Circulation, Vol 85, 769-778, Copyright © 1992 by American Heart Association
TJ Donnelly, RE Sievers, FL Vissern, WJ Welch and CL Wolfe
BACKGROUND. To test the hypothesis that the heat shock response is
associated with improved myocardial salvage after myocardial ischemia and
reperfusion, rats treated with prior whole-body hyperthermia and 24 hours
of recovery (n = 26) or 20 minutes of ischemic pretreatment and 8 hours of
recovery (n = 24) and control rats (n = 27, n = 24, for hyperthermic and
ischemic pretreatment, respectively) were subjected to 35 minutes of left
coronary artery (LCA) occlusion and 120 minutes of reperfusion. METHODS AND
RESULTS. Although ventricular samples from rats subjected to either
hyperthermia (n = 7) or ischemic pretreatment (n = 6) all showed induction
of HSP72 (heat shock protein), Western blot analysis revealed significantly
greater amounts of HSP72 in samples obtained from rats subjected to
hyperthermia compared with those from rats subjected to ischemic
pretreatment. Control rats (n = 7) showed no significant presence of
myocardial HSP72. After 35 minutes of LCA occlusion and 2 hours of
reperfusion, infarct size was significantly reduced in heat-shocked rats
compared with controls (8.4 +/- 1.7%, n = 26 versus 15.5 +/- 1.9%, n = 27;
p = 0.007; mean +/- SEM; infarct mass/left ventricular mass x 100). There
were no significant differences in left ventricular (LV) systolic pressure,
heart rate, LV dP/dt, or rate-pressure product between heat-shocked (n =
11) and control (n = 14) rats during the ischemic period. There were no
differences in infarct size between ischemically pretreated and control
rats subjected to 35 minutes of ischemia and reperfusion (9.7 +/- 2.1%, n =
23 versus 10.0 +/- 2.1, n = 24; p = NS). CONCLUSIONS. In this model of
ischemia and reperfusion, prior heat shock was associated with
significantly improved myocardial salvage after 35 minutes of LCA occlusion
and reperfusion. This improved salvage was correlated with marked HSP72
induction and was independent of the hemodynamic determinants of myocardial
oxygen supply and myocardial oxygen demand during the ischemic period. In
contrast, mild HSP72 induction by ischemic pretreatment was not associated
with improved myocardial salvage after myocardial ischemia and reperfusion.
Thus, the absolute levels of HSP72 may be important in conferring
protection from ischemic injury in this animal model.
ARTICLES
Heat shock protein induction in rat hearts. A role for improved myocardial salvage after ischemia and reperfusion?
Cardiovascular Research Institute, University of California, San Francisco.
This article has been cited by other articles:
 |
|
 |
|
  M. Sakabe, A. Shiroshita-Takeshita, A. Maguy, B. J.J.M. Brundel, A. Fujiki, H. Inoue, and S. Nattel Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia Cardiovasc Res, April 1, 2008; 78(1): 63 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Li, I. S. Ali, and R. W. Currie Insulin induces myocardial protection and Hsp70 localization to plasma membranes in rat hearts Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1709 - H1721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Thirunavukkarasu, S. V. Penumathsa, B. Juhasz, L. Zhan, G. Cordis, E. Altaf, M. Bagchi, D. Bagchi, and N. Maulik Niacin-bound chromium enhances myocardial protection from ischemia-reperfusion injury Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H820 - H826. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Sreedharan, M. Riordan, S. Wang, G. Thulin, M. Kashgarian, and N. J. Siegel Reduced tolerance of immature renal tubules to anoxia by HSF-1 decoy Am J Physiol Renal Physiol, February 1, 2005; 288(2): F322 - F326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Liu, K. W. L. Kam, J.-J. Zhou, W.-Y. Yan, M. Chen, S. Wu, and T. M. Wong Effects of Heat Shock Protein 70 Activation by Metabolic Inhibition Preconditioning or {kappa}-Opioid Receptor Stimulation on Ca2+ Homeostasis in Rat Ventricular Myocytes Subjected to Ischemic Insults J. Pharmacol. Exp. Ther., August 1, 2004; 310(2): 606 - 613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C Chi and J. S Karliner Molecular determinants of responses to myocardial ischemia/reperfusion injury: focus on hypoxia-inducible and heat shock factors Cardiovasc Res, February 15, 2004; 61(3): 437 - 447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Joyeux-Faure, C. Arnaud, D. Godin-Ribuot, and C. Ribuot Heat stress preconditioning and delayed myocardial protection: what is new? Cardiovasc Res, December 1, 2003; 60(3): 469 - 477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. White, J. Thomas, D. L. Maass, and J. W. Horton Cardiac effects of burn injury complicated by aspiration pneumonia-induced sepsis Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H47 - H58. