| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Circulation, Vol 87, 1630-1641, Copyright © 1993 by American Heart Association
M Ragosta, GA Beller, DD Watson, S Kaul and LW Gimple
BACKGROUND. Although many patients with multivessel coronary artery disease
(CAD) and severely depressed left ventricular (LV) function will benefit
from coronary artery bypass graft surgery (CABG), surgeons may be reluctant
to perform CABG on these patients without evidence of myocardial viability
in regions of severe asynergy. We hypothesized that quantitative planar
rest-redistribution 201Tl imaging would identify viable myocardium and
predict improved regional and global function after revascularization in
patients with depressed LV function and CAD. METHODS AND RESULTS.
Twenty-one patients (mean LV ejection fraction, 0.27 +/- 0.05) were
studied. Regional and global LV functions were evaluated before and 8 weeks
after CABG with radionuclide ventriculography. Segments were prospectively
classified as showing normal, mildly reduced, or severely reduced viability
on the basis of quantitative analysis of defect severity and redistribution
on planar resting 201Tl imaging. By 201Tl criteria, 90% of hypokinetic
segments were classified with normal or mildly reduced viability. Among
akinetic or dyskinetic segments, 20% had normal 201Tl uptake, 53% had
mildly reduced viability, and only 27% had severely reduced viability.
201Tl viability criteria identified segments that improved function after
CABG. Sixty-two percent of severely asynergic segments with normal
viability and 54% with mildly reduced viability improved function after
surgery, but only 23% with severely reduced viability improved function (p
= 0.002). When only adequately revascularized segments were considered, the
predictive value of a positive preoperative viability scan for functional
improvement was 73%. The greatest improvement in global LV function after
CABG occurred in patients with the greatest number of asynergic segments
classified as viable before surgery (p < 0.01). In 10 patients with more
than seven viable, asynergic segments, mean LV ejection fraction increased
significantly after CABG (0.29 +/- 0.07 to 0.41 +/- 0.11, p = 0.002). In 11
patients with seven or fewer viable, asynergic segments, mean LV ejection
fraction remained unchanged after revascularization (0.27 +/- 0.05 to 0.30
+/- 0.08, p = NS). CONCLUSIONS. In patients with CAD and severely depressed
LV function, preoperative quantitative planar rest-redistribution. 201Tl
imaging identifies viability in many asynergic myocardial segments, and
these segments frequently improve function after CABG. The presence of
numerous asynergic but viable myocardial segments before surgery correlated
significantly with improvement in global LV function after bypass surgery.
ARTICLES
Quantitative planar rest-redistribution 201Tl imaging in detection of myocardial viability and prediction of improvement in left ventricular function after coronary bypass surgery in patients with severely depressed left ventricular function
Department of Medicine, University of Virginia Health Sciences Center, Charlottesville.
This article has been cited by other articles:
 |
|
 |
|
  C. Y. Kim, H. Y. Hwang, J. C. Paeng, D. S. Lee, and K.-B. Kim Improved myocardial perfusion and thickening after off-pump revascularization: 5-year follow-up. Ann. Thorac. Surg., November 1, 2009; 88(5): 1419 - 1425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Stirrup, A. Maenhout, K. Wechalekar, and C. Anagnostopoulos Radionuclide imaging in ischaemic heart failure Br. Med. Bull., August 26, 2009; (2009) ldp029v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V Rizzello, D Poldermans, E Biagini, A F L Schinkel, E Boersma, A Boccanelli, T Marwick, J R T C Roelandt, and J J Bax Prognosis of patients with ischaemic cardiomyopathy after coronary revascularisation: relation to viability and improvement in left ventricular ejection fraction Heart, August 1, 2009; 95(15): 1273 - 1277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Cupps, D. R. Bree, J. R. Wollmuth, A. C. Howells, R. K. Voeller, J. G. Rogers, and M. K. Pasque Myocardial Viability Mapping by Magnetic Resonance-Based Multiparametric Systolic Strain Analysis Ann. Thorac. Surg., November 1, 2008; 86(5): 1546 - 1553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Rahimtoola, V. Dilsizian, C. M. Kramer, T. H. Marwick, and J.