Circulation, Vol 74, 293-305, Copyright © 1986 by American Heart Association
FH Sheehan, EL Bolson, HT Dodge, DG Mathey, J Schofer and HW Woo
We sought to identify theoretical advantages and applications of the
centerline method for quantitative assessment of regional ventricular
function. Motion was measured along 100 chords constructed perpendicular to
a centerline drawn midway between the end-diastolic and end-systolic
contours, and normalized for heart size. Abnormality was expressed in units
of standard deviations from the mean motion in a normal reference
population to indicate both the severity and significance of the wall
motion abnormality. The mean abnormality averaged over 100 chords
correlated highly with the area ejection fraction (r = .97). The centerline
method uses a "sliding window" to measure motion where it is abnormal,
because assessment of wall motion in predefined regions of the ventricular
contour underestimates abnormality. From the 100 data points, the extent (%
of contour) of regional abnormalities can also be determined. The severity
of hypokinesis at the site of acute myocardial infarction correlated better
with infarct size estimated from creatine kinase release (r = - .78) than
did the ejection fraction or the circumferential extent of hypokinesis.
Because the centerline method measures motion along locally determined
vectors, and requires no apex, origin, coordinate system, or geometric
reference figure, it can be applied to contours as dissimilar as the 60
degree left anterior oblique projection of the left ventricle and the 75
degree left anterior oblique projection of the right ventricle.
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Advantages and applications of the centerline method for characterizing regional ventricular function
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T. Sakuma, Y. Hayashi, K. Sumii, M. Imazu, and M. Yamakido Prediction of short- and intermediate-term prognoses of patients with acute myocardial infarction using myocardial contrast echocardiography one day after recanalization J. Am. Coll. Cardiol., October 1, 1998; 32(4): 890 - 897. [Abstract] [Full Text] [PDF]
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C. A. Schneider, E. Voth, S. Gawlich, F. M. Baer, M. Horst, H. Schicha, E. Erdmann, and U. Sechtem Significance of rest technetium-99m sestamibi imaging for the prediction of improvement of left ventricular dysfunction after q wave myocardial infarction: importance of infarct location adjusted thresholds J. Am. Coll. Cardiol., September 1, 1998; 32(3): 648 - 654. [Abstract] [Full Text] [PDF]
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C. A. Rinaldi, A. Z. Linka, N. D. Masani, P. G. Avery, E. Jones, H. Saunders, and R. J. C. Hall Randomized, Double-Blind Crossover Study to Investigate the Effects of Amlodipine and Isosorbide Mononitrate on the Time Course and Severity of Exercise-Induced Myocardial Stunning Circulation, August 25, 1998; 98(8): 749 - 756. [Abstract] [Full Text] [PDF]
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M. E. Pfusterer, P. Buser, S. Osswald, P. Weiss, J. Bremerich, and F. Burkart Time dependence of left ventricular recovery after delayed recanalization of an occluded infarct-related coronary artery: findings of a pilot study J. Am. Coll. Cardiol., July 1, 1998; 32(1): 97 - 102. [Abstract] [Full Text] [PDF]
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V. Dor, M. Sabatier, M. D. Donato, F. Montiglio, A. Toso, and M. Maioli Efficacy of endoventricular patch plasty in large postinfarction akinetic scar and severe left ventricular dysfunction: comparison with a series of large dyskinetic scars J. Thorac. Cardiovasc. Surg., July 1, 1998; 116(1): 50 - 59. [Abstract] [Full Text]
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M A Khan, S Sinha, S Hayton, S Fynn, R A Henderson, and D H Bennett A normal electrocardiogram precludes the need for left ventriculography in the assessment of coronary artery disease Heart, March 1, 1998; 79(3): 262 - 267. [Abstract] [Full Text]
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B. Pust and M. Surlan Pre-PTCA Detection of Chronic But Reversible Postischemic Myocardial Dysfunction by Nicardipine Angiology, February 1, 1998; 49(2): 115 - 127. [Abstract] [PDF]
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J Hancock, M R Thomas, S Holmberg, R J Wainwright, and D E Jewitt Randomised trial of elective stenting after successful percutaneous transluminal coronary angioplasty of occluded coronary arteries Heart, January 1, 1998; 79(1): 18 - 23. [Abstract] [Full Text] [PDF]
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C. A. Schneider, E. Voth, F. M. Baer, M. Horst, R. Wagner, and U. Sechtem QT Dispersion Is Determined by the Extent of Viable Myocardium in Patients With Chronic Q-Wave Myocardial Infarction Circulation, December 2, 1997; 96(11): 3913 - 3920. [Abstract] [Full Text]
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S. V. Pislaru, L. Barrios, T. Stassen, L. Jun, C. Pislaru, and F. Van de Werf Infarct Size, Myocardial Hemorrhage, and Recovery of Function After Mechanical Versus Pharmacological Reperfusion : Effects of Lytic State and Occlusion Time Circulation, July 15, 1997; 96(2): 659 - 666. [Abstract] [Full Text]
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J. Gorcsan III, D. P. Strum, W. A. Mandarino, V. K. Gulati, and M. R. Pinsky Quantitative Assessment of Alterations in Regional Left Ventricular Contractility With Color-Coded Tissue Doppler Echocardiography : Comparison With Sonomicrometry and Pressure-Volume Relations Circulation, May 20, 1997; 95(10): 2423 - 2433. [Abstract] [Full Text]
