Circulation, Vol 78, 1192-1199, Copyright © 1988 by American Heart Association
EB Henderson, JK Kahn, JR Corbett, DE Jansen, JJ Pippin, P Kulkarni, V Ugolini, MS Akers, C Hansen and LM Buja
I-123 metaiodobenzylguanidine (MIBG) is a new radiopharmaceutical with
properties that allow the characterization of the sympathetic innervation
of several organ systems. In this study, we used MIBG with tomographic
imaging to evaluate noninvasively the differences in myocardial sympathetic
innervation in 14 healthy volunteers and 16 patients with severe dilated
cardiomyopathy (CM). Initial (15-minute) images demonstrated no significant
differences in MIBG concentration in the hearts of patients with CM and of
healthy volunteers. However, the myocardial retention of MIBG was
significantly reduced in the patients with CM. Expressed as the percent
washout from 15 to 85 minutes, the patients with CM had a 28 +/- 12%
washout rate compared with 6 +/- 8% in the controls (p less than 0.001). A
small subset of patients from each group imaged at 4-hour intervals
demonstrated even greater disparity in washout rates. In addition, the
patients with CM had significantly greater heterogeneity in the MIBG
activity distribution within the myocardial images. There was 47 +/- 15%
intraimage variability in MIBG distribution in the patients with CM and 22
+/- 9% variation in the controls (p less than 0.001). We conclude from
these data that the myocardial distribution and kinetics of MIBG in images
obtained from patients with CM differ significantly from those of controls
and that the MIBG patterns may be used as a relatively noninvasive means to
evaluate the severity of altered adrenergic innervation in the hearts of
these patients.
ARTICLES
Abnormal I-123 metaiodobenzylguanidine myocardial washout and distribution may reflect myocardial adrenergic derangement in patients with congestive cardiomyopathy
Department of Internal Medicine (Cardiology Division), University of Texas Southwestern Medical Center, Dallas 75235-9047.
This article has been cited by other articles:
 |
|
 |
|
  T. Tsutamoto, K. Nishiyama, H. Sakai, T. Tanaka, M. Fujii, T. Yamamoto, M. Yamaji, and M. Horie Transcardiac increase in norepinephrine and prognosis in patients with chronic heart failure Eur J Heart Fail, December 1, 2008; 10(12): 1208 - 1214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kobayashi, H. Izawa, X. W. Cheng, H. Asano, A. Hirashiki, K. Unno, S. Ohshima, T. Yamada, Y. Murase, T. S. Kato, et al. Dobutamine stress testing as a diagnostic tool for evaluation of myocardial contractile reserve in asymptomatic or mildly symptomatic patients with dilated cardiomyopathy. J. Am. Coll. Cardiol. Img., November 1, 2008; 1(6): 718 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kasama, T. Toyama, H. Sumino, M. Nakazawa, N. Matsumoto, Y. Sato, H. Kumakura, Y. Takayama, S. Ichikawa, T. Suzuki, et al. Prognostic Value of Serial Cardiac 123I-MIBG Imaging in Patients with Stabilized Chronic Heart Failure and Reduced Left Ventricular Ejection Fraction J. Nucl. Med., June 1, 2008; 49(6): 907 - 914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tsukamoto, K. Morita, M. Naya, M. Inubushi, C. Katoh, K. Nishijima, Y. Kuge, H. Okamoto, H. Tsutsui, and N. Tamaki Decreased Myocardial {beta}-Adrenergic Receptor Density in Relation to Increased Sympathetic Tone in Patients with Nonischemic Cardiomyopathy J. Nucl. Med., November 1, 2007; 48(11): 1777 - 1782. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kioka, T. Yamada, T. Mine, T. Morita, Y. Tsukamoto, S. Tamaki, M. Masuda, K. Okuda, M. Hori, and M. Fukunami Prediction of sudden death in patients with mild-to-moderate chronic heart failure by using cardiac iodine-123 metaiodobenzylguanidine imaging Heart, October 1, 2007; 93(10): 1213 - 1218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Wu, F. M. Bengel, and S. S. Gambhir Cardiovascular Molecular Imaging Radiology, August 1, 2007; 244(2): 337 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kimura, M. Ieda, H. Kanazawa, T. Yagi, M. Tsunoda, S.