Circulation, Vol 85, 730-737, Copyright © 1992 by American Heart Association
XS Wu, DL Ewert, YH Liu and EL Ritman
BACKGROUND. The goal of this study was to explore the role of several
factors that affect intramyocardial blood volume by using minimally
invasive computed tomography. Anesthetized dogs were scanned with the
dynamic spatial reconstructor, a high-speed tomographic scanner, during
injection of a bolus of iohexol into the aortic root. METHODS AND RESULTS.
In control dogs, it is indicated that the fraction of myocardium that is
blood (FMB, %) relates to myocardial perfusion (F, milliliters per gram per
minute) in that region as FMB congruent to a.F1/2, where a = 9.5 +/- 1.2%
(milliliters times minute per gram)1/2 (mean +/- SD) in the subendocardium
and a = 9.6 +/- 1.1% in the subepicardium. In another group of dogs, for
the myocardium perfused by a stenosed epicardial artery, a increased to
approximately 10 for a 25- 43% stenosis (or pressure gradient of 9 mm Hg
across narrowing) and to greater than 11 for a 50-55% stenosis (or pressure
gradient of 40 mm Hg across narrowing). In these dogs, flow was not
impaired under control hemodynamic conditions, but the usual increase of
flow (i.e., flow reserve) observed under maximum vasodilation conditions
was impaired. In another group of dogs, progressive embolization (using
15-microns- diameter microspheres) of the left ventricular myocardial
microcirculation caused the value of a to remain at approximately 9.5 with
embolization up to 50% of the fatal dose of microspheres, but it then
decreased progressively with embolization to 4.6 at the fatal dose.
CONCLUSIONS. We conclude that the FMB/F relation reflects hemodynamic
conductance at the microvascular level.
ARTICLES
In vivo relation of intramyocardial blood volume to myocardial perfusion. Evidence supporting microvascular site for autoregulation
Beijing Anzhen Hospital, China.
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