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E. R. Holman, V. G.M. Buller, A. de Roos, R. J. van der Geest, L. H.B. Baur, A. van der Laarse, A. V.G. Bruschke, J. H.C. Reiber, and E. E. van der Wall Detection and Quantification of Dysfunctional Myocardium by Magnetic Resonance Imaging: A New Three-dimensional Method for Quantitative Wall-Thickening Analysis Circulation, February 18, 1997; 95(4): 924 - 931. [Abstract] [Full Text]
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G. Horstick, A. Heimann, O. Gotze, G. Hafner, O. Berg, P. Boehmer, P. Becker, H. Darius, H.-J. Rupprecht, M. Loos, et al. Intracoronary Application of C1 Esterase Inhibitor Improves Cardiac Function and Reduces Myocardial Necrosis in an Experimental Model of Ischemia and Reperfusion Circulation, February 4, 1997; 95(3): 701 - 708. [Abstract] [Full Text]
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C. M. Kramer, W. J. Rogers, T. M. Theobald, T. P. Power, S. Petruolo, and N. Reichek Remote Noninfarcted Region Dysfunction Soon After First Anterior Myocardial Infarction: A Magnetic Resonance Tagging Study Circulation, August 15, 1996; 94(4): 660 - 666. [Abstract] [Full Text]
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H. Ito, A. Okamura, K. Iwakura, T. Masuyama, M. Hori, S. Takiuchi, S. Negoro, Y. Nakatsuchi, Y. Taniyama, Y. Higashino, et al. Myocardial Perfusion Patterns Related to Thrombolysis in Myocardial Infarction Perfusion Grades After Coronary Angioplasty in Patients With Acute Anterior Wall Myocardial Infarction Circulation, June 1, 1996; 93(11): 1993 - 1999. [Abstract] [Full Text]
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M. Natsuaki, T. Itoh, S. Tomita, K. Furukawa, M. Yoshikai, H. Suda, and H. Ohteki Importance of Preserving the Mitral Subvalvular Apparatus in Mitral Valve Replacement Ann. Thorac. Surg., February 1, 1996; 61(2): 585 - 590. [Abstract] [Full Text]
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H. Ito, A. Maruyama, K. Iwakura, S. Takiuchi, T. Masuyama, M. Hori, Y. Higashino, K. Fujii, and T. Minamino Clinical Implications of the `No Reflow' Phenomenon : A Predictor of Complications and Left Ventricular Remodeling inReperfused Anterior Wall Myocardial Infarction Circulation, January 15, 1996; 93(2): 223 - 228. [Abstract] [Full Text]
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Y. Yabe, T. Muramatsu, H. Nakano, and K. Wagatsuma Efficacy and Issues of Emergent Percutaneous Transluminal Coronary Angioplasty: Comparison of Clinical Results in Younger and Elderly Patients Angiology, December 1, 1995; 46(12): 1085 - 1095. [Abstract] [PDF]
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G. A. Lamas, G. C. Flaker, G. Mitchell, S. C. Smith Jr, B. J. Gersh, C.-C. Wun, L. Moye, J. L. Rouleau, J. D. Rutherford, M. A. Pfeffer, et al. Effect of Infarct Artery Patency on Prognosis After Acute Myocardial Infarction Circulation, September 1, 1995; 92(5): 1101 - 1109. [Abstract] [Full Text]
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Y. Yabe and R. Tsukahara Percutaneous Transluminal Coronary Angioplasty for Culprit Lesions in Patients with Post Myocardial Infarction Angina Based on Dextrocardia and Anomalous Coronary Arteries: Case Reports and Methods Angiology, May 1, 1995; 46(5): 431 - 440. [Abstract] [PDF]
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Y. Okada, T. Shomura, Y. Yamaura, and J. Yoshikawa Comparison of the Carpentier and Duran Prosthetic Rings Used in Mitral Reconstruction Ann. Thorac. Surg., March 1, 1995; 59(3): 658 - 662. [Abstract] [Full Text]
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H. Ito, K. Iwakura, H. Oh, T. Masuyama, M. Hori, Y. Higashino, K. Fujii, and T. Minamino Temporal Changes in Myocardial Perfusion Patterns in Patients With Reperfused Anterior Wall Myocardial Infarction : Their Relation to Myocardial Viability Circulation, February 1, 1995; 91(3): 656 - 662. [Abstract] [Full Text]
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C. L. Grines, E. J. Topol, W. W. O'Neill, B. S. George, D. Kereiakes, H. R. Phillips, J. D. Leimberger, L. H. Woodlief, and R. M. Califf Effect of Cigarette Smoking on Outcome After Thrombolytic Therapy for Myocardial Infarction Circulation, January 15, 1995; 91(2): 298 - 303. [Abstract] [Full Text]
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T. Brzostek, F. Van de Werf, I. Scheys, L. Mortelmans, A. Aubert, J. S. Dubiel, and H. De Geest Determinants of Left Ventricular Function Two Weeks and One Year After an Acute Myocardial Infarction Angiology, January 1, 1995; 46(1): 27 - 36. [Abstract] [PDF]
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Y. Okita, S. Miki, Y. Ueda, T. Tahata, T. Sakai, and K. Matsuyama Mitral valve replacement with maintenance of mitral annulopapillary muscle continuity in patients with mitral stenosis J. Thorac. Cardiovasc. Surg., July 1, 1994; 108(1): 42 - 51. [Abstract] [Full Text]
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J. Muller-Ehmsen, K. L. Peterson, L. Kedes, P. Whittaker, J. S. Dow, T. I. Long, P. W. Laird, and R. A. Kloner Rebuilding a Damaged Heart: Long-Term Survival of Transplanted Neonatal Rat Cardiomyocytes After Myocardial Infarction and Effect on Cardiac Function Circulation, April 9, 2002; 105(14): 1720 - 1726. [Abstract] [Full Text] [PDF]
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