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Circulation, Vol 76, 44-51, Copyright © 1987 by American Heart Association
HD White, RM Norris, MA Brown, PW Brandt, RM Whitlock and CJ Wild
Impairment of left ventricular function is the major predictor of mortality
after acute myocardial infarction, but it is not known whether this is best
described by ejection fraction or by end-systolic or end-diastolic volume.
We measured volumes, ejection fractions, and severity of coronary arterial
occlusions and stenoses in 605 male patients under 60 years of age at 1 to
2 months after a first (n = 443) or recurrent (n = 162) myocardial
infarction and followed these patients for a mean of 78 months for
survivors (range 15 to 165 months). There were 101 cardiac deaths, 71 (70%)
of which were sudden (instantaneous or found dead). Multivariate analysis
with log rank testing and the Cox proportional hazards model showed that
end-systolic volume (chi 2 = 82.9) had greater predictive value for
survival than end-diastolic volume (chi 2 = 59.0) or ejection fraction (chi
2 = 46.6), whereas stepwise analysis showed that once the relationship
between survival and end-systolic volume had been fitted, there was no
additional significant predictive information in either end-diastolic
volume or ejection fraction. Severity of coronary occlusions and stenoses
showed additional prediction of only borderline significance (p = .04 in
one analysis), but continued cigarette smoking did remain an independent
risk factor after stepwise analysis. For a subset of patients (n = 200) who
had taken part in a randomized trial of coronary artery surgery after
recovery from infarction, surgical "intention to treat" showed no
predictive value.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction
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G. Buckberg Editorial comment: Left ventricular reconstruction for dilated ischemic cardiomyopathy: biology, registry, randomization, and credibility Eur. J. Cardiothorac. Surg., November 1, 2006; 30(5): 759 - 761. [Full Text] [PDF]
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J. D. Adams, L. M. Fedoruk, C. A. Tache-Leon, B. B. Peeler, J. A. Kern, C. G. Tribble, J. D. Bergin, and I. L. Kron Does Preoperative Ejection Fraction Predict Operative Mortality With Left Ventricular Restoration? Ann. Thorac. Surg., November 1, 2006; 82(5): 1715 - 1720. [Abstract] [Full Text] [PDF]
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N. P. Nikitin, C. Constantin, P. H. Loh, J. Ghosh, E. I. Lukaschuk, A. Bennett, S. Hurren, F. Alamgir, A. L. Clark, and J. G.F. Cleland New generation 3-dimensional echocardiography for left ventricular volumetric and functional measurements: Comparison with cardiac magnetic resonance Eur J Echocardiogr, October 1, 2006; 7(5): 365 - 372. [Abstract] [Full Text] [PDF]
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T. Schepis, O. Gaemperli, P. Koepfli, I. Valenta, K. Strobel, A. Brunner, S. Leschka, L. Desbiolles, L. Husmann, H. Alkadhi, et al. Comparison of 64-Slice CT with Gated SPECT for Evaluation of Left Ventricular Function J. Nucl. Med., August 1, 2006; 47(8): 1288 - 1294. [Abstract] [Full Text] [PDF]
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D. S. Berman, R. Hachamovitch, L. J. Shaw, J. D. Friedman, S. W. Hayes, L. E.J. Thomson, D. S. Fieno, G. Germano, N. D. Wong, X. Kang, et al. Roles of Nuclear Cardiology, Cardiac Computed Tomography, and Cardiac Magnetic Resonance: Noninvasive Risk Stratification and a Conceptual Framework for the Selection of Noninvasive Imaging Tests in Patients with Known or Suspected Coronary Artery Disease J. Nucl. Med., July 1, 2006; 47(7): 1107 - 1118. [Abstract] [Full Text] [PDF]
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S. G. Lloyd, G. D. Buckberg, and the RESTORE Group Use of cardiac magnetic resonance imaging in surgical ventricular restoration Eur. J. Cardiothorac. Surg., April 1, 2006; 29(Suppl_1): S216 - S224. [Abstract] [Full Text] [PDF]
