| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Circulation, Vol 86, 64-70, Copyright © 1992 by American Heart Association
PJ Fitzgerald, TA Ports and PG Yock
BACKGROUND. Atherosclerotic plaque fracture and dissection of the arterial
wall are frequent concomitants of the balloon angioplasty process. The
composition and morphology of plaque within the vessel may be critical in
determining the extent of plaque fracture and dissection during balloon
angioplasty. To examine this potential association in the clinical setting,
we studied patients with intravascular ultrasound imaging after balloon
angioplasty. METHODS AND RESULTS. Forty-one patients were studied with
intravascular ultrasound after angioplasty in both peripheral and coronary
arteries. Ultrasound images representing the target lesion cross section
were digitized, stored on computer, and analyzed off-line. The presence of
intralesional calcium and the relative size of dissection for each lesion
was computed. Thirty-one patients (76%) had ultrasound evidence of
significant dissection or plaque fracture immediately after balloon
dilation. In 23 of 31 (74%) of the lesions, the ultrasound scans showed
significant localized calcium deposits within the plaque substance. In 87%
of these cases, the dissections were adjacent to the calcific portion of
the vessel wall. In addition, the relative size of dissections referenced
to the neolumen area were significantly larger (p less than or equal to
0.002) in the calcified vessels (27.5 +/- 12.3%) compared with the size of
the dissections in lesions without calcium (11.2 +/- 5.8%). CONCLUSIONS.
The presence of calcium within the vessel wall appeared to be significantly
associated with both the location and size of the dissected tissue arm from
the vessel wall. These data suggest that localized calcium deposits have a
direct role in promoting dissection, presumably by increasing shear
stresses within the plaque.
ARTICLES
Contribution of localized calcium deposits to dissection after angioplasty. An observational study using intravascular ultrasound
Cardiovascular Research Institute, University of California, San Francisco 94143.
This article has been cited by other articles:
 |
|
 |
|
  M. Zeadin, M. Butcher, G. Werstuck, M. Khan, C. K. Yee, and S. G. Shaughnessy Effect of Leptin on Vascular Calcification in Apolipoprotein E-Deficient Mice Arterioscler Thromb Vasc Biol, December 1, 2009; 29(12): 2069 - 2075. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Liu, K. Tsujita, A. Maehara, G. S. Mintz, G. Weisz, G. D. Dangas, A. J. Lansky, E. M. Kreps, L. E. Rabbani, M. Collins, et al. Intravascular Ultrasound Assessment of the Incidence and Predictors of Edge Dissections After Drug-Eluting Stent Implantation J. Am. Coll. Cardiol. Intv., October 1, 2009; 2(10): 997 - 1004. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hoshino, L. A. Chow, J. J. Hsu, A. A. Perlowski, M. Abedin, J. Tobis, Y. Tintut, A. K. Mal, W. S. Klug, and L. L. Demer Mechanical stress analysis of a rigid inclusion in distensible material: a model of atherosclerotic calcification and plaque vulnerability Am J Physiol Heart Circ Physiol, August 1, 2009; 297(2): H802 - H810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ishii, Y. Kumada, T. Toriyama, T. Aoyama, H. Takahashi, T. Amano, Y. Yasuda, Y. Yuzawa, S. Maruyama, S. Matsuo, et al. Aortic valvular calcification predicts restenosis after implantation of drug-eluting stents in patients on chronic haemodialysis Nephrol. Dial. Transplant., May 1, 2009; 24(5): 1562 - 1567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Adiguzel, P. J Ahmad, C. Franco, and M. P Bendeck Collagens in the progression and complications of atherosclerosis Vascular Medicine, February 1, 2009; 14(1): 73 - 89. [Abstract] [PDF]
|
|
|
|
 |
|
