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Circulation, Vol 76, 142-154, Copyright © 1987 by American Heart Association
JH Chesebro, G Knatterud, R Roberts, J Borer, LS Cohen, J Dalen, HT Dodge, CK Francis, D Hillis and P Ludbrook
Intravenous administration of 80 mg of recombinant tissue plasminogen
activator (rt-PA, 40, 20, and 20 mg in successive hours) and streptokinase
(SK, 1.5 million units over 1 hr) was compared in a double-blind,
randomized trial in 290 patients with evolving acute myocardial infarction.
These patients entered the trial within 7 hr of the onset of symptoms and
underwent baseline coronary arteriography before thrombolytic therapy was
instituted. Ninety minutes after the start of thrombolytic therapy,
occluded infarct-related arteries had opened in 62% of 113 patients in the
rt-PA and 31% of 119 patients in the SK group (p less than .001). Twice as
many occluded infarct-related arteries opened after rt-PA compared with SK
at the time of each of seven angiograms obtained during the first 90 min
after commencing thrombolytic therapy. Regardless of the time from onset of
symptoms to treatment, more arteries were opened after rt-PA than SK. The
reduction in circulating fibrinogen and plasminogen and the increase in
circulating fibrin split products at 3 and 24 hr were significantly less in
patients treated with rt-PA than in those treated with SK (p less than
.001). The occurrence of bleeding events, administration of blood
transfusions, and reocclusion of the infarct-related artery was comparable
in the two groups. Thus, in patients with acute myocardial infarction,
rt-PA elicited reperfusion in twice as many occluded infarct-related
arteries as compared with SK at each of seven serial observations during
the first 90 min after onset of treatment.
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W.-C. Wu and P. C. Gordon Invasive Management of Patients With ST Elevation Myocardial Infarction With > 12-h Delay in Presentation: The Question Remains Unanswered Chest, July 1, 2004; 126(1): 2 - 4. [Full Text] [PDF]
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P Elsman, A.W.J van `t Hof, M.J de Boer, J.C.A Hoorntje, H Suryapranata, J.H.E Dambrink, F Zijlstra, and on behalf of the Zwolle Myocardial Infarction Stud Role of collateral circulation in the acute phase of ST-segment-elevation myocardial infarction treated with primary coronary intervention Eur. Heart J., May 2, 2004; 25(10): 854 - 858. [Abstract] [Full Text] [PDF]
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C. M. Gibson, J. Karha, S. A. Murphy, J. A. de Lemos, D. A. Morrow, R. P. Giugliano, M. T. Roe, R. A. Harrington, C. P. Cannon, E. M. Antman, et al. Association of a pulsatile blood flow pattern on coronary arteriography and short-term clinical outcomes in acute myocardial infarction J. Am. Coll. Cardiol., April 7, 2004; 43(7): 1170 - 1176. [Abstract] [Full Text] [PDF]
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A. F. Merry, P. J. Raudkivi, N. G. Middleton, J. M. McDougall, P. Nand, B. P. Mills, B. J. Webber, C. M. Frampton, and H. D. White Bivalirudin versus heparin and protamine in off-pump coronary artery bypass surgery Ann. Thorac. Surg., March 1, 2004; 77(3): 925 - 931. [Abstract] [Full Text] [PDF]
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E M Wong, C Pawsey, and H C Lowe Evidence for "lumen sealing" with sirolimus eluting stents in the treatment of complex coronary artery dissection Heart, March 1, 2004; 90(3): e13 - 13. [Abstract] [Full Text] [PDF]
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M Sezer, Y Nisanci, B Umman, E Yilmaz, A Olcay, F Erzengin, and O Ozsaruhan New support for clarifying the relation between ST segment resolution and microvascular function: degree of ST segment resolution correlates with the pressure derived collateral flow index Heart, February 1, 2004; 90(2): 146 - 150. [Abstract] [Full Text] [PDF]
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P. G. Steg, E. Bonnefoy, S. Chabaud, F. Lapostolle, P.-Y. Dubien, P. Cristofini, A. Leizorovicz, P. Touboul, and for the Comparison of Angioplasty and Prehospital Impact of Time to Treatment on Mortality After Prehospital Fibrinolysis or Primary Angioplasty: Data From the CAPTIM Randomized Clinical Trial Circulation, December 9, 2003; 108(23): 2851 - 2856. [Abstract] [Full Text] [PDF]
