Circulation, Vol 82, 922-929, Copyright © 1990 by American Heart Association
FJ Neumann, W Waas, C Diehm, T Weiss, HM Haupt, R Zimmermann, H Tillmanns and W Kubler
This study investigated local alterations in neutrophil activation and
deformability after intermittent claudication. In 17 patients with one-
sided peripheral arterial occlusive disease, neutrophil count, proportion
of activated neutrophils (by nitro blue tetrazolium test), and neutrophil
filterability as a measure of passive deformability were assessed in the
femoral arterial and venous blood of the diseased leg and in the femoral
venous blood of the healthy leg (n = 10). The values were obtained at rest,
immediately after claudication, and 10 minutes after claudication induced
by repetitive toe stands. Immediately after exercise, the arterial and
venous blood differences in the diseased leg were 1) neutrophil count, 9%
(95% confidence interval [CI], 5-14%; relative increase in the venous blood
compared with arterial blood); 2) the proportion of activated neutrophils,
26% (CI, 10-42%); and 3) the neutrophil filterability, -10% (CI, -4% to
-15%). At rest and 10 minutes after exercise, neutrophil parameters did not
differ significantly between the femoral arterial and venous blood.
Furthermore, no arterial and venous blood differences in the neutrophil
parameters were found in the healthy leg. In addition to local changes,
systemic changes occurred immediately after exercise. In the femoral
arterial blood, the total neutrophil count had risen by 13% (CI, 8- 18%),
the proportion of activated neutrophils had risen by 41% (CI, 25- 58%), and
average neutrophil rigidity had risen 17% (CI, 11-22%) compared with the
values obtained before exercise. At 10 minutes after exercise, all
neutrophil parameters were still elevated. We conclude that even short
periods of ischemia, as in intermittent claudication, cause local
alterations in neutrophil function and distribution.
ARTICLES
Activation and decreased deformability of neutrophils after intermittent claudication
Medizinische Universitatsklinik III (Kardiologie), Ruprecht-Karls Universitat Heidelberg, FRG.
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