Circulation, Vol 74, 431-441, Copyright © 1986 by American Heart Association
TI Musch, RL Moore, DJ Leathers, A Bruno and R Zelis
The response to exercise was investigated in trained and sedentary rats
with moderate compensated heart failure produced by myocardial infarction
(MI) and in rats that underwent sham operations. Trained rats ran on a
treadmill (10% grade at 20 m/min) for 60 min/day, 5 days/week for 10 to 12
weeks, whereas sedentary rats had only limited activity. Maximal oxygen
consumption normalized for body weight (ml kg- 1 min-1) was determined for
each rat and found to be (1) greater in trained rats when compared with
sedentary rats and (2) greater in sham- operated rats when compared with
their counterparts that suffered infarction. In addition, skeletal muscle
succinate dehydrogenase activities were greater and the blood lactic acid
response to submaximal exercise was lower in trained rats compared with
sedentary rats. Left ventricular infarct size for sedentary and trained
rats with infarction was 36 +/- 3% and 34 +/- 3% of the total endocardial
circumference, respectively, and resulted in (1) elevated left ventricular
end-diastolic pressures at rest and during exercise, (2) lower mean
arterial pressures at rest, and (3) lower maximal heart rates when compared
with those in their sham-operated counterparts. However, normalization of
mean arterial pressures during submaximal and maximal exercise was found
along with a trend toward normalization of maximal heart rate when trained
rats with infarction were compared with their sedentary counterparts. Blood
flows to the kidneys, organs of the gut, and skeletal muscle during both
submaximal and maximal exercise were unaffected by either myocardial
infarction or training; no differences between sedentary and trained rats
with infarction and sedentary and trained sham-operated rats were found.
These results demonstrate that an exercise training program of moderate
intensity produces beneficial hemodynamic and metabolic effects in rats
with moderate compensated heart failure.
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