| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Circulation, Vol 81, 1161-1172, Copyright © 1990 by American Heart Association
MA Pfeffer and E Braunwald
An acute myocardial infarction, particularly one that is large and
transmural, can produce alterations in the topography of both the infarcted
and noninfarcted regions of the ventricle. This remodeling can importantly
affect the function of the ventricle and the prognosis for survival. In the
early period, infarct expansion has been recognized by echocardiography as
a lengthening of the noncontractile region. The noninfarcted region also
undergoes an important lengthening that is consistent with a secondary
volume-overload hypertrophy and that can be progressive. The extent of
ventricular enlargement after infarction is related to the magnitude of the
initial damage to the myocardium and, although an increase in cavity size
tends to restore stroke volume despite a persistently depressed ejection
fraction, ventricular dilation has been associated with a reduction in
survival. The process of ventricular enlargement can be influenced by three
interdependent factors, that is, infarct size, infarct healing, and
ventricular wall stresses. A most effective way to prevent or minimize the
increase in ventricular size after infarction and the consequent adverse
effect on prognosis is to limit the initial insult. Acute reperfusion
therapy has been consistently shown to result in a reduction in ventricular
volume. The reestablishment of blood flow to the infarcted region, even
beyond the time frame for myocyte salvage, has beneficial effects in
attenuating ventricular enlargement. The process of scarification can be
interfered with during the acute infarct period by the administration of
glucocorticosteroids and nonsteroidal antiinflammatory agents, which result
in thinner infarcts and greater degrees of infarct expansion. Modification
of distending or deforming forces can importantly influence ventricular
enlargement. Even short-term augmentations in afterload have deleterious
long-term effects on ventricular topography. Conversely, judicious use of
nitroglycerin seems to be associated with an attenuation of infarct
expansion and long-term improvement in clinical outcome. Long-term therapy
with an angiotensin converting enzyme inhibitor can favorably alter the
loading conditions on the left ventricle and reduce progressive ventricular
enlargement as demonstrated in both experimental and clinical studies. With
the former therapy, this attenuation of ventricular enlargement was
associated with a prolongation in survival. The long-term clinical
consequences of long- term angiotensin converting enzyme inhibitor therapy
after myocardial infarction is currently being evaluated. Although studies
directed at attenuating left ventricular remodeling after infarction are in
the early stages, it does seem that this will be an important area in which
future research might improve long-term outcome after infarction.
ARTICLES
Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications
Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115.
This article has been cited by other articles:
 |
|
 |
|
  G. Dwivedi, R. Janardhanan, S. A. Hayat, T. K. Lim, and R. Senior Improved prediction of outcome by contrast echocardiography determined left ventricular remodelling parameters compared to unenhanced echocardiography in patients following acute myocardial infarction Eur J Echocardiogr, December 1, 2009; 10(8): 933 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. P. Singh, L. A. Sleeper, S. Lipshultz, A. Cinar, C. Canter, S. A. Webber, D. Bernstein, E. Pahl, J. A. Alvarez, J. D. Wilkinson, et al. Association of Left Ventricular Dilation at Listing for Heart Transplant With Postlisting and Early Posttransplant Mortality in Children With Dilated Cardiomyopathy Circ Heart Fail, November 1, 2009; 2(6): 