Circulation, Vol 80, 1128-1136, Copyright © 1989 by American Heart Association
NE Bowles, ML Rose, P Taylor, NR Banner, P Morgan-Capner, L Cunningham, LC Archard and MH Yacoub
Tissue from the explanted hearts of 21 patients with idiopathic dilated
cardiomyopathy or 19 patients with other specific heart muscle diseases
were investigated for presence of enterovirus-specific RNA with an
enterovirus group-specific cDNA probe. This was complementary to
coxsackievirus B2 RNA sequences between nucleotide numbers 6,550 and 7,400,
which are highly conserved between enteroviruses. Hearts from six patients
with dilated cardiomyopathy and one patient with ischemic heart disease
were found to contain virus RNA. Serology revealed that only one patient
(dilated cardiomyopathy group) was positive for coxsackievirus B-specific
IgM but negative for virus RNA in the myocardium. Quantitation of
leukocytes and T-lymphocytes in the myocardium and expression of major
histocompatibility locus antigens revealed no significant differences
associated with persistence of virus RNA. These data demonstrate that
enterovirus RNA persists in myocardium of a significant proportion of
patients with end-stage dilated cardiomyopathy in the absence of a
continuing cell-mediated or humoral immune response.
ARTICLES
End-stage dilated cardiomyopathy. Persistence of enterovirus RNA in myocardium at cardiac transplantation and lack of immune response
Department of Biochemistry, Charing Cross and Westminster Medical School, London, UK.
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