Circulation, Vol 79, 93-100, Copyright © 1989 by American Heart Association
EA Anderson and AL Mark
Studies of peripheral blood vessels in humans have focused primarily on
regulation of blood flow and vascular resistance, which are thought to
reflect small vessel caliber. Recent studies in animals have identified
flow-mediated and neurogenic changes in large artery diameter. This study
tested for flow-mediated dilatation and reflex constriction of the brachial
artery in humans. A dual-crystal pulsed Doppler system was used to measure
brachial artery diameter and blood flow proximal to the antecubital fossa.
To test for flow-mediated dilatation, flow through the brachial artery was
altered by an occluding cuff placed on the forearm distal to the site of
brachial artery flow and diameter measurement. Control blood flow was 123
+/- 20 ml/min, and brachial artery diameter was 4.74 +/- 0.17 mm (mean +/-
SEM). By inflating the distal occluding cuff (distal circulatory arrest),
flow was reduced through the brachial artery to 21 +/- 5 ml/min (p less
than 0.005), and brachial artery diameter was reduced to 4.35 +/- 0.20 mm
(p less than 0.001). By deflating the distal occluding cuff after 10
minutes (reactive hyperemia), brachial artery flow was increased to 358 +/-
55 ml/min (p less than 0.001), and diameter was increased to 5.6 +/- 0.19
mm (p less than 0.001). These interventions did not change systemic
arterial pressure and, as measured in three subjects, caused only small
changes in local brachial artery distending pressure. Thus, both increased
and decreased brachial artery blood flow produced significant changes in
brachial artery diameter without altering arterial distending pressure.
These data provide evidence for flow-mediated dilatation in
humans.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Flow-mediated and reflex changes in large peripheral artery tone in humans
Department of Medicine, University of Iowa College of Medicine, Iowa City 52242.
This article has been cited by other articles:
 |
|
 |
|
  M. Saglam, U. Bozlar, F. Kantarci, H. Ay, B. Battal, and U. Coskun Effect of Hyperbaric Oxygen on Flow-Mediated Vasodilation: An Ultrasound Study J. Ultrasound Med., February 1, 2008; 27(2): 209 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Green, A. J. Maiorana, M. E. Tschakovsky, K. E. Pyke, C. J. Weisbrod, and G. O'Driscoll Relationship between changes in brachial artery flow-mediated dilation and basal release of nitric oxide in subjects with Type 2 diabetes Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1193 - H1199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-W. Su, S.-T. Cheng, T.-S. Hsu, and W.-J. Ho Abnormal flow-mediated vasodilation in normal-tension glaucoma using a noninvasive determination for peripheral endothelial dysfunction. Invest. Ophthalmol. Vis. Sci., August 1, 2006; 47(8): 3390 - 3394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J Roman, T. Z Naqvi, J. M Gardin, M. Gerhard-Herman, M. Jaff, and E. Mohler American Society of Echocardiography Report: Clinical application of noninvasive vascular ultrasound in cardiovascular risk stratification: a report from the American Society of Echocardiography and the Society for Vascular Medicine and Biology Vascular Medicine, August 1, 2006; 11(3): 201 - 211. [PDF]
|
|
|
|
 |
|
 K. E Pyke and M. E Tschakovsky The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function J. Physiol., October 15, 2005; 568(2): 357 - 369. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Green Point: Flow-mediated dilation does reflect nitric oxide-mediated endothelial function J Appl Physiol, September 1, 2005; 99(3): 1233 - 1234. [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Moens, I. Goovaerts, M. J. Claeys, and C. J. Vrints Flow-Mediated Vasodilation: A Diagnostic Instrument, or an Experimental Tool? Chest, June 1, 2005; 127(6): 2254 - 2263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D Tousoulis, C Antoniades, and C Stefanadis Evaluating endothelial function in humans: a guide to invasive and non-invasive techniques Heart, April 1, 2005; 91(4): 553 - 558. [Full Text] [PDF]
|
|
|
|
|
|
H. A. Silber, P. Ouyang, D. A. Bluemke, S. N. Gupta, T. K. Foo, and J. A. C. Lima Why is flow-mediated dilation dependent on arterial size? Assessment of the shear stimulus using phase-contrast magnetic resonance imaging Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H822 - H828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Betik, V. B. Luckham, and R. L. Hughson Flow-mediated dilation in human brachial artery after different circulatory occlusion conditions Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H442 - H448. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Poggianti, L. Venneri, V. Chubuchny, Z. Jambrik, L. A. Baroncini, and E. Picano Aortic valve sclerosis is associatedwith systemic endothelial dysfunction J. Am. Coll. Cardiol., January 1, 2003; 41(1): 136 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Modena, L. Bonetti, F. Coppi, F. Bursi, and R. Rossi Prognostic role of reversible endothelial dysfunction in hypertensive postmenopausal women J. Am. Coll. Cardiol., August 7, 2002; 40(3): 505 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Mihmanli, V. Mihmanli, F. Kantarci, M. S. Albayram, K. Atakir, M. Cantasdemir, and C. Akman Effects of Oophorectomy and Hormone Replacement Therapy on the Pulsatility Indices of Hepatic and Renal Arteries J. Ultrasound Med., April 1, 2002; 21(4): 367 - 373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Joannides, A. Costentin, M. Iacob, P. Compagnon, A. Lahary, and C. Thuillez Influence of vascular dimension on gender difference in flow-dependent dilatation of peripheral conduit arteries Am J Physiol Heart Circ Physiol, April 1, 2002; 282(4): H1262 - H1269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Hurlimann, F. Ruschitzka, and T.F. Luscher The relationship between the endothelium and the vessel wall Eur. Heart J. Suppl., February 1, 2002; 4(suppl_A): A1 - A7. [Abstract] [PDF]
|
|
|
|
|
|
M. C. Corretti, T. J. Anderson, E. J. Benjamin, D. Celermajer, F. Charbonneau, M. A. Creager, J. Deanfield, H. Drexler, M. Gerhard-Herman, D. Herrington, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force J. Am. Coll. Cardiol., January 16, 2002; 39(2): 257 - 265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Levenson, F. Pessana, J. Gariepy, R. Armentano, and A. Simon Gender differences in wall shear-mediated brachial artery vasoconstriction and vasodilation J. Am. Coll. Cardiol., November 15, 2001; 38(6): 1668 - 1674. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Gaenzer, G. Neumayr, P. Marschang, W. Sturm, R. Kirchmair, and J. R. Patsch Flow-mediated vasodilation of the femoral and brachial artery induced by exercise in healthy nonsmoking and smoking men J. Am. Coll. Cardiol., November 1, 2001; 38(5): 1313 - 1319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Mullen, R. K. Kharbanda, J. Cross, A. E. Donald, M. Taylor, P. Vallance, J. E. Deanfield, and R. J. MacAllister Heterogenous Nature of Flow-Mediated Dilatation in Human Conduit Arteries In Vivo : Relevance to Endothelial Dysfunction in Hypercholesterolemia Circ. Res., February 2, 2001; 88(2): 145 - 151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Giller, A. M. Giller, C. R. Cooper, and M. R. Hatab Evaluation of the cerebral hemodynamic response to rhythmic handgrip J Appl Physiol, June 1, 2000; 88(6): 2205 - 2213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Guler, M. Bilge, B. Eryonucu, R. Erkoc, U. Ipeksoy, and N. Guler Brachial Artery Blood Flow Velocity Pattern in Patients with Congestive Heart Failure: Duplex Doppler Ultrasonographic Assessment Angiology, March 1, 2000; 51(3): 207 - 212. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Lambert, M. van den Berg, M. Steyn, J. A. Rauwerda, A. J.M. Donker, and C. D.A. Stehouwer Familial hyperhomocysteinaemia and endothelium-dependent vasodilatation and arterial distensibility of large arteries Cardiovasc Res, June 1, 1999; 42(3): 743 - 751. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Krzanowski, A. Surdacki, R. Nizankowski, A. Szczeklik, J. S. Dubiel, and P. Petkow Dimitrow Impaired Response of the Forearm Resistance but not Conductance Vessels to Reactive Hyperemia in Hypertrophic Cardiomyopathy Angiology, April 1, 1999; 50(4): 267 - 272. [Abstract] [PDF]
|
|
|
|
 |
|
 N. Labropoulos, K. M. Webb, M. A. Mansour, S. S. Kang, and W. H. Baker Impaired Endothelium-Dependent Dilatation Precedes Early Arterial Wall Change in Symptom-Free Smokers Vascular and Endovascular Surgery, March 1, 1999; 33(2): 167 - 173. [Abstract] [PDF]
|
|
|
|
|
|
J. Hansen, D. Sayad, G. D. Thomas, G. D. Clarke, R. M. Peshock, and R. G. Victor Exercise-induced attenuation of alpha-adrenoceptor mediated vasoconstriction in humans: evidence from phase-contrast MRI Cardiovasc Res, January 1, 1999; 41(1): 220 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.K Shoemaker, M.J MacDonald, and R.L Hughson Time course of brachial artery diameter responses to rhythmic handgrip exercise in humans Cardiovasc Res, July 1, 1997; 35(1): 125 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Iwatsubo, M. Nagano, T. Sakai, K. Kumamoto, R. Morita, J. Higaki, T. Ogihara, and T. Hata Converting Enzyme Inhibitor Improves Forearm Reactive Hyperemia in Essential Hypertension Hypertension, January 1, 1997; 29(1): 286 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lambert, M. Aarsen, A. J.M. Donker, and C. D.A. Stehouwer Endothelium-Dependent and -Independent Vasodilation of Large Arteries in Normoalbuminuric Insulin-Dependent Diabetes Mellitus Arterioscler. Thromb. Vasc. Biol., May 1, 1996; 16(5): 705 - 711. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Joannides, W. E. Haefeli, L. Linder, V. Richard, E. H. Bakkali, C. Thuillez, and T. F. Luscher Nitric Oxide Is Responsible for Flow-Dependent Dilatation of Human Peripheral Conduit Arteries In Vivo Circulation, March 1, 1995; 91(5): 1314 - 1319. [Abstract] [Full Text]
|
|