591 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W.M. van den Borne, V. A.M. van de Schans, A. E. Strzelecka, H. T.M. Vervoort-Peters, P. M. Lijnen, J. P.M. Cleutjens, J. F.M. Smits, M. J.A.P. Daemen, B. J.A. Janssen, and W. M. Blankesteijn Mouse strain determines the outcome of wound healing after myocardial infarction Cardiovasc Res, November 1, 2009; 84(2): 273 - 282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Turakhia, D. D. McManus, M. A. Whooley, and N. B. Schiller Increase in end-systolic volume after exercise independently predicts mortality in patients with coronary heart disease: data from the Heart and Soul Study Eur. Heart J., October 2, 2009; 30(20): 2478 - 2484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Ahmet, C. Morrell, E. G. Lakatta, and M. I. Talan Therapeutic Efficacy of a Combination of a {beta}1-Adrenoreceptor (AR) Blocker and {beta}2-AR Agonist in a Rat Model of Postmyocardial Infarction Dilated Heart Failure Exceeds That of a {beta}1-AR Blocker plus Angiotensin-Converting Enzyme Inhibitor J. Pharmacol. Exp. Ther., October 1, 2009; 331(1): 178 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Schachinger, B. Assmus, S. Erbs, A. Elsasser, W. Haberbosch, R. Hambrecht, J. Yu, R. Corti, D. G. Mathey, C. W. Hamm, et al. Intracoronary infusion of bone marrow-derived mononuclear cells abrogates adverse left ventricular remodelling post-acute myocardial infarction: insights from the reinfusion of enriched progenitor cells and infarct remodelling in acute myocardial infarction (REPAIR-AMI) trial Eur J Heart Fail, October 1, 2009; 11(10): 973 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Liistro, S. Grotti, P. Angioli, G. Falsini, K. Ducci, S. Baldassarre, A. Sabini, R. Brandini, E. Capati, and L. Bolognese Impact of Thrombus Aspiration on Myocardial Tissue Reperfusion and Left Ventricular Functional Recovery and Remodeling After Primary Angioplasty Circ Cardiovasc Interv, October 1, 2009; 2(5): 376 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Goldfarb, M. Roth, and J. Han Myocardial Fat Deposition after Left Ventricular Myocardial Infarction: Assessment by Using MR Water-Fat Separation Imaging Radiology, October 1, 2009; 253(1): 65 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Ostadal, I. Netuka, J. Maly, J. Besik, and I. Ostadalova Gender Differences in Cardiac Ischemic Injury and Protection--Experimental Aspects Experimental Biology and Medicine, September 1, 2009; 234(9): 1011 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Takemura, M. Nakagawa, H. Kanamori, S. Minatoguchi, and H. Fujiwara Benefits of reperfusion beyond infarct size limitation Cardiovasc Res, July 15, 2009; 83(2): 269 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. D. Boudoulas and A. K. Hatzopoulos Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease Dis. Model. Mech., July 1, 2009; 2(7-8): 344 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Nicolosi, S. Golcea, C. Ceconi, G. Parrinello, A. Decarli, M. Chiariello, W. J. Remme, L. Tavazzi, R. Ferrari, and on behalf of the PREAMI Investigators Effects of perindopril on cardiac remodelling and prognostic value of pre-discharge quantitative echocardiographic parameters in elderly patients after acute myocardial infarction: the PREAMI echo sub-study Eur. Heart J., July 1, 2009; 30(13): 1656 - 1665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yousef, C. M. Schannwell, M. Kostering, T. Zeus, M. Brehm, and B. E. Strauer The BALANCE Study: clinical benefit and long-term outcome after intracoronary autologous bone marrow cell transplantation in patients with acute myocardial infarction. J. Am. Coll. Cardiol., June 16, 2009; 53(24): 2262 - 2269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Y. Kwong and M. A. Pfeffer Infarct haemorrhage detected by cardiac magnetic resonance imaging: are we seeing the latest culprit in adverse left ventricular remodelling? Eur. Heart J., June 2, 2009; 30(12): 1431 - 1433. [Full Text] [PDF]
