Circulation, Vol 85, 420-433, Copyright © 1992 by American Heart Association
JW Fleming, PL Wisler and AM Watanabe
The role of G proteins in mediating the responses of the heart to
circulating catecholamines and to the influences of the autonomic nervous
system is of special interest to cardiologists. It is evident that G
proteins are essential links in the cascade of biochemical events that
ensure when neurotransmitters and hormones interact with receptors on
myocardial cells. It is likely [corrected] that dysfunction of G proteins
plays a role in cardiovascular pathophysiology. With current methodologies,
especially molecular biological and recombinant DNA techniques, and with
transgenic animal models that can relate physiological function and
specific gene dosage, some cardiovascular diseases may be traced to G
protein-related defects.
ARTICLES
Signal transduction by G proteins in cardiac tissues [published erratum appears in Circulation 1992 Aug;86(2):698]
Department of Medicine, Indiana University School of Medicine, Indianapolis.
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