Circulation, Vol 79, 76-82, Copyright © 1989 by American Heart Association
KE Sands, ML Appel, LS Lilly, FJ Schoen, GH Mudge Jr and RJ Cohen
Beat-to-beat heart rate variability was studied by power spectral analysis
in 17 orthotopic cardiac transplant patients. Heart rate power spectra were
calculated from eighty-four 256-second recordings and compared with those
taken from six normal subjects. The power spectra from the control subjects
resolved into discrete peaks at 0.04-0.12 Hz and 0.2-0.3 Hz, whereas those
of heart transplant recipients resembled broad-band noise without peaks.
Log total power in the 0.02-1.0 Hz range was greater in the control
subjects (0.982 +/- 0.084 [0.206], mean +/- SEM [SD]) than in the
transplanted subjects (-0.766 +/- 0.059 [0.541]), (p less than 0.0001).
Fifty-five electrocardiographic recordings from transplant patients were
done within 48 hours of an endomyocardial biopsy. When the power spectra of
those patients whose endomyocardial biopsies showed evidence of myocardial
rejection were compared with those from patients who were found to be free
of rejection, a significant difference was found in log total power (-
0.602 +/- 0.090 [0.525] vs. -0.909 +/- 0.136 [0.577], p less than 0.02). We
conclude that denervation of the heart significantly reduces heart rate
variability and abolishes the discrete spectral peaks seen in
untransplanted control subjects and that the development of allograft
rejection may significantly increase heart rate variability.
ARTICLES
Power spectrum analysis of heart rate variability in human cardiac transplant recipients
Harvard-Massachusetts Institute of Technology, Division of Health Sciences and Technology, Cambridge 02139.
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