|
|
|
|
 |
|
 C.-S. Kang, C.-C. Chen, C.-C. Lin, N.-C. Chang, and T.-M. Lee Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts Am J Physiol Heart Circ Physiol, June 1, 2009; 296(6): H1949 - H1959. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Venkatachalam, B. Venkatesan, A. J. Valente, P. C. Melby, S. Nandish, J. E. B. Reusch, R. A. Clark, and B. Chandrasekar WISP1, a Pro-mitogenic, Pro-survival Factor, Mediates Tumor Necrosis Factor-{alpha} (TNF-{alpha})-stimulated Cardiac Fibroblast Proliferation but Inhibits TNF-{alpha}-induced Cardiomyocyte Death J. Biol. Chem., May 22, 2009; 284(21): 14414 - 14427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Funaro, G. La Torre, M. Madonna, L. Galiuto, A. Scara, A. Labbadia, E. Canali, A. Mattatelli, F. Fedele, F. Alessandrini, et al. Incidence, determinants, and prognostic value of reverse left ventricular remodelling after primary percutaneous coronary intervention: results of the Acute Myocardial Infarction Contrast Imaging (AMICI) multicenter study Eur. Heart J., March 1, 2009; 30(5): 566 - 575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhong, Y. Su, S.-Y. Yeo, R.-S. Tan, D. N. Ghista, and G. Kassab Left ventricular regional wall curvedness and wall stress in patients with ischemic dilated cardiomyopathy Am J Physiol Heart Circ Physiol, March 1, 2009; 296(3): H573 - H584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kohno, T. Anzai, K. Naito, T. Miyasho, M. Okamoto, H. Yokota, S. Yamada, Y. Maekawa, T. Takahashi, T. Yoshikawa, et al. Role of high-mobility group box 1 protein in post-infarction healing process and left ventricular remodelling Cardiovasc Res, February 15, 2009; 81(3): 565 - 573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Landmesser, K. C. Wollert, and H. Drexler Potential novel pharmacological therapies for myocardial remodelling Cardiovasc Res, February 15, 2009; 81(3): 519 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hori and K. Nishida Oxidative stress and left ventricular remodelling after myocardial infarction Cardiovasc Res, February 15, 2009; 81(3): 457 - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Milliez, S. Messaoudi, J. Nehme, C. Rodriguez, J.-L. Samuel, and C. Delcayre Beneficial effects of delayed ivabradine treatment on cardiac anatomical and electrical remodeling in rat severe chronic heart failure Am J Physiol Heart Circ Physiol, February 1, 2009; 296(2): H435 - H441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Huang, J. Rubinstein, A. R. Prieto, L. V. Thang, and D. H. Wang Transient Receptor Potential Vanilloid Gene Deletion Exacerbates Inflammation and Atypical Cardiac Remodeling After Myocardial Infarction Hypertension, February 1, 2009; 53(2): 243 - 250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Kramer Insights into Myocardial Microstructure During Infarct Healing and Remodeling: Pathologists Need Not Apply Circ Cardiovasc Imaging, January 1, 2009; 2(1): 4 - 5. [Full Text] [PDF]
|
|
|
|
|
|
P. G. Masci, S. Dymarkowski, F. E. Rademakers, and J. Bogaert Determination of Regional Ejection Fraction in Patients with Myocardial Infarction by Using Merged Late Gadolinium Enhancement and Cine MR: Feasibility Study Radiology, January 1, 2009; 250(1): 50 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hishikari, J.-i. Suzuki, M. Ogawa, K. Isobe, T. Takahashi, M. Onishi, K. Takayama, and M. Isobe Pharmacological activation of the prostaglandin E2 receptor EP4 improves cardiac function after myocardial ischaemia/reperfusion injury Cardiovasc Res, January 1, 2009; 81(1): 123 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ishii, T. Amano, T. Matsubara, and T. Murohara Pharmacological Intervention for Prevention of Left Ventricular Remodeling and Improving Prognosis in Myocardial Infarction Circulation, December 16, 2008; 118(25): 2710 - 2718. [Full Text] [PDF]
