| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Circulation, Vol 86, 311-319, Copyright © 1992 by American Heart Association
JA Auchampach, M Maruyama, I Cavero and GJ Gross
BACKGROUND. Several recent studies suggest that activation of ATP-
dependent potassium (K(ATP)) channels in the myocardium plays an important
cardioprotective role during ischemia. The present study was undertaken to
examine further the role of this ion channel in vivo in a model of
"stunned" myocardium. METHODS AND RESULTS. Barbital- anesthetized dogs were
subjected to 15 minutes of left anterior descending (LAD) coronary artery
occlusion followed by 3 hours of reperfusion. Regional myocardial blood
flow was measured by radioactive microspheres and segment function by
sonomicrometry. Intravenous administration of the potassium channel opener
aprikalim (RP 52891) at a dose that produced no significant systemic
hemodynamic effects (10 micrograms/kg plus 0.1 microgram/kg/min) resulted
in a marked improvement in segment shortening in the ischemic/reperfused
myocardium compared with control animals (p less than 0.05) when given
before the ischemic insult. However, administration of aprikalim
immediately before reperfusion had no beneficial effect. Furthermore,
pretreatment with the K(ATP) channel antagonist glibenclamide antagonized
the recovery of contractile function afforded by aprikalim when
administered at a low dose (0.3 mg/kg) that alone had no effect on
postischemic recovery. In contrast, pretreatment with either a higher dose
of glibenclamide (1.0 mg/kg) or the related sulfonylurea K(ATP) channel
antagonist tolbutamide (100 mg/kg) resulted in a worsening of segment
function after reperfusion. The ability of aprikalim and the K(ATP) channel
antagonists to alter postischemic wall function occurred independently of
differences in systemic hemodynamics, area at risk, and collateral blood
flow during occlusion, the major determinants of the extent of myocardial
stunning. CONCLUSIONS. These results suggest that opening myocardial K(ATP)
channels in the ischemic heart results in a marked cardioprotective effect
in stunned myocardium and that these channels may serve an endogenous
function, which is to provide protection from ischemic insults.
ARTICLES
Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226.
This article has been cited by other articles:
 |
|
 |
|
  H. Ishii, T. Amano, T. Matsubara, and T. Murohara Pharmacological Intervention for Prevention of Left Ventricular Remodeling and Improving Prognosis in Myocardial Infarction Circulation, December 16, 2008; 118(25): 2710 - 2718. [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Gumina, D. F. O'Cochlain, C. E. Kurtz, P. Bast, D. Pucar, P. Mishra, T. Miki, S. Seino, S. Macura, and A. Terzic KATP channel knockout worsens myocardial calcium stress load in vivo and impairs recovery in stunned heart Am J Physiol Heart Circ Physiol, April 1, 2007; 292(4): H1706 - H1713. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ishii, S. Ichimiya, M. Kanashiro, T. Amano, T. Matsubara, and T. Murohara Effects of Intravenous Nicorandil Before Reperfusion for Acute Myocardial Infarction in Patients With Stress Hyperglycemia Diabetes Care, February 1, 2006; 29(2): 202 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ishii, S. Ichimiya, M. Kanashiro, T. Amano, K. Imai, T. Murohara, and T. Matsubara Impact of a Single Intravenous Administration of Nicorandil Before Reperfusion in Patients With ST-Segment-Elevation Myocardial Infarction Circulation, August 30, 2005; 112(9): 1284 - 1288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. o. Cosar and C. J. O'Connor Hibernation, Stunning, and Preconditioning: Historical Perspective, Current Concepts, Clinical Applications, and Future Implications Seminars in Cardiothoracic and Vascular Anesthesia, June 1, 2003; 7(2): 115 - 140. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Martin, G. Lutter, C. Ihling, M. Siepe, S. Wagner, J. Hilberath, M. Kemper, K. Sarai, and F. Beyersdorf Myocardial viability twenty-four hours after orthotopic heart transplantation from non-heart-beating donors J. Thorac. Cardiovasc. Surg., June 1, 2003; 125(6): 1217 - 1228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Han, N. Kim, H. Joo, E. Kim, and Y. E. Earm ATP-sensitive K+ channel activation by nitric oxide and protein kinase G in rabbit ventricular myocytes Am J Physiol Heart Circ Physiol, October 1, 2002; 283(4): H1545 - H1554. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Masai, Y. Sawa, S. Ohtake, T. Nishida, M. Nishimura, N. Fukushima, T. Yamaguchi, and H. Matsuda Hepatic dysfunction after left ventricular mechanical assist in patients with end-stage heart failure: role of inflammatory response and hepatic microcirculation Ann. Thorac. Surg., February 1, 2002; 73(2): 549 - 555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. McBride, K. S. Naunheim, A. C. Fiore, R. G. Johnson, D. A. Moroney, J. A. Brannan, and M. T. Swartz Risk analysis in patients bridged to transplantation Ann. Thorac. Surg., June 1, 2001; 71(6): 1839 - 1844. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. F. del Valle, E. C. Lascano, J. A. Negroni, and A. J. Crottogini Glibenclamide effects on reperfusion-induced malignant arrhythmias and left ventricular mechanical recovery from stunning in conscious sheep Cardiovasc Res, June 1, 2001; 50(3): 474 - 485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hara, S. Tomiyasu, C. Sungsam, M. Fukusaki, and K. Sumikawa Sevoflurane Protects Stunned Myocardium Through Activation of Mitochondrial ATP-Sensitive Potassium Channels Anesth. Analg., April 1, 2001; 92(5): 1139 - 1145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. Gross, M. Gare, W. G. Toller, J. R. Kersten, D. C. Warltier, and P. S. Pagel Ethanol Enhances the Functional Recovery of Stunned Myocardium Independent of KATP Channels in Dogs Anesth. Analg., February 1, 2001; 92(2): 299 - 305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Kersten, M. W. Montgomery, P. S. Pagel, and D. C. Warltier Levosimendan, a New Positive Inotropic Drug, Decreases Myocardial Infarct Size via Activation of KATP Channels Anesth. Analg., January 1, 2000; 90(1): 5 - 5. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. H. Thourani, R. S. Ronson, D. G.L. Van Wylen, S. T. Shearer, S. L. Katzmark, Z.-Q. Zhao, D. C. Han, R. A. Guyton, and J. Vinten-Johansen Adenosine-Supplemented Blood Cardioplegia Attenuates Postischemic Dysfunction After Severe Regional Ischemia Circulation, November 9, 1999; 100 (2009): II-376 - II-383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. J. Gross, J. R. Kersten, and D. C. Warltier Mechanisms of postischemic contractile dysfunction Ann. Thorac. Surg., November 1, 1999; 68(5): 1898 - 1904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. F. Du Toit, C. A. Muller, J. McCarthy, and L. H. Opie Levosimendan: Effects of a Calcium Sensitizer on Function and Arrhythmias and Cyclic Nucleotide Levels during Ischemia/Reperfusion in the Langendorff-Perfused Guinea Pig Heart J. Pharmacol. Exp. Ther., August 1, 1999; 290(2): 505 - 514. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Bolli and E. Marban Molecular and Cellular Mechanisms of Myocardial Stunning Physiol Rev, April 1, 1999; 79(2): 609 - 634. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Klepzig, G. Kober, C. Matter, H. Luus, H. Schneider, K.H. Boedeker, W. Kiowski, F.W. Amann, D. Gruber, S. Harris, et al. Sulfonylureas and ischaemic preconditioning; a double-blind, placebo-controlled evaluation of glimepiride and glibenclamide Eur. Heart J., March 2, 1999; 20(6): 439 - 446. [Abstract] [PDF]
|
|
|
|
|
|
R. A. Kloner, R. Bolli, E. Marban, L. Reinlib, and E. Braunwald Medical and Cellular Implications of Stunning, Hibernation, and Preconditioning : An NHLBI Workshop Circulation, May 19, 1998; 97(18): 1848 - 1867. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yamazaki, I. Komuro, S. Kudoh, Y. Zou, R. Nagai, R. Aikawa, H. Uozumi, and Y. Yazaki Role of Ion Channels and Exchangers in Mechanical Stretch–Induced Cardiomyocyte Hypertrophy Circ. Res., March 9, 1998; 82(4): 430 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C Smart, K. B Sagar, and D. C Warltier Differential roles of myocardial Ca2+ channels and Na+/Ca2+ exchange in myocardial reperfusion injury in open chest dogs: relative roles during ischemia and reperfusion Cardiovasc Res, December 1, 1997; 36(3): 337 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. Dorman, L. Hebbar, R. B. Hinton, R. C. Roy, and F. G. Spinale Preservation of Myocyte Contractile Function After Hypothermic Cardioplegic Arrest by Activation of ATP-Sensitive Potassium Channels Circulation, October 7, 1997; 96(7): 2376 - 2384. [Abstract] [Full Text]
|
|
|
|
|
|
R. P Embrey, L. A Brooks, and K. C Dellsperger Mechanism of coronary microvascular responses to metabolic stimulation Cardiovasc Res, July 1, 1997; 35(1): 148 - 157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. E. Richenbacher and W. S. Pierce Mechanical Circulatory Support Ann. Thorac. Surg., November 1, 1996; 62(5): 1558 - 1559. [Full Text]
|
|
|
|
|
|
J. A. Crestanello, J. Kamelgard, D. M. Lingle, S. A. Mortensen, M. Rhode, and G. J. R. Whitman ELUCIDATION OF A TRIPARTITE MECHANISM UNDERLYING THE IMPROVEMENT IN CARDIAC TOLERANCE TO ISCHEMIA BY COENZYME Q10 PRETREATMENT J. Thorac. Cardiovasc. Surg., February 1, 1996; 111(2): 443 - 450. [Abstract] [Full Text]
|
|
|
|
|
|
S. Shigematsu, T. Sato, T. Abe, T. Saikawa, T. Sakata, and M. Arita Pharmacological Evidence for the Persistent Activation of ATP-Sensitive K+ Channels in Early Phase of Reperfusion and Its Protective Role Against Myocardial Stunning Circulation, October 15, 1995; 92(8): 2266 - 2275. [Abstract] [Full Text]
|
|
|
|
|
|
S. L. Maskal, N. M. Cohen, P.-W. Hsia, A. S. Wechsler, and R. J. Damiano Jr. HYPERPOLARIZED CARDIAC ARREST WITH A POTASSIUM-CHANNEL OPENER, APRIKALIM J. Thorac. Cardiovasc. Surg., October 1, 1995; 110(4): 1083 - 1095. [Abstract] [Full Text]
|
|
|
|
|
|
N. M. Cohen, R. J. Damiano Jr, and A. S. Wechsler Is There an Alternative to Potassium Arrest? Ann. Thorac. Surg., September 1, 1995; 60(3): 858 - 863. [Abstract] [Full Text]
|
|
|
|
|
|
S. Sugimoto, P. E. Puddu, F. Monti, M. Schiariti, P. P. Campa, and B. Marino Pretreatment with the adenosine triphosphate-sensitive potassium channel opener nicorandil and improved myocardial protection during high-potassium cardioplegic hypoxia J. Thorac. Cardiovasc. Surg., September 1, 1994; 108(3): 455 - 466. [Abstract] [Full Text]
|
|