-L. J. Vanoverschelde Chronic ischemic left ventricular dysfunction from pathophysiology to imaging and its integration into clinical practice. J. Am. Coll. Cardiol. Img., July 1, 2008; 1(4): 536 - 555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Vesely and V. Dilsizian Nuclear Cardiac Stress Testing in the Era of Molecular Medicine J. Nucl. Med., March 1, 2008; 49(3): 399 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-W. Wu, E. Tadamura, M. Yamamuro, S. Kanao, A. Marui, K. Tanabara, M. Komeda, and K. Togashi Comparison of Contrast-Enhanced MRI with 18F-FDG PET/201Tl SPECT in Dysfunctional Myocardium: Relation to Early Functional Outcome After Surgical Revascularization in Chronic Ischemic Heart Disease J. Nucl. Med., July 1, 2007; 48(7): 1096 - 1103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Di Carli and R. Hachamovitch New Technology for Noninvasive Evaluation of Coronary Artery Disease Circulation, March 20, 2007; 115(11): 1464 - 1480. [Full Text] [PDF]
|
|
|
|
 |
|
 V. Rizzello, D. Poldermans, E. Biagini, A. F.L. Schinkel, E. Boersma, A. Elhendy, F. B. Sozzi, A. Maat, J. R.T.C. Roelandt, and J. J. Bax Benefits of coronary revascularisation in diabetic and non-diabetic patients with ischaemic cardiomyopathy: Role of myocardial viability Eur J Heart Fail, May 1, 2006; 8(3): 314 - 320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Ribeiro, C. E. da Costa, M. M. Lopes, A. N. Albuquerque, F. Antoniali, G. A. A. Reinert, and K. G. Franchini Left ventricular reconstruction benefits patients with ischemic cardiomyopathy and non-viable myocardium Eur. J. Cardiothorac. Surg., February 1, 2006; 29(2): 196 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ichikawa, H. Sakuma, N. Suzawa, K. Kitagawa, K. Makino, T. Hirano, and K. Takeda Late gadolinium-enhanced magnetic resonance imaging in acute and chronic myocardial infarction: Improved prediction of regional myocardial contraction in the chronic state by measuring thickness of nonenhanced myocardium J. Am. Coll. Cardiol., March 15, 2005; 45(6): 901 - 909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V Rizzello, D Poldermans, E Biagini, A F L Schinkel, R van Domburg, A Elhendy, E C Vourvouri, M Bountioukos, A Lombardo, B Krenning, et al. Improvement of stress LVEF rather than rest LVEF after coronary revascularisation in patients with ischaemic cardiomyopathy and viable myocardium Heart, March 1, 2005; 91(3): 319 - 323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Rizzello, D. Poldermans, E. Boersma, E. Biagini, A. F.L. Schinkel, B. Krenning, A. Elhendy, E. C. Vourvouri, F. B. Sozzi, A. Maat, et al. Opposite Patterns of Left Ventricular Remodeling After Coronary Revascularization in Patients With Ischemic Cardiomyopathy: Role of Myocardial Viability Circulation, October 19, 2004; 110(16): 2383 - 2388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. H. Rasul and E. K. W. Sim The Quality of the Coronary Arteries Influences the Outcome of Bypass Surgery Ann. Thorac. Surg., October 1, 2004; 78(4): 1515 - 1516. [Full Text] [PDF]
|
|
|
|
 |
|
 H. S. Maniar, B. P. Cupps, D. D. Potter, P. Moustakidis, C. J. Camillo, C. M. Chu, M. K. Pasque, and T. M. Sundt III Ventricular function after coronary artery bypass grafting: Evaluation by magnetic resonance imaging and myocardial strain analysis J. Thorac. Cardiovasc. Surg., July 1, 2004; 128(1): 76 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Kim and W. J. Manning Viability Assessment by Delayed Enhancement Cardiovascular Magnetic Resonance: Will Low-Dose Dobutamine Dull the Shine? Circulation, June 1, 2004; 109(21): 2476 - 2479. [Full Text] [PDF]
|
|
|
|
 |
|
