Circulation, Vol 79, 143-153, Copyright © 1989 by American Heart Association
J Nejima, DR Knight, JT Fallon, N Uemura, WT Manders, DR Canfield, MV Cohen and SF Vatner
To determine if oxygen free radical scavengers administered before coronary
artery reperfusion can limit reperfusion arrhythmias, increase the return
of regional function in ischemic myocardium, and reduce tissue necrosis at
1 week after 90-minute coronary artery occlusion and reperfusion, conscious
dogs were treated with superoxide dismutase (SOD) and catalase before and
for 1 hour after coronary artery reperfusion. Another group was treated
with recombinant SOD (rSOD) because the commercially available SOD and
catalase contained endotoxin. The conscious dogs were studied 3-4 weeks
after implanting left ventricular pressure gauges, ultrasonic wall
thickness gauges in the posterior left ventricular wall, left atrial
catheters, and arterial catheters, Doppler flow transducers, and hydraulic
occluders on the left circumflex coronary artery. The only beneficial
effect observed was that the number of arrhythmic beats per minute in the
rSOD- treated group was significantly lower (p less than 0.05) when
compared with a control group after coronary artery reperfusion. Treatment
neither increased the amount of recovery of wall thickening in the ischemic
zone nor reduced infarct size when expressed either as a percentage of the
area at risk or as a function of collateral blood flow in the ischemic
zone. For example, infarct size as a percentage of the area at risk was
32.6 +/- 5.8%, 37.4 +/- 6.4%, 28.3 +/- 5.1% in the control, SOD and
catalase-, and rSOD-treated groups, respectively. Thus, although treatment
with oxygen free radical scavengers invoked a transient reduction in the
number of reperfusion arrhythmias, this treatment in conscious dogs failed
to improve regional myocardial dysfunction or reduce the amount of necrosis
when compared with a control group. The lack of a sustained salutary effect
may indicate that longer periods of treatment with free radical scavengers
are required in chronic preparations.
ARTICLES
Superoxide dismutase reduces reperfusion arrhythmias but fails to salvage regional function or myocardium at risk in conscious dogs
Department of Medicine, Harvard Medical School, Boston, Massachusetts.
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