Circulation, Vol 84, 613-617, Copyright © 1991 by American Heart Association
E Thaulow, J Erikssen, L Sandvik, H Stormorken and PF Cohn
BACKGROUND. Experimental animal and clinical studies indicate that blood
platelets have an important role in atherosclerosis and formation of
thrombi. Prospective studies presenting evidence of an association between
blood platelet count and cardiovascular mortality have not been performed.
METHODS AND RESULTS. From 1973 to 1975, blood platelets were counted, and
their responsiveness to aggregating agents was studied in healthy
middle-aged men. The aim was to assess the possible association between
these variables and coronary heart disease. At 13.5 years of follow up, a
significantly higher coronary heart disease mortality was observed among
the 25% of subjects with the highest platelet counts. Platelet aggregation
performed in a random subsample (150 of the 487 men), moreover, revealed
that the 50% with the most rapid aggregation response after ADP stimulation
had significantly increased coronary heart disease mortality compared with
the others. These associations could not be explained by differences in
age, lipids, blood pressure, or smoking habits. CONCLUSIONS. The present
study is the first to present conclusive, prospective evidence of an
association between platelet concentration and aggregability and long-term
incidence of fatal coronary heart disease in a population of apparently
healthy middle-aged men.
ARTICLES
Blood platelet count and function are related to total and cardiovascular death in apparently healthy men
Med. Dept. B, Rikshospitalet, Oslo, Norway.
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