|
|
|
|
|
|
S. W.M. van den Borne, S. Isobe, J. W. Verjans, A. Petrov, D. Lovhaug, P. Li, H. R. Zandbergen, Y. Ni, P. Frederik, J. Zhou, et al. Molecular Imaging of Interstitial Alterations in Remodeling Myocardium After Myocardial Infarction J. Am. Coll. Cardiol., December 9, 2008; 52(24): 2017 - 2028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gnecchi, Z. Zhang, A. Ni, and V. J. Dzau Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy Circ. Res., November 21, 2008; 103(11): 1204 - 1219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Myerburg Implantable Cardioverter-Defibrillators after Myocardial Infarction N. Engl. J. Med., November 20, 2008; 359(21): 2245 - 2253. [Full Text] [PDF]
|
|
|
|
 |
|
 E. Lara-Pezzi, L. E. Felkin, E. J. Birks, P. Sarathchandra, K. D. Panse, R. George, J. L. Hall, M. H. Yacoub, N. Rosenthal, and P. J. R. Barton Expression of Follistatin-Related Genes Is Altered in Heart Failure Endocrinology, November 1, 2008; 149(11): 5822 - 5827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Mulder, V. Mellin, J. Favre, M. Vercauteren, I. Remy-Jouet, C. Monteil, V. Richard, S. Renet, J. P. Henry, A. Y. Jeng, et al. Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone Eur. Heart J., September 1, 2008; 29(17): 2171 - 2179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kelly, S. Q. Khan, M. Thompson, G. Cockerill, L. L. Ng, N. Samani, and I. B. Squire Plasma tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-9: novel indicators of left ventricular remodelling and prognosis after acute myocardial infarction Eur. Heart J., September 1, 2008; 29(17): 2116 - 2124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ichinose, H. Otani, M. Oikawa, K. Takase, H. Saito, H. Shimokawa, and S. Takahashi MRI of Cardiac Sarcoidosis: Basal and Subepicardial Localization of Myocardial Lesions and Their Effect on Left Ventricular Function Am. J. Roentgenol., September 1, 2008; 191(3): 862 - 869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Ambler, Y. K. Hodges, G. M. Jones, C. S. Long, and L. D. Horwitz Prolonged administration of a dithiol antioxidant protects against ventricular remodeling due to ischemia-reperfusion in mice Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1303 - H1310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. V. Ennezat, N. Lamblin, F. Mouquet, O. Tricot, P. Quandalle, V. Aumegeat, O. Equine, O. Nugue, B. Segrestin, P. de Groote, et al. The effect of ageing on cardiac remodelling and hospitalization for heart failure after an inaugural anterior myocardial infarction Eur. Heart J., August 2, 2008; 29(16): 1992 - 1999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Carlsson, N. F. Osman, P. C. Ursell, A. J. Martin, and M. Saeed Quantitative MR measurements of regional and global left ventricular function and strain after intramyocardial transfer of VM202 into infarcted swine myocardium Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H522 - H532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Braunwald Biomarkers in Heart Failure N. Engl. J. Med., May 15, 2008; 358(20): 2148 - 2159. [Full Text] [PDF]
|
|
|
|
|
|
D. D. Schocken, E. J. Benjamin, G. C. Fonarow, H. M. Krumholz, D. Levy, G. A. Mensah, J. Narula, E. S. Shor, J. B. Young, and Y. Hong Prevention of Heart Failure: A Scientific Statement From the American Heart Association Councils on Epidemiology and Prevention, Clinical Cardiology, Cardiovascular Nursing, and High Blood Pressure Research; Quality of Care and Outcomes Research Interdisciplinary Working Group; and Functional Genomics and Translational Biology Interdisciplinary Working Group Circulation, May 13, 2008; 117(19): 2544 - 2565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. K. Yankey, T. Li, A. Kilic, G. Cheng, A. Satpute, K. Savai, S. Li, S. L. Moainie, D. Prastein, C. DeFillipi, et al. Regional remodeling strain and its association with myocardial apoptosis after myocardial infarction in an ovine model. J. Thorac. Cardiovasc. Surg., May 1, 2008; 135(5): 991 - 998.e2. