Circulation, Vol 75, 255-264, Copyright © 1987 by American Heart Association
M Nishibatake, ML Kirby and LH Van Mierop
To investigate the contribution of cranial neural crest cells to the
developing cardiovascular system in the chick embryo, cauterization of
various regions of cranial neural crest was performed. Five regions may be
distinguished, each of which contributes mesenchyme to pharyngeal
(branchial) arches 1 through 4 and 6. Ablation of arch 3, 4, and 6 regions
resulted in a high incidence of persistent truncus arteriosus (PTA)
associated with anomalies of the aortic arch. Dextroposed aorta (DPA) or
anomalies of the inflow tract were found in all ablation groups. Although
anomalies of the aortic arch arteries were induced in all ablation groups
and were usually associated with intracardiac anomalies, those of the third
and right fourth aortic arch were most frequent in the arch 4 and arch 4 +
6 groups. Anomalies of the sixth aortic arch were most frequent after
extensive ablations that included the arch 6 region. We speculate that PTA
is a direct result of the decreased population of mesenchymal cells derived
from the arch 3 through 6 neural crest regions. DPA or anomalies of the
inflow tract may be related to altered hemodynamics due to anomalies
induced by neural crest ablation. Anomalies of the aortic arch arteries may
be caused by either the direct or indirect process.
ARTICLES
Pathogenesis of persistent truncus arteriosus and dextroposed aorta in the chick embryo after neural crest ablation
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