 S.R. Underwood, J. J Bax, J. v. Dahl, M. Y Henein, A. C van Rossum, E. R Schwarz, J.-L. Vanoverschelde, E. E.v. d. Wall, and W. Wijns Imaging techniques for the assessment of myocardial hibernation: Report of a Study Group of the European Society of Cardiology Eur. Heart J., May 2, 2004; 25(10): 815 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Go, M. R. Bhatt, and R. C. Hendel The Diagnostic and Prognostic Value of ECG-Gated SPECT Myocardial Perfusion Imaging J. Nucl. Med., May 1, 2004; 45(5): 912 - 921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R J Kim and D J Shah Fundamental concepts in myocardial viability assessment revisited: when knowing how much is "alive" is not enough Heart, February 1, 2004; 90(2): 137 - 140. [Full Text] [PDF]
|
|
|
|
 |
|
 D. A Gorog, M. Tanno, X. Cao, M. Bellahcene, R. Bassi, A. M.N Kabir, K. Dighe, R. A Quinlan, and M. S Marber Inhibition of p38 MAPK activity fails to attenuate contractile dysfunction in a mouse model of low-flow ischemia Cardiovasc Res, January 1, 2004; 61(1): 123 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C. Wu and J. A.C. Lima Noninvasive Imaging of Myocardial Viability: Current Techniques and Future Developments Circ. Res., December 12, 2003; 93(12): 1146 - 1158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. Kang, D. S. Lee, J. C. Paeng, K.-B. Kim, J.-K. Chung, and M. C. Lee Prognostic Value of Rest 201Tl-Dipyridamole Stress 99mTc-Sestamibi Gated SPECT for Predicting Patient-Based Clinical Outcomes After Bypass Surgery in Patients with Ischemic Left Ventricular Dysfunction J. Nucl. Med., November 1, 2003; 44(11): 1735 - 1740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Bax, A. F.L. Schinkel, E. Boersma, V. Rizzello, A. Elhendy, A. Maat, J. R.T.C. Roelandt, E. E. van der Wall, and D. Poldermans Early Versus Delayed Revascularization in Patients With Ischemic Cardiomyopathy and Substantial Viability: Impact on Outcome Circulation, September 9, 2003; 108(90101): II-39 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gimelli, M. Glauber, A. Giorgetti, G. Sambuceti, A. L'Abbate, and P. Marzullo Revascularization of dysfunctioning myocardium: differential prognostic effects of coronary artery bypass grafting and percutaneous transluminal coronary angioplasty in patients with three-vessel disease and mostly viable myocardium Interactive CardioVascular and Thoracic Surgery, September 1, 2003; 2(3): 301 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. I.W. Galasko and A. Lahiri The non-invasive assessment of hibernating myocardium in ischaemic cardiomyopathy--a myriad of techniques Eur J Heart Fail, June 1, 2003; 5(3): 217 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Tadamura, M. Mamede, S. Kubo, H. Toyoda, M. Yamamuro, H. Iida, N. Tamaki, K. Nishimura, M. Komeda, and J. Konishi The Effect of Nitroglycerin on Myocardial Blood Flow in Various Segments Characterized by Rest-Redistribution Thallium SPECT J. Nucl. Med., May 1, 2003; 44(5): 745 - 751. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Sciagra Nitrates and Viability: A Durable Affair J. Nucl. Med., May 1, 2003; 44(5): 752 - 755. [Full Text] [PDF]
|
|
|
|
|
|
S. Shimoni, N. G. Frangogiannis, C. J. Aggeli, K. Shan, M. S. Verani, M. A. Quinones, R. Espada, G. V. Letsou, G. M. Lawrie, W. L. Winters, et al. Identification of Hibernating Myocardium With Quantitative Intravenous Myocardial Contrast Echocardiography: Comparison With Dobutamine Echocardiography and Thallium-201 Scintigraphy Circulation, February 4, 2003; 107(4): 538 - 544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kitagawa, H. Sakuma, T. Hirano, S. Okamoto, K. Makino, and K. Takeda Acute Myocardial Infarction: Myocardial Viability Assessment in Patients Early Thereafter--Comparison of Contrast-enhanced MR Imaging with Resting 201Tl SPECT Radiology, January 1, 2003; 226(1): 138 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Perin, G. V. Silva, R. Sarmento-Leite, A. L.S. Sousa, M. Howell, R. Muthupillai, B. Lambert, W. K. Vaughn, and S. D. Flamm Assessing Myocardial Viability and Infarct Transmurality With Left Ventricular Electromechanical Mapping in Patients With Stable Coronary Artery Disease: Validation by Delayed-Enhancement Magnetic Resonance Imaging Circulation, August 20, 2002; 106(8): 957 - 961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hahalis, C. Stathopoulos, D. Apostolopoulos, P. Vasilakos, D. Alexopoulos, and A. S. Manolis Contribution of the sT elevation/T-wave normalization in q-wave leads