Circulation, Vol 85, 1899-1911, Copyright © 1992 by American Heart Association
JW Doucette, PD Corl, HM Payne, AE Flynn, M Goto, M Nassi and J Segal
BACKGROUND. An improved intravascular ultrasonic Doppler device could aid
the clinical assessment of coronary hemodynamics. We evaluated a new device
consisting of a 12-MHz piezoelectric transducer integrated onto the tip of
a 0.018-in. flexible, steerable angioplasty guide wire. METHODS AND
RESULTS. Doppler spectra were recorded in model tubes with pulsatile blood
flow and in-line electromagnetic flowmeter. In four straight tubes (i.d.,
0.79-4.76 mm), the time average of spectral peak velocity (APV) was
linearly related to blood flow (QEMF) (r2 greater than or equal to 0.98 for
each tube). A Doppler-derived quantitative flow estimate (QD) was
calculated as the product of vessel cross- sectional area and mean
velocity, with mean velocity estimated as 0.5 x APV. The slope of QD versus
QEMF for the four tubes was near unity. APV was less accurate in a 7.94-mm
straight tube and in tortuous segments. In four dogs, the left circumflex
coronary artery (LCx) was perfused from the femoral artery via a cannula
with in-line electromagnetic flowmeter. Good-quality signals were obtained
in proximal and distal LCx vessels 3.3-1.2 mm in diameter. APV varied
linearly with QEMF (r2 greater than or equal to 0.99 in the cannula, r2 =
0.93-0.99 in proximal LCx, and r2 = 0.86-0.99 in distal LCx). QD was
calculated by quantitative angiography to determine proximal LCx diameter.
For all dogs combined, the slope of QD versus QEMF was 0.95 in the cannula
and 0.85 in the proximal LCx. CONCLUSIONS. The Doppler guide wire measures
phasic flow velocity patterns and linearly tracks changes in flow rate in
small, straight coronary arteries. It should facilitate measurement of
phasic coronary flow velocity during coronary angiography and angioplasty.
ARTICLES
Validation of a Doppler guide wire for intravascular measurement of coronary artery flow velocity
Cardiovascular Research Institute, University of California, San Francisco.
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L. Gregorini, J. Marco, B. Farah, M. Bernies, C. Palombo, M. Kozakova, I. M. Bossi, B. Cassagneau, J. Fajadet, C. Di Mario, et al. Effects of Selective {alpha}1- and {alpha}2-Adrenergic Blockade on Coronary Flow Reserve After Coronary Stenting Circulation, December 3, 2002; 106(23): 2901 - 2907. [Abstract] [Full Text] [PDF]
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M. Albertal, E. Regar, G. Van Langenhove, S.G. Carlier, J.J. Piek, B. de Bruyne, C. di Mario, D. Foley, K. Kozuma, M.A. Costa, et al. Value of coronary stenotic flow velocity acceleration in prediction of angiographic restenosis following balloon angioplasty Eur. Heart J., December 1, 2002; 23(23): 1849 - 1853. [Abstract] [Full Text] [PDF]
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J. P. J. Halcox, K. R. A. Nour, G. Zalos, R. Mincemoyer, M. A. Waclawiw, C. E. Rivera, G. Willie, S. Ellahham, and A. A. Quyyumi The effect of sildenafil on human vascular function, platelet activation, and myocardial ischemia J. Am. Coll. Cardiol., October 2, 2002; 40(7): 1232 - 1240. [Abstract] [Full Text] [PDF]
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G. Oskarsson, E. Pesonen, P. Munkhammar, S. Sandstrom, and P. Jogi Normal Coronary Flow Reserve After Arterial Switch Operation for Transposition of the Great Arteries: An Intracoronary Doppler Guidewire Study Circulation, September 24, 2002; 106(13): 1696 - 1702. [Abstract] [Full Text] [PDF]
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C. V. Maniu, S. T. Higano, A. Lerman, S. M. Hollenberg, J. E. Parrillo, M. Scherer, L. W. Klein, D. Burns, P. Tamburro, M. Oberoi, et al. Assessing Coronary Endothelial Dysfunction * Response Circulation, September 10, 2002; 106 (11): e48 - e48. [Full Text] [PDF]