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Arnaud, M. Joyeux-Faure, D. Godin-Ribuot, and C. Ribuot COX-2: an in vivo evidence of its participation in heat stress-induced myocardial preconditioning Cardiovasc Res, June 1, 2003; 58(3): 582 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Arnaud, D. Godin-Ribuot, S. Bottari, A. Peinnequin, M. Joyeux, P. Demenge, and C. Ribuot iNOS is a mediator of the heat stress-induced preconditioning against myocardial infarction in vivo in the rat Cardiovasc Res, April 1, 2003; 58(1): 118 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Scott, M. Locke, and L. T. Buck Tissue-specific expression of inducible and constitutive Hsp70 isoforms in the western painted turtle J. Exp. Biol., March 2, 2003; 206(2): 303 - 311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Qing, J. F. Vazquez-Jimenez, K. Schumacher, R. S. Bhardwaj, B. Klosterhalfen, R. Minkenberg, B. J. Messmer, G. von Bernuth, and M.-C. Seghaye Moderate hypothermia during cardiopulmonary bypass increases intramyocardial synthesis of heat shock protein 72 J. Thorac. Cardiovasc. Surg., October 1, 2002; 124(4): 724 - 731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Decker, M. L. Decker, S. Nakamura, Y.-S. Zhao, S. Hedjbeli, K. R. Harris, and F. J. Klocke HSC73-tubulin complex formation during low-flow ischemia in the canine myocardium Am J Physiol Heart Circ Physiol, October 1, 2002; 283(4): H1322 - H1333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ooie, N. Takahashi, T. Saikawa, T. Nawata, M. Arikawa, K. Yamanaka, M. Hara, T. Shimada, and T. Sakata Single Oral Dose of Geranylgeranylacetone Induces Heat-Shock Protein 72 and Renders Protection Against Ischemia/Reperfusion Injury in Rat Heart Circulation, October 9, 2001; 104(15): 1837 - 1843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. N. Jew and R. L. Moore Glibenclamide improves postischemic recovery of myocardial contractile function in trained and sedentary rats J Appl Physiol, October 1, 2001; 91(4): 1545 - 1554. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. H. E. H. Snoeckx, R. N. Cornelussen, F. A. Van Nieuwenhoven, R. S. Reneman, and G. J. Van der Vusse Heat Shock Proteins and Cardiovascular Pathophysiology Physiol Rev, October 1, 2001; 81(4): 1461 - 1497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Patel and G. J. Gross Diazoxide induced cardioprotection: what comes first, KATP channels or reactive oxygen species? Cardiovasc Res, September 1, 2001; 51(4): 633 - 636. [Full Text] [PDF]
|
|
|
|
|
|
D. S Latchman Heat shock proteins and cardiac protection Cardiovasc Res, September 1, 2001; 51(4): 637 - 646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Tekin, L. Xi, T. Zhao, M. I. Tejero-Taldo, S. Atluri, and R. C. Kukreja Mitogen-activated protein kinases mediate heat shock-induced delayed protection in mouse heart Am J Physiol Heart Circ Physiol, August 1, 2001; 281(2): H523 - H532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Kevelaitis, A. P. Patel, A. Oubenaissa, J. Peynet, C. Mouas, D. M. Yellon, and P. Menasche Backtable heat-enhanced preconditioning: a simple and effective means of improving function of heart transplants Ann. Thorac. Surg., July 1, 2001; 72(1): 107 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Lipton, J. B. Delcarpio, and K. H. McDonough Effects of Endotoxin on Neutrophil-Mediated Ischemia/Reperfusion Injury in the Rat Heart In Vivo Experimental Biology and Medicine, April 1, 2001; 226(4): 320 - 327. [Abstract] [Full Text]
|
|
|
|
|
|
