Circulation, Vol 80, 299-305, Copyright © 1989 by American Heart Association
IS Anand, R Ferrari, GS Kalra, PL Wahi, PA Poole-Wilson and PC Harris
This study provides data on plasma hormone levels in patients with severe
clinical congestive cardiac failure who had never received therapy and in
whom the presence of an accumulation of excess water and sodium had been
established. Eight patients were studied; two had ischemic cardiac disease,
and six had dilated cardiomyopathy. Mean hemodynamic measurements at rest
were as follows: cardiac index, 1.8 l/min/m2; pulmonary wedge pressure, 30
mm Hg; right atrial pressure, 15 mm Hg. Total body water content was 16%
above control, extracellular liquid was 33% above control, plasma volume
was 34% above control, total exchangeable sodium was 37% above control,
renal plasma flow was 29% of control, and glomerular filtration rate was
65% of control. Plasma norepinephrine was consistently increased (on
average 6.3 times control), whereas adrenaline was unaffected. Although
plasma renin activity and aldosterone varied widely, they were on average
above normal (renin 9.5 times control, aldosterone 6.4 times control).
Plasma atrial natriuretic peptide (14.3 times control) and growth hormone
(11.5 times control) were consistently increased. Cortisol was also
increased on average (1.7 times control). Vasopressin was increased only in
one patient.
ARTICLES
Edema of cardiac origin. Studies of body water and sodium, renal function, hemodynamic indexes, and plasma hormones in untreated congestive cardiac failure
Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
This article has been cited by other articles:
 |
|
 |
|
  I. S. Anand, T. S. Rector, M. Kuskowski, S. Thomas, N.J. Holwerda, and J. N. Cohn Effect of Baseline and Changes in Systolic Blood Pressure Over Time on the Effectiveness of Valsartan in the Valsartan Heart Failure Trial Circ Heart Fail, May 1, 2008; 1(1): 34 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Alsafwah, S. P. LaGuardia, M. Arroyo, B. K. Dockery, S. K. Bhattacharya, R. A. Ahokas, and K. P. Newman Congestive Heart Failure is a Systemic Illness: A Role for Minerals and Micronutrients Clin. Med. Res., December 1, 2007; 5(4): 238 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Thomas, A. Vidal, S. K. Bhattacharya, R. A. Ahokas, Y. Sun, I. C. Gerling, and K. T. Weber Zinc dyshomeostasis in rats with aldosteronism. Response to spironolactone Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2361 - H2366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Helies-Toussaint, C. Moinard, C. Rasmusen, I. Tabbi-Anneni, L. Cynober, and A. Grynberg Aortic banding in rat as a model to investigate malnutrition associated with heart failure Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1325 - R1331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. H. Opie Cellular Basis for Therapeutic Choices in Heart Failure Circulation, October 26, 2004; 110(17): 2559 - 2561. [Full Text] [PDF]
|
|
|
|
 |
|
 K. T. Weber Furosemide in the long-term management of heart failure: The good, the bad, and the uncertain J. Am. Coll. Cardiol., September 15, 2004; 44(6): 1308 - 1310. [Full Text] [PDF]
|
|
|
|
|
|
A.-S. Androne, S. D. Katz, L. Lund, J. LaManca, A. Hudaihed, K. Hryniewicz, and D. M. Mancini Hemodilution Is Common in Patients With Advanced Heart Failure Circulation, January 21, 2003; 107(2): 226 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Mancini, S. D. Katz, C. C. Lang, J. LaManca, A. Hudaihed, and A.-S. Androne Effect of Erythropoietin on Exercise Capacity in Patients With Moderate to Severe Chronic Heart Failure Circulation, January 21, 2003; 107(2): 294 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Kalra, C. Anagnostopoulos, A. P. Bolger, A. J. S. Coats, and S. D. Anker The regulation and measurement of plasma volume in heart failure J. Am. Coll. Cardiol., June 19, 2002; 39(12): 1901 - 1908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ceconi, R. Ferrari, T. Bachetti, C. Opasich, M. Volterrani, B. Colombo, G. Parrinello, and A. Corti Chromogranin A in heart failure. A novel neurohumoral factor and a predictor for mortality Eur. Heart J., June 2, 2002; 23(12): 967 - 974. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Ferrara, F Mastrorilli, G Pasanisi, S Censi, N D'aiello, A Fucili, M Valgimigli, and R Ferrari Neurohormonal modulation in chronic heart failure Eur. Heart J. Suppl., April 1, 2002; 4(suppl_D): D3 - D11. [Abstract] [PDF]
|
|
|
|
|
|