 L. McRobb, D. J. Handelsman, and A. K. Heather Androgen-Induced Progression of Arterial Calcification in Apolipoprotein E-Null Mice Is Uncoupled from Plaque Growth and Lipid Levels Endocrinology, February 1, 2009; 150(2): 841 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tsutsumi, H. Aikawa, M. Onizuka, M. Iko, T. Kodama, K. Nii, S. Hamaguchi, H. Etou, K. Sakamoto, and K. Kazekawa Carotid Artery Stenting for Calcified Lesions AJNR Am. J. Neuroradiol., September 1, 2008; 29(8): 1590 - 1593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Aikawa, M. Nahrendorf, J.-L. Figueiredo, F. K. Swirski, T. Shtatland, R. H. Kohler, F. A. Jaffer, M. Aikawa, and R. Weissleder Osteogenesis Associates With Inflammation in Early-Stage Atherosclerosis Evaluated by Molecular Imaging In Vivo Circulation, December 11, 2007; 116(24): 2841 - 2850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Johnson, J. A. Leopold, and J. Loscalzo Vascular Calcification: Pathobiological Mechanisms and Clinical Implications Circ. Res., November 10, 2006; 99(10): 1044 - 1059. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, W. Zhang, Y. Zhang, Y. Yang, L. Sun, S. Hu, J. Chen, C. Zhang, Y. Zheng, Y. Zhen, et al. VKORC1 Haplotypes Are Associated With Arterial Vascular Diseases (Stroke, Coronary Heart Disease, and Aortic Dissection) Circulation, March 28, 2006; 113(12): 1615 - 1621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Giachelli, M. Y. Speer, X. Li, R. M. Rajachar, and H. Yang Regulation of Vascular Calcification: Roles of Phosphate and Osteopontin Circ. Res., April 15, 2005; 96(7): 717 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Castagna, G. S. Mintz, P. Ohlmann, J.-I. Kotani, A. Maehara, N. Gevorkian, E. Cheneau, E. Stabile, A. E. Ajani, W. O. Suddath, et al. Incidence, Location, Magnitude, and Clinical Correlates of Saphenous Vein Graft Calcification: An Intravascular Ultrasound and Angiographic Study Circulation, March 8, 2005; 111(9): 1148 - 1152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Giachelli Vascular Calcification Mechanisms J. Am. Soc. Nephrol., December 1, 2004; 15(12): 2959 - 2964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Fischer, S. A. Steitz, P. Y. Johnson, A. Burke, F. Kolodgie, R. Virmani, C. Giachelli, and T. N. Wight Decorin Promotes Aortic Smooth Muscle Cell Calcification and Colocalizes to Calcified Regions in Human Atherosclerotic Lesions Arterioscler Thromb Vasc Biol, December 1, 2004; 24(12): 2391 - 2396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Christian, D. A. Dumesic, T. Behrenbeck, A. L. Oberg, P. F. Sheedy II, and L. A. Fitzpatrick Prevalence and Predictors of Coronary Artery Calcification in Women with Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2562 - 2568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Davies, R. J. Lund, and K. A. Hruska BMP-7 Is an Efficacious Treatment of Vascular Calcification in a Murine Model of Atherosclerosis and Chronic Renal Failure J. Am. Soc. Nephrol., June 1, 2003; 14(6): 1559 - 1567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Steitz, M. Y. Speer, M. D. McKee, L. Liaw, M. Almeida, H. Yang, and C. M. Giachelli Osteopontin Inhibits Mineral Deposition and Promotes Regression of Ectopic Calcification Am. J. Pathol., December 1, 2002; 161(6): 2035 - 2046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Y. Speer, M. D. McKee, R. E. Guldberg, L. Liaw, H.-Y. Yang, E. Tung, G. Karsenty, and C. M. Giachelli Inactivation of the Osteopontin Gene Enhances Vascular Calcification of Matrix Gla Protein-deficient Mice: Evidence for Osteopontin as an Inducible Inhibitor of Vascular Calcification In Vivo J. Exp. Med., October 21, 2002; 196(8): 1047 - 1055. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. L Demer Vascular calcification and osteoporosis: inflammatory responses to oxidized lipids Int. J. Epidemiol., August 1, 2002; 31(4): 737 - 741. [Full Text] [PDF]
|
|
|
|
|
|
J. A. Coladonato, L. A. Szczech, E. A. Friedman, and W. F. Owen Jr Does calcium kill ESRD patients--the skeptic's perspective Nephrol. Dial. Transplant., February 1, 2002; 17(2): 229 - 232. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Wayhs, A. Zelinger, and P. Raggi High coronary artery calcium scores pose an extremely elevated risk for hard events J. Am. Coll. Cardiol., January 16, 2002; 39(2): 225 - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. P.J Brindle A transcriptional regulator of osteogenesis expressed in calcifying atherosclerotic plaques Cardiovasc Res, November 1, 2001; 52(2): 178 - 180. [Full Text] [PDF]
