Circulation, Vol 83, 2012-2020, Copyright © 1991 by American Heart Association
FC Tanner, G Noll, CM Boulanger and TF Luscher
BACKGROUND. We studied the effects of low density lipoprotein (LDL) on
endothelium function. METHODS AND RESULTS. Porcine epicardial and
intramyocardial coronary arteries suspended in organ chambers for isometric
tension recording were exposed to LDL for 2 hours and were then washed. In
epicardial coronary arteries, oxidized LDL (30-300 micrograms/ml) but not
native LDL or lysolecithin inhibited endothelium- dependent relaxations to
serotonin, thrombin, and aggregating platelets (5,000-75,000/microliter).
Endothelium-dependent relaxations to bradykinin and A23187 and
endothelium-independent relaxations to SIN-1 were unaffected by oxidized
LDL. In intramyocardial coronary arteries, oxidized LDL had no appreciable
effect on relaxations to serotonin. The effect of oxidized LDL on the
response to serotonin in epicardial coronary arteries was completely
prevented by dextran sulfate (10 micrograms/ml). The inhibitory effect of
oxidized LDL persisted in the presence of pertussis toxin. Similar to the
lipoproteins, L-NG- monomethyl arginine (L-NMMA) reduced relaxations to
serotonin but not to bradykinin in epicardial coronary arteries. In the
presence of L- NMMA, oxidized LDL further reduced the response to
serotonin. In arteries in which relaxations to serotonin were inhibited by
oxidized LDL, L-arginine but not D-arginine induced a full relaxation.
Pretreatment with L-arginine potentiated relaxations to serotonin in
arteries exposed to oxidized LDL. CONCLUSIONS. Thus, oxidized LDL activates
the scavenger receptor on endothelial cells and inhibits the
receptor-operated nitric oxide formation in epicardial but not in
intramyocardial coronary arteries. The mechanism is not related to
dysfunction of a Gi protein but is related to a reduced intracellular
availability of L-arginine. The reduced nitric oxide formation at sites of
early atherosclerotic lesions may favor platelet aggregation and vasospasm,
both of which are known clinical events in patients with coronary artery
disease.
ARTICLES
Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide
Department of Research, University Hospital, Basel, Switzerland.
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|
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|
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|
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|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
K. Egashira, Y. Hirooka, T. Kuga, M. Mohri, and A. Takeshita Effects of L-Arginine Supplementation on Endothelium-Dependent Coronary Vasodilation in Patients With Angina Pectoris and Normal Coronary Arteriograms Circulation, July 15, 1996; 94(2): 130 - 134. [Abstract] [Full Text]
|
|
|
|
|
|
K. Miwa, Y. Miyagi, A. Igawa, K. Nakagawa, and H. Inoue Vitamin E Deficiency in Variant Angina Circulation, July 1, 1996; 94(1): 14 - 18. [Abstract] [Full Text]
|
|
|
|
|
|
T. J. Anderson, I. T. Meredith, F. Charbonneau, A. C. Yeung, B. Frei, A. P. Selwyn, and P. Ganz Endothelium-Dependent Coronary Vasomotion Relates to the Susceptibility of LDL to Oxidation in Humans Circulation, May 1, 1996; 93(9): 1647 - 1650. [Abstract] [Full Text]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 K. L. Gould, D. Ornish, L. Scherwitz, S. Brown, R. P. Edens, M. J. Hess, N. Mullani, L. Bolomey, F. Dobbs, W. T. Armstrong, et al. Changes in Myocardial Perfusion Abnormalities by Positron Emission Tomography After Long-term, Intense Risk Factor Modification JAMA, September 20, 1995; 274(11): 894 - 901. [Abstract] [PDF]
|
|
|
|
|
|
J. Galle, J. Bengen, P. Schollmeyer, and C. Wanner Impairment of Endothelium-Dependent Dilation in Rabbit Renal Arteries by Oxidized Lipoprotein(a) : Role of Oxygen-Derived Radicals Circulation, September 15, 1995; 92(6): 1582 - 1589. [Abstract] [Full Text]
|
|
|
|
|
|
J. Czernin, R. J. Barnard, K. T. Sun, J. Krivokapich, E. Nitzsche, D. Dorsey, M. E. Phelps, and H. R. Schelbert Effect of Short-term Cardiovascular Conditioning and Low-Fat Diet on Myocardial Blood Flow and Flow Reserve Circulation, July 15, 1995; 92(2): 197 - 204. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Zembowicz, J.-l. Tang, and K. K. Wu Transcriptional Induction of Endothelial Nitric Oxide Synthase Type III by Lysophosphatidylcholine J. Biol. Chem., July 14, 1995; 270(28): 17006 - 17010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-B. Peng, T. B. Rajavashisth, P. Libby, and J. K. Liao Nitric Oxide Inhibits Macrophage-Colony Stimulating Factor Gene Transcription in Vascular Endothelial Cells J. Biol. Chem., July 14, 1995; 270(28): 17050 - 17055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-A. Lehr, B. Frei, A. M. Olofsson, T. E. Carew, and K.-E. Arfors Protection From Oxidized LDL–Induced Leukocyte Adhesion to Microvascular and Macrovascular Endothelium In Vivo by Vitamin C but Not by Vitamin E Circulation, March 1, 1995; 91(5): 1525 - 1532. [Abstract] [Full Text]
|
|
|
|
|
|
R. W. Alexander Hypertension and the Pathogenesis of Atherosclerosis : Oxidative Stress and the Mediation of Arterial Inflammatory Response: A New Perspective Hypertension, February 1, 1995; 25(2): 155 - 161. [Abstract] [Full Text]
|
|
|
|
|
|
J. K. Liao, W. S. Shin, W. Y. Lee, and S. L. Clark Oxidized Low-density Lipoprotein Decreases the Expression of Endothelial Nitric Oxide Synthase J. Biol. Chem., January 6, 1995; 270(1): 319 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Cooke, P. Tsao, A. Singer, B.-y. Wang, J. Kosek, and H. Drexler Anti-Atherogenic Effect of Nuts: Is the Answer NO? Arch Intern Med, April 12, 1993; 153(7): 896 - 899. [Abstract] [PDF]
|
|
|
|
 |
|
 F. C Tanner, M. R Tschudi, and T. F Luscher Endothelium, lipoproteins and atherosclerotic vascular disease Vascular Medicine, September 1, 1991; 2(2): 161 - 176. [Abstract] [PDF]
|
|
|
|
|
|
L. Cominacini, A. Rigoni, A. F. Pasini, U. Garbin, A. Davoli, M. Campagnola, A. M. Pastorino, V. Lo Cascio, and T. Sawamura The Binding of Oxidized Low Density Lipoprotein (ox-LDL) to ox-LDL Receptor-1 Reduces the Intracellular Concentration of Nitric Oxide in Endothelial Cells through an Increased Production of Superoxide J. Biol. Chem., April 20, 2001; 276(17): 13750 - 13755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Spieker, I. Sudano, D. Hurlimann, P. G. Lerch, M. G. Lang, C. Binggeli, R. Corti, F. Ruschitzka, T. F. Luscher, and G. Noll High-Density Lipoprotein Restores Endothelial Function in Hypercholesterolemic Men Circulation, March 26, 2002; 105(12): 1399 - 1402. [Abstract] [Full Text] [PDF]
|
|