
|
|
|
|
|
|
M. Jougasaki, C.-M. Wei, L. J. McKinley, and J. C. Burnett Jr Elevation of Circulating and Ventricular Adrenomedullin in Human Congestive Heart Failure Circulation, August 1, 1995; 92(3): 286 - 289. [Abstract] [Full Text]
|
|
|
|
|
|
J. P.J. Halcox, K. R.A. Nour, G. Zalos, and A. A. Quyyumi Coronary Vasodilation and Improvement in Endothelial Dysfunction With Endothelin ETA Receptor Blockade Circ. Res., November 23, 2001; 89(11): 969 - 976. [Abstract] [Full Text] [PDF]
|
|