Circulation, Vol 75, 106-114, Copyright © 1987 by American Heart Association
GL Burke, RA Arcilla, WS Culpepper, LS Webber, YK Chiang and GS Berenson
M mode echocardiograms were obtained from 654 healthy subjects, 7 to 22
years of age, whose diastolic blood pressure levels remained in the same
height-, race-, and sex-specific decile during two biannual examinations.
Echocardiographic measures of heart size, obtained according to the
recommendations of the American Society for Echocardiography, were compared
across the entire systolic and diastolic blood pressure distributions.
Echocardiographic indexes of left heart size varied as a function of both
blood pressure levels and body size. Significant positive correlations were
present between systolic blood pressure and different measures of left
ventricular size. Left ventricular wall thickness in systole correlated
with systolic blood pressure (r = .42, p less than .0001), and persistence
of this relationship was noted after adjustment for body size. Left
ventricular wall thickness in diastole correlated with blood pressure
before adjustment (r = .31, p less than .0001), but the relationship was
not significant after adjustment for body size. The ratio of left
ventricular thickness to chamber size (systole) correlated with systolic
blood pressure levels both before and after adjustment for body size (r =
.20 and r = .22, p less than .001). Male subjects of both races
demonstrated significantly higher adjusted left ventricular mass, left
ventricular wall thickness, and left ventricular chamber size. Adjusted
left ventricular wall stress was significantly related to both systolic (r
= .14) and diastolic blood pressure levels (r = .14, p less than .001).
Measures of left ventricular wall thickness increased throughout the entire
blood pressure distribution, indicating a consistent trend rather than a
threshold effect seen only in the highest blood pressure groups.(ABSTRACT
TRUNCATED AT 250 WORDS)
ARTICLES
Blood pressure and echocardiographic measures in children: the Bogalusa Heart Study
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