during routine, pre-discharge treadmill exercise test to patient management and risk stratification after acute myocardial infarction: A 2.5-year follow-up study J. Am. Coll. Cardiol., July 3, 2002; 40(1): 62 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Bax, J. Maddahi, D. Poldermans, A. Elhendy, J. H. Cornel, E. Boersma, J. R.T.C. Roelandt, and P. M. Fioretti Sequential 201Tl Imaging and Dobutamine Echocardiography to Enhance Accuracy of Predicting Improved Left Ventricular Ejection Fraction After Revascularization J. Nucl. Med., June 1, 2002; 43(6): 795 - 802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Matsunari, J. Taki, and N. Tonami Sequential Strategy Using Multimodality Viability Tests: Does It Work? J. Nucl. Med., June 1, 2002; 43(6): 803 - 805. [Full Text] [PDF]
|
|
|
|
|
|
N. G. Fisher, H. Leong-Poi, T. Sakuma, S.-J. Rim, J. P. Bin, and S. Kaul Detection of coronary stenosis andmyocardial viability using a singleintravenous bolus injection of BR14 J. Am. Coll. Cardiol., February 6, 2002; 39(3): 523 - 529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Anagnostopoulos, M Y Henein, and S R Underwood Non-invasive investigations: Ischaemic heart disease Br. Med. Bull., October 1, 2001; 59(1): 29 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Anagnostopoulos and S R Underwood Cardiac imaging Imaging, September 1, 2001; 13(3): 155 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.J. Bax, A. Elhendy, E. Boersma, and D. Poldermans Evaluation of patients with chronic ischaemic left ventricular dysfunction - assessment of tissue viability Eur. Heart J. Suppl., September 1, 2001; 3(suppl_F): F11 - F14. [Abstract] [PDF]
|
|
|
|
|
|
M. Gyongyosi, H. Sochor, A. Khorsand, L. Gepstein, and D. Glogar Online Myocardial Viability Assessment in the Catheterization Laboratory via NOGA Electroanatomic Mapping: Quantitative Comparison With Thallium-201 Uptake Circulation, August 28, 2001; 104(9): 1005 - 1011. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. F. Salman and T. L. Blackburn Critical Aortic Stenosis with Severe Congestive Heart Failure Ann Intern Med, August 21, 2001; 135(4): 304 - 304. [Full Text] [PDF]
|
|
|
|
|
|
J. Shirani, J. Lee, R. Quigg, R. Pick, S. L. Bacharach, and V. Dilsizian Relation of thallium uptake to morphologic features of chronic ischemic heart disease: evidence for myocardial remodeling in noninfarcted myocardium J. Am. Coll. Cardiol., July 1, 2001; 38(1): 84 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Saeed, G. Lund, M. F. Wendland, J. Bremerich, H.-J. Weinmann, and C. B. Higgins Magnetic Resonance Characterization of the Peri-Infarction Zone of Reperfused Myocardial Infarction With Necrosis-Specific and Extracellular Nonspecific Contrast Media Circulation, February 13, 2001; 103(6): 871 - 876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-M. J. Siebelink, P. K. Blanksma, H. J. G. M. Crijns, J. J. Bax, A. J. van Boven, T. Kingma, D. A. Piers, J. Pruim, P. L. Jager, W. Vaalburg, et al. No difference in cardiac event-free survival between positron emission tomography-guided and single-photon emission computed tomography-guided patient management: A prospective, randomized comparison of patients with suspicion of jeopardized myocardium J. Am. Coll. Cardiol., January 1, 2001; 37(1): 81 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Udelson Testing our tests: surrogate end points versus driving patient management and outcomes J. Am. Coll. Cardiol., January 1, 2001; 37(1): 89 - 92. [Full Text] [PDF]
|
|
|
|
|
|
J. J. Bax, F. C. Visser, D. Poldermans, A. Elhendy, J. H. Cornel, E. Boersma, R. Valkema, A. van Lingen, P. M. Fioretti, and C. A. Visser Relationship Between Preoperative Viability and Postoperative Improvement in LVEF and Heart Failure Symptoms J. Nucl. Med., January 1, 2001; 42(1): 79 - 86. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tawakol and H. Gewirtz Does CABG Improve Left Ventricular Ejection Fraction in Patients with Ischemic Cardiomyopathy, and Does It Matter? J. Nucl. Med., January 1, 2001; 42(1): 87 - 0. [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Kim, E. Wu, A. Rafael, E.