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gourine, S. I. Bondar, K. M. Spyer, and A. V. Gourine Beneficial Effect of the Central Nervous System {beta}-Adrenoceptor Blockade on the Failing Heart Circ. Res., March 28, 2008; 102(6): 633 - 636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. F. Lewis, E. J. Velazquez, S. D. Solomon, A. S. Hellkamp, J. J.V. McMurray, J. Mathias, J.-L. Rouleau, A. P. Maggioni, K. Swedberg, L. Kober, et al. Predictors of the first heart failure hospitalization in patients who are stable survivors of myocardial infarction complicated by pulmonary congestion and/or left ventricular dysfunction: a VALIANT study Eur. Heart J., March 2, 2008; 29(6): 748 - 756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Chachques, J. C. Trainini, N. Lago, M. Cortes-Morichetti, O. Schussler, and A. Carpentier Myocardial Assistance by Grafting a New Bioartificial Upgraded Myocardium (MAGNUM Trial): Clinical Feasibility Study Ann. Thorac. Surg., March 1, 2008; 85(3): 901 - 908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-M. Lee, M.-S. Lin, and N.-C. Chang Physiological Concentration of 17{beta}-Estradiol on Sympathetic Reinnervation in Ovariectomized Infarcted Rats Endocrinology, March 1, 2008; 149(3): 1205 - 1213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. N. Salloum, A. Abbate, A. Das, J.-E. Houser, C. A. Mudrick, I. Z. Qureshi, N. N. Hoke, S. K. Roy, W. R. Brown, S. Prabhakar, et al. Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1398 - H1406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nahrendorf, E. Aikawa, J.-L. Figueiredo, L. Stangenberg, S. W. van den Borne, W. M. Blankesteijn, D. E. Sosnovik, F. A. Jaffer, C.-H. Tung, and R. Weissleder Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction Eur. Heart J., February 2, 2008; 29(4): 445 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sato, M. Hiroe, T. Nozato, H. Hikita, Y. Ito, H. Ohigashi, M. Tamura, A. Takahashi, M. Isobe, and K. Aonuma Early validation study of 64-slice multidetector computed tomography for the assessment of myocardial viability and the prediction of left ventricular remodelling after acute myocardial infarction Eur. Heart J., February 2, 2008; 29(4): 490 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fukui, S. Kitagawa-Sakakida, S. Kawamata, G. Matsumiya, N. Kawaguchi, N. Matsuura, and Y. Sawa Therapeutic Effect of Midkine on Cardiac Remodeling in Infarcted Rat Hearts Ann. Thorac. Surg., February 1, 2008; 85(2): 562 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kelly, S. Khan, G. Cockerill, L.L. Ng, M. Thompson, N.J. Samani, and I.B. Squire Circulating Stromelysin-1 (MMP-3): A novel predictor of LV dysfunction, remodelling and all-cause mortality after acute myocardial infarction Eur J Heart Fail, February 1, 2008; 10(2): 133 - 139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Timmers, J. P.G. Sluijter, J. K. van Keulen, I. E. Hoefer, M. G.J. Nederhoff, M.-J. Goumans, P. A. Doevendans, C. J.A. van Echteld, J. A. Joles, P. H. Quax, et al. Toll-Like Receptor 4 Mediates Maladaptive Left Ventricular Remodeling and Impairs Cardiac Function After Myocardial Infarction Circ. Res., February 1, 2008; 102(2): 257 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Beeri, C. Yosefy, J. L. Guerrero, F. Nesta, S. Abedat, M. Chaput, F. del Monte, M. D. Handschumacher, R. Stroud, S. Sullivan, et al. Mitral regurgitation augments post-myocardial infarction remodeling failure of hypertrophic compensation. J. Am. Coll. Cardiol., January 29, 2008; 51(4): 476 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Agnihotri, J. C. Madsen, and W. M. Daggett Jr Surgical Treatment of Complications of Acute Myocardial Infarction: Postinfarction Ventricular Septal Defect and Free Wall Rupture Card. Surg. Adult, January 1, 2008; 3(2008): 753 - 784. [Full Text]