|
|
|
|
|
|
L. L. Demer Cholesterol in Vascular and Valvular Calcification Circulation, October 16, 2001; 104(16): 1881 - 1883. [Full Text] [PDF]
|
|
|
|
|
|
H. Huang, R. Virmani, H. Younis, A. P. Burke, R. D. Kamm, and R. T. Lee The Impact of Calcification on the Biomechanical Stability of Atherosclerotic Plaques Circulation, February 27, 2001; 103(8): 1051 - 1056. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jono, M. D. McKee, C. E. Murry, A. Shioi, Y. Nishizawa, K. Mori, H. Morii, and C. M. Giachelli Phosphate Regulation of Vascular Smooth Muscle Cell Calcification Circ. Res., September 29, 2000; 87 (7): e10 - e17. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Erbel, A Schmermund, S Mohlenkamp, S Sack, and D Baumgart Electron-beam computed tomography for detection of early signs of coronary arteriosclerosis Eur. Heart J., May 1, 2000; 21(9): 720 - 732. [PDF]
|
|
|
|
|
|
S. G. Ellis, V. Guetta, D. Miller, P. L. Whitlow, and E. J. Topol Relation Between Lesion Characteristics and Risk With Percutaneous Intervention in the Stent and Glycoprotein IIb/IIIa Era : An Analysis of Results From 10 907 Lesions and Proposal for New Classification Scheme Circulation, November 9, 1999; 100(19): 1971 - 1976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Mori, A. Shioi, S. Jono, Y. Nishizawa, and H. Morii Dexamethasone Enhances In Vitro Vascular Calcification by Promoting Osteoblastic Differentiation of Vascular Smooth Muscle Cells Arterioscler Thromb Vasc Biol, September 1, 1999; 19(9): 2112 - 2118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Ge, F Chirillo, J Schwedtmann, G Görge, M Haude, D Baumgart, V Shah, C von Birgelen, S Sack, H Boudoulas, et al. Screening of ruptured plaques in patients with coronary artery disease by intravascular ultrasound Heart, June 1, 1999; 81(6): 621 - 627. [Abstract] [Full Text]
|
|
|
|
|
|
C. M. Giachelli Ectopic Calcification : Gathering Hard Facts about Soft Tissue Mineralization Am. J. Pathol., March 1, 1999; 154(3): 671 - 675. [Full Text] [PDF]
|
|
|
|
|
|
T. Wada, M. D. McKee, S. Steitz, and C. M. Giachelli Calcification of Vascular Smooth Muscle Cell Cultures : Inhibition by Osteopontin Circ. Res., February 5, 1999; 84(2): 166 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Oshima, D. Itchhaporia, and P. Fitzgerald New developments in intravascular ultrasound Vascular Medicine, November 1, 1998; 3(4): 281 - 290. [Abstract] [PDF]
|
|
|
|
|
|
M P Moore, T Spencer, D M Salter, P P Kearney, T R D Shaw, I R Starkey, P J Fitzgerald, R Erbel, A Lange, N W McDicken, et al. Characterisation of coronary atherosclerotic morphology by spectral analysis of radiofrequency signal: in vitro intravascular ultrasound study with histological and radiological validation Heart, May 1, 1998; 79(5): 459 - 467. [Abstract] [Full Text]
|
|
|
|
|
|
K. E. Watson, M. L. Abrolat, L. L. Malone, J. M. Hoeg, T. Doherty, R. Detrano, and L. L. Demer Active Serum Vitamin D Levels Are Inversely Correlated With Coronary Calcification Circulation, September 16, 1997; 96(6): 1755 - 1760. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Ozaki, A. G. Violaris, T. Kobayashi, D. Keane, E. Camenzind, C. Di Mario, P. de Feyter, J. R. T. C. Roelandt, and P. W. Serruys Comparison of Coronary Luminal Quantification Obtained From Intracoronary Ultrasound and Both Geometric and Videodensitometric Quantitative Angiography Before and After Balloon Angioplasty and Directional Atherectomy Circulation, July 15, 1997; 96(2): 491 - 499. [Abstract] [Full Text]
|
|
|
|
|
|
I. Moussa, C. Di Mario, J. Moses, B. Reimers, L. Di Francesco, G. Martini, J. Tobis, and A. Colombo Coronary Stenting After Rotational Atherectomy in Calcified and Complex Lesions : Angiographic and Clinical Follow-Up Results Circulation, July 1, 1997; 96(1): 128 - 136. [Abstract] [Full Text]
|
|
|
|
|
|
S. Jono, Y. Nishizawa, A. Shioi, and H. Morii Parathyroid Hormone–Related Peptide as a Local Regulator of Vascular Calcification: Its Inhibitory Action on In Vitro Calcification by Bovine Vascular Smooth Muscle Cells Arterioscler Thromb Vasc Biol, June 1, 1997; 17(6): 1135 - 1142. [Abstract] [Full Text]
