Circulation, Vol 85, 1046-1055, Copyright © 1992 by American Heart Association
DJ Beuckelmann, M Nabauer and E Erdmann
BACKGROUND. Experiments were performed in human ventricular myocytes to
investigate properties of excitation-contraction coupling in patients with
terminal heart failure. Myocytes were isolated from left ventricular
myocardium of patients with cardiac failure caused by dilated or ischemic
cardiomyopathy undergoing transplantation. These results were compared with
those obtained from cells of healthy donor hearts that for technical
reasons were not suitable for transplantation. METHODS AND RESULTS. [Ca2+]i
transients and Ca2+ currents were recorded from isolated cells under
voltage clamp perfused internally with the Ca2+ indicator fura 2. In cells
that were stimulated externally, the cell-permeant form of the indicator,
fura 2- AM, was used. When action potentials were to be recorded, cells
were stimulated in current clamp mode. Unstimulated Ca2+ current densities
were not significantly different in myopathic and control cells. In
diseased myocytes, resting [Ca2+]i levels were 165 +/- 61 nmol/l, compared
with 95 +/- 47 nmol/l in normal cells. With 5 mmol/l Na+ in the pipette,
peak [Ca2+]i transients were 367 +/- 109 and 746 +/- 249 nmol/l,
respectively. The decline of [Ca2+]i during diastole was significantly
slower in myopathic cells than in control cells. This was a result of a
prolongation of the action potential and of a reduced Ca2+ sequestration by
the sarcoplasmic reticulum. CONCLUSIONS. These results may partly explain
the alterations of contractility in vivo in patients with heart failure.
ARTICLES
Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure
Department of Medicine I, University of Munich, FRG.
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J. Kneller, H. Sun, N. Leblanc, and S. Nattel Remodeling of Ca2+-handling by atrial tachycardia: evidence for a role in loss of rate-adaptation Cardiovasc Res, May 1, 2002; 54(2): 416 - 426. [Abstract] [Full Text] [PDF]
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M. Doi, M. Yano, S. Kobayashi, M. Kohno, T. Tokuhisa, S. Okuda, M. Suetsugu, Y. Hisamatsu, T. Ohkusa, M. Kohno, et al. Propranolol Prevents the Development of Heart Failure by Restoring FKBP12.6-Mediated Stabilization of Ryanodine Receptor Circulation, March 19, 2002; 105(11): 1374 - 1379. [Abstract] [Full Text] [PDF]
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J. P. Loennechen, U. Wisloff, G. Falck, and O. Ellingsen Effects of Cariporide and Losartan on Hypertrophy, Calcium Transients, Contractility, and Gene Expression in Congestive Heart Failure Circulation, March 19, 2002; 105(11): 1380 - 1386. [Abstract] [Full Text] [PDF]
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 Y. Kimura and M. Inui Reconstitution of the Cytoplasmic Interaction between Phospholamban and Ca2+-ATPase of Cardiac Sarcoplasmic Reticulum Mol. Pharmacol., March 1, 2002; 61(3): 667 - 673. [Abstract] [Full Text] [PDF]
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K. R Sipido, P. G.A Volders, M. A Vos, and F. Verdonck Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy? Cardiovasc Res, March 1, 2002; 53(4): 782 - 805. [Abstract] [Full Text] [PDF]
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F. del Monte, S. E. Harding, G. W. Dec, J. K. Gwathmey, and R. J. Hajjar Targeting Phospholamban by Gene Transfer in Human Heart Failure Circulation, February 26, 2002; 105(8): 904 - 907. [Abstract] [Full Text] [PDF]
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T. D. Gbadebo, R. W. Trimble, M. S.C. Khoo, J. Temple, D. M. Roden, and M. E. Anderson Calmodulin Inhibitor W-7 Unmasks a Novel Electrocardiographic Parameter That Predicts Initiation of Torsade de Pointes Circulation, February 12, 2002; 105(6): 770 - 774. [Abstract] [Full Text] [PDF]
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R. Sah, R. J. Ramirez, and P. H. Backx Modulation of Ca2+ Release in Cardiac Myocytes by Changes in Repolarization Rate: Role of Phase-1 Action Potential Repolarization in Excitation-Contraction Coupling Circ. Res., February 8, 2002; 90(2): 165 - 173. [Abstract] [Full Text] [PDF]
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J. B Sande, I. Sjaastad, I. B Hoen, J. Bokenes, T. Tonnessen, E. Holt, P. K Lunde, and G. Christensen Reduced level of serine16 phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity Cardiovasc Res, February 1, 2002; 53(2): 382 - 391. [Abstract] [Full Text] [PDF]
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O. Gealekman, Z. Abassi, I. Rubinstein, J. Winaver, and O. Binah Role of Myocardial Inducible Nitric Oxide Synthase in Contractile Dysfunction and {beta}-Adrenergic Hyporesponsiveness in Rats With Experimental Volume-Overload Heart Failure Circulation, January 15, 2002; 105(2): 236 - 243. [Abstract] [Full Text] [PDF]
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K. Brixius, S. Reicke, and R. H. G. Schwinger Beneficial effects of the Ca2+ sensitizer levosimendan in human myocardium Am J Physiol Heart Circ Physiol, January 1, 2002; 282(1): H131 - H137. [Abstract] [Full Text] [PDF]
