Circulation, Vol 86, 1475-1484, Copyright © 1992 by American Heart Association
A Ascherio, EB Rimm, EL Giovannucci, GA Colditz, B Rosner, WC Willett, F Sacks and MJ Stampfer
BACKGROUND. An effect of diet in determining blood pressure is suggested by
epidemiological studies, but the role of specific nutrients is still
unsettled. METHODS AND RESULTS. The relation of various nutritional factors
with hypertension was examined prospectively among 30,681 predominantly
white US male health professionals, 40-75 years old, without diagnosed
hypertension. During 4 years of follow-up, 1,248 men reported a diagnosis
of hypertension. Age, relative weight, and alcohol consumption were the
strongest predictors for the development of hypertension. Dietary fiber,
potassium, and magnesium were each significantly associated with lower risk
of hypertension when considered individually and after adjustment for age,
relative weight, alcohol consumption, and energy intake. When these
nutrients were considered simultaneously, only dietary fiber had an
independent inverse association with hypertension. For men with a fiber
intake of < 12 g/day, the relative risk of hypertension was 1.57 (95%
confidence interval, 1.20-2.05) compared with an intake of > 24 g/day.
Calcium was significantly associated with lower risk of hypertension only
in lean men. Dietary fiber, potassium, and magnesium were also inversely
related to baseline systolic and diastolic blood pressure and to change in
blood pressure during the follow-up among men who did not develop
hypertension. Calcium was inversely associated with baseline blood pressure
but not with change in blood pressure. No significant associations with
hypertension were observed for sodium, total fat, or saturated,
transunsaturated, and polyunsaturated fatty acids. Fruit fiber but not
vegetable or cereal fiber was inversely associated with incidence of
hypertension. CONCLUSIONS. These results support hypotheses that an
increased intake of fiber and magnesium may contribute to the prevention of
hypertension.
ARTICLES
A prospective study of nutritional factors and hypertension among US men
Department of Epidemiology, Harvard School of Public Health, Boston, MA.
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