A. Hammerer-Lercher, J. Mair, J. Bonatti, S. B.C. Watzka, B. Puschendorf, and S. Dirnhofer Hypoxia induces heat shock protein expression in human coronary artery bypass grafts Cardiovasc Res, April 1, 2001; 50(1): 115 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. McArdle, D. Pattwell, A. Vasilaki, R. D. Griffiths, and M. J. Jackson Contractile activity-induced oxidative stress: cellular origin and adaptive responses Am J Physiol Cell Physiol, March 1, 2001; 280(3): C621 - C627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Patel, A. Hsu, and G. J. Gross Cardioprotection is strain dependent in rat in response to whole body hyperthermia Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H1208 - H1214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. S. RAY, J. L. MARTIN, E. A. SWANSON, H. OTANI, W. H. DILLMANN, and D. K. DAS Transgene overexpression of {alpha}B crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusion FASEB J, February 1, 2001; 15(2): 393 - 402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Lipton, A. P. Bautista, J. B. Delcarpio, and K. H. McDonough Effects of endotoxin on neutrophil-mediated I/R injury in isolated perfused rat hearts Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H802 - H811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Chang, A. A. Knowlton, F. Xu, and J. S. Wasser Activation of the heat shock response: relationship to energy metabolites. A 31P NMR study in rat hearts Am J Physiol Heart Circ Physiol, January 1, 2001; 280(1): H426 - H433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Oxman, M. Shapira, A. Diver, R. Klein, N. Avazov, and B. Rabinowitz A new method of long-term preventive cardioprotection using Lactobacillus Am J Physiol Heart Circ Physiol, May 1, 2000; 278(5): H1717 - H1724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Mizushima, P. Wang, D. Jarrar, W. G. Cioffi, K. I. Bland, and I. H. Chaudry Preinduction of heat shock proteins protects cardiac and hepatic functions following trauma and hemorrhage Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2000; 278(2): R352 - R359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Chang, A. A. Knowlton, and J. S. Wasser Expression of heat shock proteins in turtle and mammal hearts: relationship to anoxia tolerance Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2000; 278(1): R209 - R214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Joyeux, P. Faure, D. Godin-Ribuot, S. Halimi, A. Patel, D. M Yellon, P. Demenge, and C. Ribuot Heat stress fails to protect myocardium of streptozotocin-induced diabetic rats against infarction Cardiovasc Res, September 1, 1999; 43(4): 939 - 946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. G. Noble, A. Moraska, R. S. Mazzeo, D. A. Roth, M. C. Olsson, R. L. Moore, and M. Fleshner Differential expression of stress proteins in rat myocardium after free wheel or treadmill run training J Appl Physiol, May 1, 1999; 86(5): 1696 - 1701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Taylor, M. B. Harris, and J. W. Starnes Acute exercise can improve cardioprotection without increasing heat shock protein content Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H1098 - H1102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Nishizawa, A. Nakai, K. Matsuda, M. Komeda, T. Ban, and K. Nagata Reactive Oxygen Species Play an Important Role in the Activation of Heat Shock Factor 1 in Ischemic-Reperfused Heart Circulation, February 23, 1999; 99(7): 934 - 941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. DiCarlo, J. M. Farrell, and T. A. Litovitz Myocardial Protection Conferred by Electromagnetic Fields Circulation, February 16, 1999; 99(6): 813 - 816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gowda, C. Yang, G. K. Asimakis, S. Rastegar, and M. Motamedi Heat shock improves recovery and provides protection against global ischemia after hypothermic storage Ann. Thorac. Surg., December 1, 1998; 66(6): 1991 - 1997. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Yamashita, S. Hoshida, N. Taniguchi, T. Kuzuya, and M. Hori Whole-Body Hyperthermia Provides Biphasic Cardioprotection Against Ischemia/Reperfusion Injury in the Rat Circulation, October 6, 1998; 98(14): 1414 - 1421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Joyeux, C. Lagneux, G. Bricca, D. M. Yellon, P. Demenge, and C. Ribuot Heat stress-induced resistance to myocardial infarction in the isolated heart from transgenic [(mREN-2)27] hypertensive rats Cardiovasc Res, October 1, 1998; 40(1): 124 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. J. Benjamin and D. R. McMillan Stress (Heat Shock) Proteins : Molecular Chaperones in Cardiovascular Biology and Disease Circ. Res., July 27, 1998; 83(2): 117 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Miyamae, M. M. Rodriguez, S. A. Camacho, I. Diamond, D. Mochly-Rosen, and V. M. Figueredo Activation of varepsilon protein kinase C correlates with a cardioprotective effect of regular ethanol consumption PNAS, July 7, 1998; 95(14): 8262 - 8267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Gaudio, G. Thulin, A. Mann, M. Kashgarian, and N. J. Siegel Role of heat stress response in the tolerance of immature renal tubules to anoxia Am J Physiol Renal Physiol, June 1, 1998; 274(6): F1029 - F1036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gowda, C.