|
|
|
|
|
|
W. Y. Szeto, R. C. Gorman, J. H. Gorman III, and M. A. Acker Ischemic Mitral Regurgitation Card. Surg. Adult, January 1, 2008; 3(2008): 785 - 802. [Full Text]
|
|
|
|
|
|
T.-M. Lee, M.-S. Lin, and N.-C. Chang Effect of pravastatin on sympathetic reinnervation in postinfarcted rats Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3617 - H3626. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nahrendorf, F. K. Swirski, E. Aikawa, L. Stangenberg, T. Wurdinger, J.-L. Figueiredo, P. Libby, R. Weissleder, and M. J. Pittet The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions J. Exp. Med., November 26, 2007; 204(12): 3037 - 3047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bujak, G. Ren, H. J. Kweon, M. Dobaczewski, A. Reddy, G. Taffet, X.-F. Wang, and N. G. Frangogiannis Essential Role of Smad3 in Infarct Healing and in the Pathogenesis of Cardiac Remodeling Circulation, November 6, 2007; 116(19): 2127 - 2138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Castardeli, D. R. Duarte, M. F. Minicucci, P. S. Azevedo, B. B. Matsubara, L. S. Matsubara, A. O. Campana, S. A.R. Paiva, and L. A.M. Zornoff Tobacco smoke-induced left ventricular remodelling is not associated with metalloproteinase-2 or -9 activation Eur J Heart Fail, November 1, 2007; 9(11): 1081 - 1085. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Galiuto, S. Barchetta, S. Paladini, G. Lanza, A. G Rebuzzi, M. Marzilli, and F. Crea Functional and structural correlates of persistent ST elevation after acute myocardial infarction successfully treated by percutaneous coronary intervention Heart, November 1, 2007; 93(11): 1376 - 1380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A.I. Virag, M. L. Rolle, J. Reece, S. Hardouin, E. O. Feigl, and C. E. Murry Fibroblast Growth Factor-2 Regulates Myocardial Infarct Repair: Effects on Cell Proliferation, Scar Contraction, and Ventricular Function Am. J. Pathol., November 1, 2007; 171(5): 1431 - 1440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sirivella and I. Gielchinsky Results of Coronary Bypass and Valve Operations for Mitral Valve Regurgitation Asian Cardiovasc Thorac Ann, October 1, 2007; 15(5): 396 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. G. Spinale Myocardial Matrix Remodeling and the Matrix Metalloproteinases: Influence on Cardiac Form and Function Physiol Rev, October 1, 2007; 87(4): 1285 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Uemura, M. Li, T. Tsutsumi, T. Yamazaki, T. Kawada, A. Kamiya, M. Inagaki, K. Sunagawa, and M. Sugimachi Efferent vagal nerve stimulation induces tissue inhibitor of metalloproteinase-1 in myocardial ischemia-reperfusion injury in rabbit Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2254 - H2261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Severino, M. Campioni, S. Straino, F. N. Salloum, N. Schmidt, U. Herbrand, S. Frede, G. Toietta, G. Di Rocco, R. Bussani, et al. Identification of Protein Disulfide Isomerase as a Cardiomyocyte Survival Factor in Ischemic Cardiomyopathy J. Am. Coll. Cardiol., September 11, 2007; 50(11): 1029 - 1037. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Beeri, C. Yosefy, J. L. Guerrero, S. Abedat, M. D. Handschumacher, R. E. Stroud, S. Sullivan, M. Chaput, D. Gilon, G. J. Vlahakes, et al. Early Repair of Moderate Ischemic Mitral Regurgitation Reverses Left Ventricular Remodeling: A Functional and Molecular Study Circulation, September 11, 2007; 116(11_suppl): I-288 - I-293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Shuros, R. W. Salo, V. G. Florea, J. Pastore, M. A. Kuskowski, Y. Chandrashekhar, and I. S. Anand Ventricular Preexcitation Modulates Strain and Attenuates Cardiac Remodeling in a Swine Model of Myocardial Infarction Circulation, September 4, 2007; 116(10): 1162 - 1169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Chen, R. Chang, B. Umakanthan, L. N. Stoletniy, and J. T. Heywood Improvement of Cardiac Function Persists Long Term With Medical Therapy for Left Ventricular Systolic Dysfunction Journal of Cardiovascular Pharmacology and Therapeutics, September 1, 2007; 12(3): 220 - 226. [Abstract] [PDF]