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F. Beygui, C. Le Feuvre, C. Maunoury, G.e. Helft, and J. P. Metzger Coronary vasodilator reserve: a clue to the explanation of 201Tl redistribution patterns early after successful primary stenting for acute myocardial infarction J. Am. Coll. Cardiol., September 4, 2002; 40(5): 877 - 881. [Abstract] [Full Text] [PDF]
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F. F. Willems, W. R. M. Aengevaeren, G. H. J. Boers, H. J. Blom, and F. W. A. Verheugt Coronary endothelial function in hyperhomocysteinemia: improvement after treatment with folic acid and cobalamin in patients with coronary artery disease J. Am. Coll. Cardiol., August 21, 2002; 40(4): 766 - 772. [Abstract] [Full Text] [PDF]
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J. P.J. Halcox, W. H. Schenke, G. Zalos, R. Mincemoyer, A. Prasad, M. A. Waclawiw, K. R.A. Nour, and A. A. Quyyumi Prognostic Value of Coronary Vascular Endothelial Dysfunction Circulation, August 6, 2002; 106(6): 653 - 658. [Abstract] [Full Text] [PDF]
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Y Ueno, Y Nakamura, M Kinoshita, T Fujita, T Sakamoto, and H Okamura Can coronary flow velocity reserve determined by transthoracic Doppler echocardiography predict the recovery of regional left ventricular function in patients with acute myocardial infarction? Heart, August 1, 2002; 88(2): 137 - 141. [Abstract] [Full Text] [PDF]
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M. Meuwissen, M. Siebes, S. A.J. Chamuleau, B. L.F. van Eck-Smit, K. T. Koch, R. J. de Winter, J. G.P. Tijssen, J. A.E. Spaan, and J. J. Piek Hyperemic Stenosis Resistance Index for Evaluation of Functional Coronary Lesion Severity Circulation, July 23, 2002; 106(4): 441 - 446. [Abstract] [Full Text] [PDF]
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T. Bartel, Y. a Yang, S. Muller, R. R. Wenzel, D. Baumgart, T. Philipp, and R. Erbel Noninvasive assessment of microvascular function in arterial hypertension by transthoracic doppler harmonic echocardiography J. Am. Coll. Cardiol., June 19, 2002; 39(12): 2012 - 2018. [Abstract] [Full Text] [PDF]
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N Noto, K Karasawa, H Kanamaru, M Ayusawa, N Sumitomo, T Okada, and K Harada Non-invasive measurement of coronary flow reserve in children with Kawasaki disease Heart, June 1, 2002; 87(6): 559 - 565. [Abstract] [Full Text] [PDF]
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G. Beran, I. Lang, W. Schreiber, S. Denk, T. Stefenelli, B. Syeda, G. Maurer, D. Glogar, and P. Siostrzonek Intracoronary Thrombectomy With the X-Sizer Catheter System Improves Epicardial Flow and Accelerates ST-Segment Resolution in Patients With Acute Coronary Syndrome: A Prospective, Randomized, Controlled Study Circulation, May 21, 2002; 105(20): 2355 - 2360. [Abstract] [Full Text] [PDF]
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G.E. Kochiadakis, E.I. Skalidis, M.D. Kalebubas, N.E. Igoumenidis, S.I. Chrysostomakis, E.M. Kanoupakis, E.N. Simantirakis, and P.E. Vardas Effect of acute atrial fibrillation on phasic coronary blood flow pattern and flow reserve in humans Eur. Heart J., May 1, 2002; 23(9): 734 - 741. [Abstract] [Full Text] [PDF]
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S. A. J. Chamuleau, R. A. Tio, C. C. de Cock, E. D. de Muinck, N. H. J. Pijls, B. L. F. van Eck-Smit, K. T. Koch, M. Meuwissen, M. G. W. Dijkgraaf, A. de Jong, et al. Prognostic value of coronary blood flow velocity and myocardial perfusion in intermediate coronary narrowings and multivessel disease J. Am. Coll. Cardiol., March 6, 2002; 39(5): 852 - 858. [Abstract] [Full Text] [PDF]
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H. M. O. Farouque, S. G. Worthley, I. T. Meredith, R. A. P. Skyrme-Jones, and M. J. Zhang Effect of ATP-Sensitive Potassium Channel Inhibition on Resting Coronary Vascular Responses in Humans Circ. Res., February 8, 2002; 90(2): 231 - 236. [Abstract] [Full Text] [PDF]
