Circulation, Vol 85, 1197-1204, Copyright © 1992 by American Heart Association
S Sasayama and M Fujita
The functional significance of coronary collaterals in humans has been
debated for many years. Correlations have now been made between the
anatomic appearance of coronary collateral vessels visualized at the time
of intracoronary thrombolytic therapy during the acute phase of myocardial
infarction and the creatine kinase time--activity curve, infarct size, and
aneurysm formation. These studies demonstrate a protective role of
collaterals in hearts with coronary obstructive disease, showing smaller
infarcts, less aneurysm formation, and improved ventricular function
compared with patients in whom collaterals were not visualized. There is
ample evidence that collaterals respond to myocardial ischemia by opening
preexistent channels. When the cardiac myocyte is rendered ischemic,
collaterals develop actively by growth with DNA replication and mitosis of
endothelial and smooth muscle cells. Heparin-binding growth factors are
present in the heart, but their biological activity is quiescent under
normal physiological conditions. Once ischemia develops, these factors are
activated and become available for receptor occupation, which may initiate
angiogenesis after exposure to exogenous heparin. This characteristic of
heparin to potentiate the mitogenic activity of acidic fibroblast growth
factor has recently been used in the clinical setting as a possible
therapeutic modality in patients with coronary artery disease. Patients
performing 20 rounds of exercise serially after receiving intravenous
injection of heparin showed significantly greater increases in exercise
capacity and improvement of clinical symptoms compared with the control
group who performed the same exercise without heparin. Further study of
neovascularization may lead to a new therapeutic strategy for ischemic
heart disease.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Recent insights into coronary collateral circulation
Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
This article has been cited by other articles:
 |
|
 |
|
  T. Higuchi, F. M. Bengel, S. Seidl, P. Watzlowik, H. Kessler, R. Hegenloh, S. Reder, S. G. Nekolla, H. J. Wester, and M. Schwaiger Assessment of {alpha}v{beta}3 integrin expression after myocardial infarction by positron emission tomography Cardiovasc Res, May 1, 2008; 78(2): 395 - 403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Heusch and R. Schulz The role of heart rate and the benefits of heart rate reduction in acute myocardial ischaemia Eur. Heart J. Suppl., September 1, 2007; 9(suppl_F): F8 - F14. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zimarino, A. Ausiello, G. Contegiacomo, I. Riccardi, G. Renda, C. Di Iorio, and R. De Caterina Rapid Decline of Collateral Circulation Increases Susceptibility to Myocardial Ischemia: The Trade-Off of Successful Percutaneous Recanalization of Chronic Total Occlusions J. Am. Coll. Cardiol., July 4, 2006; 48(1): 59 - 65. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Werner, U. Emig, O. Mutschke, G. Schwarz, P. Bahrmann, and H. R. Figulla Regression of Collateral Function After Recanalization of Chronic Total Coronary Occlusions: A Serial Assessment by Intracoronary Pressure and Doppler Recordings Circulation, December 9, 2003; 108(23): 2877 - 2882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. P. Fam, S. Verma, M. Kutryk, and D. J. Stewart Clinician Guide to Angiogenesis Circulation, November 25, 2003; 108(21): 2613 - 2618. [Full Text] [PDF]
|
|
|
|
|
|
J. Koerselman, Y. van der Graaf, P. P.Th. de Jaegere, and D. E. Grobbee Coronary Collaterals: An Important and Underexposed Aspect of Coronary Artery Disease Circulation, May 20, 2003; 107(19): 2507 - 2511. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Heil, T. Ziegelhoeffer, F. Pipp, S. Kostin, S. Martin, M. Clauss, and W. Schaper Blood monocyte concentration is critical for enhancement of collateral artery growth Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2411 - H2419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Goncalves, S. E. Epstein, and J. J. Piek Controlling collateral development: the difficult task of mimicking mother nature Cardiovasc Res, February 16, 2001; 49(3): 495 - 496. [Full Text] [PDF]
|
|
|
|
|
|