|
|
|
|
|
|
M. P. Chandler, E. E. Morgan, T. A. McElfresh, T. A. Kung, J. H. Rennison, B. D. Hoit, and M. E. Young Heart failure progression is accelerated following myocardial infarction in type 2 diabetic rats Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1609 - H1616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gomez, H. Thibault, A. Gharib, J.-M. Dumont, G. Vuagniaux, P. Scalfaro, G. Derumeaux, and M. Ovize Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1654 - H1661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Colston, S. D. de la Rosa, M. Koehler, K. Gonzales, R. Mestril, G. L. Freeman, S. R. Bailey, and B. Chandrasekar Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1839 - H1846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-M. Lee, M.-S. Lin, and N.-C. Chang Inhibition of histone deacetylase on ventricular remodeling in infarcted rats Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H968 - H977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Erbs, A. Linke, V. Schachinger, B. Assmus, H. Thiele, K.-W. Diederich, C. Hoffmann, S. Dimmeler, T. Tonn, R. Hambrecht, et al. Restoration of Microvascular Function in the Infarct-Related Artery by Intracoronary Transplantation of Bone Marrow Progenitor Cells in Patients With Acute Myocardial Infarction: The Doppler Substudy of the Reinfusion of Enriched Progenitor Cells and Infarct Remodeling in Acute Myocardial Infarction (REPAIR-AMI) Trial Circulation, July 24, 2007; 116(4): 366 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Cheung, D. A. Bluemke, R. Klein, A. R. Sharrett, F.M. A. Islam, M. F. Cotch, B. E.K. Klein, M. H. Criqui, and T. Y. Wong Retinal Arteriolar Narrowing and Left Ventricular Remodeling: The Multi-Ethnic Study of Atherosclerosis J. Am. Coll. Cardiol., July 3, 2007; 50(1): 48 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Thibault, L. Gomez, E. Donal, G. Pontier, M. Scherrer-Crosbie, M. Ovize, and G. Derumeaux Acute myocardial infarction in mice: assessment of transmurality by strain rate imaging Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H496 - H502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Udelson, F. A. McGrew, E. Flores, H. Ibrahim, S. Katz, G. Koshkarian, T. O'Brien, M. W. Kronenberg, C. Zimmer, C. Orlandi, et al. Multicenter, Randomized, Double-Blind, Placebo-Controlled Study on the Effect of Oral Tolvaptan on Left Ventricular Dilation and Function in Patients With Heart Failure and Systolic Dysfunction J. Am. Coll. Cardiol., June 5, 2007; 49(22): 2151 - 2159. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gizurarson, M. Lorentzon, T. Ramunddal, F. Waagstein, L. Bergfeldt, and E. Omerovic Effects of complete heart block on myocardial function, morphology, and energy metabolism in the rat Europace, June 1, 2007; 9(6): 411 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, M. C. de Waard, A. Sterner-Kock, H. Stepan, H.-P. Schultheiss, D. J. Duncker, and T. Walther Cardiomyocyte-restricted over-expression of C-type natriuretic peptide prevents cardiac hypertrophy induced by myocardial infarction in mice Eur J Heart Fail, June 1, 2007; 9(6-7): 548 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Abdel-Latif, R. Bolli, I. M. Tleyjeh, V. M. Montori, E. C. Perin, C. A. Hornung, E. K. Zuba-Surma, M. Al-Mallah, and B. Dawn Adult Bone Marrow-Derived Cells for Cardiac Repair: A Systematic Review and Meta-analysis Arch Intern Med, May 28, 2007; 167(10): 989 - 997. [Abstract] [Full Text] [PDF]
|
|