-L. Chen, M. A. Parker, O. Simonetti, F. J. Klocke, R. O. Bonow, and R. M. Judd The Use of Contrast-Enhanced Magnetic Resonance Imaging to Identify Reversible Myocardial Dysfunction N. Engl. J. Med., November 16, 2000; 343(20): 1445 - 1453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Narula, M. S. Dawson, B. K. Singh, A. Amanullah, E. R. Acio, F. A. Chaudhry, R. B. Arani, and A. E. Iskandrian Noninvasive characterization of stunned, hibernating, remodeled and nonviable myocardium in ischemic cardiomyopathy J. Am. Coll. Cardiol., November 15, 2000; 36(6): 1913 - 1919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Marcassa, M. Galli, C. Baroffio, E. Eleuteri, R. Campini, and P. Giannuzzi Independent and Incremental Prognostic Value of 201Tl Lung Uptake at Rest in Patients With Severe Postischemic Left Ventricular Dysfunction Circulation, October 10, 2000; 102(15): 1795 - 1801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Sciagra, M. Pellegri, A. Pupi, L. Bolognese, G. Bisi, V. Carnovale, and G. M. Santoro Prognostic implications of Tc-99m sestamibi viability imaging and subsequent therapeutic strategy in patients with chronic coronary artery disease and left ventricular dysfunction J. Am. Coll. Cardiol., September 1, 2000; 36(3): 739 - 745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G LaCanna, S.H Rahimtoola, O Visioli, R Giubbini, O Alfieri, M Zognio, E Milan, C Ceconi, M Gargano, R LoRusso, et al. Sensitivity, specificity, and predictive accuracies of non-invasive tests, singly and in combination, for diagnosis of hibernating myocardium Eur. Heart J., August 2, 2000; 21(16): 1358 - 1367. [Abstract] [PDF]
|
|
|
|
|
|
F.M Baer, P Theissen, J Crnac, M Schmidt, H.J Deutsch, U Sechtem, H Schicha, and E Erdmann Head to head comparison of dobutamine-transoesophageal echocardiography and dobutamine-magnetic resonance imaging for the prediction of left ventricular functional recovery in patients with chronic coronary artery disease Eur. Heart J., June 2, 2000; 21(12): 981 - 991. [Abstract] [PDF]
|
|
|
|
|
|
P. R. Sensky, A. Jivan, N. M. Hudson, R. P. Keal, B. Morgan, J. L. Tranter, D. de Bono, N. J. Samani, and G. R. Cherryman Coronary Artery Disease: Combined Stress MR Imaging Protocol-One-Stop Evaluation of Myocardial Perfusion and Function Radiology, May 1, 2000; 215(2): 608 - 614. [Abstract] [Full Text]
|
|
|
|
|
|
J. M. Cwajg, E. Cwajg, S. F. Nagueh, Z.-X. He, U. Qureshi, L. I. Olmos, M. A. Quinones, M. S. Verani, W. L. Winters, and W. A. Zoghbi End-diastolic wall thickness as a predictor of recovery of function in myocardial hibernation: Relation to rest-redistribution Tl-201 tomography and dobutamine stress echocardiography J. Am. Coll. Cardiol., April 1, 2000; 35(5): 1152 - 1161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Beller and B. L. Zaret Contributions of Nuclear Cardiology to Diagnosis and Prognosis of Patients With Coronary Artery Disease Circulation, March 28, 2000; 101(12): 1465 - 1478. [Full Text] [PDF]
|
|
|
|
|
|
A. Pasquet, M.S. Lauer, M.J. Williams, M.-A. Secknus, B. Lytle, and T.H. Marwick Prediction of global left ventricular function after bypass surgery in patients with severe left ventricular dysfunction. Impact of pre-operative myocardial function, perfusion, and metabolism Eur. Heart J., January 2, 2000; 21(2): 125 - 136. [Abstract] [PDF]
|
|
|
|
|
|
A Al-Mohammad, M Y Norton, I R Mahy, J C Patel, A E Welch, P Mikecz, and S Walton Can the surface electrocardiogram be used to predict myocardial viability? Heart, December 1, 1999; 82(6): 663 - 667. [Abstract] [Full Text]
|
|
|
|
|
|
T. Sharir, D. S. Berman, H. C. Lewin, J. D. Friedman, I. Cohen, R. Miranda, R. D. Agafitei, and G. Germano Incremental Prognostic Value of Rest-Redistribution 201Tl Single-Photon Emission Computed Tomography Circulation, November 9, 1999; 100(19): 1964 - 1970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F Larrazet, D Pellerin, D Daou, S Witchitz, C Fournier, A Prigent, and C Veyrat Concordance between dobutamine Doppler tissue imaging echocardiography and rest reinjection thallium-201 tomography in dysfunctional hypoperfused myocardium Heart, October 1, 1999; 82(4): 432 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Saeed, J. Bremerich, M. F. Wendland, R. Wyttenbach, H.-J. Weinmann, and C. B. Higgins Reperfused Myocardial Infarction as Seen with Use of Necrosis-specific versus Standard Extracellular MR Contrast Media in Rats Radiology, October 1, 1999; 213(1): 247 - 257. [Abstract] [Full Text]
