Circulation, Vol 86, 1310-1316, Copyright © 1992 by American Heart Association
GJ Grover, PG Sleph and S Dzwonczyk
BACKGROUND. A brief period of myocardial ischemia can result in an
increased resistance to subsequent, more severe episodes of ischemia.
Recent studies have indicated that activation of adenosine A1-receptors may
mediate this preconditioning effect. It is also known that A1- activation
can lead to ATP-sensitive potassium channel (KATP) opening via a G(i)
protein-mediated effect. Thus, we determined whether the KATP blocker
glyburide could abolish preconditioning or the protective effects of
A1-receptor activation. METHODS AND RESULTS. Anesthetized dogs were
subjected to 5 minutes of left circumflex coronary artery (LCx) occlusion
(or sham) followed by 10 minutes of reperfusion. The hearts were then
subjected to 60 minutes of LCx occlusion and 5 hours of reperfusion.
Glyburide (5 micrograms/kg/min) or vehicle was given directly into the LCx
20 minutes before preconditioning or sham preconditioning. Preconditioning
resulted in a significantly reduced infarct size compared with
nonpreconditioned animals. Glyburide abolished the protective effect of
preconditioning. To establish a link between KATP and A1-receptor
activation, the effect of the A1-agonist R- PIA with or without glyburide
on infarct size was determined. R-PIA (0.4 microgram/kg/min, directly into
the LCx) significantly reduced infarct size, and this protective effect was
abolished by glyburide. None of the treatments described above had a
significant effect on peripheral hemodynamic status or myocardial blood
flow. CONCLUSIONS. Preconditioning may be mediated by KATP activation, and
this may be linked to A1-receptor stimulation.
ARTICLES
Role of myocardial ATP-sensitive potassium channels in mediating preconditioning in the dog heart and their possible interaction with adenosine A1-receptors
Department of Pharmacology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000.
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
L. R.C Dekker Toward the heart of ischemic preconditioning Cardiovasc Res, January 1, 1998; 37(1): 14 - 20. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
P. L. Hofman, K. Hiatt, M. C. Yoder, and S. A. Rivkees A1 adenosine receptors potently regulate heart rate in mammalian embryos Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1997; 273(4): R1374 - R1380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
M. A. Leesar, M. Stoddard, M. Ahmed, J. Broadbent, and R. Bolli Preconditioning of Human Myocardium With Adenosine During Coronary Angioplasty Circulation, June 3, 1997; 95(11): 2500 - 2507. [Abstract] [Full Text]
|
|
|
|
 |
|
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|
|
|
|
|
|
O. Katayama, S. J. M. Ledingham, M. Amrani, R. T. Smolenski, D. R. Lachno, J. Jayakumar, and M. H. Yacoub Functional and Metabolic Effects of Adenosine in Cardioplegia: Role of Temperature and Concentration Ann. Thorac. Surg., February 1, 1997; 63(2): 449 - 454. [Abstract] [Full Text]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
C. Vahlhaus, R. Schulz, H. Post, R. Onallah, and G. Heusch No Prevention of Ischemic Preconditioning by the Protein Kinase C Inhibitor Staurosporine in Swine Circ. Res., September 1, 1996; 79(3): 407 - 414. [Abstract] [Full Text]
|
|
|
|
|
|
T. Mizumura, J. A. Auchampach, J. Linden, R. F. Bruns, and G. J. Gross PD 81,723, an Allosteric Enhancer of the A1 Adenosine Receptor, Lowers the Threshold for Ischemic Preconditioning in Dogs Circ. Res., September 1, 1996; 79(3): 415 - 423. [Abstract] [Full Text]
|
|
|
|
|
|
K. Hu, D. Duan, G.-R. Li, and S. Nattel Protein Kinase C Activates ATP-Sensitive K+ Current in Human and Rabbit Ventricular Myocytes Circ. Res., March 1, 1996; 78(3): 492 - 498. [Abstract] [Full Text]
|
|
|
|
|
|
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|
|
|
|
|
|
M. D. Pettersen, T. Abe, D. A. Morgan, and D. D. Gutterman Role of Adenosine in Postischemic Dysfunction of Coronary Innervation Circ. Res., January 1, 1995; 76(1): 95 - 101. [Abstract] [Full Text]
|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|