M. J. Post, R. Laham, F. W. Sellke, and M. Simons Therapeutic angiogenesis in cardiology using protein formulations Cardiovasc Res, February 16, 2001; 49(3): 522 - 531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Simons, R. O. Bonow, N. A. Chronos, D. J. Cohen, F. J. Giordano, H. K. Hammond, R. J. Laham, W. Li, M. Pike, F. W. Sellke, et al. Clinical Trials in Coronary Angiogenesis: Issues, Problems, Consensus : An Expert Panel Summary Circulation, September 12, 2000; 102 (11): e73 - e86. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y Zhu, Y Hojo, U Ikeda, K Shimada;, and G F BAXTER Production of hepatocyte growth factor during acute myocardial infarction Heart, April 1, 2000; 83(4): 450 - 455. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. D. Pearlman, R. J. Laham, and M. Simons Coronary Angiogenesis: Detection in Vivo with MR Imaging Sensitive to Collateral Neocirculation-Preliminary Study in Pigs Radiology, March 1, 2000; 214(3): 801 - 807. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Fujita Heparin and angiogenic therapy Eur. Heart J., February 2, 2000; 21(4): 270 - 274. [PDF]
|
|
|
|
 |
|
 E. Landau, R. Tirosh, A. Pinson, S. Banai, S. Even-Ram, M. Maoz, S. Katzav, and R. Bar-Shavit Protection of Thrombin Receptor Expression under Hypoxia J. Biol. Chem., January 28, 2000; 275(4): 2281 - 2287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M Goncalves Angiogenic growth factors: potential new treatment for acute myocardial infarction? Cardiovasc Res, January 14, 2000; 45(2): 294 - 302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Seiler, M. Fleisch, M. Billinger, and B. Meier Simultaneous intracoronary velocity- and pressure-derived assessment of adenosine-induced collateral hemodynamics in patients with one- to two-vessel coronary artery disease J. Am. Coll. Cardiol., December 1, 1999; 34(7): 1985 - 1994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fleisch, M. Billinger, F. R. Eberli, A. R. Garachemani, B. Meier, and C. Seiler Physiologically Assessed Coronary Collateral Flow and Intracoronary Growth Factor Concentrations in Patients With 1- to 3-Vessel Coronary Artery Disease Circulation, November 9, 1999; 100(19): 1945 - 1950. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. D Henry Science, medicine, and the future: Therapeutic angiogenesis BMJ, June 5, 1999; 318(7197): 1536 - 1539. [Full Text]
|
|
|
|
|
|
G. Holmvang, S. Fry, H. A. Skopicki, S. A. Abraham, N. M. Alpert, A. J. Fischman, M. H. Picard, and H. Gewirtz Relation Between Coronary "Steal" and Contractile Function at Rest in Collateral-Dependent Myocardium of Humans With Ischemic Heart Disease Circulation, May 18, 1999; 99(19): 2510 - 2516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Seiler, M. Fleisch, A. Garachemani, and B. Meier Coronary collateral quantitation in patients with coronary artery disease using intravascular flow velocity or pressure measurements J. Am. Coll. Cardiol., November 1, 1998; 32(5): 1272 - 1279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Senti, M. Fleisch, M. Billinger, B. Meier, and C. Seiler Long-term physical exercise and quantitatively assessed human coronary collateral circulation J. Am. Coll. Cardiol., July 1, 1998; 32(1): 49 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Bombardini, E. Picano, and T. Bombardini The Coronary Angiogenetic Effect of Heparin: Experimental Basis and Clinical Evidence Angiology, November 1, 1997; 48(11): 969 - 976. [Abstract] [PDF]
|
|
|
|
 |
|
 C.-H. Chen, J. Cartwright Jr, Z. Li, S. Lou, H. H. Nguyen, A. M. Gotto Jr, and P. D. Henry Inhibitory Effects of Hypercholesterolemia and Ox-LDL on Angiogenesis-like Endothelial Growth in Rabbit Aortic Explants : Essential Role of Basic Fibroblast Growth Factor Arterioscler Thromb Vasc Biol, July 1, 1997; 17(7): 1303 - 1312. [Abstract] [Full Text]
|
|
|
|
|
|
K. Ono, A. Matsumori, T. Shioi, Y. Furukawa, and S. Sasayama Enhanced Expression of Hepatocyte Growth Factor/c-Met by Myocardial Ischemia and Reperfusion in a Rat Model Circulation, June 3, 1997; 95(11): 2552 - 2558. [Abstract] [Full Text]
|
|
|
|
|
|
M. Fujita, M. Ikemoto, M. Kishishita, H. Otani, R. Nohara, T. Tanaka, S.-i. Tamaki, A. Yamazato, and S. Sasayama Elevated Basic Fibroblast Growth Factor in Pericardial Fluid of Patients With Unstable Angina Circulation, August 15, 1996; 94(4): 610 - 613. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Muhlhauser, M. J. Merrill, R. Pili, H. Maeda, M. Bacic, B. Bewig, A. Passaniti, N. A. Edwards, R. G. Crystal, and M. C. Capogrossi VEGF165 Expressed by a Replication-Deficient Recombinant Adenovirus Vector Induces Angiogenesis In Vivo Circ. Res., December 1, 1995; 77(6): 1077 - 1086. [Abstract] [Full Text]
|
|
|
|
|
|
M. Gerhard and P. Ganz How Do We Explain the Clinical Benefits of Estrogen? : From Bedside to Bench Circulation, July 1, 1995; 92(1): 5 - 8. [Full Text]
|
|
|
|
|
|
F. Ottani, M. Galvani, D. Ferrini, F. Sorbello, P. Limonetti, D. Pantoli, and F. Rusticali Prodromal Angina Limits Infarct Size : A Role for Ischemic Preconditioning Circulation, January 15, 1995; 91(2): 291 - 297. [Abstract] [Full Text]
|
|
|
|
|
|
H. Matsuo, S. Watanabe, T. Kadosaki, T. Yamaki, S. Tanaka, S. Miyata, T. Segawa, Y. Matsuno, M. Tomita, and H. Fujiwara Validation of Collateral Fractional Flow Reserve by Myocardial Perfusion Imaging Circulation, March 5, 2002; 105(9): 1060 - 1065. [Abstract] [Full Text] [PDF]
|
|