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T Hozumi, Y Kanzaki, Y Ueda, A Yamamuro, T Takagi, T Akasaka, S Homma, K Yoshida, and J Yoshikawa Coronary flow velocity analysis during short term follow up after coronary reperfusion: use of transthoracic Doppler echocardiography to predict regional wall motion recovery in patients with acute myocardial infarction Heart, October 1, 2003; 89(10): 1163 - 1168. [Abstract] [Full Text] [PDF]
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A. Schomig, G. Ndrepepa, J. Mehilli, M. Schwaiger, H. Schuhlen, S. Nekolla, J. Pache, S. Martinoff, H. Bollwein, and A. Kastrati Therapy-Dependent Influence of Time-to-Treatment Interval on Myocardial Salvage in Patients With Acute Myocardial Infarction Treated With Coronary Artery Stenting or Thrombolysis Circulation, September 2, 2003; 108(9): 1084 - 1088. [Abstract] [Full Text] [PDF]
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R. P. Giugliano, M. T. Roe, R. A. Harrington, C. M. Gibson, U. Zeymer, F. Van de Werf, K. W. Baran, H.-P. Hobbach, L. H. Woodlief, K. L. Hannan, et al. Combination reperfusion therapy with eptifibatide and reduced-dose tenecteplase for ST-elevation myocardial infarction: Results of the integrilin and tenecteplase in acute myocardial infarction (INTEGRITI) Phase II Angiographic urial J. Am. Coll. Cardiol., April 16, 2003; 41(8): 1251 - 1260. [Abstract] [Full Text] [PDF]
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E. Balcells, E. R. Powers, W. Lepper, T. Belcik, K. Wei, M. Ragosta, H. Samady, and J. R. Lindner Detection of myocardial viability by contrast echocardiography in acute infarction predicts recovery of resting function and contractile reserve J. Am. Coll. Cardiol., March 5, 2003; 41(5): 827 - 833. [Abstract] [Full Text] [PDF]
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A. J. Karavidas, A. D. Vrachatis, M. A. Alpert, D. J. Nikas, D. J. Achtypis, M. G. Foukarakis, E. P. Matsakus, C. S. Thedocharis, and A. A. Zacharoulis Primary Stenting Produces Earlier and More Efficient Myocardial Reperfusion than Primary PTCA Alone in Patients with Acute ST Segment Elevation MI Angiology, March 1, 2003; 54(2): 195 - 203. [Abstract] [PDF]
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S. R. Mehta and S. Yusuf Short- and long-term oral antiplatelet therapy in acute coronary syndromes and percutaneous coronary intervention J. Am. Coll. Cardiol., February 19, 2003; 41(4_Suppl_S): 79S - 88S. [Abstract] [Full Text] [PDF]
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A. Yamamuro, T. Akasaka, K. Tamita, K. Yamabe, M. Katayama, T. Takagi, and S. Morioka Coronary Flow Velocity Pattern Immediately After Percutaneous Coronary Intervention as a Predictor of Complications and In-Hospital Survival After Acute Myocardial Infarction Circulation, December 10, 2002; 106(24): 3051 - 3056. [Abstract] [Full Text] [PDF]
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P. Voci, E. Mariano, F. Pizzuto, P. E. Puddu, and F. Romeo Coronary recanalization in anterior myocardial infarction: The open perforator hypothesis J. Am. Coll. Cardiol., October 2, 2002; 40(7): 1205 - 1213. [Abstract] [Full Text] [PDF]
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Z. R. Yousef, S. R. Redwood, C. A. Bucknall, A. N. Sulke, and M. S. Marber Late intervention after anterior myocardial infarction: effects on left ventricular size, function, quality of life, and exercise tolerance: Results of the Open Artery Trial (TOAT Study) J. Am. Coll. Cardiol., September 4, 2002; 40(5): 869 - 876. [Abstract] [Full Text] [PDF]
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C.-K. Wong, J.K. French, M.W. Krucoff, W. Gao, P.E. Aylward, and H.D. White Slowed ST segment recovery despite early infarct artery patency in patients with Q waves at presentation with a first acute myocardial infarction. Implications of initial Q waves on myocyte reperfusion Eur. Heart J., September 2, 2002; 23(18): 1449 - 1455. [Abstract] [Full Text] [PDF]
