Circulation, Vol 81, 482-490, Copyright © 1990 by American Heart Association
H Yasue, K Matsuyama, K Matsuyama, K Okumura, Y Morikami and H Ogawa
We examined the response of left coronary arteries to intracoronary
injection of acetylcholine (ACh) 50 micrograms in 74 patients by measuring
the diameter changes with a videodensitometric analysis system. Patients
with angiographically normal coronary arteries were subdivided into a
younger group of 26 patients (age, 9-29 years) and an older group of 23
patients (age, 31-68 years). In the younger group, the diameter at the
distal segment of the left anterior descending artery (LAD) and at the
proximal, middle, and distal segments of the left circumflex artery (LCx)
increased significantly (16.7 +/- 19.3%, p less than 0.01, for LAD and 8.0
+/- 18.8%, p less than 0.05; 11.0 +/- 16.1%, p less than 0.01; and 19.8 +/-
17.5%, p less than 0.01, for LCx segments, respectively) in response to
ACh. In the older group, on the other hand, the diameter at the proximal
and middle segments of LAD and LCx decreased significantly (-20.8 +/-
16.9%, p less than 0.01; and - 17.9 +/- 28.4%, p less than 0.01, for LAD
segments and -14.6 +/- 17.4%, p less than 0.01; and -11.3 +/- 21.4%, p less
than 0.05, for LCx segments, respectively). The dilator response to ACh in
the younger group was significantly greater in the distal segment than in
the proximal segment in both LAD and LCx (p less than 0.01 for LAD and p
less than 0.05 for LCx). The constrictor response to ACh in the older group
was significantly greater in the proximal than the distal segment in both
LAD and LCx (p less than 0.05 for LAD and LCx, respectively).(ABSTRACT
TRUNCATED AT 250 WORDS)
ARTICLES
Responses of angiographically normal human coronary arteries to intracoronary injection of acetylcholine by age and segment. Possible role of early coronary atherosclerosis
Division of Cardiology, Kumamoto University Medical School, Japan.
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