|
|
|
|
|
|
H. Samady, J. A. Elefteriades, B. G. Abbott, J. A. Mattera, C. A. McPherson, and F. J. Th. Wackers Failure to Improve Left Ventricular Function After Coronary Revascularization for Ischemic Cardiomyopathy Is Not Associated With Worse Outcome Circulation, September 21, 1999; 100(12): 1298 - 1304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Chaudhry, J. T. Tauke, R. S. Alessandrini, G. Vardi, M. A. Parker, and R. O. Bonow Prognostic implications of myocardial contractile reserve in patients with coronary artery disease and left ventricular dysfunction J. Am. Coll. Cardiol., September 1, 1999; 34(3): 730 - 738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. Nagueh, I. Mikati, D. Weilbaecher, M. J. Reardon, G. J. Al-Zaghrini, D. Cacela, Z.-X. He, G. Letsou, G. Noon, J. F. Howell, et al. Relation of the Contractile Reserve of Hibernating Myocardium to Myocardial Structure in Humans Circulation, August 3, 1999; 100(5): 490 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Auerbach, H. Schoder, C. Hoh, S. S. Gambhir, S. Yaghoubi, J. W. Sayre, D. Silverman, M. E. Phelps, H. R. Schelbert, and J. Czernin Prevalence of Myocardial Viability as Detected by Positron Emission Tomography in Patients With Ischemic Cardiomyopathy Circulation, June 8, 1999; 99(22): 2921 - 2926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Senior, S. Kaul, and A. Lahiri Myocardial viability on echocardiography predicts long-term survival after revascularization in patients with ischemic congestive heart failure J. Am. Coll. Cardiol., June 1, 1999; 33(7): 1848 - 1854. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. Morse, S. Noe, J. Caravalho Jr., A. Balingit, and A. J. Taylor Rest-Redistribution 201Tl Single-Photon Emission CT Imaging for Determination of Myocardial Viability: Relationship Among Viability, Mode of Therapy, and Long-term Prognosis Chest, June 1, 1999; 115(6): 1621 - 1626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Faraggi, G Montalescot, L Sarda, J F Heintz, D Doumit, G Drobinski, I Sotirov, D Le Guludec, and D Thomas Spontaneous late improvement of myocardial viability in the chronic infarct zone is possible, depending on persistent TIMI 3 flow and a low grade stenosis of the infarct artery Heart, April 1, 1999; 81(4): 424 - 430. [Abstract] [Full Text]
|
|
|
|
|
|
E. Teiger, J. Garot, E. Aptecar, P. Bosio, J. Woscoboinik, J.M. Pernes, P. Gueret, M. Kern, J.-L. Dubois-Rande, and P. Dupouy Coronary blood flow reserve and wall motion recovery in patients undergoing angioplasty for myocardial infarction Eur. Heart J., February 2, 1999; 20(4): 285 - 292. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Firoozan, K. Wei, A. Linka, D. Skyba, N. C. Goodman, and S. Kaul A canine model of chronic ischemic cardiomyopathy: characterization of regional flow-function relations Am J Physiol Heart Circ Physiol, February 1, 1999; 276(2): H446 - H455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ramani, R. M. Judd, T. A. Holly, T. B. Parrish, V. H. Rigolin, M. A. Parker, C. Callahan, S. W. Fitzgerald, R. O. Bonow, and F. J. Klocke Contrast Magnetic Resonance Imaging in the Assessment of Myocardial Viability in Patients With Stable Coronary Artery Disease and Left Ventricular Dysfunction Circulation, December 15, 1998; 98(24): 2687 - 2694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Gunning, C. Anagnostopoulos, C. J. Knight, J. Pepper, E. D. Burman, G. Davies, K. M. Fox, D. J. Pennell, P. J. Ell, and S. R. Underwood Comparison of 201Tl, 99mTc-Tetrofosmin, and Dobutamine Magnetic Resonance Imaging for Identifying Hibernating Myocardium Circulation, November 3, 1998; 98(18): 1869 - 1874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Afridi, P. A. Grayburn, J. A. Panza, J. K. Oh, W. A. Zoghbi, and T. H. Marwick Myocardial viability during dobutamine echocardiography predicts survival in patients with coronary artery disease and severe left ventricular