-i. Ninomiya, H. Kurosawa, K. Yoshimi, H. Mochizuki, K. Yamazaki, et al. Cardiac Sympathetic Rejuvenation: A Link Between Nerve Function and Cardiac Hypertrophy Circ. Res., June 22, 2007; 100(12): 1755 - 1764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Kasama, T Toyama, T Hatori, H Sumino, H Kumakura, Y Takayama, S Ichikawa, T Suzuki, and M Kurabayashi Effects of torasemide on cardiac sympathetic nerve activity and left ventricular remodelling in patients with congestive heart failure Heart, October 1, 2006; 92(10): 1434 - 1440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yoshita, J. Taki, K. Yokoyama, M. Noguchi-Shinohara, Y. Matsumoto, K. Nakajima, and M. Yamada Value of 123I-MIBG radioactivity in the differential diagnosis of DLB from AD Neurology, June 27, 2006; 66(12): 1850 - 1854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Kasama, T Toyama, T Hatori, H Sumino, H Kumakura, Y Takayama, S Ichikawa, T Suzuki, and M Kurabayashi Comparative effects of valsartan and enalapril on cardiac sympathetic nerve activity and plasma brain natriuretic peptide in patients with congestive heart failure Heart, May 1, 2006; 92(5): 625 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kasama, T. Toyama, H. Kumakura, Y. Takayama, S. Ichikawa, T. Suzuki, and M. Kurabayashi Effects of candesartan on cardiac sympathetic nerve activity in patients with congestive heart failure and preserved left ventricular ejection fraction J. Am. Coll. Cardiol., March 1, 2005; 45(5): 661 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Tachikawa, M. Kodama, K. Watanabe, T. Takahashi, M. Ma, T. Kashimura, M. Ito, S. Hirono, Y. Okura, K. Kato, et al. Amiodarone Improves Cardiac Sympathetic Nerve Function to Hold Norepinephrine in the Heart, Prevents Left Ventricular Remodeling, and Improves Cardiac Function in Rat Dilated Cardiomyopathy Circulation, February 22, 2005; 111(7): 894 - 899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Tanabe, H. Harada, S. Sugihara, T. Ogawa, and Y. Inoue 123I-Metaiodobenzylguanidine Myocardial Scintigraphy in Panic Disorder J. Nucl. Med., August 1, 2004; 45(8): 1305 - 1308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kasama, T. Toyama, H. Kumakura, Y. Takayama, T. Ishikawa, S. Ichikawa, T. Suzuki, and M. Kurabayashi Effects of Intravenous Atrial Natriuretic Peptide on Cardiac Sympathetic Nerve Activity in Patients with Decompensated Congestive Heart Failure J. Nucl. Med., July 1, 2004; 45(7): 1108 - 1113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. J. Akashi, K. Nakazawa, M. Sakakibara, F. Miyake, H. Musha, and K. Sasaka 123I-MIBG Myocardial Scintigraphy in Patients with "Takotsubo" Cardiomyopathy J. Nucl. Med., July 1, 2004; 45(7): 1121 - 1127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kyuma, T. Nakata, A. Hashimoto, K. Nagao, H. Sasao, T. Takahashi, K. Tsuchihashi, and K. Shimamoto Incremental Prognostic Implications of Brain Natriuretic Peptide, Cardiac Sympathetic Nerve Innervation, and Noncardiac Disorders in Patients with Heart Failure J. Nucl. Med., February 1, 2004; 45(2): 155 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-s. Liang Sympatholysis and cardiac sympathetic nerve function in the treatment of congestive heart failure J. Am. Coll. Cardiol., August 6, 2003; 42(3): 549 - 551. [Full Text] [PDF]
|
|
|
|
|
|
S. Kasama, T. Toyama, H. Kumakura, Y. Takayama, S. Ichikawa, T. Suzuki, and M. Kurabayashi Addition of Valsartan to an Angiotensin-Converting Enzyme Inhibitor Improves Cardiac Sympathetic Nerve Activity and Left Ventricular Function in Patients with Congestive Heart Failure J. Nucl. Med., June 1, 2003; 44(6): 884 - 890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Muxi, J. Magrina, F. Martin, M. Josa, D. Fuster, F. J. Setoain, F. Perez-Villa, J. Pavia, and X. Bosch Technetium 99m-labeled tetrofosmin and iodine 123-labeled metaiodobenzylguanidine scintigraphy in the assessment of transmyocardial laser revascularization J. Thorac. Cardiovasc. Surg., June 1, 2003; 125(6): 1493 - 