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U. Schotten, M. Greiser, D. Benke, K. Buerkel, B. Ehrenteidt, C. Stellbrink, J. F Vazquez-Jimenez, F. Schoendube, P. Hanrath, and M. Allessie Atrial fibrillation-induced atrial contractile dysfunction: a tachycardiomyopathy of a different sort Cardiovasc Res, January 1, 2002; 53(1): 192 - 201. [Abstract] [Full Text] [PDF]
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A. O. Verkerk, M. W. Veldkamp, A. Baartscheer, C. A. Schumacher, C. Klopping, A. C.G. van Ginneken, and J. H. Ravesloot Ionic Mechanism of Delayed Afterdepolarizations in Ventricular Cells Isolated From Human End-Stage Failing Hearts Circulation, November 27, 2001; 104(22): 2728 - 2733. [Abstract] [Full Text] [PDF]
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 S. Kaab and M. Nabauer Diversity of ion channel expression in health and disease Eur. Heart J. Suppl., September 1, 2001; 3(suppl_K): K31 - K40. [Abstract] [PDF]
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H. Kubo, K. B. Margulies, V. Piacentino III, J. P. Gaughan, and S. R. Houser Patients With End-Stage Congestive Heart Failure Treated With {beta}-Adrenergic Receptor Antagonists Have Improved Ventricular Myocyte Calcium Regulatory Protein Abundance Circulation, August 28, 2001; 104(9): 1012 - 1018. [Abstract] [Full Text] [PDF]
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G. Munch, B. Bolck, A. Sugaru, K. Brixius, W. Bloch, and R. H.G. Schwinger Increased Expression of Isoform 1 of the Sarcoplasmic Reticulum Ca2+-Release Channel in Failing Human Heart Circulation, June 5, 2001; 103(22): 2739 - 2744. [Abstract] [Full Text] [PDF]
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R. Sah, R. J Ramirez, R. Kaprielian, and P. H Backx Alterations in action potential profile enhance excitation-contraction coupling in rat cardiac myocytes J. Physiol., May 15, 2001; 533(1): 201 - 214. [Abstract] [Full Text] [PDF]
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I. A. Hobai and B. O'Rourke Decreased Sarcoplasmic Reticulum Calcium Content Is Responsible for Defective Excitation-Contraction Coupling in Canine Heart Failure Circulation, March 20, 2001; 103(11): 1577 - 1584. [Abstract] [Full Text] [PDF]
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M. Periasamy Adenoviral-Mediated SERCA Gene Transfer Into Cardiac Myocytes : How Much Is Too Much? Circ. Res., March 2, 2001; 88(4): 373 - 375. [Full Text] [PDF]
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A. C. Nicolosi, C. S. Kwok, S. J. Contney, G. N. Olinger, and Z. J. Bosnjak Gadolinium prevents stretch-mediated contractile dysfunction in isolated papillary muscles Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H1122 - H1128. [Abstract] [Full Text] [PDF]
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Y. Wu, R. J. Colbran, and M. E. Anderson Calmodulin kinase is a molecular switch for cardiac excitation -contraction coupling PNAS, February 27, 2001; 98(5): 2877 - 2881. [Abstract] [Full Text] [PDF]
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A Baartscheer Adenovirus gene transfer of SERCA in heart failure. A promising therapeutic approach ? Cardiovasc Res, February 1, 2001; 49(2): 249 - 252. [Full Text] [PDF]
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N. Chossat, F. Griscelli, P. Jourdon, D. Logeart, T. Ragot, M. Heimburger, M. Perricaudet, A.-M. Lompre, S. Hatem, and J.-J. Mercadier Adenoviral SERCA1a gene transfer to adult rat ventricular myocytes induces physiological changes in calcium handling Cardiovasc Res, February 1, 2001; 49(2): 288 - 297. [Abstract] [Full Text] [PDF]
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S. S. Chugh, S. B. Johnson, and D. L. Packer Altered response to ibutilide in a heart failure model Cardiovasc Res, January 1, 2001; 49(1): 94 - 102. [Abstract] [Full Text] [PDF]
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T. G. Hampton, J.-F. Wang, J. DeAngelis, I. Amende, K. D. Philipson, and J. P. Morgan Enhanced gene expression of Na+/Ca2+ exchanger attenuates ischemic and hypoxic contractile dysfunction Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2846 - H2854. [Abstract] [Full Text] [PDF]
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K. R. Sipido Local Ca2+ Release in Heart Failure : Timing Is Important Circ. Res., November 24, 2000; 87(11): 966 - 968. [Full Text] [PDF]
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N. Satoh, T. M. Suter, R. Liao, and W. S. Colucci Chronic {alpha}-Adrenergic Receptor Stimulation Modulates the Contractile Phenotype of Cardiac Myocytes In Vitro Circulation, October 31, 2000; 102(18): 2249 - 2254. [Abstract] [Full Text] [PDF]
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K. Ito, X. Yan, M. Tajima, Z. Su, W. H. Barry, and B. H. Lorell Contractile Reserve and Intracellular Calcium Regulation in Mouse Myocytes From Normal and Hypertrophied Failing Hearts Circ. Res., September 29, 2000; 87(7): 588 - 595. [Abstract] [Full Text] [PDF]
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