systolic dysfunction J. Am. Coll. Cardiol., October 1, 1998; 32(4): 921 - 926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Matsunari, G. Boning, S. I. Ziegler, S. G. Nekolla, J. C. Stollfuss, I. Kosa, E. P. Ficaro, and M. Schwaiger Attenuation-corrected 99mTc-tetrofosmin single-photon emission computed tomography in the detection of viable myocardium: comparison with positron emission tomography using 18F-fluorodeoxyglucose J. Am. Coll. Cardiol., October 1, 1998; 32(4): 927 - 935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Miller, I. L. Kron, and J. T. Cope Viability Assessment Before CABG • Response Circulation, September 29, 1998; 98 (13): 1350 - 1353. [Full Text] [PDF]
|
|
|
|
|
|
A. N. Kitsiou, G. Srinivasan, A. A. Quyyumi, R. M. Summers, S. L. Bacharach, and V. Dilsizian Stress-Induced Reversible and Mild-to-Moderate Irreversible Thallium Defects : Are They Equally Accurate for Predicting Recovery of Regional Left Ventricular Function After Revascularization? Circulation, August 11, 1998; 98(6): 501 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Wijns, S. F. Vatner, and P. G. Camici Hibernating Myocardium N. Engl. J. Med., July 16, 1998; 339(3): 173 - 181. [Full Text] [PDF]
|
|
|
|
|
|
O. Parodi, R. De Maria, R. Testa, E. Vitali, L. Ruffini, G. Paleari, E. Gronda, J. Campolo, and A. Pellegrini Super-normal retention in hibernating myocardium: an ex-vivo study using the failing human heart Cardiovasc Res, June 1, 1998; 38(3): 727 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Hunt and O.H. Frazier Mechanical Circulatory Support and Cardiac Transplantation Circulation, May 26, 1998; 97(20): 2079 - 2090. [Full Text] [PDF]
|
|
|
|
|
|
R. A. Kloner, R. Bolli, E. Marban, L. Reinlib, and E. Braunwald Medical and Cellular Implications of Stunning, Hibernation, and Preconditioning : An NHLBI Workshop Circulation, May 19, 1998; 97(18): 1848 - 1867. [Full Text] [PDF]
|
|
|
|
|
|
J. E. Udelson Steps Forward in the Assessment of Myocardial Viability in Left Ventricular Dysfunction Circulation, March 10, 1998; 97(9): 833 - 838. [Full Text] [PDF]
|
|
|
|
|
|
M. Gheorghiade and R. O. Bonow Chronic Heart Failure in the United States : A Manifestation of Coronary Artery Disease Circulation, January 27, 1998; 97(3): 282 - 289. [Full Text] [PDF]
|
|
|
|
|
|
M. Salati, M. Lemma, D. G. Di Mattia, P. Danna, A. Cialfi, A. Salvaggio, and C. Santoli Myocardial Revascularization in Patients With Ischemic Cardiomyopathy: Functional Observations Ann. Thorac. Surg., December 1, 1997; 64(6): 1728 - 1734. [Abstract] [Full Text]
|
|
|
|
|
|
H. A. Dakik, J. F. Howell, G. M. Lawrie, R. Espada, D. G. Weilbaecher, Z.-X. He, J. J. Mahmarian, and M. S. Verani Assessment of Myocardial Viability With 99mTc-Sestamibi Tomography Before Coronary Bypass Graft Surgery : Correlation With Histopathology and Postoperative Improvement in Cardiac Function Circulation, November 4, 1997; 96(9): 2892 - 2898. [Abstract] [Full Text]
|
|
|
|
|
|
Z.-X. He, R. Medrano, J. T. Hays, J. J. Mahmarian, and M. S. Verani Nitroglycerin-Augmented 201Tl Reinjection Enhances Detection of Reversible Myocardial Hypoperfusion : A Randomized, Double-Blind, Parallel, Placebo-Controlled Trial Circulation, April 1, 1997; 95(7): 1799 - 1805. [Abstract] [Full Text]
|
|
|
|
|
|
J.-L. J. Vanoverschelde, W. Wijns, M. Borgers, G. Heyndrickx, C. Depre, W. Flameng, and J. A. Melin Chronic Myocardial Hibernation in Humans: From Bedside to Bench Circulation, April 1, 1997; 95(7): 1961 - 1971. [Full Text]
|
|
|
|
|
|
U. Qureshi, S. F. Nagueh, I. Afridi, P. Vaduganathan, A. Blaustein, M. S. Verani, W. L. Winters, and W. A. Zoghbi Dobutamine Echocardiography and Quantitative Rest-Redistribution 201Tl Tomography in Myocardial Hibernation: Relation of Contractile Reserve to 201Tl Uptake and Comparative Prediction of Recovery of Function Circulation, February 4, 1997; 95(3): 626 - 635. [Abstract] [Full Text]
|
|
|
|
|
|
R. O. Bonow Identification of Viable Myocardium Circulation, December 1, 1996; 94(11): 2674 - 2680. [Full Text]
|
|
|
|
|
|
G. A. Beller Comparison of 201Tl Scintigraphy and Low-Dose Dobutamine Echocardiography for the Noninvasive Assessment of Myocardial Viability Circulation, December 1, 1996; 94(11): 2681 - 2684. [Full Text]
