This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kugiyama, K. Articles by Takahashi, M. Search for Related Content PubMed PubMed Citation Articles by Kugiyama, K. Articles by Takahashi, M.

Circulation, Vol 74, 374-380, Copyright © 1986 by American Heart Association

ARTICLES

Effects of propranolol and nifedipine on exercise-induced attack in patients variant angina: assessment by exercise thallium-201 myocardial scintigraphy with quantitative rotational tomography

K Kugiyama, H Yasue, Y Horio, Y Morikami, H Fujii, Y Koga, A Kojima and M Takahashi

To examine the effects of propranolol and nifedipine on exercise- induced attack in patients with variant angina, exercise 201Tl myocardial scintigraphy with quantitative analysis by emission-computed tomography was performed in 20 patients with variant angina after oral propranolol (80 mg), nifedipine (20 mg), and placebo. Exercise-induced attack occurred in 11 patients on placebo, in 14 on propranolol, and in none on nifedipine. The exercise duration was significantly shorter in those on propranolol (p less than .05), but significantly longer in patients on nifedipine (p less than .05) than in those on placebo. The peak rate-pressure product was significantly lower in patients on propranolol (p less than .01), but did not change in those on nifedipine, as compared with that in patients on placebo. The size of the perfusion defect as measured by 201Tl tomography was significantly greater in patients on propranolol (p less than .05), but significantly less in those on nifedipine (p less than .01) than in those on placebo. In conclusion, propranolol does not suppress but rather may aggravate exercise-induced attack in patients with variant angina, while nifedipine suppresses it. This unfavorable effect of propranolol on exercise-induced attack in patients with variant angina is likely to be due to a reduction of regional myocardial blood flow.

This article has been cited by other articles:

				V. Piriou, A. Aouifi, and J.J. Lehot Interet des beta-bloquants en medecine perioperatoire. Premiere partie: notions fondamentales Can J Anesth, July 1, 2000; 47(7): 653 - 663. [Abstract] [Full Text] [PDF]