|
|
|
|
|
|
M. Balica, K. Bostrom, V. Shin, K. Tillisch, and L. L. Demer Calcifying Subpopulation of Bovine Aortic Smooth Muscle Cells Is Responsive to 17ß-Estradiol Circulation, April 1, 1997; 95(7): 1954 - 1960. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Tsurumi, S. Takeshita, D. Chen, M. Kearney, S. T. Rossow, J. Passeri, J. R. Horowitz, J. F. Symes, and J. M. Isner Direct Intramuscular Gene Transfer of Naked DNA Encoding Vascular Endothelial Growth Factor Augments Collateral Development and Tissue Perfusion Circulation, December 15, 1996; 94(12): 3281 - 3290. [Abstract] [Full Text]
|
|
|
|
|
|
L. Wexler, B. Brundage, J. Crouse, R. Detrano, V. Fuster, J. Maddahi, J. Rumberger, W. Stanford, R. White, and K. Taubert Coronary Artery Calcification: Pathophysiology, Epidemiology, Imaging Methods, and Clinical Implications: A Statement for Health Professionals From the American Heart Association Circulation, September 1, 1996; 94(5): 1175 - 1192. [Full Text]
|
|
|
|
 |
|
 R. E. Schmieder, P. Martus, and A. Klingbeil Reversal of Left Ventricular Hypertrophy in Essential Hypertension: A Meta-analysis of Randomized Double-blind Studies JAMA, May 15, 1996; 275(19): 1507 - 1513. [Abstract] [PDF]
|
|
|
|
|
|
G. S. Mintz, J. A. Kovach, S. P. Javier, A. D. Pichard, K. M. Kent, J. J. Popma, L. F. Salter, and M. B. Leon Mechanisms of Lumen Enlargement After Excimer Laser Coronary Angioplasty : An Intravascular Ultrasound Study Circulation, December 15, 1995; 92(12): 3408 - 3414. [Abstract] [Full Text]
|
|
|
|
|
|
A. Shioi, Y. Nishizawa, S. Jono, H. Koyama, M. Hosoi, and H. Morii ß-Glycerophosphate Accelerates Calcification in Cultured Bovine Vascular Smooth Muscle Cells Arterioscler Thromb Vasc Biol, November 1, 1995; 15(11): 2003 - 2009. [Abstract] [Full Text]
|
|
|
|
|
|
L. L. Demer A Skeleton in the Atherosclerosis Closet Circulation, October 15, 1995; 92(8): 2029 - 2032. [Full Text]
|
|
|
|
|
|
J. A. Berliner, M. Navab, A. M. Fogelman, J. S. Frank, L. L. Demer, P. A. Edwards, A. D. Watson, and A. J. Lusis Atherosclerosis: Basic Mechanisms : Oxidation, Inflammation, and Genetics Circulation, May 1, 1995; 91(9): 2488 - 2496. [Abstract] [Full Text]
|
|
|
|
|
|
G. S. Mintz, J. J. Popma, A. D. Pichard, K. M. Kent, L. F. Satler, Y. C. Chuang, C. J. Ditrano, and M. B. Leon Patterns of Calcification in Coronary Artery Disease : A Statistical Analysis of Intravascular Ultrasound and Coronary Angiography in 1155 Lesions Circulation, April 1, 1995; 91(7): 1959 - 1965. [Abstract] [Full Text]
|
|
|
|
|
|
K. Sudhir, T. A. Ports, T. M. Amidon, J. J. Goldberger, V. Bhushan, J. P. Kane, P. Yock, and M. J. Malloy Increased Prevalence of Coronary Ectasia in Heterozygous Familial Hypercholesterolemia Circulation, March 1, 1995; 91(5): 1375 - 1380. [Abstract] [Full Text]
|
|
|
|
|
|
A. Itoh, S. Miyazaki, H. Nonogi, S. Daikoku, and K. Haze Angioscopic Prediction of Successful Dilatation and of Restenosis in Percutaneous Transluminal Coronary Angioplasty : Significance of Yellow Plaque Circulation, March 1, 1995; 91(5): 1389 - 1396. [Abstract] [Full Text]
|
|
|
|
|
|
D. Hausmann, R. Erbel, M.-J. Alibelli-Chemarin, W. Boksch, E. Caracciolo, J. M. Cohn, S. C. Culp, W. G. Daniel, I. De Scheerder, C. DiMario, et al. The Safety of Intracoronary Ultrasound : A Multicenter Survey of 2207 Examinations Circulation, February 1, 1995; 91(3): 623 - 630. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Jono, C. Peinado, and C. M. Giachelli Phosphorylation of Osteopontin Is Required for Inhibition of Vascular Smooth Muscle Cell Calcification J. Biol. Chem., June 23, 2000; 275(26): 20197 - 20203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Steitz, M. Y. Speer, G. Curinga, H.-Y. Yang, P. Haynes, R. Aebersold, T. Schinke, G. Karsenty, and C. M. Giachelli Smooth Muscle Cell Phenotypic Transition Associated With Calcification: Upregulation of Cbfa1 and Downregulation of Smooth Muscle Lineage Markers Circ. Res., December 7, 2001; 89(12): 1147 - 1154. [Abstract] [Full Text] [PDF]
|
|