|
|
|
|
|
|
A. I. McGhie and A. Weyman Searching for Hibernating Myocardium: Time to Reevaluate Investigative Strategies? Circulation, December 1, 1996; 94(11): 2685 - 2688. [Full Text]
|
|
|
|
|
|
P. Perrone-Filardi, L. Pace, M. Prastaro, F. Squame, S. Betocchi, A. Soricelli, F. Piscione, C. Indolfi, T. Crisci, M. Salvatore, et al. Assessment of Myocardial Viability in Patients With Chronic Coronary Artery Disease: Rest–4-Hour–24-Hour 201Tl Tomography Versus Dobutamine Echocardiography Circulation, December 1, 1996; 94(11): 2712 - 2719. [Abstract] [Full Text]
|
|
|
|
|
|
F. S. Villanueva, G. Camarano, S. Ismail, N. C. Goodman, J. Sklenar, and S. Kaul Coronary Reserve Abnormalities in the Infarcted Myocardium: Assessment of Myocardial Viability Immediately Versus Late After Reflow by Contrast Echocardiography Circulation, August 15, 1996; 94(4): 748 - 754. [Abstract] [Full Text]
|
|
|
|
|
|
R. K. M. Chan, J. Raman, K. J. Lee, A. Rosalion, R. J. Hicks, S. Pornvilawan, B. S. T. Sia, J. D. Horowitz, A. M. Tonkin, and B. F. Buxton Prediction of Outcome After Revascularization in Patients With Poor Left Ventricular Function Ann. Thorac. Surg., May 1, 1996; 61(5): 1428 - 1434. [Abstract] [Full Text]
|
|
|
|
|
|
M. R. Costanzo, S. Augustine, R. Bourge, M. Bristow, J. B. O'Connell, D. Driscoll, and E. Rose Selection and Treatment of Candidates for Heart Transplantation : A Statement for Health Professionals From the Committee on Heart Failure and Cardiac Transplantation of the Council on Clinical Cardiology, American Heart Association Circulation, December 15, 1995; 92(12): 3593 - 3612. [Abstract] [Full Text]
|
|
|
|
|
|
C. R. deFilippi, D. L. Willett, W. N. Irani, E. J. Eichhorn, C. E. Velasco, and P. A. Grayburn Comparison of Myocardial Contrast Echocardiography and Low-Dose Dobutamine Stress Echocardiography in Predicting Recovery of Left Ventricular Function After Coronary Revascularization in Chronic Ischemic Heart Disease Circulation, November 15, 1995; 92(10): 2863 - 2868. [Abstract] [Full Text]
|
|
|
|
|
|
J.-L. J. Vanoverschelde, B. L. Gerber, A.-M. D'Hondt, M. De Kock, R. Dion, W. Wijns, and J. A. Melin Preoperative Selection of Patients With Severely Impaired Left Ventricular Function for Coronary Revascularization : Role of Low-Dose Dobutamine Echocardiography and Exercise-Redistribution-Reinjection Thallium SPECT Circulation, November 1, 1995; 92(9): 37 - 44. [Abstract] [Full Text]
|
|
|
|
|
|
V. Sansoy, D. K. Glover, D. D. Watson, M. Ruiz, W. H. Smith, J. P. Simanis, and G. A. Beller Comparison of Thallium-201 Resting Redistribution With Technetium-99m–Sestamibi Uptake and Functional Response to Dobutamine for Assessment of Myocardial Viability Circulation, August 15, 1995; 92(4): 994 - 1004. [Abstract] [Full Text]
|
|
|
|
|
|
P. Perrone-Filardi, L. Pace, M. Prastaro, F. Piscione, S. Betocchi, F. Squame, P. Vezzuto, A. Soricelli, C. Indolfi, M. Salvatore, et al. Dobutamine Echocardiography Predicts Improvement of Hypoperfused Dysfunctional Myocardium After Revascularization in Patients With Coronary Artery Disease Circulation, May 15, 1995; 91(10): 2556 - 2565. [Abstract] [Full Text]
|
|
|
|
|
|
N. Tamaki, M. Kawamoto, E. Tadamura, Y. Magata, Y. Yonekura, R. Nohara, S. Sasayama, K. Nishimura, T. Ban, and J. Konishi Prediction of ReversibleIschemia After Revascularization : Perfusion and Metabolic Studies WithPositron Emission Tomography Circulation, March 15, 1995; 91(6): 1697 - 1705. [Abstract] [Full Text]
|
|
|
|
|
|
J. A. Panza, V. Dilsizian, J. M. Laurienzo, R. V. Curiel, and P. T. Katsiyiannis Relation Between Thallium Uptake and Contractile Response to Dobutamine : Implications Regarding Myocardial Viability in Patients With Chronic Coronary Artery Disease and Left Ventricular Dysfunction Circulation, February 15, 1995; 91(4): 990 - 998. [Abstract] [Full Text]
|
|
|
|
|
|
R. Zimmermann, G. Mall, B. Rauch, G. Zimmer, M. Gabel, J. Zehelein, B. Bubeck, H. Tillmanns, S. Hagl, and W. Kubler Residual 201Tl Activity in Irreversible Defects as a Marker of Myocardial Viability : Clinicopathological Study Circulation, February 15, 1995; 91(4): 1016 - 1021. [Abstract] [Full Text]
|
|