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M. Di Donato, P. Dabic, S. Castelvecchio, C. Santambrogio, J. Brankovic, L. Collarini, T. Joussef, A. Frigiola, G. Buckberg, L. Menicanti, et al. Left ventricular geometry in normal and post-anterior myocardial infarction patients: sphericity index and 'new' conicity index comparisons Eur. J. Cardiothorac. Surg., April 1, 2006; 29(Suppl_1): S225 - S230. [Abstract] [Full Text] [PDF]
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S. A. de Oliveira, L. H. W. Gowdak, G. Buckberg, J. E. Krieger, and the RESTORE Group Cell biology, MRI and geometry: insight into a microscopic/macroscopic marriage Eur. J. Cardiothorac. Surg., April 1, 2006; 29(Suppl_1): S259 - S265. [Abstract] [Full Text] [PDF]
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M. Maczewski, M. Borys, P. Kacprzak, T. Gdowski, and D. Wojciechowski Angiotensin II AT1 receptor density on blood platelets predicts early left ventricular remodelling in non-reperfused acute myocardial infarction in humans Eur J Heart Fail, March 1, 2006; 8(2): 173 - 178. [Abstract] [Full Text] [PDF]
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D. Barker, S. G. Williams, H. McLoughlin, and L.-B. Tan Impaired left ventricular function in obesity? Eur. Heart J., December 2, 2005; 26(24): 2742 - 2742. [Full Text] [PDF]
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O. Carbonara, R. Torella, and F. C. Sasso Impaired left ventricular function in obesity?: reply Eur. Heart J., December 2, 2005; 26(24): 2742 - 2743. [Full Text] [PDF]
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N. D. Patel, J. A. Williams, C. J. Barreiro, P. N. Bonde, M. M. Waldron, D. C. Chang, D. A. Bluemke, and J. V. Conte Surgical ventricular remodeling for multiterritory myocardial infarction: Defining a new patient population J. Thorac. Cardiovasc. Surg., December 1, 2005; 130(6): 1698 - 1706. [Abstract] [Full Text] [PDF]
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G. H.L. Tang, S. Fazel, R. D. Weisel, S. Verma, and R.-K. Li Optimizing cardiac cell therapy: From processing to delivery J. Thorac. Cardiovasc. Surg., October 1, 2005; 130(4): 966 - 968. [Full Text] [PDF]
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H. Thiele, L. Engelmann, K. Elsner, M. J. Kappl, W.-H. Storch, K. Rahimi, A. Hartmann, D. Pfeiffer, G. D. Kneissl, D. Schneider, et al. Comparison of pre-hospital combination-fibrinolysis plus conventional care with pre-hospital combination-fibrinolysis plus facilitated percutaneous coronary intervention in acute myocardial infarction Eur. Heart J., October 1, 2005; 26(19): 1956 - 1963. [Abstract] [Full Text] [PDF]
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C.-M. Yu, G. B. Bleeker, J. W.-H. Fung, M. J. Schalij, Q. Zhang, E. E. van der Wall, Y.-S. Chan, S.-L. Kong, and J. J. Bax Left Ventricular Reverse Remodeling but Not Clinical Improvement Predicts Long-Term Survival After Cardiac Resynchronization Therapy Circulation, September 13, 2005; 112(11): 1580 - 1586. [Abstract] [Full Text] [PDF]
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J. J.M. Westenberg, R. J. van der Geest, H. J. Lamb, M. I.M. Versteegh, J. Braun, J. Doornbos, A. de Roos, E. E. van der Wall, R. A.E. Dion, J. H.C. Reiber, et al. MRI to Evaluate Left Atrial and Ventricular Reverse Remodeling After Restrictive Mitral Annuloplasty in Dilated Cardiomyopathy Circulation, August 30, 2005; 112(9_suppl): I-437 - I-442. [Abstract] [Full Text] [PDF]
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F. Bogun, S. Krishnan, M. Siddiqui, E. Good, J. E. Marine, C. Schuger, H. Oral, A. Chugh, F. Pelosi, and F. Morady Electrogram Characteristics in Postinfarction Ventricular Tachycardia: Effect of Infarct Age J. Am. Coll. Cardiol., August 16, 2005; 46(4): 667 - 674. [Abstract] [Full Text] [PDF]
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