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C. L. Grines, D. R. Westerhausen Jr, L. L. Grines, J. T. Hanlon, T. L. Logemann, M. Niemela, W. D. Weaver, M. Graham, J. Boura, W. W. O'Neill, et al. A randomized trial of transfer for primary angioplasty versus on-site thrombolysis in patients with high-risk myocardial infarction: The air primary angioplasty in myocardial infarction study J. Am. Coll. Cardiol., June 5, 2002; 39(11): 1713 - 1719. [Abstract] [Full Text] [PDF]
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M.-J. de Boer, J.-P. Ottervanger, A. W. J. van't Hof, J. C. A. Hoorntje, H. Suryapranata, F. Zijlstra, and the Zwolle Myocardial Infarction Study Group Reperfusion therapy in elderly patients with acute myocardial infarction: A randomized comparison of primary angioplasty and thrombolytic therapy J. Am. Coll. Cardiol., June 5, 2002; 39(11): 1723 - 1728. [Abstract] [Full Text] [PDF]
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E.M. Antman, H.A. Cooper, C.M. Gibson, J.A. de Lemos, C.H. McCabe, R.P. Giugliano, P. Coussement, S. Murphy, J. Scherer, K. Anderson, et al. Determinants of improvement in epicardial flow and myocardial perfusion for ST elevation myocardial infarction. Insights from TIMI 14 and InTIME-II Eur. Heart J., June 2, 2002; 23(12): 928 - 933. [Abstract] [Full Text] [PDF]
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J. L. Januzzi Jr, S. M. Snapinn, P. M. DiBattiste, I.-K. Jang, and P. Theroux Benefits and Safety of Tirofiban Among Acute Coronary Syndrome Patients With Mild to Moderate Renal Insufficiency: Results From the Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms (PRISM-PLUS) Trial Circulation, May 21, 2002; 105(20): 2361 - 2366. [Abstract] [Full Text] [PDF]
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C. K. Dyke, R. C. Becker, N. S. Kleiman, J. S. Hochman, E. G. Bovill, A. M. Lincoff, G. Gerstenblith, V. Dzavik, L. H. Gardner, V. Hasselblad, et al. First Experience With Direct Factor Xa Inhibition in Patients With Stable Coronary Disease: A Pharmacokinetic and Pharmacodynamic Evaluation Circulation, May 21, 2002; 105(20): 2385 - 2391. [Abstract] [Full Text] [PDF]
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R. A. Kerensky, M. Wade, P. Deedwania, W. E. Boden, C. J. Pepine, and Veterans Affairs Non-Q-Wave Infarction Strategies Revisiting the culprit lesion in non-Q-wave myocardial infarction: Results from the VANQWISH trial angiographic core laboratory J. Am. Coll. Cardiol., May 1, 2002; 39(9): 1456 - 1463. [Abstract] [Full Text] [PDF]
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J. A. Goldstein Angiographic plaque complexity: the tip of the unstable plaque iceberg J. Am. Coll. Cardiol., May 1, 2002; 39(9): 1464 - 1467. [Full Text] [PDF]
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H. Luciardi, S. Berman, J. Muntaner, F. De La Serna, and R. Altman Facilitated Thrombolysis: Dethrombosis? Clinical and Applied Thrombosis/Hemostasis, April 1, 2002; 8(2): 133 - 138. [Abstract] [PDF]
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C.-K. Wong, J.K. French, J. Andrews, M.J. Frey, A.A.J. Adgey, P.E. Aylward, and H.D. White Usefulness of the presenting electrocardiogram in predicting myocardial salvage with thrombolytic therapy in patients with a first acute myocardial infarction Eur. Heart J., March 1, 2002; 23(5): 399 - 404. [Abstract] [Full Text] [PDF]
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S D Carley, R Gamon, P A Driscoll, G Brown, and P Wallman What's the point of ST elevation? Emerg. Med. J., March 1, 2002; 19(2): 126 - 128. [Abstract] [Full Text] [PDF]
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S. J. Brener, U. Zeymer, A. A. J. Adgey, T. R. Vrobel, S. G. Ellis, K.-L. Neuhaus, N. Juran, T. B. Ivanc, E. M. Ohman, J. Strony, et al. Eptifibatide and low-dose tissue plasminogen activator in acute myocardial infarction: The integrilin and low-dose thrombolysis in acute myocardial infarction (INTRO AMI) trial J. Am. Coll. Cardiol., February 6, 2002; 39(3): 377 - 386. [Abstract] [Full Text] [PDF]
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