1498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Sipola, E. Vanninen, H. J. Aronen, K. Lauerma, S. Simula, P. Jaaskelainen, M. Laakso, K. Peuhkurinen, J. Kuusisto, and J. T. Kuikka Cardiac Adrenergic Activity Is Associated with Left Ventricular Hypertrophy in Genetically Homogeneous Subjects with Hypertrophic Cardiomyopathy J. Nucl. Med., April 1, 2003; 44(4): 487 - 493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kasama, T. Toyama, H. Kumakura, Y. Takayama, S. Ichikawa, T. Suzuki, and M. Kurabayashi Effect of spironolactone on cardiacsympathetic nerve activity and left ventricular remodeling in patients with dilated cardiomyopathy J. Am. Coll. Cardiol., February 19, 2003; 41(4): 574 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yamada, T. Shimonagata, M. Fukunami, K. Kumagai, H. Ogita, A. Hirata, M. Asai, N. Makino, H. Kioka, H. Kusuoka, et al. Comparison of the prognostic value of cardiac iodine-123 metaiodobenzylguanidine imaging and heart rate variability in patients with chronic heart failure: A prospective study J. Am. Coll. Cardiol., January 15, 2003; 41(2): 231 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kasama, T. Toyama, H. Kumakura, Y. Takayama, S. Ichikawa, T. Suzuki, and M. Kurabayashi Spironolactone Improves Cardiac Sympathetic Nerve Activity and Symptoms in Patients with Congestive Heart Failure J. Nucl. Med., October 1, 2002; 43(10): 1279 - 1285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kasama, T. Toyama, H. Hoshizaki, S. Oshima, K. Taniguchi, T. Suzuki, and M. Kurabayashi Dobutamine Gated Blood Pool Scintigraphy Predicts the Improvement of Cardiac Sympathetic Nerve Activity, Cardiac Function, and Symptoms After Treatment in Patients With Dilated Cardiomyopathy* Chest, August 1, 2002; 122(2): 542 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Watanabe, T. Takahashi, M. Nakazawa, M. I. I. Wahed, K. Fuse, N. Tanabe, M. Kodama, Y. Aizawa, H. Ashino, and S. Tazawa Effects of Carvedilol on Cardiac Function and Cardiac Adrenergic Neuronal Damage in Rats with Dilated Cardiomyopathy J. Nucl. Med., April 1, 2002; 43(4): 531 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Simula, E. Vanninen, L. Viitanen, A. Kareinen, S. Lehto, P. Pajunen, M. Syvanne, J. Kuikka, M. Laakso, and J. Hartikainen Cardiac Adrenergic Innervation Is Affected in Asymptomatic Subjects with Very Early Stage of Coronary Artery Disease J. Nucl. Med., January 1, 2002; 43(1): 1 - 7. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Daliento, A. F. Folino, L. Menti, P. Zanco, M. C. Baratella, and S. Dalla Volta Adrenergic nervous activity in patients after surgical correction of tetralogy of Fallot J. Am. Coll. Cardiol., December 1, 2001; 38(7): 2043 - 2047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Wakabayashi, T. Nakata, A. Hashimoto, S. Yuda, K. Tsuchihashi, M. I. Travin, and K. Shimamoto Assessment of Underlying Etiology and Cardiac Sympathetic Innervation to Identify Patients at High Risk of Cardiac Death J. Nucl. Med., December 1, 2001; 42(12): 1757 - 1767. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F.M. Bengel, B. Permanetter, M. Ungerer, S.G. Nekolla, and M. Schwaiger Relationship between altered sympathetic innervation, oxidative metabolism and contractile function in the cardiomyopathic human heart; a non-invasive study using positron emission tomography Eur. Heart J., September 1, 2001; 22(17): 1594 - 1600. [Abstract] [PDF]
|
|
|
|
|
|
M Toyono, C Kondo, Y Nakajima, M Nakazawa, K Momma, and K Kusakabe Effects of carvedilol on left ventricular function, mass, and scintigraphic findings in isolated left ventricular non-compaction Heart, July 1, 2001; 86(1): e4 - 4. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zhao, N. Shuke, W. Yamamoto, A. Okizaki, J. Sato, Y. Ishikawa, T. Ohta, N. Hasebe, K. Kikuchi, and T. Aburano Comparison of Cardiac Sympathetic Nervous Function with Left Ventricular Function and Perfusion in Cardiomyopathies by 123I-MIBG SPECT and 99mTc-Tetrofosmin Electrocardiographically Gated SPECT J. Nucl. Med., July 1, 2001; 42(7): 1017 - 1024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Carrio Cardiac Neurotransmission Imaging J. Nucl. Med., July 1, 2001; 42(7): 1062 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.N Simantirakis, V.K Prassopoulos, S.I Chrysostomakis, G.E Kochiadakis, S.I Koukouraki, J.P Lekakis, N.S Karkavitsas, and P.E Vardas Effects of asynchronous ventricular activation on myocardial adrenergic innervation in patients with permanent dual-chamber pacemakers. An I123-metaiodobenzylguanidine cardiac scintigraphic study Eur. Heart J., February 2, 2001; 22(4): 323 - 332. [Abstract] [PDF]
