Circulation, Vol 84, 558-566, Copyright © 1991 by American Heart Association
JH Levine, ED Mellits, RA Baumgardner, EP Veltri, M Mower, L Grunwald, T Guarnieri, D Aarons and LS Griffith
BACKGROUND. Two hundred eighteen patients were evaluated in a two-phase
approach (time to first appropriate discharge, survival after discharge) to
identify factors that may be related to maximal benefit derived from use of
an automatic implantable cardioverter-defibrillator (AICD). METHODS AND
RESULTS. One hundred ninety-seven patients survived implantation of AICD,
with or without concomitant cardiac surgery. One hundred five patients had
an AICD discharge associated with syncope, presyncope, documented sustained
ventricular tachycardia or fibrillation, or sleep at 9.1 +/- 11.1 months
after implantation. Patients survived 23.8 +/- 18.0 months after AICD
discharge. Left ventricular dysfunction (p = 0.008 for ejection fraction
less than 25%) was associated with earlier AICD discharge and shortened
survival after AICD discharge (p = 0.008 for ejection fraction less than
25%; p = 0.01 for New York Heart Association functional class III and IV).
beta- Blocker administration (p = 0.006) and coronary bypass surgery (p =
0.06) were associated with later AICD discharge. Coronary bypass surgery (p
= 0.035) but not beta-blockers was associated with more prolonged survival
after AICD discharge. CONCLUSIONS. These data suggest that a relatively
easy algorithm can be applied to predict which patient will benefit most
from AICD implantation.
ARTICLES
Predictors of first discharge and subsequent survival in patients with automatic implantable cardioverter-defibrillators
Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Md.
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