-j. Yang, G. K. Asimakis, J. Ruef, S. Rastegar, M. S. Runge, and M. Motamedi Cardioprotection by Local Heating: Improved Myocardial Salvage After Ischemia and Reperfusion Ann. Thorac. Surg., May 1, 1998; 65(5): 1241 - 1247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Meldrum Tumor necrosis factor in the heart Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1998; 274(3): R577 - R595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. J. Schultz, A. K. Hsu, H. Nagase, and G. J. Gross TAN-67, a delta 1-opioid receptor agonist, reduces infarct size via activation of Gi/o proteins and KATP channels Am J Physiol Heart Circ Physiol, March 1, 1998; 274(3): H909 - H914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Amrani, N. Latif, K. Morrison, Gray, J. Jayakumar, J. Corbett, Goodwin, Dunn, and Yacoub Relative induction of heat shock protein in coronary endothelial cells and cardiomyocytes: Implications for myocardial protection J. Thorac. Cardiovasc. Surg., January 1, 1998; 115(1): 200 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Martin, R. Mestril, R. Hilal-Dandan, L. L. Brunton, and W. H. Dillmann Small Heat Shock Proteins and Protection Against Ischemic Injury in Cardiac Myocytes Circulation, December 16, 1997; 96(12): 4343 - 4348. [Abstract] [Full Text]
|
|
|
|
|
|
E.-X. Lu, S.-X. Chen, M.-D. Yuan, T.-H. Hu, H.-C. Zhou, W.-J. Luo, G.-H. Li, and L.-M. Xu Preconditioning Improves Myocardial Preservation in Patients Undergoing Open Heart Operations Ann. Thorac. Surg., November 1, 1997; 64(5): 1320 - 1324. [Abstract] [Full Text]
|
|
|
|
|
|
J. B. Hoag, Y.-Z. Qian, M. A. Nayeem, M. D'Angelo, and R. C. Kukreja ATP-sensitive potassium channel mediates delayed ischemic protection by heat stress in rabbit heart Am J Physiol Heart Circ Physiol, November 1, 1997; 273(5): H2458 - H2464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nakano, D. L. Mann, and A. A. Knowlton Blocking the Endogenous Increase in HSP 72 Increases Susceptibility to Hypoxia and Reoxygenation in Isolated Adult Feline Cardiocytes Circulation, March 18, 1997; 95(6): 1523 - 1531. [Abstract] [Full Text]
|
|
|
|
|
|
J. Nishizawa, A. Nakai, T. Higashi, M. Tanabe, S. Nomoto, K. Matsuda, T. Ban, and K. Nagata Reperfusion Causes Significant Activation of Heat Shock Transcription Factor 1 in Ischemic Rat Heart Circulation, November 1, 1996; 94(9): 2185 - 2192. [Abstract] [Full Text]
|
|
|
|
|
|
J. J. Hutter, R. Mestril, E. K.W. Tam, R. E. Sievers, W. H. Dillmann, and C. L. Wolfe Overexpression of Heat Shock Protein 72 in Transgenic Mice Decreases Infarct Size In Vivo Circulation, September 15, 1996; 94(6): 1408 - 1411. [Abstract] [Full Text]
|
|
|
|
|
|
M. Amrani, J. Corbett, S. Y. Boateng, M. J. Dunn, and M. H. Yacoub Kinetics of Induction and Protective Effect of Heat-Shock Proteins After Cardioplegic Arrest Ann. Thorac. Surg., May 1, 1996; 61(5): 1407 - 1411. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Auyeung, R. E. Sievers, D. Weng, V. Barbosa, and C. L. Wolfe Catalase Inhibition With 3-Amino-1,2,4-Triazole Does Not Abolish Infarct Size Reduction in Heat-Shocked Rats Circulation, December 1, 1995; 92(11): 3318 - 3322. [Abstract] [Full Text]
|
|
|
|
|
|
N. Maulik, R. M. Engelman, Z. Wei, X. Liu, J. A. Rousou, J. E. Flack, D. W. Deaton, and D. K. Das Drug-Induced Heat-Shock Preconditioning Improves Postischemic Ventricular Recovery After Cardiopulmonary Bypass Circulation, November 1, 1995; 92(9): 381 - 388. [Abstract] [Full Text]
|
|
|
|
|
|
B. L. Robinson, T. Morita, D. O. Toft, and J. J. Morris Accelerated recovery of postischemic stunned myocardium after induced expression of myocardial heat-shock protein (HSP70) J. Thorac. Cardiovasc. Surg., April 1, 1995; 109(4): 753 - 764. [Abstract] [Full Text]
|
|
|
|
|
|
L. B. McGrath, M. Locke, M. Cane, C. Chen, and C. D. Ianuzzo Heat shock protein (HSP 72) expression in patients undergoing cardiac operations J. Thorac. Cardiovasc. Surg., February 1, 1995; 109(2): 370 - 376. [Abstract] [Full Text]
|
|
|
|
|
|
H. H. Patel, A. Hsu, and G. J. Gross Attenuation of heat shock-induced cardioprotection by treatment with the opiate receptor antagonist naloxone Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2011 - H2017. [Abstract] [Full Text] [PDF]
|
|