K. K. A. Witte, A. L. Clark, and J. G. F. Cleland Chronic heart failure and micronutrients J. Am. Coll. Cardiol., June 1, 2001; 37(7): 1765 - 1774. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. S. Azzam, F. J. Saldias, A. Comellas, K. M. Ridge, D. H. Rutschman, and J. I. Sznajder Catecholamines increase lung edema clearance in rats with increased left atrial pressure J Appl Physiol, March 1, 2001; 90(3): 1088 - 1094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Friberg, S Werner, G Eggertsen, and S Ahnve Growth hormone and insulin-like growth factor-1 in acute myocardial infarction Eur. Heart J., September 2, 2000; 21(18): 1547 - 1554. [Abstract] [PDF]
|
|
|
|
|
|
H. L. Hillege, A. R. J. Girbes, P. J. de Kam, F. Boomsma, D. de Zeeuw, A. Charlesworth, J. R. Hampton, and D. J. van Veldhuisen Renal Function, Neurohormonal Activation, and Survival in Patients With Chronic Heart Failure Circulation, July 11, 2000; 102(2): 203 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Berry and A.L Clark Catabolism in chronic heart failure Eur. Heart J., April 1, 2000; 21(7): 521 - 532. [PDF]
|
|
|
|
|
|
M. S. Feigenbaum, M. A. Welsch, M. Mitchell, K. Vincent, R. W. Braith, and C. J. Pepine Contracted plasma and blood volume in chronic heart failure J. Am. Coll. Cardiol., January 1, 2000; 35(1): 51 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Comini, T. Bachetti, L. Agnoletti, G. Gaia, S. Curello, B. Milanesi, M. Volterrani, G. Parrinello, C. Ceconi, A. Giordano, et al. Induction of functional inducible nitric oxide synthase in monocytes of patients with congestive heart failure. Link with tumour necrosis factor-{alpha} Eur. Heart J., October 2, 1999; 20(20): 1503 - 1513. [Abstract] [PDF]
|
|
|
|
 |
|
 D R Murdoch, E Rooney, H J Dargie, D Shapiro, J J Morton, and J J V McMurray Inappropriately low plasma leptin concentration in the cachexia associated with chronic heart failure Heart, September 1, 1999; 82(3): 352 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Anker and A. J. S. Coats Cardiac Cachexia: A Syndrome With Impaired Survival and Immune and Neuroendocrine Activation Chest, March 1, 1999; 115(3): 836 - 847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Y. Henein, C. A. O'Sullivan, A. J. S. Coats, and D. G. Gibson Angiotensin-converting enzyme (ACE) inhibitors revert abnormal right ventricular filling in patients with restrictive left ventricular disease J. Am. Coll. Cardiol., November 1, 1998; 32(5): 1187 - 1193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Niebauer, C.-D. Pflaum, A. L. Clark, C. J. Strasburger, J. Hooper, P. A. Poole-Wilson, A. J. S. Coats, and S. D. Anker Deficient insulin-like growth factor I in chronic heart failure predicts altered body composition, anabolic deficiency, cytokine and neurohormonal activation J. Am. Coll. Cardiol., August 1, 1998; 32(2): 393 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Dreifuss, S. D. Anker, and A. J.S. Coats Growth Hormone in Chronic Heart Failure • Response Circulation, April 28, 1998; 97(16): 1650 - 1651. [Full Text] [PDF]
|
|
|
|
|
|
S. D. Anker, T. P. Chua, P. Ponikowski, D. Harrington, J. W. Swan, W. J. Kox, P. A. Poole-Wilson, and A. J. S. Coats Hormonal Changes and Catabolic/Anabolic Imbalance in Chronic Heart Failure and Their Importance for Cardiac Cachexia Circulation, July 15, 1997; 96(2): 526 - 534. [Abstract] [Full Text]
|
|
|
|
|
|
G. F. Mitchell, M. A. Pfeffer, P. V. Finn, and J. M. Pfeffer Equipotent Antihypertensive Agents Variously Affect Pulsatile Hemodynamics and Regression of Cardiac Hypertrophy in Spontaneously Hypertensive Rats Circulation, December 1, 1996; 94(11): 2923 - 2929. [Abstract] [Full Text]
|
|
|
|
|
|
H. Asanoi, T. Kameyama, S. Ishizaka, T. Nozawa, and H. Inoue Energetically Optimal Left Ventricular Pressure for the Failing Human Heart Circulation, January 1, 1996; 93(1): 67 - 73. [Abstract] [Full Text]
|
|
|
|
|
|
R. Ferrari, T. Bachetti, R. Confortini, C. Opasich, O. Febo, A. Corti, G. Cassani, and O. Visioli Tumor Necrosis Factor Soluble Receptors in Patients With Various Degrees of Congestive Heart Failure Circulation, September 15, 1995; 92(6): 1479 - 1486. [Abstract] [Full Text]
|
|
|
|
|
|
R. Yang, S. Bunting, N. Gillett, R. Clark, and H. Jin Growth Hormone Improves Cardiac Performance in Experimental Heart Failure Circulation, July 15, 1995; 92(2): 262 - 267. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. W. Kurz, F. Stockenhuber, C. Jahn, C. Wurnig, and P. Balcke Serum-Erythropoietin Concentration During Acute Cardiogenic Pulmonary Edema Angiology, April 1, 1991; 42(4): 281 - 288. [Abstract] [PDF]
|
|