Circulation, Vol 78, 941-950, Copyright © 1988 by American Heart Association
RG Asmar, B Pannier, JP Santoni, S Laurent, GM London, BI Levy and ME Safar
Blood pressure, forearm arterial hemodynamics (with a pulsed Doppler
flowmeter), and echocardiographic parameters were studied in 16 patients
with sustained essential hypertension before and 3 months after
administration of the converting enzyme inhibitor perindopril. In a
single-blind study versus placebo, it was shown that perindopril
significantly reduced blood pressure (p less than 0.01), whereas there was
an increase in brachial blood flow (p less than 0.01) because of a
simultaneous increase in blood flow velocity (p less than 0.01) and
arterial diameter (p less than 0.01). During a 5-minute period of wrist
occlusion, blood flow velocity was reduced to a greater extent with
perindopril than with placebo (p less than 0.001), whereas corresponding
reductions in arterial diameter were equivalent, indicating that the
increase in diameter after perindopril could not be explained simply on the
basis of flow-dependent dilatation. During active treatment, brachial
artery compliance increased (p less than 0.01) and pulse wave velocity
decreased (p less than 0.01), whereas there was no change in the tangential
tension of the arterial wall, defined as the product of mean arterial
pressure and arterial diameter. Four weeks after treatment was stopped,
blood pressure and forearm arterial hemodynamics returned toward baseline
values. Cardiac mass was significantly decreased after perindopril (p less
than 0.01) and remained decreased 4 weeks after cessation of
treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Reversion of cardiac hypertrophy and reduced arterial compliance after converting enzyme inhibition in essential hypertension
Diagnostic Center, Broussais Hospital, Paris.
This article has been cited by other articles:
 |
|
 |
|
  S. Laurent, J. Cockcroft, L. Van Bortel, P. Boutouyrie, C. Giannattasio, D. Hayoz, B. Pannier, C. Vlachopoulos, I. Wilkinson, H. Struijker-Boudier, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications Eur. Heart J., November 1, 2006; 27(21): 2588 - 2605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Juonala, M. J. Jarvisalo, N. Maki-Torkko, M. Kahonen, J. S.A. Viikari, and O. T. Raitakari Risk Factors Identified in Childhood and Decreased Carotid Artery Elasticity in Adulthood: The Cardiovascular Risk in Young Finns Study Circulation, September 6, 2005; 112(10): 1486 - 1493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Ahimastos, A. K. Natoli, A. Lawler, P. A. Blombery, and B. A. Kingwell Ramipril Reduces Large-Artery Stiffness in Peripheral Arterial Disease and Promotes Elastogenic Remodeling in Cell Culture Hypertension, June 1, 2005; 45(6): 1194 - 1199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Fox, H. A. Taylor Jr, E. J. Benjamin, J. Ding, P. R. Liebson, D. Arnett, E. M. Quin, and T. N. Skelton Left Ventricular Mass Indexed to Height and Prevalent MRI Cerebrovascular Disease in an African American Cohort: The Atherosclerotic Risk in Communities Study Stroke, March 1, 2005; 36(3): 546 - 550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Nakanishi, K. Suzuki, and K. Tatara Clustered Features of the Metabolic Syndrome and the Risk for Increased Aortic Pulse Wave Velocity in Middle-aged Japanese Men Angiology, September 1, 2003; 54(5): 551 - 559. [Abstract] [PDF]
|
|
|
|
 |
|
 W.J. Remme Reconsider the management of all coronary artery disease patients: Importance of the EUROPA trial Eur. Heart J. Suppl., July 1, 2003; 5(suppl_E): E23 - E30. [Abstract] [PDF]
|
|
|
|
 |
|
 J. J. Oliver and D. J. Webb Noninvasive Assessment of Arterial Stiffness and Risk of Atherosclerotic Events Arterioscler Thromb Vasc Biol, April 1, 2003; 23(4): 554 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Lage, L. Kopel, C. C. J. Medeiros, R. T. Carvalho, and M. A. Creager Angiotensin II contributes to arterial compliance in congestive heart failure Am J Physiol Heart Circ Physiol, October 1, 2002; 283(4): H1424 - H1429. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Dart and B. A. Kingwell Pulse pressure--a review of mechanisms and clinical relevance J. Am. Coll. Cardiol., March 15, 2001; 37(4): 975 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Guerin, J. Blacher, B. Pannier, S. J. Marchais, M. E. Safar, and G. M. London Impact of Aortic Stiffness Attenuation on Survival of Patients in End-Stage Renal Failure Circulation, February 20, 2001; 103(7): 987 - 992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Manche, J. Galea, and W. Busuttil Tolerance to ACE inhibitors after cardiac surgery Eur. J. Cardiothorac. Surg., January 1, 1999; 15(1): 55 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Lehmann, K. D. Hopkins, A. Rawesh, R. C. Joseph, K. Kongola, S. W. Coppack, and R. G. Gosling Relation Between Number of Cardiovascular Risk Factors/Events and Noninvasive Doppler Ultrasound Assessments of Aortic Compliance Hypertension, September 1, 1998; 32(3): 565 - 569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Gatzka, J. D. Cameron, B. A. Kingwell, and A. M. Dart Relation Between Coronary Artery Disease, Aortic Stiffness, and Left Ventricular Structure in a Population Sample Hypertension, September 1, 1998; 32(3): 575 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Edouard, B. M. Pannier, G. M. London, J. L. Cuche, and M. E. Safar Venous and arterial behavior during normal pregnancy Am J Physiol Heart Circ Physiol, May 1, 1998; 274(5): H1605 - H1612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Isnard, P. Lechat, H. Kalotka, H. Chikr, S. Fitoussi, J. Salloum, J.-L. Golmard, D. Thomas, and M. Komajda Muscular blood flow response to submaximal leg exercise in normal subjects and in patients with heart failure J Appl Physiol, December 1, 1996; 81(6): 2571 - 2579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Tatchum-Talom, N. Niederhoffer, F. Amin, T. Makki, P. Tankosic, and J. Atkinson Aortic Stiffness and Left Ventricular Mass in a Rat Model of Isolated Systolic Hypertension Hypertension, December 1, 1995; 26(6): 963 - 970. [Abstract] [Full Text]
|
|
|
|
|
|
M. E. Safar and E. D. Frohlich The Arterial System in Hypertension : A Prospective View Hypertension, July 1, 1995; 26(1): 10 - 14. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. E. Schmieder, J. K. Rockstroh, and F. H. Messerli Antihypertensive Therapy: To Stop or Not to Stop? JAMA, March 27, 1991; 265(12): 1566 - 1571. [Abstract] [PDF]
|
|