This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pasipoularides, A. Articles by Krayenbuehl, H. P. Search for Related Content PubMed PubMed Citation Articles by Pasipoularides, A. Articles by Krayenbuehl, H. P.

Circulation, Vol 74, 991-1001, Copyright © 1986 by American Heart Association

ARTICLES

Myocardial relaxation and passive diastolic properties in man

A Pasipoularides, I Mirsky, OM Hess, J Grimm and HP Krayenbuehl

We have developed a model for assessing the influence of the decaying contractile systolic tension on diastolic wall dynamics and the passive properties of left ventricular muscle. Total measured left ventricular diastolic pressure and stress (sigma T) are determined by two overlapping processes: the decay of actively developed pressure and stress (sigma A) and the buildup of passive filling pressure and stress (sigma*). The decaying contractile stress sigma A is formulated in terms of a relaxation pressure with a time constant (T) assessed during the isovolumic relaxation interval. By subtracting the contribution of sigma A from sigma T we obtain sigma*. With micromanometry, echocardiography, and cineangiography, total and passive stress-strain relations and strain rates were evaluated over the entire filling period in six normal control subjects and in seven patients with aortic stenosis. Elastic stiffness constants (k), the slopes of the linear passive stiffness vs sigma* relations, did not differ in the two groups over a common lower stress range (6/6 normal, k = 9.37 +/- 1.23; 7/7 aortic stenosis, k = 9.34 +/- 1.08). Over a higher sigma* range, transition into a much steeper linear region occurred, and k values were much larger (4/7 aortic stenosis, k = 28.76 +/- 2.02). When diastolic stress levels are elevated, passive stiffness-stress relations can be better described as bilinear, with a much greater wall stiffness constant in the higher than in the lower stress range. Dynamic effects of decaying systolic contractile wall stress components are important in the rapid filling phase in normal hearts as well as in those with aortic stenosis.

This article has been cited by other articles:

				W. Zhang and S. J. Kovacs The diastatic pressure-volume relationship is not the same as the end-diastolic pressure-volume relationship Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2750 - H2760. [Abstract] [Full Text] [PDF]

				W. A. Jaber, C. S. P. Lam, D. M. Meyer, and M. M. Redfield Revisiting methods for assessing and comparing left ventricular diastolic stiffness: impact of relaxation, external forces, hypertrophy, and comparators Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2738 - H2746. [Abstract] [Full Text] [PDF]

				M. R. Zile, C. F. Baicu, and W. H. Gaasch Diastolic Heart Failure -- Abnormalities in Active Relaxation and Passive Stiffness of the Left Ventricle N. Engl. J. Med., May 6, 2004; 350(19): 1953 - 1959. [Abstract] [Full Text] [PDF]

				A. D. Pasipoularides, M. Shu, A. Shah, and D. D. Glower Right ventricular diastolic relaxation in conscious dog models of pressure overload, volume overload, and ischemia J. Thorac. Cardiovasc. Surg., November 1, 2002; 124(5): 964 - 972. [Abstract] [Full Text] [PDF]

				A. Pasipoularides, M. Shu, A. Shah, S. Silvestry, and D. D. Glower Right ventricular diastolic function in canine models of pressure overload, volume overload, and ischemia Am J Physiol Heart Circ Physiol, November 1, 2002; 283(5): H2140 - H2150. [Abstract] [Full Text] [PDF]

				A. C. Cicogna, K. G. Robinson, C. H. Conrad, K. Singh, R. Squire, M. P. Okoshi, and O. H. L. Bing Direct Effects of Colchicine on Myocardial Function : Studies in Hypertrophied and Failing Spontaneously Hypertensive Rats Hypertension, January 1, 1999; 33(1): 60 - 65. [Abstract] [Full Text] [PDF]

				A. Banerjee, A. M. Mendelsohn, T. K. Knilans, R. A. Meyer, and D. C. Schwartz Effect of myocardial hypertrophy on systolic and diastolic function in children: insights from the force-frequency and relaxation-frequency relationships J. Am. Coll. Cardiol., October 1, 1998; 32(4): 1088 - 1095. [Abstract] [Full Text] [PDF]

				C. H. Conrad, W. W. Brooks, J. A. Hayes, S. Sen, K. G. Robinson, and O. H. L. Bing Myocardial Fibrosis and Stiffness With Hypertrophy and Heart Failure in the Spontaneously Hypertensive Rat Circulation, January 1, 1995; 91(1): 161 - 170. [Abstract] [Full Text]

				J. R. Fioretto, S. S. Querioz, C. R. Padovani, L. S. Matsubara, K. Okoshi, and B. B. Matsubara Ventricular remodeling and diastolic myocardial dysfunction in rats submitted to protein-calorie malnutrition Am J Physiol Heart Circ Physiol, April 1, 2002; 282(4): H1327 - H1333. [Abstract] [Full Text] [PDF]