|
|
|
|
|
|
U. Lotze, S. Kaepplinger, A. Kober, B. M. Richartz, D. Gottschild, and H. R. Figulla Recovery of the Cardiac Adrenergic Nervous System After Long-Term {beta}-Blocker Therapy in Idiopathic Dilated Cardiomyopathy: Assessment by Increase in Myocardial 123I-Metaiodobenzylguanidine Uptake J. Nucl. Med., January 1, 2001; 42(1): 49 - 54. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Wichter, M. Schafers, C. G. Rhodes, M. Borggrefe, H. Lerch, A. A. Lammertsma, F. Hermansen, O. Schober, G. Breithardt, and P. G. Camici Abnormalities of Cardiac Sympathetic Innervation in Arrhythmogenic Right Ventricular Cardiomyopathy : Quantitative Assessment of Presynaptic Norepinephrine Reuptake and Postsynaptic {beta}-Adrenergic Receptor Density With Positron Emission Tomography Circulation, April 4, 2000; 101(13): 1552 - 1558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Igawa, T. Nozawa, N. Yoshida, N. Fujii, M. Inoue, S. Tazawa, H. Asanoi, and H. Inoue Heterogeneous cardiac sympathetic innervation in heart failure after myocardial infarction of rats Am J Physiol Heart Circ Physiol, April 1, 2000; 278(4): H1134 - H1141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Sakamaki, T. Satoh, N. Nagaya, S. Kyotani, N. Nakanishi, and Y. Ishida Abnormality of Left Ventricular Sympathetic Nervous Function Assessed by 123I-Metaiodobenzylguanidine Imaging in Patients With COPD* Chest, December 1, 1999; 116(6): 1575 - 1581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cohen-Solal, Y. Esanu, D. Logeart, F. Pessione, C. Dubois, G. Dreyfus, R. Gourgon, and P. Merlet Cardiac metaiodobenzylguanidine uptake in patients with moderate chronic heart failure: relationship with peak oxygen uptake and prognosis J. Am. Coll. Cardiol., March 1, 1999; 33(3): 759 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Kakuchi, T Sasaki, Y Ishida, K Komamura, and K Miyatake Clinical usefulness of 123I meta-iodobenzylguanidine imaging in predicting the effectiveness of beta blockers for patients with idiopathic dilated cardiomyopathy before and soon after treatment Heart, February 1, 1999; 81(2): 148 - 152. [Abstract] [Full Text]
|
|
|
|
 |
|
 W. H. Frishman Carvedilol N. Engl. J. Med., December 10, 1998; 339(24): 1759 - 1765. [Full Text] [PDF]
|
|
|
|
|
|
M. Ungerer, F. Hartmann, M. Karoglan, A. Chlistalla, S. Ziegler, G. Richardt, M. Overbeck, H. Meisner, A. Schomig, and M. Schwaiger Regional In Vivo and In Vitro Characterization of Autonomic Innervation in Cardiomyopathic Human Heart Circulation, January 20, 1998; 97(2): 174 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Rundqvist, G. Eisenhofer, M. Elam, and P. Friberg Attenuated Cardiac Sympathetic Responsiveness During Dynamic Exercise in Patients With Heart Failure Circulation, February 18, 1997; 95(4): 940 - 945. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. D. Sackner-Bernstein and D. M. Mancini Rationale for Treatment of Patients With Chronic Heart Failure With Adrenergic Blockade JAMA, November 8, 1995; 274(18): 1462 - 1467. [Abstract] [PDF]
|
|
|
|
|
|
B. L. Zaret and F. J. Wackers Nuclear Cardiology- Second of Two Parts N. Engl. J. Med., September 16, 1993; 329(12): 855 - 863. [Full Text]
|
|
|
|
|
|
T. Wichter, P. Matheja, L. Eckardt, P. Kies, K. Schafers, E. Schulze-Bahr, W. Haverkamp, M. Borggrefe, O. Schober, G. Breithardt, et al. Cardiac Autonomic Dysfunction in Brugada Syndrome Circulation, February 12, 2002; 105(6): 702 - 706. [Abstract] [Full Text] [PDF]
|
|