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T Reffelmann, H G Klues, P Hanrath, and E R Schwarz Post-stenotic coronary blood flow at rest is not altered by therapeutic doses of the oral antidiabetic drug glibenclamide in patients with coronary artery disease Heart, January 1, 2002; 87(1): 54 - 60. [Abstract] [Full Text] [PDF]
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S. M. Hollenberg, L. W. Klein, J. E. Parrillo, M. Scherer, D. Burns, P. Tamburro, M. Oberoi, M. R. Johnson, and M. R. Costanzo Coronary Endothelial Dysfunction After Heart Transplantation Predicts Allograft Vasculopathy and Cardiac Death Circulation, December 18, 2001; 104(25): 3091 - 3096. [Abstract] [Full Text] [PDF]
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M. Billinger, C. Seiler, M. Fleisch, F. R. Eberli, B. Meier, and O. M. Hess Do beta-adrenergic blocking agents increase coronary flow reserve? J. Am. Coll. Cardiol., December 1, 2001; 38(7): 1866 - 1871. [Abstract] [Full Text] [PDF]
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T. Pohl, C. Seiler, M. Billinger, E. Herren, K. Wustmann, H. Mehta, S. Windecker, F. R. Eberli, and B. Meier Frequency distribution of collateral flow and factors influencing collateral channel development: Functional collateral channel measurement in 450 patients with coronary artery disease J. Am. Coll. Cardiol., December 1, 2001; 38(7): 1872 - 1878. [Abstract] [Full Text] [PDF]
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T. P. Cappola, D. A. Kass, G. S. Nelson, R. D. Berger, G. O. Rosas, Z. A. Kobeissi, E. Marban, and J. M. Hare Allopurinol Improves Myocardial Efficiency in Patients With Idiopathic Dilated Cardiomyopathy Circulation, November 13, 2001; 104(20): 2407 - 2411. [Abstract] [Full Text] [PDF]
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A. Prasad, J. P. J. Halcox, M. A. Waclawiw, and A. A. Quyyumi Angiotensin type 1 receptor antagonism reverses abnormal coronary vasomotion in atherosclerosis J. Am. Coll. Cardiol., October 1, 2001; 38(4): 1089 - 1095. [Abstract] [Full Text] [PDF]
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T Pohl, P Hochstrasser, M Billinger, M Fleisch, B Meier, and C Seiler Influence on collateral flow of recanalising chronic total coronary occlusions: a case-control study Heart, October 1, 2001; 86(4): 438 - 443. [Abstract] [Full Text] [PDF]
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J. Taki, S. Fujino, K. Nakajima, I. Matsunari, H. Okazaki, T. Saga, H. Bunko, and N. Tonami 99mTc-Sestamibi Retention Characteristics During Pharmacologic Hyperemia in Human Myocardium: Comparison with Coronary Flow Reserve Measured by Doppler Flowire J. Nucl. Med., October 1, 2001; 42(10): 1457 - 1463. [Abstract] [Full Text] [PDF]
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S. Mohlenkamp, T. R. Behrenbeck, A. Lerman, L. O. Lerman, V. S. Pankratz, P. F. Sheedy II, A. L. Weaver, and E. L. Ritman Coronary Microvascular Functional Reserve: Quantification of Long-term Changes with Electron-Beam CT—Preliminary Results in a Porcine Model Radiology, October 1, 2001; 221(1): 229 - 236. [Abstract] [Full Text] [PDF]
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J.J Piek, E Boersma, M Voskuil, C di Mario, E Schroeder, C Vrints, P Probst, B de Bruyne, C Hanet, E Fleck, et al. The immediate and long-term effect of optimal balloon angioplasty on the absolute coronary blood flow velocity reserve. A subanalysis of the DEBATE study Eur. Heart J., September 2, 2001; 22(18): 1725 - 1732. [Abstract] [PDF]
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B. Hennen, T. Markwirth, B. Scheller, H.-J. Schafers, and O. Wendler Impaired flow in left internal mammary artery grafts due to subclavian artery stenosis Ann. Thorac. Surg., September 1, 2001; 72(3): 917 - 919. [Abstract] [Full Text] [PDF]
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